One of the important things in structural planning is structural analysis. Indonesia has earthquake resistance guidelines for building structures starting from SNI 1726-1989 to the latest version, namely SNI 1726-2019. Yogyakarta Special Region is an active and complex seismic area due to tectonic plate collision activity accompanied by local fault activity on the mainland, so it has a high level of seismic activity, therefore structural planning must pay attention to seismic aspects. Not all buildings in the special area of Yogyakarta use the latest earthquake-resistant building structure guidelines, so a review of the structure must be reviewed. In analyzing the structure, there are two models, namely, 2D and 3D structural analysis using structural analysis software to obtain the internal force value. The study of internal force comparison between 2D and 3D models of dynamic response spectrum method according to SNI 1726-2019 is carried out on the 4-floor lecture building structure used to determine the advantages and disadvantages of the two models. The results of the internal force structure analysis show that the value of the internal force with the 2D model is greater than the 3D model due to differences in the distribution of the working load.