Formulation of the problem. The growth of cities numbers and their population determines the urgent need to study urban demographic processes. According to the UN [2], in 2007, urban population of the world exceeded the rural population and accounted for 54%, respectively, while the figure continues to grow. Most studies of global cities are reduced to building their hierarchical classification and studying global networks. Therefore, an increase in the proportion of urban population, in particular, population of global cities which are currently the leading centers of economic, financial, political, cultural and social development, makes the study of the demographic processes of these territories more urgent.The purpose of the article. The purpose of this study is to analyze the population dynamics of the global cities in Eastern European region.Results. The vast majority of studies and their corresponding publications devoted to global cities, in their essence, has a theoretical component and is the basis for the emergence of global cities concept. Despite a large number of publications, most authors emphasize the importance of the economic component in the development of world cities in their research, in relation to the demographic situation, which is considered only as one of the factors in the development of global cities.Current political and economic situation in Europe and the fact that more than 30% of the population lives in this macro-region makes the formation of an interest in studying the countries of East European region, and, in particular, the cities.The conducted research on the dynamics of population size and the share of the population of the global cities in East European region in the respective countries allowed us to group the studied cities according to the indicators (Fig. 5). Analyzing population dynamics, it can be concluded that most of the global cities of the region are attractive for the inhabitants, which is expressed in the increase of this indicator for the period of research. Analyzing the proportion of urban population in the total population of the countries, it can be argued that with the preservation of existing trends in the development of such cities as Bratislava, Wroclaw and Budapest, their loss of global status is possible.Consequently, the dynamics of the number is an important factor in the development of global cities and regions in general, and it directly affects their status and demographic characteristics of the rest of the territory.