Objectives: Cerebral palsy is an umbrella term covering a group of non-progressive, but often changing, motor impairment syndromes secondary to lesions or anomalies of the brain arising in the early stages of its development (DM & CN, 1992, 34: 547–55). Cerebral palsy is the most frequent motor impairment in childhood, but, it is more than merely a motor disorder. There can be also problems of development, perceptual- cognitive impairment, social and functional problems of daily living, emotional and behavioural problems, Epilepsy, and many other difficulties. There are an estimated 15 million people with cerebral palsy around the world and more then half of them are mentally retarded and one third have epilepsy How to treat it? Having in mind a broad spectrum of differences in age of persons at which firm diagnosis is made, inclusions and exclusions criteria, denominator for clinical features (topographical or other classification), and especially what was a cause and timing of insult, size and location of lesion, maturational state of system injured, integrity of areas surrounding and contralateral to lesion, genetic and environmental background, gene-gene and geneenvironment interactions, and intervening conditions (timing of start, quality, duration and intensity), it is obvious that there are currently no evidence-based strategies for preventing cerebral palsy and to say which method of treatment is superior. In addition to this fact we should find a balance between physiotherapy (among them nowadays the most used Neurodevelopmental treatment – Bobath, Vojta, Conductive education and Constrain induced therapy), pharmacology, and neurosurgical approaches (Local anaesthetics, Local neurolytics -Alcohol, Phenol-, Botulinum toxin, Baclofen pump, Selective dorsal rhizotomy, Peripheral neurectomy, Deep brain stimulation). Beside this there are many not proven therapies (Biofeedback, Functional Motor Learning, Acupuncture, The “Adeli” suit, Hyperbaric oxygenation, Homeopathy, Bio-energy, and others). Gene and transplantation therapies? Even for genetic causes of early brain lesions (e.g. as is thrombophilias) are only a very small proportion of potential candidate genes have been examined to date, how can we expect that in the near future we will have a gene therapy. Stem cells – to repopulate brain? Indeed, there is now ample evidence that stem cells exist in the central nervous system throughout life, and the progeny of these stem cells may have the ability to assume the functional role of neural cells that have been lost. In addition, once transplanted, stem cells have been shown to survive, migrate, and differentiate. But nevertheless, the clinical utility of stem cell therapy for neurorestoration remains elusive.