Cropping practices that reduce damage from reniform nematode (Rotylenchulus reniformis) and browntop millet (Urochlora ramosa) are needed for improved cotton (Gossypium hirsutum) management. The impacts of early planting dates and reduced tillage systems on these pests were investigated from 2005 to 2007. Planting dates (April 1 or May 1) and tillage systems (conventional or minimum-tillage) were evaluated on four commercial cotton cultivars in a field study at Stoneville, MS. Despite some variability in early-season root infection, reniform nematode soil populations were not affected by any of the treatments. Thus, it appears that neither the tillage practices nor the planting dates examined in this study should be recommended for inclusion in a reniform nematode management program at this time. Mid- and late-season browntop millet pressure was greater in minimum-till plots and in plots planted early. More effective season-long suppression of browntop millet was associated with the traditional planting date and conventional tillage system, so these production practices could benefit producers who need to manage this weed. Accepted for publication 9 November 2010. Published 27 December 2010.