Heavy-duty diesel engines are an essential part of road transportation. Since viable alternatives are not expected in the short and medium term, the problematic emission characteristics of compression ignition engines have to be addressed. Low temperature combustion (LTC) is an alternative combustion method for compression ignition engines that allows low particulate matter and nitrogen oxide emissions while improving efficiency. To overcome the difficulties of market introduction, the realization of such alternative combustion methods should come with marginal engine modifications. Thus, this work investigates the possible realization of LTC in an unmodified diesel engine. LTC methods with and without injection strategy modifications were also studied to provide sufficient recommendations for other researchers. It was concluded that techniques requiring early direct injection, such as homogeneous charge compression ignition (HCCI) require a narrow cone angle injector to reduce wall impingement. It was also concluded that modulated kinetics (MK) type LTC can be easily achieved by applying a conventional injection strategy and high amounts of cooled exhaust gas recirculation. The realized MK combustion resulted in an enhanced NOx-PM trade-off and a lower peak pressure rise rate compared to normal operation.