This paper discusses the concept of geotechnical seismic isolation (GSI) systems, characterized by new principles of action, to reduce seismic loads on buildings. The advantages and disadvantages of GSIs and their environmental and economic reliability are analyzed. The aim of the study is to develop a geotechnical seismic isolation system in the form of vertical barriers, using a rubber–soil mixture (RSM). The novelty of the work lies in the definition of effective structural and technical solutions of vertical seismic barriers made of RSM, characterized by reliability in providing seismic isolation. The ground and superstructure interactions are modeled in PLAXIS 2D software from 2021, using the finite element method, using the accelerogram of the Kobe and Northridge earthquakes. The results confirm the positive impact of using an RSM as an effective GSI geometrical. The results show that the GSI system using an RSM reduces horizontal accelerations by 60%. Significant acceleration reductions of 40–60% are also observed when the thickness and depth of GSI seismic barriers are increased. The results of the study contribute to the substantiation of methodology and scientific and technical efficiency of geotechnical seismic isolation as an economically favorable design alternative to the traditional seismic isolation system.