Early Time Research Articles

Approximate Solutions of the Boussinesq Equation for Horizontal Unconfined Aquifers During Pure Drainage Phase

In this work, conceptual approximations of the Boussinesq equation were introduced and analyzed, resulting into a very accurate and well-applicable model for horizontal unconfined aquifers during the pure drainage phase, without any recharge and zero-inflow conditions. The model was constructed by employing a variety of methods that included wave solution, variable separation, and series expansion, and its analysis and performance against the Boussinesq equation, at early and later times, providing fruitful insights enlightening the main mechanisms and physical characteristics of the drainage phase. The modeled non-linear forms were finally linearized, concluding with explicit analytical expressions that accurately incorporated most of the basic characteristics regarding the evolution of the water table and the outflow from the exact Boussinesq equation under different initial conditions. The endeavors of this work can be utilized for theoretical and modeling purposes related to this problem.

Phosphate-Driven Interfacial Self-Assembly of Silk Fibroin for Continuous Noncovalent Growth of Nanothin Defect-Free Coatings.

Silk fibroin is a fiber-forming protein derived from the thread of Bombyx mori silkworm cocoons. This biocompatible protein, under the kosmotropic influence of potassium phosphate, can undergo supramolecular self-assembly driven by a random coil to β-sheet secondary structure transition. By leveraging concurrent nonspecific adsorption and self-assembly of silk fibroin, we demonstrate an interfacial phenomenon that yields adherent, defect-free nanothin protein coatings that grow continuously in time, without observable saturation in mass deposition. This noncovalent growth of silk fibroin coatings is a departure from traditionally studied protein adsorption phenomena, which generally yield adsorbed layers that saturate in mass with time and often do not completely cover the surface. Here, we explore the fundamental mechanisms of coating growth by examining the effects of coating solution parameters that promote or inhibit silk fibroin self-assembly. Results show a strong dependence of coating kinetics and structure on solution pH, salt species, and salt concentration. Moreover, coating growth was observed to occur in two stages: an early stage driven by protein-surface interactions and a late stage driven by protein-protein interactions. To describe this phenomenon, we developed a kinetic adsorption model with Langmuir-like behavior at early times and a constant steady-state growth rate at later times. Structural analysis by FTIR and photoinduced force microscopy show that small β-sheet-rich structures serve as anchoring sites for absorbing protein nanoaggregates, which is critical for coating formation. Additionally, β-sheets are preferentially located at the interface between protein nanoaggregates in the coating, suggesting their role in forming stable, robust coatings.

Environmental stress and salivary cortisol levels in preterm infants.

Preterm infants are exposed to numerous environmental stressors during their Neonatal Intensive Care Unit (NICU) stay, particularly during the first week after birth. The aim of this study is to assess whether salivary cortisol levels are correlated with Neonatal Infant Stressor Scale (NISS) scores in preterm infants during the first week of life. We also quantified the changes in both NISS scores and cortisol levels in the first week, and whether cortisol levels are associated with gestational age. Preterm infants (n = 38, birth weight <1250 g and/or gestational age <29 weeks) were included. Saliva samples were collected on day 0-3 (early) and day 4-7 (late), and cortisol concentrations were measured by immunoassay. NISS scores were assessed retrospectively for the six hours preceding each saliva collection. NISS scores were not significantly correlated with salivary cortisol levels at either time point. However, infants born at <28 weeks gestation had higher median cortisol levels than infants born at >28 weeks (p = 0.0068), and there was also a significant inverse relationship between NISS score and gestational age (p = 0.04). There was no significant difference between the early and late time points for either NISS scores or cortisol levels. Cortisol levels are elevated in infants <28 weeks gestation but do not correlate with NISS scores. NISS scores are inversely related to gestational age, likely reflecting increased exposure to interventions and invasive procedures for the smallest infants.

Artificial Intelligence, Genuine Outcome: Analysis of 72 Consecutive Cases of Subfascial Augmentation Mastopexy With Smooth Round Implants Supported by P4HB Scaffold.

Ptosis recurrence often leads to unsatisfactory results after mastopexy, even more so when additional stress is provided by implants on compromised native tissue. The poly-4-hydroxybutyrate(P4HB) scaffold (GalaFLEX) with its favorable safety profile and proven long-term mechanical strength represents a preferred option for soft tissue support. The primary endpoint was assessment of lower pole stretch from the early postoperative period up to 3 years. Out of 151 patients who underwent surgery by G.B. from March 2020 to December 2023, a total of 72 with a 12-month-mininum follow-up who had primary (46) or secondary (26) augmentation mastopexy with subfascial round smooth implants and P4HB scaffold support were included in the study. Three-dimensional artificial intelligence software was utilized for all measurements. Further analysis included evaluation of ptosis recurrence and all complications. No recurrent ptosis, bottoming out, implant displacement, or capsular contracture was reported during follow-up (mean, 24.8 months). The lower pole arch's elongation was 8.04% and 9.44% at 1 and 3 years respectively, comparing favorably with previous reports. Statistically significant correlation (P < .05) between implant size and lower pole stretch was noted, this being greater for larger implants (> 400 cc; P = .0011) and primary cases (P = .1376). Progressive volume redistribution from upper to lower pole was observed in the first year, with substantial stability thereafter. This is the largest published series reporting long-term results (up to 45 months) in mastopexy augmentation with GalaFLEX, suggesting its supportive role in lower pole stability even in the setting of concurrent breast augmentation with smooth implants in a subfascial plane.

Character and Evolution of Sunken Groundwater-Harvesting Agroecosystems in Aeolian Sand since Early Islamic Times, between Iran and Iberia

ABSTRACT By reviewing traditional, sunken, groundwater-harvesting agroecosystems (SGHAS) in coastal and inland aeolian sand situated in Iran, Egypt, Gaza Strip, Algeria and Iberia, coupled with image interpretation and geospatial analysis, we study the innovation and function of recently excavated Early Islamic (EI; tenth-twelfth century), Plot-and-Berm agroecosystems along the southeastern Mediterranean coast of Israel. The SGHAS and EI agroecosystems, usually affiliated with nearby towns, possess an aeolian sand substrate enrichened with urban refuse and/or organic material. The long-term investment in SGHAS attained profitable water security in the form of temporally continuous, shallow groundwater, replenished by rainfall. The crops in SGHASs include a wide range of vegetables, watermelons, dates and grapes, implying that the EI crops were partly or fully different. The spotty, historic appearance of SGHAS since the fifteenth–sixteenth centuries temporally lags after the abandonment of the EI agroecosystems, does not support spatial and temporal connectivity of sand agriculture knowledge, but probably exemplifies the appearance of site-specific ingenuities derived from growing agro-technological knowledge, crop variety and needs for food security. This study demonstrates the importance of traditional analogues for interpreting research gaps of archaeological, agricultural landscapes and provides insight for establishing traditionally-based, sustainable agriculture in sand.

Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing

Postnatal kidney growth is substantial and involves expansion in kidney tubules without growth of new nephrons, which are the functional units of the kidney. Proliferation and differentiation pathways underpinning nephron elongation are not well defined. To address this, we performed sequential characterization of mouse kidney transcriptomics at the single cell level. Single nuclear RNA sequencing (snRNA-seq) was performed on kidney tissue from male and female mice at 1, 2, 4 and 12 weeks of age using the 10x Chromium platform. Unbiased clustering was performed on 68,775 nuclei from 16 animals. 31 discrete cellular clusters were seen, which were identified through comparison of their gene expression profiles to canonical markers of kidney cell populations. High levels of proliferation were evident at early time points in some cell types, especially tubular cells, but not in other cell types, for example podocytes. Proliferation was especially evident in Proximal Tubular Cells (PTCs) which are the most abundant cell type in the adult kidney. Uniquely when compared to other kidney cell types, PTCs demonstrated sex-specific expression profiles at late, but not early, time points. Mapping of PTC differentiation pathways using techniques including trajectory and RNA Velocity analyses delineated increasing PTC specialization and sex-specific phenotype specification. Our single-cell transcriptomics data characterise cellular states observed during kidney growth. We have identified PTC differentiation pathways that lead to sex-specific tubular cell phenotypes. Tubular proliferative responses are of central importance in postnatal kidney growth and have also been linked to kidney recovery versus fibrosis following injury. Our unbiased and comprehensive dataset of tubular cell development can be used to identify candidate pathways for therapeutic targeting.

The Myth of the Decline Effect in Psi Research: The Empirical Evidence

The decline effect (DE) has been discussed in “psi” research since the early times of experimental investigations, and many causes have been advanced from: individual psychology, social attitudes, electromagnetic fields, experimental artifacts, or physical properties often related to quantum physics. Bierman (2001) found small and statistically significant decline slopes in all experimental protocols, but the mind-matter interaction with random number generators, where he found a positive quadratic polynomial slope. This study aimed to update Bierman’s results, taking into account all studies completed up to 2023 and analyzed in different meta-analyses. Five experimental protocols were analyzed: including anomalous perception in a Ganzfeld condition, remote viewing, forced-choice design in extra-sensory perception, predictive physiological anticipation, and dream extra-sensory perception studies. The results showed that only one slope coefficient out of the five examined was statistically significant, indicating that there was no evidence of a general DE across the different experimental protocols.

Conditional modeling of recurrent event data with terminal event.

Recurrent event data with a terminal event arise in follow-up studies. The current literature has primarily focused on the effect of covariates on the recurrent event process using marginal estimating equation approaches or joint modeling approaches via frailties. In this article, we propose a conditional model for recurrent event data with a terminal event, which provides an intuitive interpretation of the effect of the terminal event: at an early time, the rate of recurrent events is nearly independent of the terminal event, but the dependence gets stronger as time goes close to the terminal event time. A two-stage likelihood-based approach is proposed to estimate parameters of interest. Asymptotic properties of the estimators are established. The finite-sample behavior of the proposed method is examined through simulation studies. A real data of colorectal cancer is analyzed by the proposed method for illustration.

Universal early-time growth in quantum circuit complexity

We show that quantum circuit complexity for the unitary time evolution operator of any time-independent Hamiltonian is bounded by linear growth at early times, independent of any choices of the fundamental gates or cost metric. Deviations from linear early-time growth arise from the commutation algebra of the gates and are manifestly negative for any circuit, decreasing the linear growth rate and leading to a bound on the growth rate of complexity of a circuit at early times. We illustrate this general result by applying it to qubit and harmonic oscillator systems, including the coupled and anharmonic oscillator. By discretizing free and interacting scalar field theories on a lattice, we are also able to extract the early-time behavior and dependence on the lattice spacing of complexity of these field theories in the continuum limit, demonstrating how this approach applies to systems that have been previously difficult to study using existing techniques for quantum circuit complexity.

Sensitivity of Bayesian 21 cm power spectrum estimation to foreground model errors

Abstract Power spectrum estimators are an important tool in efforts to detect the 21 cm brightness temperature fluctuations from neutral hydrogen at early times. An initial detection will likely be statistical in nature, meaning that it will not be possible to make a coherent map of the brightness temperature fluctuations; instead, only their variance will be measured against a background of noise and residual systematic effects. Optimal Quadratic Estimator (OQE)-based methods often apply an inverse covariance weighting to the data. However, inaccurate covariance modelling can lead to reduced sensitivity and, in some cases, severe signal loss. We recently proposed a Bayesian method to jointly estimate the 21 cm fluctuations, their power spectrum, and foreground emission. Instead of requiring a fixed a priori estimate of the covariance, we estimate the covariance as part of the inference. Choices of parametrization, particularly of the foregrounds, are subject to model errors and could lead to biases and other ill effects if not properly controlled. In this paper, we investigate the effects of inaccurate foreground models on 21 cm power spectrum recovery. Using simulated visibilities, we find that, even in the most extreme scenarios tested, our approach is capable of recovering 21 cm delay power spectrum estimates consistent with a known input signal for delays ≳ 300 ns (∼88% of the available Fourier modes). This is true even when using foreground models derived from modified foreground catalogs containing spatial and spectral perturbations at the quoted level of uncertainty on our foreground catalogs.

Maternal adiposity and perinatal and offspring outcomes: an umbrella review.

Maternal adiposity deleteriously affects obstetrical health and has been associated with long-term adverse consequences in offspring. Here we conducted an umbrella review encompassing 194 observational meta-analyses, 10 Mendelian randomization studies and 748 interventional meta-analyses to appraise the published evidence on the associations between maternal adiposity and perinatal and offspring outcomes. Evidence grading suggested that 17 (8.8%) observational meta-analyses were supported by convincing evidence for 12 outcomes: maternal adiposity was associated with an increased risk of caesarean delivery following labour induction, infant mortality, Apgar score <7 at 1 min, antenatal depression, offspring overweight and obesity, early timing of puberty onset in daughters, attention deficit hyperactivity disorder, cerebral palsy, congenital heart disease and spina bifida (OR/RR ranging from 1.14 to 2.31), as well as increased offspring body fat percent and fat mass (SMD 0.31 and 0.35, respectively). Among these outcomes, interventional meta-analyses supported that maternal weight loss interventions significantly reduced the risk of antenatal depression but not low Apgar scores; these interventions also could not reduce offspring fat mass or body fat percent. Evidence from Mendelian randomization studies supported a causal relationship between maternal adiposity and gestational diabetes mellitus, preeclampsia, birth size and offspring adiposity. Our findings highlight that while observational meta-analyses reveal associations between maternal adiposity and various adverse perinatal and offspring outcomes, convincing, unbiased evidence or support from Mendelian randomization studies is limited. Maternal pre-conceptional and prenatal weight loss interventions can reduce some, but not all, of these adverse effects.

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension.

Macrophages play a significant role in the onset and progression of vascular disease in pulmonary hypertension, and cell-based immunotherapies aimed at treating vascular remodeling are lacking. To evaluate the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/proresolving phenotype in attenuating early pulmonary inflammation and progression of experimentally induced pulmonary hypertension. Mouse bone marrow-derived macrophages were polarized in vitro to a regulatory (M2reg) phenotype. M2reg profile and anti-inflammatory capacity were assessed in vitro upon lipopolysaccharide/IFNγ (interferon-γ) restimulation, before their administration to 8- to 12-week-old mice. M2reg protective effect was evaluated at early (2-4 days) and late (4 weeks) time points during hypoxia (8.5% O2) exposure. Levels of inflammatory markers were quantified in alveolar macrophages and whole lung, while pulmonary hypertension development was ascertained by right ventricular systolic pressure (RVSP) and right ventricular hypertrophy measurements. Bronchoalveolar lavage from M2reg-transplanted hypoxic mice was collected and its inflammatory potential evaluated on naive bone marrow-derived macrophages. M2reg macrophages expressing Tgfβ, Il10, and Cd206 demonstrated a stable anti-inflammatory phenotype in vitro, by downregulating the induction of proinflammatory cytokines and surface molecules (Cd86, Il6, and Tnfα) upon a subsequent proinflammatory stimulus. A single dose of M2reg attenuated hypoxic monocytic recruitment and perivascular inflammation. Early hypoxic lung and alveolar macrophage inflammation leading to pulmonary hypertension development was significantly reduced, and, importantly, M2reg attenuated right ventricular hypertrophy, right ventricular systolic pressure, and vascular remodeling at 4 weeks post-treatment. Adoptive transfer of M2reg halts the recruitment of monocytes and modifies the hypoxic lung microenvironment, potentially changing the immunoreactivity of recruited macrophages and restoring normal immune functionality of the lung. These findings provide new mechanistic insights into the diverse role of macrophage phenotype on lung vascular homeostasis that can be explored as novel therapeutic targets.

Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.

Traumatic brain injury (TBI) affects neural function at the local injury site and also at distant, connected brain areas. However, the real-time neural dynamics in response to injury and subsequent effects on sensory processing and behavior are not fully resolved, especially across a range of spatial scales. We used in vivo calcium imaging in awake, head-restrained male and female mice to measure large-scale and cellular resolution neuronal activation, respectively, in response to a mild/moderate TBI induced by focal controlled cortical impact (CCI) injury of the motor cortex (M1). Widefield imaging revealed an immediate CCI-induced activation at the injury site, followed by a massive slow wave of calcium signal activation that traveled across the majority of the dorsal cortex within approximately 30 s. Correspondingly, two-photon calcium imaging in primary somatosensory cortex (S1) found strong activation of neuropil and neuronal populations during the CCI-induced traveling wave. A depression of calcium signals followed the wave, during which we observed atypical activity of a sparse population of S1 neurons. Longitudinal imaging in the hours and days after CCI revealed increases in the area of whisker-evoked sensory maps at early time points, in parallel to decreases in cortical functional connectivity and behavioral measures. Neural and behavioral changes mostly recovered over hours to days in our M1-TBI model, with a more lasting decrease in the number of active S1 neurons. Our results in unanesthetized mice describe novel spatial and temporal neural adaptations that occur at cortical sites remote to a focal brain injury.

What guides the judgment of learning: Memory or heuristics? An event-related potential study

Memory monitoring ability is essential for the effectiveness of learning processes. Judgment of Learning (JOL), a metacognitive judgment, is commonly used to measure this ability. An ongoing debate questions whether JOL is an outcome of an inferential or recollective experience, as suggested by different hypotheses regarding the underlying cognitive mechanisms of this judgment. To address this question through a neuroscientific perspective, we aimed to investigate the temporal dynamic of JOL adopting event-related potential (ERP) methodology. Seventy-two young adults participated in an episodic memory task involving word-pairs as stimuli. Their JOLs were obtained through categorical choices in a delayed condition. Additionally, their memory performance was tested in the recognition phase. ERP components were compared for different JOL levels, as well as for the hit responses in the recognition test according to their JOL levels. The analyses showed that JOL processes are observable within an early time window after stimulus presentation, as evidenced by elicitation of the P100, N100, P200, N200, and P300 components across all JOL levels. However, only the amplitude of the N100 varied among these levels. A negative ERP component with 330–500 ms latency was also evident for all JOL levels in the central and parietal electrodes, which did not differ in amplitude. The analyses of the recognition phase ERPs showed that the hit responses did not exhibit a significant difference in the familiarity-related mid-frontal old/new effect (FN400) amplitude; however, those with high level of JOL elicited recollection-related parietal old-new effect with a smaller amplitude. These findings support both hypotheses suggesting that JOL is influenced by heuristics and the retrievability of information.

Psychedelic research, assisted therapy and the role of the anaesthetist: A review and insights for experimental and clinical practices.

Recent years have witnessed an unprecedented increase in the search for the use of psychedelics in improving physical and mental health. Anaesthesia has evolved since very early times, born from the need to eliminate pain and reduce suffering and there are reports of the use of anaesthetics to achieve mystical states since the nineteenth century. Nowadays, the renaissance of psychedelics in anaesthesia has been inspired by their potential in the treatment of chronic pain syndromes, palliative care and in the emergency department and pre-hospital care with the administration of psychedelics in cases of ischaemia, given their potential in neuroprotection. Although there are already some published protocols for the administration of psychedelics in patients with mental illness, little has been addressed concerning non-mental medical applications. In this sense, in patients with multiple comorbidities, functional limitations and polymedicated, the anaesthetist may play a fundamental role, not only in clinical practice, but also in translational research. This article focuses on the description of psychedelics, with a particular focus on dimethyltryptamine (DMT) and ayahuasca pharmacology, effects, safety and toxicity. A detailed description of the role of the anaesthetist in clinical and experimental research is provided, from participant's screening to preparation and dosing session, expected adverse effects and how to manage them, based on the protocol and standard procedures of a current study with neuroimaging during the psychedelic experience. Specific considerations regarding the management of psychedelic toxicity are also provided as well as future directions for safe psychedelic use in clinical practice.

Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in Aspergillus niger.

Citric acid is produced on industrial scale by batch fermentation of the filamentous fungus Aspergillus niger. High-yield citric acid production requires a low (<5 ppb) manganese(II) ion concentration in the culture broth. However, the requirement for this deficiency has not been investigated on a functional genomics level. Here, we compared the transcriptome of a citric acid hyper-producer A. niger strain grown under citric acid-producing conditions in 6-L scale bioreactors at Mn2+ ion-deficient (5 ppb) and Mn2+ ion-sufficient (100 ppb) conditions at three early time points of cultivation. We observed that Mn2+ deficiency triggers an upregulation of the citrate exporter gene cexA and provides functional evidence that this event is responsible for citrate overflow. In addition to the industrial relevance, this is the first study that examined the role of Mn2+ ion deficiency in a heterotrophic eukaryotic cell on a genome-wide scale.

The HSV-1 encoded CCCTC-binding factor, CTRL2, impacts the nature of viral chromatin during HSV-1 lytic infection.

HSV-1 genomes are rapidly heterochromatinized following entry by host cells to limit viral gene expression. Efficient HSV-1 genome replication requires mechanisms that de-repress chromatin associated with the viral genome. CCCTC-binding factors, or CTCF insulators play both silencing and activating roles in cellular transcriptional regulation. Importantly, the HSV-1 genome encodes several CTCF insulators that flank IE genes, implying that individual HSV-1 encoded CTCF insulators regulate IE transcription during all stages of the HSV-1 life cycle. We previously reported that the HSV-1 encoded CTCF insulator located downstream of the LAT (CTRL2) controlled IE gene silencing during latency. To further characterize the role of this insulator during the lytic infection we leveraged a ΔCTRL2 recombinant virus to show that there was a genome replication defect that stemmed from decreased IE gene expression in fibroblasts and epithelial cells at early times following initiation of infection. Further experiments indicated that the defect in gene expression resulted from chromatin inaccessibility in the absence of the insulator. To elucidate how chromatin accessibility was altered in the absence of the CTRL2 insulator, we showed that enrichment of Alpha-thalassemia/mental retardation, X-linked chromatin remodeler (ATRX), and the histone variant H3.3, both of which are known for their roles in maintaining repressive histone markers on the HSV-1 viral genome were increased on IE regions of HSV-1. Finally, both H3K27me3 and H3K9me3 repressive histone marks remained enriched by 4 hours post infection in the absence of the CTRL2 insulator, confirming that the CTRL2 insulator is required for de-repression of IE genes of viral genomes. To our knowledge these are the first data that show that a specific CTCF insulator in the HSV-1 genome (CTRL2) regulates chromatin accessibility during the lytic infection.

A novel valve strategy for particulate matter reduction in a gasoline direct injection engine operated at cold conditions

In this study, we proposed a novel intake strategy to reduce Particulate matter (PM) emissions from gasoline direct-injection (GDI) engines during cold-start conditions emissions. This strategy is characterized by generating strong intake turbulence and low in-cylinder pressure during fuel injection through delayed intake valve opening, which theoretically promotes fuel atomization and fuel-air mixture, thereby suppressing PM formation during combustion. Experiments were conducted on a single-cylinder GDI research engine, operating at 1500 rpm, 3, 6, and 8 bar IMEP, and stoichiometric air-fuel ratio conditions with low coolant and lubricant temperatures to experimentally demonstrate the effectiveness of the proposed valve strategy in reducing PM emissions. Benchmark tests were performed using an intake camshaft with intake valve opening (IVO) at −13 °aTDC and intake valve closing (IVC) at 227 °aTDC. The novel strategy uses an intake camshaft with very late IVO at 66 °aTDC and IVC at 226 °aTDC. Two injection pressures (Pinj = 100/200 bar) were used to evaluate the pressure requirement for achieving low PM emissions with both strategies. Start of injection was swept and optimized to match the valve strategy. The results showed that the novel valve strategy leads to a 50%–90% reduction in particle number and mass emissions in cold-start conditions, and a lower injection pressure requirement to achieve comparable particle number and mass emissions compared with the normal one. For the novel valve strategy, the fuel impingement with early injection timings is largely mitigated, and thus an early injection timing shortly before the IVO is recommended.

Health promotion and prevention in early times of the COVID-19 pandemic: insights from a Delphi study in Switzerland.

COVID-19 pandemic and confinement measures had a major impact on the health and well-being of the population. Health promotion and prevention (HP&P) professionals had to rethink their practices to respond to the challenges raised by the pandemic context. This study aimed to build a professional consensus on the HP&P priorities (apart from the COVID-19 fight) in the early times of the pandemic in Switzerland and to identify the most relevant interventions to respond to these issues. HP&P experts from the three main linguistic regions of Switzerland reached a consensus through a two-round Delphi methodology with online questionnaires in June-July and October-November, 2020. Out of 282 experts contacted, 121 (43%) contributed in the first round and 99 (35%) in the second. A strong consensus emerged about the importance of tackling mental health problems, non-communicable diseases and their main risk factors, as well as multiple social determinants of health. Although they believed that HP&P priorities changed in this context, experts reported that professional practices had only partially adapted to this new context due to multiple constraints (political, strategic, financial). The experts noted the need to adapt the means of communication to reach the different target groups. They underlined the potential of communication via digital technologies, but also drew attention to the risk of widening social inequalities due to the unequal access to these resources. This study generated new insights and confirmed pre-established knowledge regarding the orientations the field of HP&P should follow. While stressing the need to consolidate the traditional missions of the field (i.e. the fight against non-communicable diseases and the actions on social determinants of health), experts surveyed in this study also revaluated health priorities and rethought the way of developing HP&P actions in this specific context of the early pandemic of COVID-19.

Acoustic behaviour and acoustic treatment strategies for the baroque church of Santuari del Miracle, Solsonès, Lleida

The church of Santuari del Miracle, located in the Catalan region of Solsonès, Lleida, is a unique barroque church in Catalonia that hosts Baroque music performances, like the festival Espurnes Barroques. However, according to the musicians and the audience, it is too reverberant to play this style of music. The objective of this work is to examine the current acoustic performance of the church and to propose acoustic treatment strategies that are respectful of this unique heritage building. Impulse response measurements are first performed following ISO 3382-1 standards, using Odeon software to assess reverberation time (T30), Early Decay Time (EDT), Clarity (C50), and Definition (D50). Simulations are next performed using Odeon. They are used to refine the smallest perceptible differences from the measured data and to examine potential treatment strategies. The proposed solution consists of elements based on variable acoustics that can be easily hidden or removed, thus preserving the original acoustics of this heritage building.