Early Planning Research Articles

Psychometric properties of the Autonomic Symptoms Checklist in the Lewy body disease module of the uniform dataset.

Autonomic dysfunction is an important feature of Lewy Body Dementia (DLB), but measurement of autonomic symptoms has been limited in both previous research and clinical practice. Accurate measurement of autonomic dysfunction has the potential to improve our understanding of the course and progression of DLB, given that autonomic symptoms typically precede cognitive impairment and are associated with functional impairment. The primary aim of this study was to examine the psychometric properties of the two versions (3.0 and 3.1) of the NACC LBD-module Autonomic Symptom Checklist (ASC). Psychometric analyses of the ASC (internal consistency, reliability, factor structure, and validity) were conducted on data acquired from 245 individuals with DLB from the NACC database. ASC V3.0 was contrasted on these attributes to V3.1. Results suggested an underlying factor structure for the ASC, and confirmatory factor analysis (CFA) revealed 3 factors, which generally aligned with discrete autonomic systems. The ASC V3.0 and CFA-identified scales were comparable in terms of reliability, which were both improved relative to the ASC V3.1. In terms of ecological validity, CFA-identified items related to gastrointestinal/thermoregulation symptoms were significantly more associated with functional outcomes compared to the unitary ASC. Findings underscore the importance of differentiation within the autonomic system. Future research into autonomic symptom classes and lab-based pathophysiological measurement of autonomic dysfunction in DLB has the potential to support early identification and inform treatment planning.

Trait-Related Impulsivity, Affective Temperaments and Mood Disorders: Results from a Real-World Multicentric Study.

Trait-related impulsiveness is highly prevalent in patients with mood disorders, being associated with negative outcomes. The predictive role of affective temperaments on trait-related impulsivity is still understudied. The aim of the present study is to investigate the relationship between impulsivity and affective temperaments in a sample of euthymic patients with mood disorders. This is a real-world multicentric observational study, carried out at the outpatient units of seven university sites in Italy. All patients filled in the short version of Munster Temperament Evaluation of the Memphis, Pisa, Paris and San Diego and the Barratt Impulsiveness Scale. The study sample included 653 participants, mainly female (58.2%), with a mean age of 46.9 (±14.1). Regression analyses showed that higher levels of trait-related impulsivity were associated to suicide attempts (p < 0.000), the presence of psychotic symptoms during acute phases (p < 0.05), a seasonal pattern (p < 0.05), a lower age at onset of the disorder (p < 0.05), cyclothymic (p < 0.01) and irritable temperaments (p < 0.01). The results of our study highlight the importance to screen patients with mood disorders for impulsivity and affective temperaments in order to identify patients who are more likely to present a worse outcome and to develop personalized and integrated early pharmacological and psychosocial treatment plans. Novelties of the present paper include the recruitment of patients in a stable phase, which reduced possible bias in patients' self-reports, and the multicentric nature of the study, resulting in the recruitment of a large sample of patients with mood disorders, geographically distributed across Italy, thus improving the generalizability of study results.

Sustainable Development, Regional Planning, and Information Management as an Evolving Theme in Waqf Research: A Bibliometric Analysis

This study assesses the bibliometric analysis of sustainable waqf development that highlights new topics and provides insightful commentary for the waqf’s strategic growth and ongoing research. This work uses bibliometric analysis to count the number of studies that have been carried out in this domain and determine whether they have advanced knowledge on sustainable waqf development. The study specifically highlights the depth to which academics have investigated these relationships and maps to arrive at a conceptual framework of the area being studied. Bibliometric analysis within 30 years of a publication generally arises in three main areas, namely waqf fundamentals, analysis of cash waqf, as well as studies on the numerous waqf uses in Islamic social finance. Whereas analysis within 107 years shows publications concerning waqf increased after the year 2010, from 2017 onwards, despite the rising number of total publications, total citations decreased. Thus, this study focuses on the current ten years from 2011–2020 and dissects 281 papers to study the dynamic topic for current mass research. Three main areas are highlighted in the early study, namely, sustainable development, regional planning, and information management. At the end of the study, the findings show the state of development and the top trends in influence, as well as the major journals, articles, subjects, authors, and countries. Both scholars and practitioners can benefit from the analysis and graphical presentations since they will be able to better grasp the state of the art of waqf in the experiential and current digital eras.

Artificial Intelligence Based Dam Concrete Seepage Prediction Using Wireless Sensor Network

Leakage checking is a fundamental errand in the gamble the executives of substantial dams. Dams assume a fundamental part in reaping energy and using the energy for zap and water system purposes. Aside from that dam safeguard against flooding by gathering and holding waters when they arrive at a specific level. When gathered, a dam may be intended to deliver the water once again into the stream at a controlled speed or redirect the water somewhere else for different purposes. Because of unexpected circumstances blunder of dams would prompt devastating harms, which is exceptionally obvious on account of 2018 Kerala floods, where 35 of its 54 dams were let open without earlier alerts and early activity plans prompting loss of lives, property harms and so on Thus, the issue referenced above is corrected by continuous sensors, for example, temperature, water level, and precipitation and water pressure. These qualities are likewise shown through LCD

273 ‘HOME ON TIME’: MULTIDISCIPLINARY INTERVENTION REDUCES LENGTH OF STAY AND DELAYS IN CARE TRANSFERS ON AN ACUTE GERIATRIC MEDICINE WARD

Abstract Background Unnecessarily prolonged hospital admission can have a profound effect on a frail, older person’s confidence, mood, functional status and cognition.This study examined whether a structured multidisciplinary intervention, embedded within an acute geriatric medicine ward, could reduce unnecessary days in hospital for acutely unwell older patients. Methods The study site is a 28-bed acute geriatric medicine ward in a large urban teaching hospital; data was collected from 1/1/22 to 11/4/22. Patients aged ≥70 years and admitted to the ward were randomly allocated to the Home On Time (HOT) Pathway (n=50) or usual care (n=100). All patients were cared for by a specialist geriatric team. The HOT Pathway involved daily multidisciplinary team (physiotherapy, nursing, occupational therapy, social work and medical) huddles focusing on enhanced communication, early discharge planning and identification of barriers to discharge home. Huddles typically lasted for <15 minutes. Results Almost two-thirds (92/150) of the study sample (mean age 83 years, 60% female) were discharged directly from the ward while one-fifth (29/150) were transferred for rehabilitation and one-tenth ultimately to long term care (16/150). The average acute ward Length-of-Stay (LOS) for HOT pathway patients was 10.4 days, compared to 14.4 days for usual care. The average LOS for HOT pathway patients discharged directly home (i.e. not via rehabilitation or to long-term care) was 8.0 days, compared to 10.2 days for usual care. One-fifth (10/50) of HOT pathway patients were discharged home within 48 hours of admission compared to one tenth (10/100) of usual care patients. Conclusion A structured, multidisciplinary intervention focusing on enhanced communication and early discharge planning within a geriatric medicine ward can reduce length of inpatient stay, delays in transitions of care and increase the rate of discharge home within 48 hours, potentially averting complications related to prolonged hospital admission.

Advanced nursing practice model for head and neck cancer: A practice development project

Advanced nursing practice model for head and neck cancer: A practice development project Abstract. Background: Head and neck cancer confronts patients and their families with big challenges due to complex treatments as well as changes in vital functions and appearance. They require multifaceted support and benefit from coordinated, interprofessional collaboration and advanced nursing practice. Problem/aim: In a tertiary head and neck cancer center, a coordinating contact person was missing for patients, families and the care team. Therefore, a project was launched to develop an advanced nursing practice program. Methods: Methods included an advanced nursing practice concept, approaches for practice development, and action research. The project consisted of four phases: Stakeholder analysis and literature review were followed by the definition of the advanced nursing practice program, which was then tested during a pilot phase, and evaluated using structural/process data and stakeholder interviews. Results: Evidence-based, continuous, person-centered care was improved across the care continuum for patients/families. The nurses' expertise was supported and the collaboration with internal/external clinicians was facilitated. Patients/families valued the continuity offered by the advanced practice nurse. Discussion: The methodological approaches supported a goal-oriented approach; especially participatory practice development helped to address employees' concerns. Limitations/transfer: To date, a sustainable program cannot yet be warranted. For similar projects, an approach with stakeholder analysis, multidisciplinary focus, and early evaluation planning is recommended.

Study on the Application of Satir’s Iceberg Theory in the Psychological and Emotional Relief of College Students

In today’s society, college students are facing greater pressure to study. On the one hand, they don’t fit into colleges after leaving home and their lively schoolmates; on the other hand, they have to make early plans for the future in society. As all this burdens adult students with great strain, they often suffer from depression during their studies and become less confident after self-denial. This paper proposes to design a dialogue system based on Satir's iceberg theory to help alleviate the psychological emotions of the college students mentioned above.

Comparative parotid gland segmentation by using ResNet‐18 and MobileNetV2 based DeepLab v3+ architectures from magnetic resonance images

SummaryNowadays, artificial intelligence‐based medicine plays an important role in determining correlations not comprehensible to humans. In addition, the segmentation of organs at risk is a tedious and time‐consuming procedure. Segmentation of these organs or tissues is widely used in early diagnosis, treatment planning, and diagnosis. In this study, we trained semantic segmentation networks to segment healthy parotid glands using deep learning. The dataset we used in the study was obtained from Recep Tayyip Erdogan University Training and Research Hospital, and there were 72 T2‐weighted magnetic resonance (MR) images in this dataset. After these images were manually segmented by experts, masks of these images were obtained according to them and all images were cropped. Afterward, these cropped images and masks were rotated 45°, 120°, and 210°, quadrupling the number of images. We trained ResNet‐18/MobileNetV2‐based DeepLab v3+ without augmentation and ResNet‐18/MobileNetV2‐based DeepLab v3+ with augmentation using these datasets. Here, we set the training set and testing set sizes for all architectures to be 80% and 20%, respectively. We designed two different graphical user interface (GUI) applications so that users can easily segment their parotid glands by utilizing all of these deep learning‐based semantic segmentation networks. From the results, mean‐weighted dice values of MobileNetV2‐based DeepLab v3+ without augmentation and ResNet‐18‐based DeepLab v3+ with augmentation were equal to 0.90845–0.93931 and 0.93237–0.96960, respectively. We also noted that the sensitivity (%), specificity (%), F1 score (%) values of these models were equal to 83.21, 96.65, 85.04 and 89.81, 97.84, 87.80, respectively. As a result, these designed models were found to be clinically successful, and the user‐friendly GUI applications of these proposed systems can be used by clinicians. This study is competitive as it uses MR images, can automatically segment both parotid glands, the results are meaningful according to the literature and have software application.

Clinical Practice of Targeted Capture Sequencing to Identify Actionable Alterations in Cholangiocarcinoma.

Simple SummaryGenetic testing promises to provide guidance for early diagnosis and treatment of cholangiocarcinoma (CCA). Due to the different mutation landscapes across populations and the paucity of sequencing data of Chinese patients with CCA, the existing mutation landscape is insufficient to reflect the mutation characteristics of Chinese patients. We retrospectively analyzed 72 Chinese patients with CCA who had received genetic testing of targeted capture sequencing. A total of 2152 somatic mutations were detected in 56 (77.78%, 56/72) patients, of which, the frequently mutated driver genes were TP53, KMT2D, KMT2C, BCOR, APC, BAP1, ARID1A, NF1, PIK3CA, KRAS, and LRP1B. Most mutations were enriched in NRF2, TP53, and TGF-Beta oncogenic signaling pathways and cadherin repeat domain which were associated with intercellular adhesion. We identified 118 novel pathogenic or likely pathogenic somatic mutations and 77 actionable alterations, which provided potential targets for early diagnosis and treatment planning of CCA.The early diagnosis and treatment of cholangiocarcinoma (CCA) remain a challenge worldwide. Genetic testing promises to solve these problems. Due to the different mutation landscapes across populations and the paucity of sequencing data of Chinese patients with CCA, the existing mutation landscape is insufficient to reflect the mutation characteristics of Chinese patients. Thus, we retrospectively analyzed 72 Chinese patients with CCA who had received genetic testing of targeted capture sequencing. A total of 2152 somatic mutations were detected in 56 (77.78%) patients, of which, the frequently mutated driver genes were TP53 (27.78%), KMT2D (23.81%), KMT2C (20.63%), BCOR (18.06%), APC (15.28%), BAP1 (13.89%), ARID1A (12.50%), NF1 (12.50%), PIK3CA (12.50%), KRAS (11.11%), and LRP1B (11.11%). Most mutations were enriched in NRF2, TP53, and TGF-Beta oncogenic signaling pathways and cadherin repeat domains which were associated with intercellular adhesion. Based on cancer-related public databases and multiple protein function prediction algorithms, we identified 118 novel pathogenic or likely pathogenic somatic mutations and 77 actionable alterations. Molecular analysis of tumors from a precision oncology perspective can provide potential targets for early diagnosis and treatment of CCA and assist physicians in clinical decision making.

STUDY OF ANALYSIS OF COMPUTED TOMOGRAPHY SCORE IN COVID 19 SEVERE PATIENTS

Introduction: Computerized tomography (CT) is a crucial technique for determining the severity of COVID-19. Ground glass opacities (GGO), crazy-paving patterns, and parenchymal consolidations are the most frequent patterns. Fibrosis, subpleural lines, the reversed "halo sign," pleural effusion, and lymphadenopathy are additional related CT features. The course and severity of the disease are related to CT results in COVID-19 patients. For patients with COVID-19, evaluation of laboratory and chest CT imaging features for prognostic prediction would be benecial for a better knowledge of disease pathogenesis, risk stratication, and the development of early treatment plans that ultimately minimise mortality Materials and Methods: Present study was performed on 100 laboratory conrmed cases of COVID–19 diagnosed on reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR). Cases were divided into two groups based on clinical disease severity scoring based on the criteria provided by Chinese Centre of Disease Control (CDC)5 as Group A (Disease presenting with dyspnoea, respiratory rate ≥ 30/min and SpO2 ≤ 93%) and Group B (Disease presenting with mild symptoms without dyspnoea, respiratory rate < 30/ min and SpO2 > 93 %). Patients Information on demography, clinical data with symptoms, comorbidity and disease severity were collected. CT Chest was sent in every patient at the time of admission. Observations and Results: Right and left lower lobe was affected in majority i.e 47 (47 %) and 52 (52 %) respectively. In group A moderate 25 (25 %) and severe CT 17 (17 %) score was found in majority whereas in group B mild 33 (33 %) CT score was in majority. Result was statistically signicant (P<0.00001). Ground glass opacity was the main CT pattern found in majority 47 (47 %). In group B compared to group A maximum patients got discharged within 10 days. Also ICU admissions were less 1 (1 %). Result was statistically signicant (P=0.008) Conclusion: Temporal changes of chest CT features and severity scores were closely associated with the outcome of COVID-19, which may be valuable for early identication of severe cases and eventually reducing the morbidity of COVID-19

Stop ‘under-mind-ing’ early childhood educators: Honouring subjectivity in pre-service education to build intellectual and relational capacities

The stubborn dominance of objectivity in child observation in pre-service early childhood education warrants letting go of as we confront its limitations as outdated, problematic, Eurocentric, neo-liberal and even racist. In the context of recent aims to establish ‘critically reflective’ practices, such as ‘pedagogical documentation’ and ‘collaborative inquiry’ as the ‘new way’ to ‘do’ early childhood curriculum planning in Ontario, Canada, the authors are concerned that the hard work of naming and creating conditions to ‘think together’ with concepts of subjectivity has been missed and misunderstood. The risk of missing this shared thinking and not persevering in the struggles of subjectivities, especially in curriculum courses and placement, underestimates and ‘under-minds’ the intellectual capacity of students and positions theory as neutral in its relation to practice. How, then, does one take up subjectivity and recognize its affordance in building the intellectual and relational capacity of pre-service students? What conditions need to be created to lead with critical thinking and engage in subjectivities in the context of early childhood education pre-service programs? Drawing on critical educational perspectives, the authors work to define subjectivity in the context of early childhood education; identify the conceptual barriers that they have encountered in their work as a professor and a field liaison; and propose potentially generative conditions for pre-service programs.

Predicting factors and outcomes of acute myocarditis in children - a 5-year experience in a teaching hospital from the Eastern province of Saudi Arabia.

Myocarditis in children is not very common, but the state of the disease is similar to viral influenza, making it challenging for a clinician to make an early diagnosis and treatment plan. Elevated levels of inflammatory biomarkers like C-reactive protein, serum lactate, troponin, and abnormal ECG may be helpful for high-index suspicion of myocarditis. This study aimed to determine the predicting factors and outcomes of acute myocarditis in children admitted to a teaching hospital in the Eastern province of Saudi Arabia. Complete medical records of 80 pediatric patients with acute myocarditis over 5 years (from 2015 to 2019) were retrieved, including demographic characteristics, laboratory investigations including cardiac enzymes (serum lactate, CPR, and troponin), and ECG findings for the diagnosis of myocarditis based on tachycardia and bradycardia. There were 22 (27.5%) mortalities that took place during the hospital stay. Low WBC (mmol/dl) levels were associated with in-hospital mortality (p 0.001), whereas high serum lactate levels (>2 mmol) were not. Association of troponin level (0.15ng/mL) was not significantly associated with mortality (p=0.496). The area under the ROC=0.947 (95% C.I: 0.88-1.0) revealed highly significant predictive validity at the 2.3 best cutoff point, having 90.9% and 87.9% sensitivity and specificity, respectively. Clinical factors and elevated biomarkers were associated with poor prognosis and in-hospital mortality in pediatric myocarditis. Serum lactate and troponin levels demonstrated high predictive validity for early diagnosis.

Myths and Realities of the Salt Lake Temple Foundation

Myths and Realities of the Salt Lake Temple Foundation

SURVIVAL OUTCOMES OF INTUBATED COVID-19 PATIENTS WHO UNDERGO CPR: A SYSTEMATIC REVIEW

SURVIVAL OUTCOMES OF INTUBATED COVID-19 PATIENTS WHO UNDERGO CPR: A SYSTEMATIC REVIEW

A digital twin approach for tunnel construction safety early warning and management

Accidents tend to happen during tunnel construction due to the harsh environmental and geological conditions. Towards high safety risk during tunnel construction, a digital-twin based multi-information intelligent early warning and safety management platform is proposed in this study. At first, a communication line is built inside tunnel through multifunctional base stations. Multi-source information from tunnel construction could be collected and transmitted automatically. Then, dynamic tunnel construction information and surrounding rock conditions are virtual simulated. Meanwhile, four-level early warning and emergency response plan are built to provide judgement on the construction status. At last, application effects of the platform are validated in a deep buried tunnel project, Dongtianshan Tunnel in China, which has extreme weather, harmful gas, and bad geological conditions. A collapse accident of tunnel excavation face was successfully predicted by the platform. Early warning and appropriate emergency measures were taken in time, and the personnel safety was ensured.

P38 The gut that leaks

Introduction/BackgroundSystemic lupus erythematosus is a chronic inflammatory autoimmune disease which can affect multiple organ systems. Symptoms of intestinal involvement in SLE may vary from common and non-specific such as heartburn, oral ulcers and dysphagia to less common but more serious including abdominal pain due to serositis and intestinal vasculitis.Description/MethodA 20 year old girl was referred to the gastroenterology team for the management of ascites. Her past medical history included SLE diagnosed aged 10, class IV lupus nephritis, autoimmune haemolytic anaemia secondary to SLE, Haemoglobin H, gastrostomy feeding due to poor growth.At the time of the transition from paediatric to adult service her SLE was under good control. She was on Prednisolone 6 mg on alternate days, Mycophenolate (MMF) 750 mg BD, Septrin 240 mg OD and Enalapril 2.5 mg OD. After the transition, MMF was reduced to 500 mg OD. The rest were unchanged. Serum total protein was 57 (60-80), serum albumin 32 (35-50). Weight was 41.2 kg.Ten months after the transition, she presented with bilateral leg swelling and subsequently tense ascites over 3 weeks. Serum total protein reduced to 31, albumin 13.24 hour urine total protein was 0.15 (0-0.1), urine volume 1.7 L. Serum creatinine 20 µmol/L and eGFR >90. Urine PCR was 16 mg/mmol.Total protein in ascites drain fluid was <20 g/L, albumin <10 g/L, glucose 5.7 mol/L. There were no malignant cells and no growth on enrichment culture.She was referred to the dietitians who advised that her oral intake was adequate.There was no evidence of heart failure on echocardiogram.Small bowel meal showed oedematous bowel wall but no abnormalities in terminal ileum. Coeliac serology was negative.CT abdomen and pelvis showed normal appearances to the liver, hepatic and portal veins; no features of Budd-Chiari syndrome; normal size kidneys; incidental finding of non-occlusive right internal jugular thrombus and moderate lymphadenopathy in mesenteric and retroperitoneal regions.She developed swelling in the right calf. Doppler ultrasound confirmed major DVT with occlusive thrombus extending to distal superficial femoral veins. Clots in inferior vena cava and portal veins were excluded.Discussion/ResultsDuodenal biopsy confirmed villous oedema and dilated lymphatics consistent with changes seen in protein losing enteropathy. She was referred to Rheumatology. Prednisolone was increased to 15 mg. The response was rapid with reduction in ascites. MMF was increased to maximum tolerable dose 750 mg AM and 500 mg PM.Hb had been persistently low around 50 during this illness. She had longstanding hypocomplementaemia. C3 dropped to 0.37 (baseline 0.6). C4 remained low around 0.04. IgG was 5.9 (baseline >7). Serology showed DsDNA was 5 (normal range 0-15), positive ANA, trace positive RNP and negative Rheumatoid factor and APL antibodies. CRP was 10.Abdominal lymphadenopathy was felt to be due reactive changes due to active lupus.With increased steroids and immunosuppressants, she improved significantly both clinically and biochemically within a few weeks. Hb rose to over 90, serum albumin > 25 and serum protein above 50 by the end of 3 months after treatment escalation.Warfarin was stopped upon completion of 6 month anticoagulation.On repeat CT, previous abdominal lymphadenopathy had resolved completely. Splenomegaly measuring 17.6 cm was noted. This was discussed in haematology MDT and thought to be due to the haemoglobinopathy and haemolysis.Haemolysis continued to be a challenge. She remained on relatively high dose steroids varying between 20 mg and 10 mg over the years. Vitamin D was prescribed. Weight was very low but stable just above 38 kg.Protein Losing Enteropathy (PLE) is rare but recognised in SLE. It typically occurs in young women with clinically severe disease with multi organ involvement. Clinical presentation is characterised by the onset of profound oedema, hypoalbuminaemia in the absence of nephrotic range proteinuria. Severe diarrhoea is present in 50% of the patients. It is important to investigate and exclude other causes of hypoalbuminaemia (e.g cardiac failure, liver diseases, malnutrition) and PLE.Key learning points/ConclusionPLE can be the initial manifestation of SLE.Lupus nephritis and PLE can be present successively or simultaneously in a lupus patient.Stringent diagnostic evaluation is required to exclude other mimicking conditions.Multidisciplinary team involvement is crucial in the management of patients with multi-organ involvement.PLE associated with SLE usually responds well to corticosteroids. However additional immunosuppressant(s) are generally required to treat other SLE symptoms as well as to help with the steroid reduction regime.As well as treating the underlying disease, advice from dietitians is important to improve and maximise the nutritional status of these patients.A clinically significant hyper-coagulable state is reportedly attributed to PLE associated with SLE. Therefore, VTE prophylaxis especially in hospitalised patients is recommended. Moreover, clinicians should have high index of suspicion for VTE in these patients with multiple risk factors to arrange early appropriate investigations and treatment plan.

Paediatric Inflammatory Bowel Disease: A Multi-Stakeholder Perspective to Improve Development of Drugs for Children and Adolescents.

Despite recent approvals for new drugs to treat adults with Crohn's disease or ulcerative colitis, there are only two approved advanced treatment options [infliximab and adalimumab] for children with inflammatory bowel disease [IBD]. There are many potential new therapies being developed for adult and paediatric IBD. Moreover, regulatory agencies in both the European Union and USA have processes in place to support the early planning and initiation of paediatric studies. Nevertheless, unacceptable delays in approvals for use of drugs in children persist, with an average 7-year gap, or longer, between authorization of new IBD drugs for adults and children. A 2-day virtual meeting was held during April 14-15, 2021 for multi-stakeholders [clinical academics, patient community, pharmaceutical companies and regulators] to discuss their perspectives on paediatric drug development for IBD. The multi-stakeholder group presented, discussed and proposed actions to achieve expediting the approval of new drugs in development for paediatric IBD. Collaborative action points for all stakeholders are required to make progress and facilitate new drug development for children with IBD.

Evaluation between the Association of Chronicle of Tooth Extraction with Oral Alveolar Carcinoma: An Observational Clinco-pathological Institutional Assessment

malignant tumors of the jaws. One of the most important reasons for the increase in the number of patients diagnosed with oral carcinoma and its association with the high mortality rates is the late detection of the carcinoma. Aims: The aim of the study was to analyse the clinic-pathological relationship between oral alveolus carcinoma and with history of tooth extraction. Materials &amp; Methods: It was an observational, clinic-pathological study.952 Patients aged 30–80 years diagnosed with alveolus carcinoma of the jaws with a history of recent tooth extraction and unhealed socket at the extraction site were included in the study. Demographic, clinical, and disease-related continuous variables were computed for each subject and presented as descriptive statistics including calculation of percentages (% age). Categorical variables were analysed using Chi-square test. Regression analysis was used to identify habits and disease-related variables which can affect the incidence of oral carcinoma. Results: 2655 (33.78%) were diagnosed with alveolus carcinoma while 952(12.11%) patients were associated with a history of dental extraction as a chief complaint. 553(58.08%) patients had developed carcinoma in the proximity of the site of placement of the tobacco, and 431(45.27%) patients underwent extractions as they do not want preventive treatment. Conclusions: The focus of the current study is on early diagnosis and appropriate treatment planning, both of which can affect prognosis. It will also contribute to the enhancement of clinical awareness following tooth extraction.

A Recent Systematic Review of Cervical Cancer Diagnosis: Detection and Classification

Women around the world are frequently diagnosed with cervical cancer. In the beginning, there were no symptoms for the fourth most common cause of fatality in women. Cells of cervical cancer develop gradually at the cervix. Several studies have mentioned that the initial detection of cervical tumours is essential for cancer to be properly treated and to make sure cancer can be successfully treated while minimizing deaths due to cervical cancer. The diagnosis of such cancer before it spreads fast is currently a pressing issue for healthcare professionals. This also provides an extensive understanding with respect to the physical characteristics of the healthy and unhealthy cervix and aids in early treatment planning by giving detailed information about one another. Utilizing image segmentation, several techniques are employed to find malignancy. The dataset contains four distinct pathological pictures, including normal, malignancy, and high-grade squamous intraepithelial lesions (HSIL). While pap tests are the most popular way to diagnose cervical cancer, their accuracy depends a lot on how well cytotechnicians can use brightfield microscopy to spot abnormal cells on smears.

Quantitative evaluation of provincial government plans for public health emergencies in China

In order to rationalize public health emergency plans (PHEPs) and compensate for the shortcomings of current public health emergency (PHE) management, we conducted a quantitative study on evaluating and analyzing provincial PHEPs in China from the perspective of the consistency and completeness of plan texts. Based on the policy modeling consistency index (PMC-Index) model, we developed an evaluation variable system for PHEPs, which consists of 9 main variables and 57 sub-variables. We used stratified sampling to randomly select five provincial PHEPs in China as samples for empirical analysis. Each plan was evaluated and improved according to its PMC-Index value and PMC-Surface diagram. The results showed that the overall design of the PHEPs was generally reasonable, despite much room for improvement. The PMC-Index values of the five plans were 7.06, 6.23, 5.66, 6.34 and 3.70, respectively, with an average value of 5.80. Among the five plans, three were rated as good, one was rated as acceptable, and one was rated as unacceptable. According to the average values of the main variables, we found weaknesses in the plans in monitoring, early warning, evaluating and reporting, early disposal, emergency support, recovery, working mechanism and plan reliability and proposed optimization methods to improve the weaknesses. This study contributes to evaluating PHEPs and identifying their shortcomings, which provides not only a beneficial experience to plan-makers but also a supplement for the field of plan evaluation.