Abstract Background The objective of this study was to evaluate the interest of a parietal prosthesis (Cyclomesh ™) soaked with ropivacaine in the management of early postoperative pain. Materials and Methods This is a randomized, phase III, comparative superiority, double-blind, international multicentre study. 290 patients (October 2019 February 2022) underwent surgery for inguinal hernia, by Liechtenstein technique, under general anaesthesia, and with placement of a ropivacaine or saline soaked parietal prosthesis. The primary endpoint was the coughing pain assessment (EVA) at H6. The secondary endpoints were the overall pain assessment at H2, H4 and H6 and the evaluation of the painkillers consumption. Results The prosthesis type had no significant effect on the coughing pain at H6, either for the ITT population (3.3 vs 3.2, p=0.12) or for the PP population (3.3 vs 3.7, p=0.15). The ropivaciane soaked prosthesis resulted in a decrease in the overall pain at H2 (2.3 vs 3.2, p<0.0001), H4 (2.3 vs 3.1, p<0.0001) and H6 (2.3 vs 2.7, p=0.0039). Regarding the painkillers consumption, the postoperative complications and the number of ambulatory conversions, there was no difference between the two groups. Conclusion The placement of a parietal prosthesis (Cyclomesh ™) soaked with ropivacaine did not reduce the coughing pain at H6 but allowed a decrease in the overall pain over the first 6 hours after the surgery and could simplify the management of patients.