The multi-story buildings are constructed to accommodate numerous residents in confined spaces due to the growing population and lack of available land. The population growth and industrial revolution caused a migration of people from rural to urban areas resulting in the need for the construction of multi-story buildings for both residential and commercial uses. The tall buildings, which are not adequately constructed to resist lateral stresses, result in the total collapse of the structure. Buildings that can withstand earthquake forces are created by considering different criteria such as the building’s inherent frequency, damping factor, kind of base, significance of the building and ductility of the structure. Because they have better moment distribution properties, structures designed for ductility need to be designed for lower lateral loads. To ensure safety against the seismic stresses of multi-story buildings, it is essential to understand seismic analysis in order to develop earthquake-resistant structures. Both a regular moment resisting frame and a special moment-resisting frame were taken into account for the seismic study. In the present study, a G + 8 storey reinforced concrete (RC) structure in three different seismic zones was compared in terms of percentage longitudinal steel, reinforcement details, and design base shear. The structure was examined for seismic zones III, IV, and V in accordance with the guidelines of IS 1893 (Part 1): 2016. Results showed that base shear increased with the change in the seismic zone from III to V.