The Alto Tiberina Fault system, located in Central Italy, is an active structure about 60 km long composed of a principal low-angle normal fault and several minor synthetic and antithetic splays. The system is monitored by a dense seismic network, giving us the opportunity to construct high-definition seismic catalogs with a low completeness magnitude. We analyze the clustering properties of the 2010-2015 seismicity by using a 3D stochastic declustering algorithm that also includes the earthquakes’ depth. We demonstrate that the earthquake size distribution is strongly correlated with the clustering of seismic events and their depth; in particular, the principal fault and secondary faults show an opposite behavior both in terms of earthquake size distribution and clustering properties.