A branch of artificial intelligence called machine learning is well-positioned as a prediction method that can take into consideration several influencing factors and complex inter-factor connections. Without being specifically trained to do so, these machine learning models have the ability to generalize, predict, and learn from data. Regression theory is a key topic in statistical modelling and machine learning. The main goal of this study is to compare the performance of several popular machine learning regression models for predicting the early-age compressive strength of concretes made from recycled concrete aggregates from a structure that demolished following the Sivrice-Elazig earthquake on January 24, 2020. Early-age concrete compressive strength is even more crucial due to factors like the fact that there are thousands of newly built structures in the aftermath of the earthquake, the quick manufacturing of these structures, and the completion of the project in the lowest amount of time. Determining the early-age concrete strength with high accuracy and in a useful manner is crucial for this reason. Seven different classical machine learning algorithms were employed in this study to achieve all of these goals. Early-age concrete compressive strength values were considered for 1 and 3 days. The relationship between the experimental results and the predicted outcomes of the employed algorithms was investigated, and a thorough comparison of these intelligent regression algorithms was conducted. Within the scope of sustainable development and circular economy goals, it is thought that this article will make significant contributions to the literature in terms of utilizing these waste materials and determining the early-age compressive strengths of the concretes produced with high accuracy.