You have accessJournal of UrologyBladder Cancer: Invasive IV1 Apr 2014MP61-08 PROGRESSION OF T1 HIGH RISK INTO MUSCLE-INVASIVE BLADDER CANCER IS AN INDEPENDENT PROGNOSTIC FACTOR OF MORTALITY AFTER RADICAL CYSTECTOMY Federico Pellucchi, Marco Moschini, Lorenzo Rocchini, Giovanni La Croce, Vito Cucchiara, Franco Bergamaschi, Valerio Di Girolamo, Roberto Bertini, Vincenzo Scattoni, Shahrokh François Shariat, Francesco Montorsi, Alberto Briganti, and Renzo Colombo Federico PellucchiFederico Pellucchi More articles by this author , Marco MoschiniMarco Moschini More articles by this author , Lorenzo RocchiniLorenzo Rocchini More articles by this author , Giovanni La CroceGiovanni La Croce More articles by this author , Vito CucchiaraVito Cucchiara More articles by this author , Franco BergamaschiFranco Bergamaschi More articles by this author , Valerio Di GirolamoValerio Di Girolamo More articles by this author , Roberto BertiniRoberto Bertini More articles by this author , Vincenzo ScattoniVincenzo Scattoni More articles by this author , Shahrokh François ShariatShahrokh François Shariat More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , and Renzo ColomboRenzo Colombo More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1885AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the impact of high risk T1 non-muscle invasive (NMIBC) bladder cancer progression into muscle-invasive disease (MIBC) on cancer-specific-survival (CSS) after radical cystectomy METHODS Overall, 1037 consecutive patients submitted to radical cystectomy (RC) at our institute between 1999 and 2012 were retrospectively evaluated. For the aim of the study, 441 consecutive patients with history of high risk NMIBC who progressed to MIBC and were submitted to RC or treated with early cystectomy before progression. Complete clinical and pathological data (including age, gender, number of TUR, pathological stage at TUR and pathological stage, grade and nodal status at RC) as well as survival status, were retrospectively obtained from our institutional database. Univariate and multivariate Cox regression analyses were adopted to assess the impact of progression to muscle-invasive pattern on CSS and to compare the CSS of patients treated with early cystectomy. RESULTS : Overall, mean age was 65.8 yr (median: 67; range: 35-88). Of the 441 patients, 64 (14.5%) patients were female and 377 (85.5%) were male. Mean number of TUR before cystectomy was 3,6 (range: 2-15). 261 (59.1%) patients had history of high risk NMIBC who progressed to MIBC and were submitted to RC; 180 (40.9%) patients were treated with early cystectomy before progression. Overall pathologic stage distribution was pT0 49 (11.1%), pT1 70 (15.9%), pT2 101 (23.2%), pT3 136 (30.5%) and pT4 in 85 (19.3%). The pathologic nodal status was pN0 in 285 (64.6%), and pN1 in 36 (8.2%) and pN2 in 81 (18.4%), pN3 18 (4,1%). Mean follow-up time was 35 months (range 1-253). At univariate analysis the progression into MIBC correlated with worst CSS (p<0.03; HR 1.43). After adjustments for stage, grade and nodal status, the progression pattern MIBC remains correlated with worst CSS (p=0.08; HR 1.45). CONCLUSIONS T1 high risk NMIBC patients progressing into MIBC have a worst prognosis compared to patients submitted to early radical cystectomy. These data should be considered in decision making of these patients. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e685-e686 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Federico Pellucchi More articles by this author Marco Moschini More articles by this author Lorenzo Rocchini More articles by this author Giovanni La Croce More articles by this author Vito Cucchiara More articles by this author Franco Bergamaschi More articles by this author Valerio Di Girolamo More articles by this author Roberto Bertini More articles by this author Vincenzo Scattoni More articles by this author Shahrokh François Shariat More articles by this author Francesco Montorsi More articles by this author Alberto Briganti More articles by this author Renzo Colombo More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...