Earlier Work Research Articles

Cicchetti's organizational-developmental perspective of Down syndrome: Contributions to the emergence of developmental psychopathology and the study of persons with neurodevelopmental conditions.

Dante Cicchetti's earliest work, his studies of social-emotional development in infants and children with Down syndrome, set the stage for the emergence of the larger field of developmental psychopathology. By applying basic developmental principles, methodologies, and questions to the study of persons with Down syndrome, Dante took on the challenge of searching for patterns in atypical development. In doing so, he extended traditional developmental theory and introduced a more "liberal" approach that both continues to guide developmentally based research with persons with neurodevelopmental conditions (NDCs), including Down syndrome. We highlight five themes from Dante's work: (1) appreciating the importance of developmental level; (2) prioritizing the organization of development; (3) examining whether developmental factors work similarly in those with known genetic conditions; (4) rethinking narratives about ways of being; and (5) examining the influence of multiple levels of the environment on the individual's functioning. We highlight ways that these essential lessons anticipated present-day research with persons with a variety of NDCs, including Down syndrome, other genetic syndromes associated with intellectual disability, and autism. We conclude with visions to the future for research with these populations as well as for the field of developmental psychopathology more generally.

Development of a vocational rehabilitation intervention to support return-to-work and well-being following major trauma: a person-based approach

ObjectivesMajor trauma centres (MTCs) save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following...

HER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB family proteins.

Human epidermal growth factor receptors (HER)-also known as EGFR or ErbB receptors-are a subfamily of receptor tyrosine kinases (RTKs) that play crucial roles in cell growth, division, and differentiation. HER4 (ErbB4) is the least studied member of this family, partly because its expression is lower in later stages of development. Recent work has suggested that HER4 can play a role in metastasis by regulating cell migration and invasiveness; however, unlike EGFR and HER2, the precise role that HER4 plays in tumorigenesis is still unresolved. Early work on HER family proteins suggested that there are direct interactions between the four members, but to date, there has been no single study of all four receptors in the same cell line with the same biophysical method. Here, we quantitatively measure the degree of association between HER4 and the other HER family proteins in live cells with a time-resolved fluorescence technique called pulsed interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS). PIE-FCCS is sensitive to the oligomerization state of membrane proteins in live cells, while simultaneously measuring single-cell protein expression levels and diffusion coefficients. Our PIE-FCCS results demonstrate that HER4 interacts directly with all HER family members in the cell plasma membrane. The interaction between HER4 and other HER family members intensified in the presence of a HER4-specific ligand. Our work suggests that HER4 is a preferred dimerization partner for all HER family proteins, even in the absence of ligands.

Reification as Ecological Critique

In Kohei Saito's ecological Marxism, reification explains how formal economic categories lead to ecological crisis. Saito, however, lacks an account of praxis; of the collective political agency capable of overcoming reification. The relationship between reification and praxis was a central motif of Georg Lukács’ early Marxist work. An integrated concept of reification could then fill this gap in Saito's theory, thereby illuminating the political transition towards ecosocialism. Further, by resolving the ambiguous status of “nature” in Lukács critical theory, which currently blocks the possibility of such a conceptual integration, the critique of reification can be extended to the natural sciences.

Deniability in Automated Contact Tracing: Impossibilities and Possibilities

Automated contact tracing (ACT) emerged as a promising measure to curb the spread of Covid-19. Users enable ACT on their smartphones to automatically record contacts with other users. If a user tests positive for the disease, they report their diagnosis to alert their contacts. Designing effective ACT protocols is challenging since they need to be efficient and secure while also ensuring users' privacy. As ACT protocols necessarily leak some information by design, defining privacy is difficult. For example, a user cannot deny having met another user. Ideally, however, the user can plausibly deny everything else, in particular, when they met. We call this privacy property contact-time deniability. While some early works discussed contact-time deniability informally, it has received little attention since then. We investigate deniability from a rigorous, theoretical point of view and arrive at the following impossibility result: A decentralized protocol with unidirectional communication cannot be contact-time deniable and replay-secure. This holds even if malicious users treat smartphones as black-boxes. Unidirectional protocols are usually very efficient and many proposals are unidirectional, e.g., the widely-deployed Google-Apple Exposure Notifications. So the impossibility result considerably constrains the design space of efficient, secure, and private ACT protocols. However, it can also be used as a guide; we discuss several possibilities to achieve contact-time deniability in practice.

On a generalized Möbius invariant function space

In this paper, we introduce a new class of generalized Möbius function space of analytic functions in the unit disk, that contains Bα, Bαp, BMOApα, and F(p,pα−2,s) as particular cases. We study several basic properties of such new spaces and also characterize these spaces via Carleson-type measures. As for some applications, we study the corresponding little-o spaces, as well as establish several embedding relations of these new spaces with Bloch-type spaces. Our result generalizes an early work of Zhu in 2007.

The extraordinary Atlantic silverside and me

Abstract My career is inextricably linked to the remarkable characteristics and astonishing insights provided by a simple yet elegant species, the Atlantic silverside, Menidia menidia. My initial field and laboratory studies provided the first demonstration of temperature-dependent sex determination (TSD) and its adaptive significance in fish, as well as the first empirical confirmation of frequency-dependent sex ratio selection. This early work then led to the discovery of countergradient variation in growth, evolutionary trade-offs associated with growth, pioneered the study of fisheries-induced evolution, and furthered our understanding of the spatial scale of local adaptation in marine species. Most of these topics are now vigorous areas of research encompassing numerous species and systems. Here I describe how these unforeseen discoveries were made and led to other findings on bluefish (Pomatomus saltatrix) and striped bass (Morone saxatilis). An interest in leadership during my early years was later rekindled as I took on administrative roles. It all began with an intriguing observation stemming from my MS thesis that I was compelled to follow. My career illustrates the value of exploring deeply the natural history of lesser-known yet easy-to-study species and to follow unexpected observations even if peripheral to a preconceived plan of research.

Anatomical and molecular development of the human primary visual cortex.

The human primary visual cortex (V1) development is pivotal to understanding cortical maturation and neuroplasticity. Theories on V1 development range from early maturation models, which emphasize the early peak of synapses in infancy, to those suggesting an extended developmental timeline where key plasticity mechanisms continue to mature well into adulthood. Classic histological approaches have supported early development, while recent molecular studies highlight prolonged or multiple windows of plasticity, indicating that V1 remains susceptible to experience-dependent modifications beyond childhood. This review consolidates findings from both anatomical and molecular studies, tracing the development of V1 from prenatal stages through aging. The evidence reveals that human V1 develops across multiple timescales, with some aspects maturing early and others gradually changing across the lifespan. Reflecting on Cajal's early work, this review underscores the importance of methodological advancements in revealing the intricate details of V1's development.

François Hotman and the Critique of Gratian’s Decree: From the Investigation of Early Councils (De statu primitivae Ecclesiae, 1553) to the Rewriting of Europe’s Legal History (Antitribonian, 1567)

François Hotman (1524–1590) was one of the leading Reformed jurisconsults of his time. Past research has stressed his innovative interpretations and practices in the study of Roman, feudal, and French constitutional law. Little has yet been said about his views on canon law, another fundamental legal body in Western history that experienced renewed intellectual scrutiny during the sixteenth century. This paper investigates some of Hotman’s early work on canon law, focusing on his legal–historical reconstruction of the early Church in De statu primitivae Ecclesiae (1553) and his contribution to a budding historical field in Catholic circles: conciliar history. Despite the general lack of interest in the history of councils on the part of some leading Protestant theologians (Luther, Calvin, Bullinger), Hotman clearly believed that the textual tradition of councils provided a prime example of sustained popish efforts to control and deform the historical narrative and the legal structure of the Church. Yet, although he seems to have worked on demonstrating just that over more than forty years, he never again voiced his views on the matter in a dedicated work. Comparing in its conclusion De statu primitivae Ecclesiae with Antitribonian, this paper suggests that, in parallel to his better known ‘complex of Tribonian’ (Pierre Mesnard), Hotman seems to have suffered from a ‘complex of Gratian’: the doctrinal unity and institutional accomplishments of the early Church, as represented by the first councils, may well have dazzled Hotman and kept him from writing some definitive work against Gratian.

Reflections on the Early Works of Ghassan Kanafani 1

Reflections on the Early Works of Ghassan Kanafani 1

Vida humana, hombre y persona en Julián Marías: análisis de una transición conceptual y de sus resultados

Julián Marías's interest in the human being appears from his earliest works, but his conceptualization of this reality undergoes a complex evolution. Initially, he is thought of through the concepts of human life (Ortega) and, later, of human life and man, a period that concludes masterfully with Antropología metafísica (1970). Only from then on does the person become the central category of his anthropology, a position that is totally explicit in texts such as Mapa del mundo personal (1993) and Persona (1996). This new, more ontological perspective will allow Marías to draw on some previous intuitions, proposing, for example, with force and originality the idea of ​​the personal, the nuclear element of the person, although distinct from it, which could be identified with the who.

Specific Emitter Identification Algorithm Based on Time–Frequency Sequence Multimodal Feature Fusion Network

Specific emitter identification is a challenge in the field of radar signal processing. Its aims to extract individual fingerprint features of the signal. However, early works are all designed using either signal or time–frequency image and heavily rely on the calculation of hand-crafted features or complex interactions in high-dimensional feature space. This paper introduces the time–frequency multimodal feature fusion network, a novel architecture based on multimodal feature interaction. Specifically, we designed a time–frequency signal feature encoding module, a wvd image feature encoding module, and a multimodal feature fusion module. Additionally, we propose a feature point filtering mechanism named FMM for signal embedding. Our algorithm demonstrates high performance in comparison with the state-of-the-art mainstream identification methods. The results indicate that our algorithm outperforms others, achieving the highest accuracy, precision, recall, and F1-score, surpassing the second-best by 9.3%, 8.2%, 9.2%, and 9%. Notably, the visual results show that the proposed method aligns with the signal generation mechanism, effectively capturing the distinctive fingerprint features of radar data. This paper establishes a foundational architecture for the subsequent multimodal research in SEI tasks.

Incidence and risk of post-COVID-19 thromboembolic disease and the impact of aspirin prescription; nationwide observational cohort at the US Department of Veteran Affairs.

COVID-19 triggers prothrombotic and proinflammatory changes, with thrombotic disease prevalent in up to 30% SARS-CoV-2 infected patients. Early work suggests that aspirin could prevent COVID-19 related thromboembolic disorders in some studies but not others. This study leverages data from the largest integrated healthcare system in the United States to better understand this association. Our objective was to evaluate the incidence and risk of COVID-19 associated acute thromboembolic disorders and the potential impact of aspirin. This retrospective, observational study utilized national electronic health record data from the Veterans Health Administration. 334,374 Veterans who tested positive for COVID-19 from March 2, 2020, to June 13, 2022, were included, 81,830 of whom had preexisting aspirin prescription prior to their COVID-19 diagnosis. Patients with and without aspirin prescriptions were matched and the odds of post-COVID acute thromboembolic disorders were assessed. 10.1% of Veterans had a documented thromboembolic disorder within 12 months following their COVID-19 diagnosis. Those with specific comorbidities were at greatest risk. Preexisting aspirin prescription was associated with a significant decrease risk of post-COVID-19 thromboembolic disorders, including pulmonary embolism (OR [95% CI]: 0.69 [0.65, 0.74]) and deep vein thrombosis (OR [95% CI]: 0.76 [0.69, 0.83], but an increased risk of acute arterial diseases, including ischemic stroke (OR [95% CI]: 1.54 [1.46, 1.60]) and acute ischemic heart disease (1.33 [1.26, 1.39]). Findings demonstrated that preexisting aspirin prescription prior to COVID-19 diagnosis was associated with significantly decreased risk of venous thromboembolism and pulmonary embolism but increased risk of acute arterial disease. The risk of arterial disease may be associated with increased COVID-19 prothrombotic effects superimposed on preexisting chronic cardiovascular disease for which aspirin was already prescribed. Prospective clinical trials may help to further assess the efficacy of aspirin use prior to COVID-19 diagnosis for the prevention of post-COVID-19 thromboembolic disorders.

The History of Polyarchion (πολυάρχιον), John Chrysostom’s Illness, and Access to Medicinal Treatments at the End of Late Antiquity

John Chrysostom’s (c. 347‑407) works are valuable for medical historians because they provide us with a first-hand insight into his health problems and the therapies he was treated with. John’s correspondence gives us a unique opportunity to assess the popularity of certain drugs and the availability of healthcare, enabling us to verify the extant medical data. In the present study we will discuss the information on Chrysostom’s illness including his mention of a medicament named polyarchion (πολυάρχιον) which had been sent to the archbishop by Carteria. On the basis of the recipes preserved in medical treatises by Galen as well as other medical data, we will introduce the main properties of the medicine and treatments in which it was administered. Having outlined the scope of its action, and having analysed the symptoms of Chrysostom’s condition described in his correspondence to Olympias, we will establish the nature of the ecclesiastic’s main ailments fully. Finally, we will also conclude on the drug’s availability in the Byzantine world and on the inclusion of drug formulas in early Byzantine medical works.

Digital Image Sensor Evolution and New Frontiers

This article reviews nearly 60 years of solid-state image sensor evolution and identifies potential new frontiers in the field. From early work in the 1960s, through the development of charge-coupled device image sensors, to the complementary metal oxide semiconductor image sensors now ubiquitous in our lives, we discuss highlights in the evolutionary chain. New frontiers, such as 3D stacked technology, photon-counting technology, and others, are briefly discussed.

Dr. Dharmendra's Enduring Influence on Leprosy: From Laboratory to Disease Control.

A stalwart of Indian dermatology, Dr. Dharmendra was particularly known for his breakthrough research on leprosy. Spanning over several decades, his work was marked by significant contributions, including the development of Dharmendra's lepromin, which served as a critical diagnostic tool and in advancing the understanding of immunological aspects of leprosy. Born in 1900 in present-day Pakistan, his early education and work experiences set the foundation for his later achievements in leprosy research. Despite the social stigma associated with the disease at the time, Dr. Dharmendra's dedication led him to take up key roles, such as the first director of the National Leprosy Control Programme and head of the Central Leprosy Teaching and Research Institute in Chengalpattu. His work significantly impacted leprosy control efforts in India. ⁤⁤His legacy was further cemented by his leadership in founding the Indian Association of Leprologists and his tireless editorial work in the Indian Journal of Leprosy. Through his publications and ongoing research, even after retirement, he continued to influence the field. Dr. Dharmendra's life and work remain a cornerstone of leprosy research, inspiring future generations. His legacy continues to be felt in the ongoing efforts to combat leprosy.

Vyacheslav Ivanov’s Dionysian-mysterial Plot and his Mystical Anthropology (the Concept of «Thou art»). Second Article

The purpose of the second article on Ivanov’s mystical anthropology is to demonstrate how the plot «thou art» grows out of the Dionysian-mysterial plot that developed in Ivanov’s early work. The research material was Ivanov’s poetic, philosophical, scientific and epistolary texts. Comparative, hermeneutic, structural and semantic methods were used. Ivanov’s mystical anthropology appears as a detailed narrative, the elements of which are symbols denoting mystical entities. This narrative represents the story of the relationship between Anima and Animus, feminine, irrational and masculine, rational. This story is symbolic, it can be interpreted psychologically, mystically, cosmologically. The plot of «thou art» is modeled on the Dionysian-mysterial plot and can be divided into two lines – the mysterial and soteriological ones. Each of them is divided into «male» and «female» versions. In the «male» version of the mysterial line, the Animus distorts the divine Self in itself and separates from the Anima; in the «female» version, the Anima assumes a priestly role and renounces the God-fighting Animus. In the «male» version of the soteriological plot, the Animus acquires its God-human primordial image and transforms into the son of God, Adam, who has risen from the mortal dream. This transformed Animus appears as a Godhuman Bridegroom, with whom the Anima-Bride marries, as a result of which a complete transformation of the human personality is accomplished, the reconciliation of the male and female principles and the birth of a new Dionysus-Bacchus.

Memory representations during slow change blindness.

Classic change blindness is the phenomenon where seemingly obvious changes that coincide with visual disruptions (such as blinks or brief blanks) go unnoticed by an attentive observer. Some early work into the causes of classic change blindness suggested that any pre-change stimulus representation is overwritten by a representation of the altered post-change stimulus, preventing change detection. However, recent work revealed that, even when observers do maintain memory representations of both the pre- and post-change stimulus states, they can still miss the change, suggesting that change blindness can also arise from a failure to compare the stored representations. Here, we studied slow change blindness, a related phenomenon that occurs even in the absence of visual disruptions when the change occurs sufficiently slowly, to determine whether it could be explained by conclusions from classic change blindness. Across three different slow change blindness experiments we found that observers who consistently failed to notice the change had access to at least two memory representations of the changing display. One representation was precise but short lived: a detailed representation of the more recent stimulus states, but fragile. The other representation lasted longer but was fairly general: stable but too coarse to differentiate the various stages of the change. These findings suggest that, although multiple representations are formed, the failure to compare hypotheses might not explain slow change blindness; even if a comparison were made, the representations would be too sparse (longer term stores) or too fragile (short-lived stores) for such comparison to inform about the change.

Challenges in Early Years data and their implications on programme evaluations

The Welsh Government funds a wide range of Early Years programmes to both support parents to remain in work and children’s social, emotional and educational development. The interest of Welsh Ministers in this policy area has grown in recent years with expansions in this area carefully considered. The potential for expanding the offer has generated a greater need for evidence to understand the effectiveness of the delivery against the proposed objectives. Data linking is a valuable and efficient way to provide complex evaluations of policy programmes as it maximises the use of existing data sources without increasing the burdens on data providers and provides comprehensive information that would otherwise be limited with a single dataset. However, Welsh Government research on programme evaluation in Early Years is facing challenges and this work aims at providing an overview of these issues, their impact on Early Years analytical work and progress made to address them. In particular, the main challenges are related to data quality and data availability that stem from lack of metadata and contextual information, poor technological infrastructure and, at times, a disconnect between policy / operational delivery and data collection. Progress is being made to address these challenges, such as acquiring new datasets or improving the quality of existing ones but these developments take time. At the same time as helping to tackle these structural challenges, the Early Years analytical team is exploring a range of novel approaches to provide robust evaluation of Early Years interventions despite the data issues.

Heterogeneous E‐Textiles: Materials, Manufacturing and Sustainability

AbstractElectronic textiles (e‐textiles) combine electronic functions (e.g., sensing, actuating, data processing) with textiles. E‐textiles are a platform technology with the potential for ubiquitous deployment in any application scenario where textiles can be found. E‐textiles have attracted significant research interests from materials and manufacturing process development to applications such as sports/fitness, healthcare, and workwear. While significant advances have been made in the research domain regarding the integration of electronic functionality, the technology is relatively immature and significant challenges remain in the manufacturing of commercialized e‐textile systems. This paper reviews the state of the art in e‐textile manufacturing including materials (e.g., yarns, inks), fabrication (e.g., weaving, knitting, printing), electronic integration and interconnections. This paper also reviews the key principles of textile sustainability and electronic waste (e‐wastemanagement, which provide useful guidance on e‐textile design and manufacturing to minimize their impact on the environment. Examples are given to demonstrate the early work toward sustainable e‐textiles. The remaining research challenges regarding scalable and sustainable manufacturing of e‐textiles are presented.