Introduction: Enhanced recovery after surgery (ERAS) has been successfully employed in various gastrointestinal surgeries with favourable postoperative outcomes. However, pancreatic surgeons are reluctant to embrace the ERAS concept. The evidence for ERAS protocol in chronic pancreatitis (CP) patients undergoing Frey’s procedure is limited. Method: All patients who underwent Frey’s procedure for CP between April 2017 to December 2018 were included in the prospective study. Patient with a recent acute episode of pancreatitis (<4 weeks) and requiring concomitant mutivisceral resection were excluded. Twenty-two components of ERAS protocol were implemented. The prospective data were compared with patients who underwent Frey’s procedure before implementation of the ERAS protocol (January 2016 to March 2017). Result: Of the 26 patients who underwent Frey’s procedure during the study period 5 patients were excluded. Remaining patients (n=21, Group B) were compared with patients (n=23, Group A) who underwent Frey’s procedure before implementation of ERAS protocol. The compliance was 100% for all ERAS components except for the avoidance of postoperative opioids. More number of patients in Group A received intraoperative opioids than group B (p=0.01). Group B patient had early drain removal (4.07 Vs 1.07 days, p=0.00) early urinary catheter removal (2.4 Vs 1.53 days, p=0.002), early bowel movement (mean= 2.4 days, p=0.002) and tolerated oral semisolid diet earlier (mean=3.4 days, p=0.039) than Group A patients. Postoperative complications (p=0.234), duration of ICU stay (p=1), postoperative hospital stay (p=0.241) and readmission rate were comparable between both groups. Conclusion: Implementation of ERAS protocol in CP patients undergoing Frey’ procedure is feasible and safe. ERAS protocol reduced intraoperative opioids requirements with early recovery of bowel movement and tolerance to semisolid diet. However, compliance for the avoidance of postoperative opioids was poor.
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