Recent studies carried out in the High Andes of central-western Argentina in the provinces of San Juan and Mendoza have established its stratigraphic and structural evolution. This paper presents new data on the Triassic–Early Jurassic rift system, the depositional sequences, and a synthesis of the tectonic evolution of the region, along with a correlation with the Chilean continental margin. The paleogeographic evolution of the Cordillera Principal at these latitudes is controlled by the development of the Mercedario rift system. This rift began with the sedimentation of synrift deposits of the Rancho de Lata Formation, during the Rhetian (about 190 Ma). Subsidence was driven by normal faults, locally preserved in spite of the severe tectonic inversion of the Andes during the Cenozoic. Different authors have emphasized that an important extension dominated the transition between the Triassic and Jurassic periods along the magmatic arc in the Coastal Cordillera of Chile on the western side of the Andes. Extension was related to the bimodal magmatism that characterized the evolution of this segment (30°–33° SL). The granitic plutonism and the associated mafic volcanism indicate that they were controlled by extension during 220–200 Ma. The first subduction related granitoids at these latitudes are 170 Ma old (Bathonian). The geometry of the Mercedario rift system may be reconstructed by the pattern of the normal faults. Rifting was followed by a thermal subsidence that expanded the original area of sedimentation and controlled the paleogeography of the Los Patillos Formation during Pliensbachian to early Callovian times. This period of cooling and thermal subsidence is correlated with magmatic quiescence in the continental margin. The evolution of the basin closely matches the magmatic history of the Chilean continental margin. Subduction at the continental margin began in the Bathonian, together with deposition of the upper section of Los Patillos Formation. Arc magmatism shifted to the Cordillera Principal during the Kimmeridgian, where it is represented by the volcanic and volcaniclastic deposits of Tordillo Formation. Early Mesozoic evolution of the Andean system at these latitudes is, thus, reconstructed by a comparative analysis of these two adjacent regions, driven by a common tectonic regime, but through different geological processes.