Deformational field relations, compositional and U–Pb geochronological data of magmatic rocks of the northwestern Colombian Andes provide insights to recognize the different pre to post-collisional stages in an arc-arc collisional scenario until the re-initiation of a new subduction zone. A western belt of undeformed to mylonitized volcanic rocks with flat REE patterns and a weak LREE depletion present similar geochemical features of adjacent oceanic plateau basalts that were intruded by arc-related dykes at ca. 82 Ma, before their accretion to the continental margin. A sequence of greenschist and quartz + muscovite + graphite schist, and their associated mylonitized dikes, are part of the eastern continental arc, and present ages between 69 and 71 Ma, show tholeiitic affinity, flat rare-earth patterns, and Nb–Ti anomalies. These characteristics mark a decrease in the mantle wedge and older crustal signatures during magma genesis, as the oceanic-continent collision was advancing. Both suites were metamorphosed in a high geothermal gradient with temperatures between 490 and 400 °C and pressures between 2 and 4 Kbar. After this metamorphic event associated to the end of the collision a series of dykes intrude the different units at ca. 58 Ma, including basalts and andesites with Nb–Ti anomalies, adakite-like, and high niobium compositional signatures, suggesting that they were probably formed associated with slab melting in a young subduction environment that evolved after 62 Ma, following a ≤7 Ma magmatic hiatus. This magmatic and metamorphic record can be related to an arc-arc collision scenario in which mantle involvement in the late stages of collision influence both the magmatic and thermal regimes.