Early Detection Of Cervical Cancer Research Articles

The Effect of Health Education Using Audiovisuals on The Knowledge of Adolescent Girls about Breast Self-Examination (BSE)

Cancer is a non-communicable disease with the second-largest death rate in the world. Breast cancer is one of the main diseases treated by palliative care services. Breast cancer is the most common cancer among women in the world. Early detection is a very important first step to find out early the presence of tumors or lumps in the breast to reduce the death rate due to cancer. The advantage of early detection of breast cancer is beneficial to increase the chances of life expectancy in women with breast cancer. Almost 85% of disorders or lumps are found by the patient through proper examination. In addition, BSE is the easiest, fastest, cheapest, and simplest method that can detect breast cancer early. Knowing the Effect of Health Education Using Audio Visual Media on Adolescent Girls' Knowledge about BSE at SMAN 10 Tangerang Regency Banten 2023. The research design used was quasi-experimental research with a one-group pretest-posttest design approach. The population used in this study was class X adolescent girls at SMAN 10 Tangerang Regency totaling 155 people. The number of samples taken was 30 samples obtained through the Proportionate Stratified Random Sampling technique. Data were collected using a questionnaire. Data analysis was done by Paired T Test. The results of univariate analysis before conducting health education using audio-visual video exposure were 10.67, while the average knowledge of adolescent girls increased after health education to 15.60. The results of bivariate analysis with paired sample t-test P value = 0.001 means that there is an effect of counseling with audiovisual media on increasing the knowledge of adolescent girls about breast self-examination. Using audiovisual media to increase knowledge about breast self-examination (BSE) for early detection of cervical cancer.

The Relationship of Delivery Method and Family Planning History with Via Examination Results (Visual Inspection of Acetic Acid)”

VIA (Visual Acetic Acid Inspection) is a type of examination to detect cervical cancer. There are several factors that can cause positive VIA results and every couple of childbearing age (PUS) should carry out early detection of cervical cancer once a year, one of which is through an VIA examination. However, unfortunately there are still many couples of childbearing age who have not done so and when the examination is carried out, some of the results are positive and are even in an advanced stage. The Objective of this study was to determine the relationship between delivery method and birth control history with the results of VIA examination (visual inspection of acetic acid).
 This type of observational analytic research, cross-sectional design. The research population was all couple of childbearing age (PUS) in Malang Regency. The inclusion criteria were carrying out a VIA examination at the Polowijen Malang Community Health Center and having given birth. The sample consisted of 34 respondents. The research was carried out on November 8 2023. Data was collected by conducting interviews about birth methods and family planning history as well as conducting VIA examinations. Data were analyzed using the chi-square test. There is no relationship between the method of delivery and the results of the VIA examination which is statistically significant with a P value = 0.223. Vaginal delivery does not always cause cervical injury which is needed by HPV to penetrate the transformation zone which can gradually lead to precancerous lesions or positive VIA results. There is no relationship between history of family planning use and VIA examination results which is statistically significant with p value = 0.994. Women who have never used hormonal or non-hormonal contraception can also experience precancerous lesions or positive VIA examination results.

Pemberdayaan Perempuan Dalam Upaya Deteksi Dini Kanker Serviks Melalui Metode Reproductive Organ Self Examination (Rose) di Wilayah Kerja UPT Puskesmaskecamatan Sumbawa Unit 1

Cervical cancer is the most common cancer in women, and mostly occurs in developing countries including Indonesia. In 2020, the World Health Organization found that cervical cancer was the seventh most common cause of death in the world, and caused 604,127 events annually. In the United States, cervical cancer cases are estimated at 13,800 cases of invasive cervical cancer and 4,290 deaths from cervical cancer occurred in 2020. For the ASEAN region, the incidence of cervical cancer in Singapore is 25.0 in Chinese, 17.8 in Malays, and Thai at 23.7 per 100,000 population. Every year there are about 90-100 new cases of cervical cancer, and every year about 40,000 people are affected by this disease. Cervical cancer ranks second as many as 36,633 or 9.20% of the total cancer cases in Indonesia in 2020. The purpose of this community service activity is to convey information about cervical cancer and improve early detection skills of cervical cancer with the ROSE method in women of childbearing age in the Working Area of the Puskesmas Sumbawa District Unit I. Reproductive Organ Self Examination (ROSE) is a simple method that can be done by mothers themselves to find out any problems in their reproductive organs. Health education needs to be done to improve mothers' knowledge and attitudes about cervical cancer. This community service activity aims to improve the behavior of mothers in the working area of UPT Puskesmas Sumbawa District Unit 1 in conducting early detection of cervical cancer through the IVA method and the ROSE technique and continued with questions and answers with activity participants. Women of childbearing age (WUS) in the Working Area of UPT Puskesmas Sumbawa District Unit I.

Pengetahuan Dan Sikap Wanita Terhadap Kanker Serviks : Scoping Review

Background: Cervical cancer is the fourth most common disease of the female reproductive system worldwide. The incidence of cervical cancer in the world is entering a critical period, where every year the incidence of cervical cancer is increasing. Until now, cervical cancer is the leading cause of death in developing countries. Aim: To find out about women's knowledge and attitudes towards cervical cancer. Method: Scoping review using Arksey and O'Malley frameworks, using databases from PubMed, EBSCO and Wiley. Result: A total of 14 articles from 2016-2021 used critical appraisal from JBI (Joanna Briggs Institute). Women's knowledge and attitudes towards cervical cancer have six themes. The first theme is knowledge about cervical cancer which consists of knowledge about risk factors, signs and symptoms and early detection of cervical cancer. The second theme is the attitude of women towards cervical cancer consisting of positive and negative attitudes. The third theme is the factors that influence knowledge consisting of age, education, family income and sexual frequency. The fourth theme of factors that influence attitudes is age and education. The fifth theme of information sources consists of mass media, family and friends, health workers and health services. Theme six is the barriers to accessing information and services consisting of a lack of awareness and the high cost of vaccination. Conclusion: Knowledge about cervical cancer in women is still low. Women only have a general idea of cervical cancer. However, women show a good attitude about cervical cancer screening, because cervical cancer can cause death and if early diagnosis of the disease is very helpful in preventing disease.

Hubungan Pengetahuan Kanker Serviks Dengan Deteksi Dini Pemeriksaan IVA Pada Wanita Usia Subur Di Kelurahan Tawaang Barat Manado

Cervical cancer generally affects women aged between 15 and 49 years. Globally in 2020, there were 19.2 million new cancer cases which caused nearly 10 million deaths, according to data from WHO. The WHO cancer profile also recorded around 604,127 cases of cervical cancer worldwide, where this incidence was the second largest in Asia with a percentage of 58.2%, or around 351,720 individuals affected by the disease. In Indonesia, based on data from Global Burden Cancer (GLOBCAN) described in the Indonesia Cancer Care Community (ICCC) article, cervical cancer is in second place in terms of the highest number of sufferers after breast cancer in women, with around 32,469 cases (17.2%) and the death rate was around 18,279 people (8.8%). Objective. Knowing the Relationship between Cervical Cancer Knowledge and Early Detection of Visual Inspection of Acetic Acid (IVA) in Women of Childbearing Age in Tawaang Barat Subdistrict, Manado City in 2023 Research Method. This research uses quantitative research with analytical survey methods and a cross-sectional approach. The sample in this study was women of childbearing age aged 25-49 years. The sample was taken using Cluster random sampling, obtaining a sample of 135 respondents. Data analysis used Chi square. Results. For sufficient knowledge, 53 people (39.3%), 78 people (57.8%) did not carry out early detection. The results of Chi square analysis for the relationship between knowledge of cervical cancer and early detection of VIA examination are p value (0.000) ˂α (0.05).

Handling Early Detection of Cervical Cancer on the Motivation of Women of Childbearing Age to Perform VIA Examinations in the Work Area of the Community Health Center

The incidence of cervical cancer in Indonesia in 2011 reached 100 per 100,000 population per year and the spread appears to be accumulating in Java and Bali. This figure is estimated to continue to increase by 25% in the next 10 years if preventive measures are not taken. Cervical cancer ranks second among all cancers in women with an incidence rate of 9.7 % and a death rate of 9.3% of all cancers in women in the world. Early detection of cervical cancer is an innovative breakthrough in health development to reduce mortality and morbidity due to cervical cancer. The aim is to determine the effect of health education regarding early detection of cervical ca on the motivation of women of childbearing age to undergo VIA examinations in the Antang Community Health Center working area. This type of research is research using an analytical survey method with a cross sectional study approach. With a population of 197 people and a sample size of 30 people with a sampling technique using purposive sampling. Data analysis was carried out using the Mc.Nemar Test. The results of the statistical test research on all respondents using the Mc. Nemar test obtained a p value of 0.000<p value 0.05. HO is rejected Ha is accepted, then there is an influence of Health Education regarding Early Detection of Cervical Ca on Women of Childbearing Age Carrying out IVA Examinations in the Antang Health Center Work Area.

Regional variations and inequalities in testing for early detection of breast and cervical cancer: evidence from a nationally representative survey in India.

The burden of cancer in India has been rising, yet testing for early detection remains low. This study explored inequalities in the uptake of breast cancer (BC) examination and cervical cancer (CC) among Indian women, focusing on socioeconomic, regional, and educational differences. Data from the 2019-21 National Family Health Survey (n=353,518) were used to assess the uptake of BC examination and CC testing. Inequalities were quantified using the slope index of inequality (SII), relative index of inequality (RII), and relative concentration index (RCI). SII measured absolute inequality, while RII and RCI assessed relative inequality between disadvantaged and advantaged groups. The ever uptake of tests for early detection of BC and CC were low at 9 and 20 per 1,000 women, respectively. Higher uptake was observed among women from the richest households compared to the poorest (SII: 1.1 for BC and 1.8 for CC). The magnitude of relative socioeconomic inequalities was more pronounced in rural areas (RCI: 22.5 for BC and 21.3 for CC) compared to urban areas. Similarly, higher-educated women were 4.84 times (RII: 4.84) and 2.12 times (RII: 2.12) more likely to undergo BC examination and CC testing, respectively, compared to non-educated women. The northeastern region exhibited greater socioeconomic inequality, while the western region showed more education-based inequality. The lower uptake of BC examination and CC testing and the marked inequalities underscore the need for targeted interventions to improve access and utilization of testing services, especially among lower-educated women, and those in rural areas.

CER818: A Highly Specific and Sensitive HPV L1 High-Risk Serological Lateral Flow Rapid Test for Early Detection of Cervical Cancer and Its Precursor Lesions.

Objective: The objective of the study is to validate a new human papillomavirus (HPV) L1 high-risk specific serological assay in a case-control study. Methods: Serum samples of 138 patients (cervical intraepithelial neoplasia (CIN) 1, 2, and 3 and cervical cancer), 21 vaccinees, and 246 female controls were tested for the presence of HPV L1 high-risk specific antibodies. Results: HPV L1 high-risk antibodies were detected in 100% of the CIN1 and 2, 86.6% of the CIN3 and 82.4% of the cervical cancer cases, 100% of the vaccinees, and 3.9% of the female controls. Area under the curve (AUC) was calculated with 0.91 for controls versus CIN2+, 0.923 for controls versus CIN1+, and 0.968 for controls versus CIN1/2. Conclusion: The HPV L1 high-risk specific serological lateral flow rapid test shows promising data in the field of early detection of HPV high-risk induced cervical cancer and its precursor lesions. This easy-to-use, robust, and affordable approach could offer a chance to reach women in low- or middle-income countries (LMICs) that could not be reached by HPV molecular testing-based cervical cancer screening programs.

Nucleus Cell Segmentation on Pap Smear Image Using Bradley Modification Algorithm

Early detection of cervical cancer can help patients obtain the best treatment through various means. In general, computer-aided diagnosis has a high impact on the accuracy, reliability, and convenience of cervical cancer. However, several limitations have been faced through the design process in detecting or classifying the cells, such as variation of image features and low-image resolution. Moreover, shape indifference is one of the limitations in terms of image processing scope. The metrics used to measure the size and shape of the cells have not been developed to distinguish the differences between the shape of the objects. This paper focused on the detection and segmentation of the nucleus cell region in Pap smear images based on Bradley local thresholding. The proposed method evolved several steps, such as color adjustment, k-means, and a Bradley modification algorithm. Based on image quality assessment (IQA), the numerical evaluation results indicate that the proposed approach has segmented a full area of the nucleus cell region significantly and efficiently compared to the original Bradley algorithm. We obtained F-measure (98.62%), sensitivity (99.13%), and accuracy (97.96%). It has also been proven that the proposed method can effectively address the issue of low contrast and black noise. Hence, the proposed method differs from the previous research in terms of color disproportion adjustment and the modification of Bradleys algorithm for Pap smear image convenience.

A Clinical Evaluation of the HPV Antigen Rapid Test for Early Detection of Cervical Cancer

A Clinical Evaluation of the HPV Antigen Rapid Test for Early Detection of Cervical Cancer

A study to evaluate the effectiveness of planned teaching programme (PTP) regarding the knowledge on early detection and prevention of cervical cancer among nursing students in selected nursing colleges of Ujjain, M.P.

A study to evaluate the effectiveness of planned teaching programme (PTP) regarding the knowledge on early detection and prevention of cervical cancer among nursing students in selected nursing colleges of Ujjain, M.P.

Successful Routine Cervical Cancer Screening Facilitated by Pelvic Floor Physical Therapy for a Woman With Developmental Disability and a History of Trauma: Case Report

Background: Women with intellectual and developmental disabilities (I/DD) are not getting routine cervical cancer screens at the recommended frequency, limiting opportunities for early detection and treatment of cervical cancer. Pelvic floor physical therapy plans of care can be used to successfully address this health care disparity. Case Description: This is the case of a patient who had diagnoses of developmental delay, oppositional defiant disorder, attention-deficit disorder, unilateral hearing loss, and a history of trauma. The patient was referred by her primary care physician after a halted first pelvic examination due to tension of the patient's pelvic floor and her overall discomfort and dissociation from the session. Clinical findings revealed pelvic floor tension. Interventions were employed over the course of 18 sessions. Outcomes: Sessions focused on education, positioning, relaxation, and graded vaginal dilator insertion while keeping the patient engaged to prevent dissociation. The patient showed minimal clinically important differences on the Patient-Specific Functional Scale, met the short- and long-term goals including undergoing a pain-free pelvic examination, and had a significantly decreased pelvic floor resting tone. Discussion: For patients with I/DD, pelvic floor physical therapy can be a valuable tool to help them undergo a successful and pain-free routine cervical cancer screen. It may take longer than typical plans of care, but the outcomes justify the length of the intervention. Practices that promote self-determination are a key to success. Informed consent was obtained and signed by the patient's medical guardian. Video Abstract: Supplemental Digital Content available at: http://links.lww.com/JWHPT/A128

Comparison of multiplex PCR capillary electrophoresis assay and PCR-reverse dot blot assay for human papillomavirus DNA genotyping detection in cervical cancer tissue specimens.

The study aimed to evaluate the positivity rates and genotype distribution of the multiplex PCR capillary electrophoresis (MPCE) and PCR-Reverse Dot Blot (PCR-RDB) assays for human papillomavirus (HPV) detection in cervical cancer tissue specimens, and to explore their detection principles and applications in large-scale population screening. The MPCE and PCR-RDB assays were performed separately on 425 diagnosed cervical cancer tissue specimens. Subsequently, the results of both assays were compared based on the HPV infection positivity rates and genotype distribution. The overall positive rates of HPV genotypes for the MPCE and PCR-RDB assays were 97.9% and 92.9%, respectively. A p-value < 0.001 indicated a statistically significance difference in consistency between the two assays. The kappa value was 0.390, indicating that the consistency between both assays was fair. HPV16 was the most common single-genotype infection type, with infection rates detected via MPCE and PCR-RDB assays being 75.7% and 68.3%, respectively. In the age group >50 years, the HPV multiple-type infection rate detected via MPCE assay was significantly higher than that detected by the PCR-RDB assay, with a statistically significant difference (p = 0.002). To reduce the false-negative rate and improve screening efficiency, the MPCE assay, which targets the oncogenic gene E6/E7 segments, can be extended to the general female population for the early detection, diagnosis, and treatment of cervical cancer.

TGFA expression is associated with poor prognosis and promotes the development of cervical cancer.

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the second most common cancers in women aged 20-39. While HPV screening can help with early detection of cervical cancer, many patients are already in the medium to late stages when they are identified. As a result, searching for novel biomarkers to predict CESC prognosis and propose molecular treatment targets is critical. TGFA is a polypeptide growth factor with a high affinity for the epidermal growth factor receptor. Several studies have shown that TGFA can improve cancer growth and progression, but data on its impact on the occurrence and advancement of CESC is limited. In this study, we used clinical data analysis and bioinformatics techniques to explore the relationship between TGFA and CESC. The results showed that TGFA was highly expressed in cervical cancer tissues and cells. TGFA knockdown can inhibit the proliferation, migration and invasion of cervical cancer cells. In addition, after TGFA knockout, the expression of IL family and MMP family proteins in CESC cell lines was significantly reduced. In conclusion, TGFA plays an important role in the occurrence and development of cervical cancer. Therefore, TGFA may become a new target for cervical cancer treatment.

Relationship of Knowledge About Cervical Cancer and PAP SMEAR with Early Detection Behavior of PAP SMEAR

&lt;div&gt;&lt;table cellspacing="0" cellpadding="0" align="left"&gt;&lt;tbody&gt;&lt;tr&gt;&lt;td align="left" valign="top"&gt;&lt;p&gt;&lt;em&gt;Cervical cancer is the third leading cause of death in Indonesia. Cervical cancer is usually only diagnosed when the cancer has entered an advanced stage. So the need for early detection as an effort to prevent cervical cancer. One of the most effective and commonly used methods to detect cervical cancer is Pap smear. The purpose of this study was to see the relationship between knowledge about cervical cancer and Pap smear with Pap smear early detection behavior. This study used analytic method with quantitative approach. The population of this study were all married women in Pancoran District, South Jakarta. Then, consecutive non-random sampling technique was used and 153 respondents were obtained with a questionnaire as a tool to obtain research data. Data collection was carried out from September to November 2023. Followed by analysis with the Chi-Square test using SPSS. Based on the results of the study, 58.2% of respondents have good knowledge and 72.5% of respondents have not done Pap smear examination from 158 respondents, there is no significant relationship between knowledge about cervical cancer and Pap smear with Pap smear early detection behavior (p-value=0.093). The conclusion of this study is that there is no relationship between knowledge about cervical cancer and Pap smear with early detection behavior of Pap smear in Pancoran District, South Jakarta. &lt;/em&gt;&lt;em&gt; &lt;/em&gt;&lt;em&gt;For further research, it is recommended to provide insight into cervical cancer in depth so that readers are aware of the importance of early detection of cervical cancer&lt;/em&gt;&lt;em&gt;.&lt;/em&gt;&lt;strong&gt;&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;/p&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/tbody&gt;&lt;/table&gt;&lt;/div&gt;&lt;strong&gt;&lt;em&gt;Keyword: Cervival cancer, Knowledge, Pap smear&lt;/em&gt;&lt;/strong&gt;

Promising role of molecular biomarkers in cytological samples for early detection of cervical cancer: a systematic review

Introduction: Cervical cancer is a preventable and treatable disease. Early detection is crucial for improving patient prognosis and quality of life. The Pap smear has limitations in sensitivity and specificity. Molecular biomarkers in cytological samples can improve early detection. Method: A literature review was conducted on the evaluation of molecular biomarkers in cytological samples for the early detection of cervical cancer. Studies were searched in PubMed, Scopus, and Web of Science. Results: We identified 6 studies that evaluated various molecular biomarkers, including HPV DNA, DNA methylation, miRNAs, and proteins. The studies demonstrated that molecular biomarkers have a higher sensitivity and specificity than the Pap smear for detecting cervical cancer. Conclusion: The evaluation of molecular biomarkers in cytological samples is a promising tool for the early detection of cervical cancer. Further research is needed to standardize detection techniques, validate their clinical utility in different populations and contexts, and reduce the cost of testing.

Enhancing early cervical cancer detection through the mobile-based DEDIKASI application

The incidence rate of cervical cancer in Indonesia remains high; however, it can be prevented through early detection. The study aimed to assess the effectiveness of the DEDIKASI mobile application, a continuation of the Early Warning System (EWS) cancer application for cervical cancer risk assessment in women of reproductive age. Employed a quasi-experimental design with a nonequivalent group posttest-only approach, the research included 388 participants chosen through random sampling. The EWS Application group showed a majority categorized as "Very Suspect" (52.6%), while the DEDIKASI group had the majority in the "High Risk" category (40.7%). ISO 25010 testing revealed an excellent overall score of 92% for the DEDIKASI application, indicating strong functional suitability and usability. The t-test results (p-value = 0.000) indicated that the DEDIKASI application was more effective than the EWS Cervical Ca application in assessing cervical cancer risk. The findings underscore the potential of the DEDIKASI mobile application for improving early detection and risk assessment of cervical cancer in women of childbearing age, offering a valuable tool to address the high incidence rate of cervical cancer in Indonesia.

Circular RNAs in Cervical Cancer: What are the Prospects?

C ervical cancer remains a pressing global health problem, creating a significant health burden for women worldwide. High incidence and mortality rates necessitate further research to unravel its underlying molecular mechanisms and identify new diagnostic and treatment strategies. Recent advances in non-coding RNAs have opened up new avenues for research, including circular RNAs (circRNAs) as molecules that play a multifaceted role in cellular processes. Research into circRNAs revealed their unique structure, characterized by the covalent formation of a closed loop, thereby distinguishing them from their linear counterparts. These circRNAs are involved in regulating various aspects of cell physiology with a particular focus on cell growth and development. Interestingly, circRNAs have context-dependent functions, acting both as promoters and inhibitors of oncogenic processes, depending on the complex cellular environment in which they operate. Recent studies have identified aberrant expression patterns of circRNAs in the context of cervical cancer, implying their key role in the disease development. The different expression profiles of circRNAs associated with cervical cancer offer promising opportunities for early detection, accurate prognosis assessment, and personalized treatment strategies. The presented comprehensive review offers an in-depth study of cervical cancer-associated circRNAs, their specific functions and complex molecular mechanisms driving the onset and progression of cervical cancer. Increasing evidence suggests that circRNAs can serve as invaluable biomarkers for early detection of cervical cancer and promising therapeutic targets for intervention. Delving into the complex interaction between circRNAs and cervical cancer paves the way for innovative and personalized approaches to combat this serious disease, aiming at reducing its impact on women’s health worldwide and improve patient outcomes. Unraveling the mysteries of circRNAs in the context of cervical cancer makes the prospects for a breakthrough in its diagnosis and treatment more promising.

Cervical pre-cancer classification using entropic features and CNN: In vivo validation with a handheld fluorescence probe.

Cervical cancer is one of the most prevalent forms of cancer, with a lengthy latent period and a gradual onset phase. Conventional techniques are found to be severely lacking in real time detection of disease progression which can greatly enhance the cure rate. Due to their high sensitivity and specificity, optical techniques are emerging as reliable tools, particularly in case of cancer. It has been seen that biochemical changes are better highlighted through intrinsic fluorescence devoid of interference from absorption and scattering. Its effectiveness in in-vivo conditions is affected by the fact that the intrinsic spectral signatures vary from patient to patient, as well as in different population groups. Here, we overcome this limitation by collectively enumerating the subtle changes in the spectral profiles and correlations through an information theory based entropic approach, which significantly amplifies the minute spectral variations. In conjunction with artificial intelligence (AI)/machine learning (ML) tools, it yields high specificity and sensitivity with a small dataset from patients in clinical conditions, without artificial augmentation. We have used an in-house developed handheld probe (i-HHP) for extracting intrinsic fluorescence spectra of human cervix from 110 different subjects drawn from diverse population groups. The average classification accuracy of the proposed methodology using 10-fold cross validation is 93.17%. A combination of polarised fluorescence spectra from i-HHP and the proposed classifier is proven to be minimally invasive with the ability to diagnose patients in real time. This paves the way for effective use of relatively smaller sized sensitive fluorescence data with advanced AI/ML tools for early cervical cancer detection in clinics.

“Easy women get it”: pre-existing stigma associated with HPV and cervical cancer in a low-resource setting prior to implementation of an HPV screen-and-treat program

BackgroundCervical cancer is preventable with vaccination and early detection and treatment programs. However, for these programs to work as intended, stigma related to HPV and cervical cancer must be understood and addressed. We explored pre-existing stigma associated with HPV and cervical cancer in the public healthcare system and community of a low-resource setting prior to implementation of an HPV screen-and-treat program.MethodsThis study conducted thematic analysis of data collected during implementation of a novel HPV screen-and-treat system for cervical cancer early detection and treatment in Iquitos, Peru. We included 35 semi-structured interviews (19 health professionals, 16 women with cervical precancer or cancer), eight focus groups (70 community women), one workshop (14 health professionals), 210 counseling observations (with 20 nurse-midwives), and a document review. We used the Socio-Ecological Model to organize the analysis.ResultsWe identified three main themes: 1. the implication that women are to blame for their HPV infection through characterizations of being easy or promiscuous, 2. the implication that men are to blame for women’s HPV infections through being considered careless or unfaithful, 3. HPV is shameful, embarrassing, and something that should be hidden from others. Consequently, in some cases, women refrained from getting screened for HPV. These themes were seen at the individual level among women, relationship level among women, men, and family members, community level among healthcare staff, and societal level within components of cervical cancer guidelines and male chauvinism.ConclusionsCervical cancer early detection and treatment programs in limited resource settings must address stigma entrenched throughout the entire healthcare system and community in order to sustainably and successfully implement and scale-up new programs. Interventions to tackle this stigma can incorporate messages about HPV infections and latency to lessen the focus on the influence of sexual behavior on HPV acquisition, and instead, promote screening and treatment as paramount preventative measures.