East Asian Participants Research Articles

Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies.

Despite the dramatic underrepresentation of non-European populations in human genetics studies, researchers continue to exclude participants of non-European ancestry, as well as variants rare in European populations, even when these data are available. This practice perpetuates existing research disparities and can lead to important and large effect size associations being missed. Here, we conducted genome-wide association studies (GWAS) of 31 serum and urine biomarker quantitative traits in African (n=9354), East Asian (n=2559) and South Asian (n=9823) ancestry UK Biobank (UKBB) participants. We adjusted for all known GWAS catalog variants for each trait, as well as novel signals identified in a recent European ancestry focused analysis of UKBB participants. We identify 7 novel signals in African ancestry and 2 novel signals in South Asian ancestry participants (p < 1.61E-10). Many of these signals are highly plausible, including a cis pQTL for the gene encoding gamma-glutamyl transferase and PIEZO1 and G6PD variants with impacts on HbA1c through likely erythrocytic mechanisms. This work illustrates the importance of using the genetic data we already have in diverse populations, with novel discoveries possible in even modest sample sizes.

Emotion regulation of social exclusion: a cross-cultural study

Social exclusion is harmful to basic human needs. Emotion regulation represents a potential coping strategy. As culture can influence how people react and regulate their emotions, this study examined whether emotional reaction and regulation in response to social exclusion differ between individualistic and collectivistic cultures. A total of 80 college students, half White (n = 40, recruited in Manchester, UK) and half East Asian (n = 40, recruited in Shenzhen, China) viewed social exclusion pictures expressed by same-race or other-race characters. Both groups of participants viewed these pictures under no-reappraisal (passive viewing) and reappraisal (reinterpretation) conditions. Participants rated their vicarious negative emotional experience after each picture presentation. Results showed that both White and East Asian participants expressed greater negative emotion and showed stronger emotion regulation effects when facing own-race social exclusion, i.e., the “own-race bias”. In addition, White participants were more capable of regulating the negative emotions elicited by social exclusion compared to East Asian participants. Findings highlight the importance of considering the role of culture in emotional reaction to and emotion regulation of social exclusion, which may help the development of appropriate interventions across diverse populations.

Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank.

To investigate cross-ancestry genetics of complex traits, we conducted a phenome-wide analysis of loci with heterogeneous effects across African, Admixed-American, Central/South Asian, East Asian, European and Middle Eastern participants of the UK Biobank (N = 441 331). Testing 843 phenotypes, we identified 82 independent genomic regions mapping variants showing genome-wide significant (GWS) associations (P < 5 × 10-8) in the trans-ancestry meta-analysis and GWS heterogeneity among the ancestry-specific effects. These included (i) loci with GWS association in one ancestry and concordant but heterogeneous effects among the other ancestries and (ii) loci with a GWS association in one ancestry group and an experiment-wide significant discordant effect (P < 6.1 × 10-4) in at least another ancestry. Since the trans-ancestry GWS associations were mostly driven by the European ancestry sample size, we investigated the differences of the allele frequency (ΔAF) and linkage disequilibrium regulome tagging (ΔLD) between European populations and the other ancestries. Within loci with concordant effects, the degree of heterogeneity was associated with European-Middle Eastern ΔAF (P = 9.04 × 10-6) and ΔLD of European populations with respect to African, Admixed-American and Central/South Asian groups (P = 8.21 × 10-4, P = 7.17 × 10-4 and P = 2.16 × 10-3, respectively). Within loci with discordant effects, ΔAF and ΔLD of European populations with respect to African and Central/South Asian ancestries were associated with the degree of heterogeneity (ΔAF: P = 7.69 × 10-3 and P = 5.31 × 10-3, ΔLD: P = 0.016 and P = 2.65 × 10-4, respectively). Considering the traits associated with cross-ancestry heterogeneous loci, we observed enrichments for blood biomarkers (P = 5.7 × 10-35) and physical appearance (P = 1.38 × 10-4). This suggests that these specific phenotypic classes may present considerable cross-ancestry heterogeneity owing to large allele frequency and LD variation among worldwide populations.

Differences in Predicted Warfarin Dosing Requirements Between Hmong and East Asians Using Genotype-Based Dosing Algorithms.

Warfarin's narrow therapeutic index and high variability in dosage requirements make dosage selection critical. Genetic factors are known to impact warfarin dosage selection. The Hmong are a unique Asian subpopulation numbering over 278,000 in the United States whose participation in genetics-based research is virtually nonexistent. The translational significance of early reports of warfarin pharmacogene differences in Hmong has not been evaluated. (i) To validate previously identified allele frequency differences relevant to warfarin dosing in Hmong versus East Asians and (ii) to compare predicted warfarin sensitivity and maintenance doses between a Hmong population and an East Asian cohort. DNA collected from two independent cohorts (n=236 and n=198) of Hmong adults were genotyped for CYP2C9 (*2, *3), VKORC1 (G-1639A), and CYP4F2 (*3). Allele frequencies between the combined Hmong cohort (n=433) and East Asians (n=1165) from the 2009 International Warfarin Pharmacogenetics Consortium (IWPC) study were compared using a χ2 test. Percentages of Hmong and East Asian participants predicted to be very sensitive to warfarin were compared using a χ2 test, and the predicted mean warfarin maintenance dose was compared with a t test. The allele frequencies of CYP2C9*3 in the combined Hmong cohort and CYP4F2*3 in the VIP-Hmong cohort are significantly different from those in East Asians (18.9% vs 3.0%, p<0.001 and 9.8% vs 22.1%, p<0.001, respectively). Comparing the combined Hmong cohort to the East Asian cohort, the percentage of participants predicted to be very sensitive to warfarin was significantly higher (28% vs 5%, p<0.01) and the mean predicted warfarin maintenance dose was significantly lower (19.8 vs 21.3mg/week, p<0.001), respectively. The unique allele frequencies related to warfarin when combined with nongenetic factors observed in the Hmong translate into clinically relevant differences in predicted maintenance dose requirements for Hmong versus East Asians.

Looking at the own-race bias: Eye-tracking investigations of memory for different race faces

ABSTRACT Humans remember the faces of members of their own race more accurately than the faces of members of other races, in an effect known as the own-race bias. Previous studies indicate that patterns of eye fixations play an important role in this bias, but the exact nature of their influence on face memory is not clear. The present study examined the role of eye fixations on memory for racially East Asian, Black, and White faces in East Asian and White participants. Results revealed greater looking at the eyes of East Asian and White faces than the eyes of Black faces, and greater looking at the nose/mouth of Black faces than the nose/mouth of East Asian and White faces. In addition, longer time looking at the eyes of all faces predicted better memory for all faces, and longer time looking at the nose/mouth of Black faces predicted better memory for Black faces. These findings are best characterized by a model of face memory in which the eyes are critical for all faces, but certain features (e.g., nose/mouth) may be additionally important for certain race faces (e.g., Black faces).

Discrepancies in East Asians’ perceived actual and ideal phenotypic facial features.

The present study tested for the existence of a phenotypic actual–ideal discrepancy in East Asians’ appraisals of their own faces, in the direction of idealizing a phenotypically “Whiter” face than they perceived themselves to have. The study was conducted in 2 phases. In the first phase, East Asian participants residing in the United States (N = 104; Mage = 18.73) came into the lab to have their photograph taken. They were sent a link to complete the second phase online. Participants were required to recall either their previous day, an experience of racial discrimination, or an experience of racial acceptance. They then selected their actual and ideal face from an array of faces comprising their actual face and 8 variants of their face that had been transformed to look phenotypically more “White” or more “East Asian.” A robust actual–ideal discrepancy emerged: Participants both idealized a phenotypically “Whiter” face and perceived themselves as having a more phenotypically “East Asian” face than they objectively did. This discrepancy arose irrespective of whether participants were reminded of an incident of racial discrimination or acceptance.

Emotion regulation difficulties and borderline personality disorder: The moderating role of race.

Borderline personality disorder (BPD) is a disorder characterized by emotion regulation (ER) difficulties. Although research indicates that patterns of ER differ across racial groups, few studies have examined the role of race in the ER-BPD association. This study sought to address this gap. Participants in this study identified as either East Asian, White, or Black, and were recruited from sites in Western Canada and the Southern United States. Two samples were included in this study: (a) 194 university students who self-reported BPD features and (b) 88 adults from the community who underwent diagnostic interviews and had a BPD diagnosis. All participants self-reported ER difficulties. Results revealed that race moderated the link between some aspects of ER difficulties and BPD. For instance, relations between (a) nonacceptance of emotions and BPD affect instability, (b) limited access to ER strategies and BPD identity disturbance, and (c) low emotional awareness and BPD diagnosis were stronger among White (vs. Black or East Asian) participants. Implications of these findings for the diagnosis and treatment of BPD across racial groups are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

How robust is the own-group face recognition bias? Evidence from first- and second-generation East Asian Canadians.

There is mounting evidence that North Americans are better able to remember faces of targets who belong to the same social group, and this is true even when the social groups are experimentally created. Yet, how Western cultural contexts afford the development of this own group face recognition bias remains unknown. This question is particularly important given that recent findings suggest that first-generation East Asian Canadians do not show this bias. In the current research, we examined the own-group bias among first- and second-generation East Asian Canadians, who vary systematically in their exposure to and engagement in a Western cultural context, and tested mediators that could explain any difference. In Study 1, second-generation East Asian Canadians showed better memory for same-group (vs. other-group) faces. In Studies 2 and 3, as well as a meta-analysis of all three studies, we found some additional evidence that second-generation East Asian Canadians show better memory for same-group (vs. other-group) faces, whereas first-generation East Asian Canadians do not, but only when each cultural group was examined separately in each study, as no interaction with generational status emerged. In Study 2, and in a higher powered pre-registered Study 3, we also examined whether second- (vs. first-) generational status had a positive indirect effect on same-group face recognition through the effects of acculturation and perceived relational mobility in the immediate social environment, however this mediation model was not supported by the data. Overall, the results provide some additional evidence that the effect of mere social categorization on face recognition may not be as consistently found among East Asian participants.

Cross-cultural exploration of the characteristics, content and themes of intrusive autobiographical memories recalled during depression

ABSTRACTThe recall of intrusive memories is highly prevalent during depression. While past research has examined memory themes and characteristics (e.g., frequency), possible cultural differences in these variables have not been investigated. Furthermore, cross-cultural research has documented content differences in voluntary autobiographical remembering, but such content analyses have not been conducted in regard to intrusive memories. This study, therefore, investigated the characteristics, content and themes of intrusive memories using a 2 (group: European Australian, East Asian) × 2 (depression: depressed, control) cross-sectional design. European Australian (n = 46) and East Asian (n = 45) participants living in Australia reported two memories in real-time using an online memory diary and rated the characteristics of their memories. East Asian participants reported more frequent and distressing memories, compared to European Australians, while the European Australian group reported more specific memories than the East Asian group. Most of the characteristics, themes and content variables, however, did not differ between cultural groups. Additionally, depressed participants, regardless of cultural group, reported more frequent, distressing and numbing memories, compared to healthy controls. These findings suggest that while depressive symptomatology impacts the experience of intrusive memories, memory content and characteristics are largely similar across the two cultural groups.

Kripkeans of the world, unite!

Abstract This paper revisits a study by Machery et al. (2004), suggesting that, in experimental versions of Kripke’s (1980) fictional cases on the use of proper names, Westerners are more likely than East Asian participants to show intuitions compatible with Kripke’s causal-historical (CH) theory of reference. We conducted two experiments, recruting participants from Norway and Bangladesh, either in English (experiment 1; N = 75) or in the participants’ native languages (experiment 2; N = 60), using modified cases and a new approach to data analysis. We replicated the results of Machery et al. (2004), but we show that the residual finding—i.e., that participants who are not aligned with CH produce responses consistent with a definite descriptions (DD) theory of reference—does not hold. Most participants in our experiments, and nearly all those who do not provide CH answers, respond as predicted by a theory that accommodates speaker’s reference in reasoning about uses of proper names, not according to DD. We suggest that cross-cultural variation in this task is real. However, explanations of variation within or across cultures need not invoke competing theories of reference (CH vs DD), and can be unified within a single, broadly Kripkean analysis that honors the basic distinction between semantic reference and speaker’s reference.

Differential item functioning of the Multidimensional Schizotypy Scale and Multidimensional Scale-Brief across ethnicity.

Schizotypy refers to traits or symptoms similar to schizophrenia, but in a diminished form, and schizotypy is thought to reflect a liability for the future development of schizophrenia. The Multidimensional Schizotypy Scale (MSS) is a new measure of schizotypy that improves on existing measures. The MSS contains full and brief subscales for positive, negative, and disorganized schizotypy. Although MSS scores have been validated in a variety of populations, the scales have not been thoroughly examined for differential item functioning in East Asian, Southeast Asian, Hispanic, Multiracial, and White participants. The current study included 567 East Asian, 351 Southeast Asian, 360 Hispanic, 230 Multiracial, and 345 White undergraduate participants from the United States. Overall, few of the items in the full or brief versions of the scales displayed differential item functioning across groups. The full and brief versions of the scales also displayed similar and not-significantly different validity coefficients with the Detachment and Psychoticism scales of the Personality Inventory for DSM-5. These findings suggest that the MSS measures the same constructs across ethnic groups, and the scale scores represent the same latent level of schizotypy among groups. Future research may use the MSS in these diverse groups without concern that the psychometric properties differ significantly among groups. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Culture variation in the average identity extraction: The role of global vs. local processing orientation

ABSTRACT Research has shown that observers often spontaneously extract a mean representation from multiple faces/objects in a scene even when this is not required by the task. This phenomenon, now known as ensemble coding, has so far mainly been based on data from Western populations. This study compared East Asian and Western participants in an implicit ensemble-coding task, where the explicit task was to judge whether a test face was present in a briefly exposed set of faces. Although both groups showed a tendency to mistake an average of the presented faces as target, thus confirming the universality of ensemble coding, East Asian participants displayed a higher averaging tendency relative to the Westerners. To further examine how a cultural default can be adapted to global or local processing demand, our second experiment tested the effects of priming global or local processing orientation on ensemble coding via a Navon task procedure. Results revealed a reduced tendency for ensemble coding following the priming of local processing orientation. Together, these results suggest that culture can influence the proneness to ensemble coding, and the default cultural mode is malleable to a temporary processing demand.

Measurement Invariance of the Self-Concept Clarity Scale across Race and Sex

Self-concept clarity refers to the extent to which one holds a coherent, consistent, and stable view of one’s attributes and conceptualization of the self. Self-concept clarity is related to a number of constructs including psychopathology, adaptive development, cultural identity, coping style, and leadership. The most commonly used measure is the Self-Concept Clarity Scale (SCCS; Campbell et al. 1996). The SCCS has been used in diverse groups and provides evidence that self-concept clarity varies among ethnicities and between sexes. This study tested the measurement invariance of SCCS scores across large samples of White (n = 696), East Asian (n = 794), Southeast Asian (n = 489), Pacific Islander (n = 238), and Multiracial (n = 490) participants, and between sexes. Findings indicate that the SCCS has configural, metric, scalar, and strict invariance among races and between sexes. The latent factor variance and means were also equal across groups. These results suggest that the SCCS measures the same construct among groups and that scores represent the same level of self-concept clarity among groups. The current study found small but statistically significant differences among races in SCCS scores, which likely represent actual differences in self-concept clarity rather than different psychometric properties among groups.

Comparative genetic architectures of schizophrenia in East Asian and European populations.

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (rg = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits

Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as an instrumental variable) and summary-level data from the consortia (43 single-nucleotide polymorphisms were used as an instrumental variable). Data from 180 056 participants from 49 studies were included. Type 2 diabetes and glycemic traits. This mendelian randomization analysis included 49 studies with 41 155 patients with T2D and 80 008 control participants from study-level data and 34 840 patients with T2D and 114 981 control participants from summary-level data. Study-level data showed that a 1-SD decrease in birth weight due to the genetic risk score was associated with higher risk of T2D among all participants (odds ratio [OR], 2.10; 95% CI, 1.69-2.61; P = 4.03 × 10-5), among European participants (OR, 1.96; 95% CI, 1.42-2.71; P = .04), and among East Asian participants (OR, 1.39; 95% CI, 1.18-1.62; P = .04). Similar results were observed from summary-level analyses. In addition, each 1-SD lower birth weight was associated with 0.189 SD higher fasting glucose concentration (β = 0.189; SE = 0.060; P = .002), but not with fasting insulin, 2-hour glucose, or hemoglobin A1c concentration. In this study, a genetic predisposition to lower birth weight was associated with increased risk of T2D and higher fasting glucose concentration, suggesting genetic effects on retarded fetal growth and increased diabetes risk that either are independent of each other or operate through alterations of integrated biological mechanisms.

Feeling misidentified: Understanding migrant's readiness to engage in health care screening

National Institute for Health and Research; Research for Patient Benefit; Public Health England; The Hepatitis C Trust; South East Asian Community Leaders and participants; Muslim Council of Britain; Woking Borough Council; The Royal Surrey County Hospital NHS Trust

The impact of depression and culture on responses to intrusive autobiographical memories: Cognitive appraisals, cognitive avoidance, and brooding rumination.

Those with depression ascribe more negative appraisals to intrusive autobiographical memories and use maladaptive strategies to regulate intrusive memory distress. However, it is unknown whether these patterns extend to East Asian samples. This study investigated the influence of culture and depression on intrusive remembering. The study used a 2 (group: European Australian, East Asian)×2 (depression: depressed, control) cross-sectional design, with an online intrusive memory diary. European Australian (n=46) and East Asian (n=45) participants living in Australia, with and without depression, reported two intrusive memories in real-time and completed self-report measures indexing their appraisals of the memories, and their use of cognitive avoidance and brooding rumination in response to the memories. East Asian participants reported significantly greater negative, control, and responsibility appraisals than European Australian participants. Regardless of cultural group, depressed participants endorsed greater maladaptive memory appraisals and brooding compared to controls. Additionally, among East Asian participants, those with depression cognitively avoided memories significantly more than controls. When comparing the two depressed groups, East Asians reported significantly greater brooding and avoidance in response to intrusive memories than Australians. The findings suggest that depression may be associated with some similar maladaptive responses to intrusive autobiographical memories across cultural groups. Clinical interventions targeting unhelpful responses may, therefore, be beneficial for those with depression, regardless of cultural background. Across both European Australian and East Asian cultures, depressed participants endorsed higher maladaptive intrusive memory appraisals and brooded more in response to memories. Clinical interventions targeting appraisals and emotion regulation in response to intrusive memories may be beneficial for those with depression across both cultural groups. Language and acculturation may have impacted findings, as measures were administered in English and in Australia. Replication using a cross-country design and larger sample would be beneficial to confirm findings.

Learning own- and other-race facial identities from natural variability

Exposure to multiple varying face images of the same person encourages the formation of identity representations which are sufficiently robust to allow subsequent recognition from new, never-before seen images. While recent studies suggest that identity information is initially harder to perceive in images of other- relative to own-race identities, it remains unclear whether these difficulties propagate to face learning, that is, to the formation of robust face representations. We report two experiments in which Caucasian and East Asian participants sorted multiple images of own- and other-race persons according to identity in an implicit learning task and subsequently either matched novel images of learnt and previously unseen faces for identity (Experiment 1) or made old/new decisions for new images of learnt and unfamiliar identities (Experiment 2). Caucasian participants demonstrated own-race advantages during sorting, matching, and old/new recognition, while corresponding effects were absent in East Asian participants with substantial other-race expertise. Surprisingly, East Asian participants showed enhanced learning for other-race identities during matching in Experiment 1, which may reflect their increased motivation to individuate other-race faces. Thus, our results highlight the importance of perceptual expertise for own- and other-race processing, but may also lend support to recent suggestions on how expertise and socio-cognitive factors can interact.

Intentionally remembering or forgetting own- and other-race faces: Evidence from directed forgetting.

People are better at remembering faces of their own relative to another ethnic group. This so-called own-race bias (ORB) has been explained in terms of differential perceptual expertise for own- and other-race faces or, alternatively, as resulting from socio-cognitive factors. To test predictions derived from the latter account, we examined item-method directed forgetting (DF), a paradigm sensitive to an intentional modulation of memory, for faces belonging to different ethnic and social groups. In a series of five experiments, participants during learning received cues following each face to either remember or forget the item, but at test were required to recognize all items irrespective of instruction. In Experiments 1 and 5, Caucasian participants showed DF for own-race faces only while, in Experiment 2, East Asian participants with considerable expertise for Caucasian faces demonstrated DF for own- and other-race faces. Experiments 3 and 4 found clear DF for social in- and outgroup faces. These results suggest that a modulation of face memory by motivational processes is limited to faces with which we have acquired perceptual expertise. Thus, motivation alone is not sufficient to modulate memory for other-race faces and cannot fully explain the ORB.

Cultural Differences in Interpersonal Emotion Regulation.

Cultural differences exist in the use of emotion regulation (ER) strategies, but the focus to date has been on intrapersonal ER strategies such as cognitive reappraisal. An emerging literature highlights the importance of interpersonal ER, which utilizes social cues to facilitate the regulation of emotional states. In cultures that place high value on social interconnectedness as integral to their collectivistic self-construal, including East Asian cultures, interpersonal ER strategies may be particularly effective in reducing negative affect but this has not been previously tested. In this study, two groups comprising East Asian (n = 48) and Western European (n = 38) participants were randomly assigned to receive a priming narration depicting the use of either interpersonal (e.g., social modeling, perspective taking) or intrapersonal (e.g., cognitive reappraisal) ER strategies during a stressful experience. They were then instructed to utilize similar ER strategies in an emotion reactivity task during which they viewed high arousing negative pictorial stimuli while their heart rate (HR), heart rate variability (high frequency power – HF-HRV) and subjective affective states were measured. First we found that the East Asian group reported higher use of interpersonal ER strategies of social modeling and perspective taking in daily life. During the experimental interpersonal prime exposure, the East Asian group showed elevated HF-HRV (relative to baseline) compared to the Western European group, indicating more adaptive ER, but this pattern was not sustained during the reactivity or recovery phases. Instead, the East Asian group demonstrated increased HF-HRV and decreased HR across both prime conditions. The East Asian group also showed greater decreases in positive affect across the course of the experiment. Furthermore, individual differences in social modeling and individualistic self-construal moderated the effect of the ER prime in the East Asian group at trend levels, and main effects for perspective taking and reappraisal were observed in the Western European group. The findings support the notion that engaging in interpersonal ER strategies may be more beneficial for East Asian groups when immediately exposed to a stressful situation, as these strategies are congruent with cultural context and preferences, but our priming methodology may have limited the longer-term benefits.