East Anglia Research Articles

The association between intra-arrest arterial blood pressure and return of spontaneous circulation in out-of-hospital cardiac arrest

BackgroundThe optimal haemodynamic parameter for goal-directed resuscitation in out-of-hospital cardiac arrest (OHCA) remains uncertain. This study aimed to characterise the association between invasive blood pressure (IBP) measurements and return of spontaneous circulation (ROSC) in adult OHCA patients, to identify this parameter. MethodsA retrospective observational study was conducted at East Anglian Air Ambulance (EAAA). Adult (≥18 years) medical OHCA patients attended by EAAA between 01/02/2015 and 01/02/2024, who had arterial IBP measurement during chest compressions were included. The initial, minimum, maximum, average (mean) and Δ (maximum-initial) were calculated for systolic (SBP), diastolic (DBP) and mean arterial (MAP) components of IBP. Logistic regression and receiver operating characteristic curves tested the association between IBP variables and ROSC. ResultsDuring the study period, 4363 OHCA patients were attended and 80 met inclusion criteria. Thirty-four patients (42.5 %) achieved ROSC and 4 (5.0 %) survived to discharge. The maximum, average and Δ DBP; and maximum and average MAP were positively associated with ROSC. Maximum DBP had an AUC of 0.83 (95 % CI 0.74–0.92) with an optimal cut-off of 35 mmHg (sensitivity 94.1 %; specificity 58.7 %) for predicting ROSC. The odds ratio for ROSC was 1.05 (95 % CI 1.03–1.08) for every 1 mmHg increase in maximum DBP. ConclusionsThis study supports the use of arterial DBP as an important haemodynamic parameter for goal-directed resuscitation in adult OHCA. Maximising DBP may increase the chances of ROSC. These data suggest that a DBP threshold of 35 mmHg is optimal for identifying patients who may achieve ROSC with continued resuscitation.

Interview with Professor Colin Murrell

Prof. Colin Murrell, a distinguished microbiologist and Emeritus Professor at the University of East Anglia, UK, is well known for his contributions to various areas of environmental microbiology and microbial ecology. Prof. Murrell has received several awards, including election to membership of the European Molecular Biology Organisation, the European Academy of Microbiology, the Chinese Academy of Sciences Distinguished Professor (Einstein) Award. He was awarded a highly prestigious European Research Council Advanced Grant and has been member of many editorial boards of leading microbiological journals including Environmental Microbiology and the ISME Journal. He has graduated over 60 PhD students and supervised around 150 researchers throughout his career. His research interests are immense, extending from the development of analytical tools in molecular microbial ecology to their testing in the field, which is reflected in his extensive publication list of over 350 highly cited papers in prestigious journals. His pioneering research has significantly improved our understanding of microbial processes in diverse environments, from soil to aquatic and marine ecosystems. More recently, he has extended his scientific curiosity to karst and caves, in particular to the Movile Cave in Romania, which represents a cornerstone for understanding the role of chemolithoautotrophy in caves.

Migration patterns, habitat use and genetic origins of sea trout (Salmo trutta) in Norfolk chalk streams: implications for management of a mixed stock fishery

Sea trout, the anadromous ecotype of the species Salmo trutta, are subject to multiple threats, including exploitation and aquaculture impacts in the marine environment, habitat fragmentation and pollution in freshwaters, loss of genetic resilience due to interbreeding with hatchery strains and environmental change. Small streams contribute relatively little biomass to European sea trout stocks but are thought to be important in maintaining genetic diversity and therefore wider population resilience. The current study combined data from acoustic telemetry, stable isotopes, genetics and scalimetry to assess the current status of sea trout in the rivers Stiffkey and Glaven, two locally important chalkstreams in East Anglia, UK, to provide an evidence base for future management. The incidence of anadromy was low, and most sea trout were near migrants, residing in the lower reaches of rivers and close to the tidal outfalls. A small number migrated to the North Sea where they were vulnerable to exploitation in the coastal fishery, which comprises a mixed stock. Straying between the two rivers was recorded among 10% of sea trout, leading to apparent high gene flow. Nonetheless, genetic data also demonstrated structuring of River Glaven trout into two distinct groups. Quantification of patterns of freshwater and estuarine habitat use, and of passage at cross-channel obstructions, was used to identify where remedial measures such as habitat restoration would be most effectively targeted. Findings are discussed in the context of local supplementary stocking and the potential impact of the nearshore fishery on limited and vulnerable small stream anadromous trout populations.

A revised terrace stratigraphy and chronology for the Little Ouse River as a framework for interpreting the late Lower and early Middle Palaeolithic of central East Anglia, UK

The Breckland of central East Anglia has a Pleistocene geological sequence spanning c. 1 million years, providing a framework for assessing changes in human technology and behaviour within a single changing palaeolandscape. The geological record and its associated Palaeolithic archaeology divides into three chronological periods: the fluvial deposits of the River Bytham, which span c. 1 ma to 450 ka; the Hoxnian interglacial sites (c. 400 ka); and the fluvial terraces of the post-Anglian drainage network, which records the past c. 400,000 years. This paper focuses on the third of these periods, presenting results from new work on the fluvial sediments and Palaeolithic archaeology associated with the Little Ouse River. Fieldwork was conducted at four Palaeolithic sites; Barnham Heath, Redhill, Santon Downham, and Broomhill Pit. The new sedimentological and stratigraphic data are used in conjunction with existing borehole records to construct long profiles for the river terrace aggradations and establish a terrace stratigraphy for the Little Ouse. Correlation with the marine isotope record is supported by age estimates from electron spin resonance (ESR) dating of sand units within the terrace aggradations. The results provide an age-constrained lithostratigraphic framework for understanding the Lower and Middle Palaeolithic records of the Little Ouse. The results can be added to previous work on the Bytham and Hoxnian sites, enabling an assessment of human activity in the region from c. 800-200 ka.

Chloride in the Chalk aquifer of East Anglia, UK, Part 1: Distribution of chloride in brackish and saline groundwater

The Chalk aquifer of East Anglia is heavily exploited as a groundwater source. During exploration and exploitation, it has become clear that some of the groundwater in the Chalk is brackish and unsuitable for drinking (>250 mg/l chloride). Data comprising chemical analyses of pumped water samples and borehole depth samples (> 900 results in total), and downhole geophysical surveys have been used to assemble maps of the distribution of chloride areally and with depth. Brackish or saline water is probably present at depth in the Chalk, even where shallow fresh water is present, over much of the area where Crag Group marine sediments have been deposited. The depth below surface at which brackish water is encountered varies between 50 to >100 m, and the elevation of the transition varies from +16 mAOD to below 91 mAOD. From its chemistry it is deduced that most of the brackish water is of ancient marine origin, but that there has been localised intrusion of modern seawater in coastal areas, especially around Ipswich. Saline water most probably entered the aquifer during Crag Group times (late Pliocene-early Pleistocene) and its chemistry has been modified subsequently. The most saline old water that has been encountered has full marine salinity.

Chloride in the Chalk aquifer of East Anglia, UK, Part 2: Causes of elevated chloride in fresh water

Chloride in the Chalk aquifer of East Anglia, UK, Part 2: Causes of elevated chloride in fresh water

Long term changes in Chalk groundwater quality in East Anglia, UK

Groundwater abstraction quantity from the Chalk is limited to what is sustainable. Water quality data collected in the 1970s and 1980s have been compared with modern water quality monitoring data for 25 public supply abstraction sites. This comparison has established that there has been both substantial (magnitude) and significant (statistical) change in composition at all sites. Identified changes generally represent real changes in groundwater composition. At some sites in the south of the area considered, water that is not the result of present-day recharge processes is being replaced by water from present-day recharge. It is also clear that, at those sites where ancient brackish water is known to be present at depth, it is generally not being mobilised by pumping. In the north of the area, changes are more subtle but there is a tendency of groundwater composition to approach the regional average, apart from calcium which is trending higher. Nitrate has not increased here, suggesting that reduction is a still-active process. Thus, although quantity has been sustained, quality is changing but not to a degree that impacts potable use.

Discord-based counterfactual explanations for time series classification

The opacity inherent in machine learning models presents a significant hindrance to their widespread incorporation into decision-making processes. To address this challenge and foster trust among stakeholders while ensuring decision fairness, the data mining community has been actively advancing the explainable artificial intelligence paradigm. This paper contributes to the evolving field by focusing on counterfactual generation for time series classification models, a domain where research is relatively scarce. We develop, a post-hoc, model agnostic counterfactual explanation algorithm that leverages the Matrix Profile to map time series discords to their nearest neighbors in a target sequence and use this mapping to generate new counterfactual instances. To our knowledge, this is the first effort towards the use of time series discords for counterfactual explanations. We evaluate our algorithm on the University of California Riverside and University of East Anglia archives and compare it to three state-of-the-art univariate and multivariate methods.

Late Middle Pleistocene Wolstonian Stage (MIS 6) glaciation in lowland Britain and its North Sea regional equivalents – a review

Two major glaciations have been identified on land in England during the Middle Pleistocene. The earliest occurred during the Anglian Stage (= Elsterian, c. Marine Isotope Stage, MIS 12), evidence for which is best developed in lowland Britain, as well as offshore in the southern North Sea and Irish Sea basins. The second took place during the late Middle Pleistocene, with the most compelling evidence found in the West Midlands, intermediate between the Hoxnian (= Holsteinian; broadly MIS 11) and Ipswichian (= Eemian; broadly MIS 5e) interglacial stages during the Late Wolstonian Substage. Until recently this younger glacial episode was less clearly represented in the Pleistocene record and, as a result, had been little studied and weakly defined. Interpreted as the Moreton Stadial glaciation during the Late Wolstonian Substage (= Late Saalian Substage/Drenthe Stadial, c. MIS 6), it was originally recognized in the English Midlands, subsequently being identified in Yorkshire, Lincolnshire and northern East Anglia, and potentially further SW as far as the Bristol Channel. Mapping, in particular by members of the British Geological Survey, however, resulted in the Wolstonian Stage glacial deposits being thought to pre‐date the stage. This was particularly so in East Anglia where there was considerable controversy concerning the number and relationships of glacial sequences, during the 1970–1980s. Yet to the west of East Anglia there remained unequivocal evidence for glaciation during the stage, particularly in Fenland and the eastern English Midlands. Recent radiometric dating across lowland Britain on glacial sediments long thought to belong to a glaciation event in the Wolstonian Stage have now placed a geochronological control on the established regional stratigraphy and confirmed that glaciation occurred in two phases between 199 and 147 ka during the Late Wolstonian Substage. The glacial events of the British Middle Pleistocene can clearly be correlated with the European continent.

Engagement with online resources and widening participation status: observations from a large, diverse Foundation Year science cohort

Despite focused effort and attention over recent years, many potential barriers to progression and success remain within Higher Education. This study focuses on a cohort of 168 students studying on two semester-long Foundation Year Biological Sciences modules delivered at the University of East Anglia in the academic year 2021/22. These modules take place in consecutive semesters within the same academic year and specifically target students from underrepresented and widening participation backgrounds. This study seeks to understand whether a student’s widening participation background influences their engagement with online study resources. We analysed the engagement of individual students with resources provided on the virtual learning environment (VLE) and related this to POLAR4 quintiles. POLAR4 classifies local areas across the UK according to the young participation rate in Higher Education within that area. All POLAR4 categories saw lower modules marks as well as engagement with practice assessments VLE-hosted resources in the second of the two semesters. These differences were greatest for students from the lowest POLAR4 quintile, POLAR4q1. POLAR4q1 students have significantly lower average module grades than all other categories across both semesters but with the gap widest in semester 2, despite the student engagement score increasing. There was no difference in the engagement scores for students from POLAR4q1 backgrounds compared to others in their cohort during the autumn semester but in in the spring semester, students from POLAR4q1 backgrounds had on average, higher engagement scores. Students who grew up in a POLAR4q1 area are more likely to have had disrupted education journeys than their peers from other quintiles. As a result, it is likely they will need more than one intervention to be able to close the attainment gap that we see on these modules. We discuss this along with other potential causes and consequences for these findings alongside recommendations for interventions and further research.

Women of Influence: interdisciplinary participatory approaches to understanding female leadership in the Peruvian Amazon

The Mujeres que influyen (Women of Influence) project is a collaboration between researchers at University of East Anglia and PUCP, and young women from the Junín area of Peru who are members of the National Council of Indigenous Women of Peru. It takes its starting point from an acknowledgement that although women play a fundamental role in the preservation of biodiversity and ancestral knowledge, these contributions often go unrecognized and underdeveloped (Ketty Marcelo, 2018), to the detriment of the very culture and environment that should be preserved. Our women-led participatory project, uses film (production, screening, analysis) to highlight the potential and importance for active and organised participation by these young women in their communities in order to protect and nurture their natural resources. Working alongside Asháninka and Yanesha young women, we seek to demonstrate the value of young female involvement in community decision-making, addressing the cultural and societal inequalities that may disrupt their path to leadership and influence. In this paper, we focus on the methods developed in the project, particularly the value of participatory video production as a form of activism, with the outputs serving as creative manifestos in themselves. The co-designed activities have led us to reframe fieldwork as auto-ethnographic digital collaborations that have sought to disrupt power hierarchies and facilitate the co-production of new knowledge. We reflect on how our Indigenous partners have helped us rethink issues of sustainability, resilience and alternative strategies to respond to gender dynamics, political ecologies and environmental challenges.

Pride of the East: Motorcycle Speedway, Transnational Encounters and Provincial Heartlands

AbstractFor a century, speedway has operated on a transnational basis. Its riders, competitions and machinery regularly traverse national and continental borders. The imposition of the Cold War's Iron Curtain did little to impede its growth. This article focuses on one of speedway's far‐flung and diverse provincial heartlands to show how the sport generated frequent transnational and transsystemic interactions and forged deep relationships that often stood in contrast to the prevailing trends of international politics. As one of speedway's ‘entangled peripheries’, rural East Anglia owes a debt of gratitude to Australasian pioneers. From the 1950s—decades before imported talent became commonplace in football—the region welcomed Scandinavian and Eastern Bloc riders and hosted visiting clubs and national representations from across the continent. Later, East Anglia became a bridgehead for the successful assault of communist‐built machinery on the Western market. These bold endeavours were not without controversy, as British riders voiced objections to foreign men and machines deemed a threat to their livelihoods. The Cold War's end accelerated existing trends and also created exciting new opportunities for itinerant East Anglians abroad. Archival material, conversations with the sport's foreign trailblazers and fans, Swedish and Czechoslovak sources, photographs and official publications serve to demonstrate speedway's enduring ability to forge unexpected ties and give voice to regions at the so‐called margins of twentieth‐century history.

Diversity in Irish and British avifauna assemblages: What can variation in diversity profiles reveal about the forces that drive assemblage composition and structure?

Ireland and Britain are two islands located at Europe's westernmost edge, both of which act as the final breeding outposts for many bird species within their European ranges. Despite their similar geographic locations and geological histories, Ireland and Britain host different breeding avifauna assemblages. Diversity profiles, which can serve as more robust alternatives to classic diversity indices, were employed in this study to explore disparities in the two islands' breeding avifauna assemblages. Variations in assemblages were explored, along with their potential drivers, through analyses at three levels: island-scale breeding bird assemblage compositions, island-scale diversity profiles considering 49 common breeding species, and habitat-specific diversity profiles considering assemblages in east/central Irish farmland and East Anglian farmland. Analysis of the two islands' breeding avifauna assemblages revealed that the Irish assemblage is a complete subset of the British assemblage. Analyses of Irish and British assemblages at both an island scale and a habitat scale revealed patterns linking land use to trends within the two islands' avifauna assemblages. Irish assemblages contained greater proportions of insectivorous farmland species by abundance, while British assemblages contained greater proportions of seed-eating farmland species; both trends appeared to be related to structural differences in agricultural land use on the two islands. The British and East Anglian assemblages exhibited higher diversity across all analyses, which appeared to be driven by the assemblages' higher relative abundances of species that were most genetically distinct. This study highlights the ability of diversity profiles to impart more information than classic diversity indices by incorporating species similarity data.

Eigen-entropy based time series signatures to support multivariate time series classification

Most current algorithms for multivariate time series classification tend to overlook the correlations between time series of different variables. In this research, we propose a framework that leverages Eigen-entropy along with a cumulative moving window to derive time series signatures to support the classification task. These signatures are enumerations of correlations among different time series considering the temporal nature of the dataset. To manage dataset’s dynamic nature, we employ preprocessing with dense multi scale entropy. Consequently, the proposed framework, Eigen-entropy-based Time Series Signatures, captures correlations among multivariate time series without losing its temporal and dynamic aspects. The efficacy of our algorithm is assessed using six binary datasets sourced from the University of East Anglia, in addition to a publicly available gait dataset and an institutional sepsis dataset from the Mayo Clinic. We use recall as the evaluation metric to compare our approach against baseline algorithms, including dependent dynamic time warping with 1 nearest neighbor and multivariate multi-scale permutation entropy. Our method demonstrates superior performance in terms of recall for seven out of the eight datasets.

‘This has given me the peace of mind I needed’: ethnographic insights into Barrett’s oesophagus screening using the capsule sponge test

In 2021 and 2022, researchers carried out an implementation trial that considered how the capsule sponge test might be used to screen for Barrett’s oesophagus using a mobile clinic in...

Burhs, burghal territories and hundreds in the English central Midlands in the early tenth century (Part 2)

INTRODUCTION The first part of this paper has shown that the burghal territories of burhs created in the early tenth century in what later became Buckinghamshire and southwest Northamptonshire comprised one or more large ‘proto-hundreds’, typically of around 300–350 hides. As new cadastral units, these burghal territories are seen as essential aspect of the infrastructure of burghal formation. This hypothesis carries the implication that these units were subsequently subdivided into the hundreds of Domesday, which were typically of around 100 hides. From both a spatial and functional point of view these became subdivisions of the new shires which would have been formed at the same time. This thesis is examined here in the second part of this paper in relation to the development of burhs in the area of the shires of Bedfordshire, Hertfordshire and Middlesex, and of Huntingdonshire and Cambridgeshire further to the east. (The development of burhs in Essex is not considered here.) By the end of 917, as the Anglo-Saxon Chronicle makes clear, all this area (with Essex and East Anglia) had been taken under the control of King Edward the Elder, in effect extending the area of the West Saxon hegemony to the east coast.

Creation of an international laboratory network towards global microplastics monitoring harmonisation

Infrastructure is often a limiting factor in microplastics research impacting the production of scientific outputs and monitoring data. International projects are therefore required to promote collaboration and development of national and regional scientific hubs. The Commonwealth Litter Programme and the Ocean Country Partnership Programme were developed to support Global South countries to take actions on plastics entering the oceans. An international laboratory network was developed to provide the infrastructure and in country capacity to conduct the collection and processing of microplastics in environmental samples. The laboratory network was also extended to include a network developed by the University of East Anglia, UK. All the laboratories were provided with similar equipment for the collection, processing and analysis of microplastics in environmental samples. Harmonised protocols and training were also provided in country during laboratory setup to ensure comparability of quality-controlled outputs between laboratories. Such large networks are needed to produce comparable baseline and monitoring assessments.

Implementation of a point-of-care ultrasound archiving system and governance framework in a UK physician-paramedic staffed helicopter emergency medical service

IntroductionThere has been a rapid expansion in the use of point-of-care ultrasonography (POCUS) by emergency medical services (EMS). However, less than a third of UK EMS utilise imaging archiving for POCUS, and fewer review saved images as part of a clinical governance structure. This paper describes the implementation of a novel image archiving system and a robust clinical governance framework in our UK physician-paramedic staffed helicopter emergency medical service (HEMS).MethodsA retrospective database review was conducted of all patients attended by East Anglian Air Ambulance (EAAA) between the introduction of a new POCUS device and image archiving system on 1 December 2020 to 31 January 2024. All patients with recorded POCUS examinations were included. Images from POCUS examinations at EAAA are archived on a cloud-based server, and retrospectively reviewed within 24 h by an EAAA POCUS supervisor. Image quality is graded using a 5-point Likert-type scale, agreement between reviewer and clinician is recorded and feedback is provided on scanning technique. T-tests were used to assess the difference in image quality between physicians and paramedics. Inter-rater reliability between reviewers and clinicians was assessed using Cohen’s kappa (κ).ResultsDuring the study period, 5913 patients were attended by EAAA. Of these, 1097 patients had POCUS images recorded. The prevalence of POCUS during the study period was 18.6%. 1061 patient examinations underwent quality assurance (96.7%). The most common POCUS examination was echocardiography (60%), predominantly during cardiac arrest. The primary scanning clinician was a paramedic in 25.4% of POCUS examinations. Across all examination types; image quality was not significantly different between physicians and paramedics and agreement between reviewers and clinicians was strong (κ > 0.85).ConclusionsIn this service evaluation study, we have described outcomes following the introduction of a new POCUS device, image archiving system and governance framework in our HEMS. Paramedics were the primary scanning clinician in a quarter of scans, with image quality comparable to physicians. Almost all scans underwent quality assurance and inter-rater reliability was strong between clinicians and reviewers. Further research is required to investigate the diagnostic accuracy of POCUS and to demonstrate the effect of utilising prehospital POCUS to refine diagnosis on clinical outcomes.

An explainable dual-mode convolutional neural network for multivariate time series classification

Multivariate time series classification (MTSC) is a crucial machine learning problem prevalent across various real-life domains. Traditional deep learning approaches with high accuracy in MTSC are often criticized for their “black box” nature, offering no insight into their operational mechanisms or decision-making processes. Explainable artificial intelligence (XAI) becomes a key idea for dealing with such limitations in decision-sensitive areas. While some researchers have explored the interpretability of MTSC, the majority have focused on elucidating the relationship between variables over time, neglecting the intricate connections among different variables. To address the interpretability issue in MTSC, we introduce an explainable dual-mode convolutional neural network (XDM-CNN) designed specifically for MTSC. The proposed XDM-CNN framework comprises two modules: a classification module and an explanation module. The classification module can ensure exceptional classification performance by combining both one-dimensional and two-dimensional convolutional neural networks, while the explanation module can mine the underlying logical relationships among variables during the classification process by utilizing a synergy of visualization and quantification techniques. We validate our approach using 26 datasets sourced from the University of East Anglia (UEA) archive. The experimental results demonstrate that XDM-CNN not only exhibits excellent performance in classification accuracy, but also has strong explainability. By combining visual and numerical explanation, the hidden logical relationships among multivariate time series are explored and interpreted, providing human users with a decidable basis for classification decisions.

Influence of changes in solar activity on Nigerian Rainfall

This paper focuses on the impact of solar activity changes on rainfall in Nigeria. Rainfall data were got from Gridded Time Series (CRU TS v4) of the University of East Anglia, United Kingdom. Various statistical tools like Pearson rank correlation coefficient, regression analysis, covariance, skewness, and kurtosis are employed in the study. The results show that there are generally weak correlations between rainfall and solar activity in most seasons. However, low correlation coefficients (0.0424 and 0.1040, respectively for sunspot numbers and F10.7 mean a very weak positive relationship between early rainfall, main rainfall and annual rainfall and negative for dry season rainfall and Harmattan rainfall. Also, there is a negative time-series relationship between the rainfall amount in dry and Harmattan seasons, with the highest rainfall amount during low solar activity and vice versa. Therefore, it can be concluded that solar activity has little effect on Nigeria's annual and main season rainfall. However, during the dry season and Harmattan, heavy rainfall appears to be associated with low solar activity, while high solar activity appears to be associated with low rainfall. This study will be beneficial to farmers in Nigeria, majority of whom are peasant farmers that practice rain-fed farming.