SESSION TITLE: Venous Thromboembolism SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, November 1, 2017 at 01:30 PM - 02:30 PM PURPOSE: Transthoracic echocardiography (TTE) offers diagnostic clue and hemodynamic status in patients with pulmonary embolism (PE). Many indices have been suggested to play a useful diagnostic role. This study aimed to certify peak early diastolic mitral inflow velocity (E velocity) as diagnostic predictors of PE in patients who underwent chest computed tomography (CT) scanning for rule out PE. METHODS: During the period of January 2013 to May 2014, we enrolled a total of 131 consecutive patients (44.3% men, mean age 71±13 years) as following inclusion criteria: 1) Underwent chest embolism CT for the stated indication of rule out PE, 2) Underwent contemporary TTE within 48 hours interval, 3) Pulmonary arterial systolic pressure (PASP) ≥ 30 mmHg, using peak tricuspid regurgitation (TR) velocity. The patients were divided into two groups; 1) PE group (n=43), who was diagnosed as submassive or massive PE by chest CT scanning, 2) Non-PE group (n=88), who didn’t have an evidence of PE in chest CT scanning; and the clinical and echocardiographic parameters were compared between two groups. RESULTS: Baseline clinical characteristics were not different between two groups. The PE group had significantly lower mitral E velocity (56.61±19.02 vs. 85.16±28.29 cm/s, P<0.001), E/A ratio (0.62±0.16 vs. 1.26±0.92, P<0.001), E/E’ ratio (11.0±4.0 vs. 17.1±9.2, P<0.001). PASP (48.8±13.7 vs. 43.3±13.7 mmHg, P=0.03) and peak TR velocity (3.09±0.52 vs. 2.89±0.50 mmHg, P=0.036) were higher in the PE group. In multivariate regression analysis, mitral E velocity was independent predictor in diagnosis of PE (HR 0.955, 95% CI 0.929-0.983, P=0.002). The cut-off value of mitral E velocity (AUC 0.808, 95% CI 0.731-0.885, P<0.001) for diagnosis of PE was < 68.2 cm/s (Sensitivity 69.3%, Specificity 81.4%). CONCLUSIONS: These results suggest that the peak transmitral E velocity would be important adjunctive predictor for diagnosis of PE, which maybe related with left ventricular underfilling. CLINICAL IMPLICATIONS: This study certified the peak early diastolic mitral inflow velocity (E velocity) as a simple diagnostic predictor of pulmonary embolism. DISCLOSURE: The following authors have nothing to disclose: Chan-Hee Lee, Hyun Jung Kim No Product/Research Disclosure Information