Early Pioneers Research Articles

Advanced Deep-Plane Rhytidectomy: Advantages for Neck Treatment and Volumization of the Midface.

The aged neck is the most common motivator for patients seeking facial rejuvenation. Unlike the deflated midface, surgical treatment is still the gold standard for optimal outcomes. It is our view that the majority etiology of both the aged neck and deflated midface is gravity's effects on the superficial soft tissue envelope, leading to soft tissue redundancy. It is also our view that the deep-plane rhytidectomy is supported by anatomy, embryology, and clinical evidence as the best methodology to treat soft tissue redundancy without producing the aesthetic and longevity issues associated with superficial musculoaponeurotic system techniques. As one of the early pioneers in deep-plane rhytidectomy, the lead author will define contemporary advances in deep-plane technique such as dissection entry point, flap design, and flap fixation concepts that allow aggressive approach to treating both the aged neck and deflated midface.

Beyond Human and Machine: An Architecture and Methodology Guideline for Centaurian Design

The concept of the centaur, symbolizing the fusion of human and machine intelligence, has intrigued visionaries for decades. Recent advancements in artificial intelligence have made this concept not only realizable but also actionable. This synergistic partnership between natural and artificial intelligence promises superior outcomes by leveraging the strengths of both entities. Tracing its origins back to early pioneers of human–computer interaction in the 1960s, such as J.C.R. Licklider and Douglas Engelbart, the idea initially manifested in centaur chess but faced challenges as technological advances began to overshadow human contributions. However, the resurgence of generative AI in the late 2010s, exemplified by conversational agents and text-to-image chatbots, has rekindled interest in the profound potential of human–AI collaboration. This article formalizes the centaurian model, detailing properties associated with various centaurian designs, evaluating their feasibility, and proposing a design methodology that integrates human creativity with artificial intelligence. Additionally, it compares this model with other integrative theories, such as the Theory of Extended Mind and Intellectology, providing a comprehensive analysis of its place in the landscape of human–machine interaction.

Standing Still, Go Along, and Zooming In: Complementary Strategies of Participant-Observations in Urban Ethnography

This paper seeks to complement conventional ethnographic participant observation methods, proposing the integration of three distinct strategies. Motivated by own ethnographic studies, conducted in an urban supermarket and a food festival site, the paper contends that traditional long-term immersion may not always suffice for investigating transient urban phenomena. The paper advocates for the integration of complementary methodological strategies for participant observation adaptable to evolving contexts and research questions. Firstly, the "standing still" approach involves minimal engagement while observing a specific scene or interaction, offering a detached yet insightful perspective on fleeting moments or events. Secondly, the "go along" strategy entails tracking a particular individual, group, or object through movements and networks, providing valuable insights into routines, relationships, and controversies. Lastly, the "zooming in" technique uncovers unexpected details within scenes, interactions, or subject matter, enriching understanding of what might otherwise go unnoticed. While the first two strategies are practices employed by early pioneers in the field, the latter gains relevance in an era where video recordings are increasingly prevalent. The paper argues for the complementarity of the three strategies, fostering a more advanced comprehension of the supermarket and social landscape at large. This study holds significant implications for the practice of participant observation, encouraging researchers to embrace a repertoire of strategies tailored to the unique demands of each research inquiry and situational context. This attentive and context-driven approach allows for a more nuanced and comprehensive grasp of the social world under scrutiny.

Veronica Moss: early pioneer in the care of patients with AIDS

Veronica Moss: early pioneer in the care of patients with AIDS

Religious Education and Ecumenical Formation in Post-confessional Settings – Essentials for the Theological Education of Pastors and Teachers of Religion

Abstract The article discusses the significance of international discourse on ecumenical formation for debates about the future of religious education in diverse environments, both from a German and global perspective. It emphasizes the historical importance of education in the ecumenical movement, tracing back to the early pioneers with a background in the World Student Christian Fellowship. The author draws from his longstanding involvement in international ecumenical work on education to advocate for ecumenical formation for students of theology, including those training to be religious education teachers. The article surveys key policy documents from German and international church bodies and concludes with six essential learnings for theological education in post-confessional environments.

The Church Museums’ Evolution of the Idea and Methods of Missionary Work in China: A Study of Tsinanfu Institute

The Church Museums’ Evolution of the Idea and Methods of Missionary Work in China: A Study of Tsinanfu Institute

Contributions and Legacies of Selected Black Pioneers in Ophthalmology and Institutional Milestones

PurposeEstablishing a record of key contributions of early Black ophthalmologists can help illuminate future generations. We aimed to identify major physician pioneers in Ophthalmology, delineate their contributions, and place their ascendance in an historical context to understand the institutional and cultural barriers they overcame to achieve success. MethodsPubmed and other databases were searched, along with death notices and archeological records, using "Black," "African American," "eye surgeon," "Negro," "Journal of the National Medical Association" and other search terms. Librarians from the Library of Congress, National Institutes of Health, and key ophthalmology-training institutions were consulted, as were the American Academy of Ophthalmology and American Board of Ophthalmology. Family members and colleagues of selected deceased pioneers were interviewed. ResultsMany early pioneers emerged from historically black institutions, as Black students and practitioners were then typically excluded elsewhere. Mentorship is a key theme that emerged in the careers of many pioneers and the Black ophthalmologists they trained. ConclusionsBlack ophthalmologists have contributed tremendously to eye-care practice, education, and innovation. Efforts to recruit and train Black ophthalmologists should include highlighting the roles of Black pioneers, increasing educational and training access for underrepresented in medicine at the institutional level, and expanding pathway and mentorship programs.

A comprehensive history of injection therapy for erectile dysfunction, 1982-2023.

Although oral phosphodiesterase 5 inhibitors represent a first choice and long-term option for about half of all patients with erectile dysfunction (ED), self-injection therapy with vasoactive drugs remains a viable alternative for all those who are not reacting or cannot tolerate oral drug therapy. This current injection therapy has an interesting history beginning in 1982. To provide a comprehensive history of self-injection therapy from the very beginnings in 1982 by contemporary witnesses and some members of the International Society for Sexual Medicine's History Committee, a complete history of injection therapy is prepared from eyewitness accounts and review of the published literature on the subject, as well as an update of the current status of self-injection therapy. Published data on injection therapy, as a diagnostic and therapeutic tool for ED, were reviewed thoroughly by PubMed and Medline research from 1982 until June 2023. Early pioneers and witnesses added firsthand details to this historical review. Therapeutic reports of injection therapy were reviewed, and results of side effects and complications were thoroughly reviewed. The pioneers of the first hours were Ronal Virag (1982) for papaverine, Giles Brindley (1983) for cavernosal alpha-blockade (phentolamine and phenoxybenzamine), Adrian Zorgniotti (1985) for papaverine/phentolamine, and Ganesan Adaikan and N. Ishii (1986) for prostaglandin E1. Moxisylyte (thymoxamine) was originally marketed but later withdrawn. The most common side effect is priapism, with the greatest risk of this from papaverine, which has modified its use for therapy. Currently, prostaglandin E1 and trimixes continue to be the agents of choice for diagnostic and therapeutic use in ED. A recent agent is a mixture of a vasoactive intestinal polypeptide (aviptadil) and phentolamine. After 40years, self-injection therapy represents the medication with the highest efficacy and reliability rates and remains a viable option for many couples with ED. The history of this therapy is rich.

In the beginning, there was the analogue. An alternative history of the beginnings of computer art

Since the late 1960s, the historiography of computer art has been developing a canon that is progressively broadening. However, this canon reveals significant blind spots, particularly due to the predominant success of digital computers leading to computer art being almost exclusively identified with digital technology. This identification overlooks other significant classes of computers, notably analogue and hybrid systems, leaving the contributions, artworks, and ideas of many early pioneers in the field unrecognized. Consequently, the history of art created with analogue and hybrid computers remains largely unexplored both in art history and media archaeology. This article seeks to illuminate this relatively obscure chapter of history by introducing the individuals and projects that utilized analogue computers, drawing on previously unknown historical sources. The aim is to underscore the historical significance of a technology that is currently experiencing a resurgence of interest in the field of computer science. The findings reveal that before the advent of artistic experiments with digital computers, analogue computers were the subject of pioneering exploration. The real-time intuitive operation of analogue computers was a unique advantage, foreshadowing a human-machine relationship now commonplace with digital technology. The narrative of the analogue computer constitutes an essential domain for understanding the diversity of computing technologies at the dawn of the computer age. Despite the scarcity of sources documenting these artistic endeavors, this article serves as a call to action for further research in this neglected area.

An Interview with Dr. Stanley White, One of NASA's First Flight Surgeons.

BACKGROUND: In the early days of the National Aeronautics and Space Administration (NASA), medicine in support of the astronauts was led by military experts from the U.S. Air Force as well as experts from the U.S. Navy and U.S. Army. In the early years, a physician with expertise in aerospace medicine was assigned to the Space Task Group and then to NASA. One of these individuals was Dr. Stanley White, a U.S. Air Force physician. To capture more of the early space medicine pioneers, a contract was established between the National Library of Medicine and the principal investigator at the University of Cincinnati to conduct a series of interviews with these early pioneers. An interview with Dr. White took place in his home while he was in hospice care. This audiotaped interview and other written and oral histories within NASA archives and the literature were reviewed to support this work. A series of questions were prepared for the interaction with Dr. White. These questions provided further clarification on his background and contribution. Responses to questions elicited open-ended discussion. The conversation provided a historical summary of Dr. White's contribution to NASA as one of its first flight surgeons.Doarn CR. An interview with Dr. Stanley White, one of NASA's first flight surgeons. Aerosp Med Hum Perform. 2024; 95(4):223-225.

Advanced Deep-Plane Rhytidectomy: Advantages for Neck Treatment and Volumization of the Midface.

The aged neck is the most common motivator for patients seeking facial rejuvenation. Unlike the deflated midface, surgical treatment is still the gold standard for optimal outcomes. It is our view that the majority etiology of both the aged neck and deflated midface is gravity's effects on the superficial soft tissue envelope, leading to soft tissue redundancy. It is also our view that the deep-plane rhytidectomy is supported by anatomy, embryology, and clinical evidence as the best methodology to treat soft tissue redundancy without producing the aesthetic and longevity issues associated with superficial musculoaponeurotic system techniques. As one of the early pioneers in deep-plane rhytidectomy, the lead author will define contemporary advances in deep-plane technique such as dissection entry point, flap design, and flap fixation concepts that allow aggressive approach to treating both the aged neck and deflated midface.

Colin Walker: early pioneer of neonatal intensive care who developed national database for newborn infants

Colin Walker: early pioneer of neonatal intensive care who developed national database for newborn infants

A comprehensive review on the development of sporadic cerebral arteriovenous malformations: from Padget to next-generation sequencing.

Cerebral arteriovenous malformations (AVMs) are a leading cause of intracerebral hemorrhage in both children and young adults. With the continued advancement of science and technology, the understanding of the pathophysiology behind the development of these lesions has evolved. From early theory published by Harvey Cushing and Percival Bailey in 1928, Tumors Arising from the Blood-vessels of the Brain: Angiomatous Malformations and Hemangioblastoma, which regarded AVMs as tumors arising from blood vessels, to the meticulous artistry of Dorcas Padget's embryological cataloguing of the cerebral vasculature in 1948, to the proliferative capillaropathy theory of Yaşargil in 1987, to Ramey's 2014 hierarchical model of vascular development, there have been multiple hypotheses of congenital, developmental, and genetic two-hit theories in the pathogenesis of AVMs. Most recent evidence implicates somatic KRAS mutations in the cerebral endothelium, producing an important understanding of the pathogenesis of this disease, which is critical to the development of targeted therapeutics. The authors present the historical progression of their understanding of AVM pathogenesis. They focus on the foundation laid by early pioneers, discussing embryological anatomy and vasculogenesis, the prominent theories of AVM development that have emerged over time, and culminate in an overview of the most current understanding of the pathogenesis of these complex vascular lesions and the clinical implications of our scientific progress.

Systems thinking: fostering collaboration and connections to strengthen the field. A conversation with Umberta Telfener

AbstractUmberta Telfener is a highly respected figure known for her diverse contributions to various facets of family and systemic therapy. Her leadership style has earned her a reputation as somewhat of a ‘cultural anthropologist,’ reflecting her aptitude for creating connections, establishing relationships, and developing partnerships. Her unique ‘Umberta style’ is known for boundless energy, active leadership, and fierce commitment to challenging the status quo. Despite being in office for just a year at the European Family Therapy Association (EFTA), Umberta has conceived and developed numerous projects, establishing networks with practitioners, and systemic thinkers across the world. Rooted in classical philosophical training, her pursuit aligns with the systematic study of fundamental questions about existence, reason, knowledge, value, mind, and language. Umberta's role reminds one of a ‘Chasqui,’ a Quechua term for a ‘messenger,’ which aptly describes her agile networking skills. She actively communicates and shares vital messages, supporting the international community of systemic practitioners. This paper is based on an in‐person conversation held in July 2023 at Umberta's country home in Tuscany. Our discussion delves into her extensive professional experience, from training at the Philadelphia Child Guidance Clinic, being mentored by Boscolo and Cecchin in Milan, to her leadership role as the current EFTA president. Umberta reflects on early pioneers who influenced her thinking and her impactful work with systems.

التدريس المصغر

We can consider 1963 as the year of birth of this method, which will witness the establishment of the first micro-learning laboratory in the Department of Teacher Education at Stanford University in America. The teacher preparation department at this university faced the problem of the reluctance of graduates who were prepared to teach to study in the department to obtain a degree Educational rehabilitation, which prompted some professors in this department to search for methods that satisfy the needs of the trainees and make them attractive to the training courses to practice teaching. Regarding the backgrounds of the birth of this method, Wasif Aziz (1999) argues that the emergence of micro-teaching goes back to the belief that was prevalent among university graduates in the sixties. Since the last century and their success in arts colleges in the United States, they did not benefit from the studies they received to prepare them for the teaching profession. This was the opinion of Allen, one of the early pioneers of minor teaching. Teachers were critical of the education they received during their preparation for service or during service, and considered them responsible for not providing them with the necessary skills to ensure that their students reach the required level of achievement. Perhaps the most important justification for these criticisms lies in the tendency of the traditional model in preparing teachers to be verbal and pay attention to the cognitive aspect, as well as the lack of Integration between theoretical studies, practical experiences and the experimental aspect. Criticism was directed at practical education for its insufficiency, and this was coupled with what some educational researchers admitted that the research that took place over half a century on teaching and learning did not have the slightest impact on the interaction taking place inside the classroom, as MacDonald (1973) suggested. He is the second person who was credited with establishing microteaching, to researching its theoretical foundations, and he believed that teacher preparation programs should be viewed as behavior modification systems, designed to modify complex systems of behavior to suit diverse learning problems.

G. Carl Huber (1865-1934): A Michigan Pioneer in Peripheral Nerve Injury and Regeneration.

The treatment of peripheral nerve injuries has seen tremendous innovations over the past century. Dr Gotthelf Carl Huber, an American immigrant and early experimental pioneer in the field of peripheral nerve injury, created a foundation of scientific knowledge for these advancements. At the beginning of his career, Huber published novel work in peripheral nerve injury, supporting the concept of Wallerian degeneration and demonstrating the use of nerve grafting for repair. As his scientific career evolved into other research areas at the University of Michigan, Huber's impact extended far beyond just the study of peripheral nerve injury. Because of the external forces of the First World War, Dr Huber's focus returned to translational projects concentrated on the treatment of neuromas and war time peripheral nerve injuries. Huber's scientific impact in the field of peripheral nerve injury and repair came as a result of his incredible work ethic, mentorship, and tremendous leadership qualities; through this, his work still influences clinical practice today, a century later.

Unearthing, preserving, and promoting Sikh American history: The Sikh American history project

ABSTRACT The Sikh American History Project (SAHP) is a grassroots organization of scholars, students, and community members committed to unearthing, preserving, and promoting the stories and experiences of Sikh Americans. By sharing these stories from the early pioneer era to the present day, SAHP aims to build greater understanding and respect for Sikh American history. SAHP also offers a variety of educational resources and programs designed to engage and inform individuals both within and outside of the Sikh American community about Sikh American history and culture.

Development of Cross-Sector Collaboration Indicators in the Child-Friendly City Program in Makassar City

Purpose: This research aims to produce indicators for the cross-sector collaboration process in the KLA Program to measure and evaluate cross-sector performance based on health and welfare indicators in Indonesia. Theoretical reference: This research uses theories from Thomson and Perry in 2006 and also research by Balqis, 2023. Thomson and Perry perfected Gray's theory, which was an early pioneer in the formation of collaboration theory (describing a multidimensional model of collaboration). Method: This research uses a qualitative method with a Rapid Assessment Procedure design, discussing child-friendly district/city programs which are then validated by policymakers. Results and Conclusion: This research produces indicators of cross-collaboration in the KLA program. 17 indicators were identified in five dimensions of collaboration, namely governance dimension which consists of 3 indicators (membership, institutional rules, structural changes) and 7 sub-indicators; The administrative dimension consists of 6 indicators (communication channels, clarity of roles and responsibilities, coordination of policy makers and implementers, completeness of information media data, program evaluation/monitoring) and 14 sub-indicators; The autonomy dimension consists of 2 indicators (programs and budgets) and 9 sub-indicators; The mutuality dimension consists of 3 indicators (exchange of resources, appreciation, HR training in understanding children's rights conventions) and 6 sub-indicators; The norms dimension consist of 3 indicators (trust, commitment, and reward) and 5 sub-indicators. The conclusion of this research is the indicators resulting from the five dimensions of collaboration can be used as a reference to prove quantitatively and used as a tool in measuring cross-sectoral performance in child-friendly district/city programs. Implications of research: These findings contribute to cross-sector collaboration in child-friendly city programs. Apart from that, this can also have implications for policymakers and other stakeholders in developing collaboration indicators to achieve the goals of the child-friendly city program. Originality/Value: This research is conducted using a collaborative approach with five key dimensions of collaboration, namely governance, administration, mutuality, norms, and organizational autonomy. Novelty in this research is original because it offers the concept of developing cross-sector collaboration indicators in the health sector category.

On determining Navier's slip parameter at a solid boundary in flows of a Navier–Stokes fluid

While the assumption of the “no-slip” condition at a solid boundary is unquestioningly applied to study the flow characteristics of a Navier–Stokes fluid, there was considerable debate among the early pioneers of fluid mechanics, Du Buat, Girard, Navier, Coulomb, Poisson, Prony, Stokes, and others, as to the proper condition that has to be met at a solid boundary due to a fluid, such as water flowing adjacent to the same. Contemporary usage of the no-slip boundary condition notwithstanding, in our previous study [Málek and Rajagopal, “On a methodology to determine whether the fluid slips adjacent to a solid surface,” Int. J. Non-Linear Mech. 157, 104512 (2023)], we outlined a methodology to test the validity of the assumption. In this study, we continue the investigation further by providing a scheme for determining the slip parameter that characterizes the extent of slip, if one presumes that Navier's slip boundary condition is satisfied. We find that depending on whether the volumetric flow rate is greater or less than the volumetric flow rate corresponding to the no-slip case, different scenarios present themselves regarding what transpires at the boundary.

History of Microglia.

The term 'microglia' was first introduced into the scientific literature a century ago. The various eras of microglial research have been defined not only by the number of reports subsequently generated but, more critically, also by the concepts that have shaped our present-day views and understanding of microglia. Key methods, technologies, and models, as well as seminal discoveries made possible through their deployment have enabled breakthroughs, and now pave the way for lines of investigation that could not have been anticipated even a decade ago. Advances in our understanding of the microglial origin, forms, and functions have relied fundamentally on parallel developments in immunology. As the 'neuro-immune' cells of the brain, microglia are now under the spotlight in various disciplines. This chapter surveys the gradual processes and precipitous events that helped form ideas concerning the developmental origin of microglia and their roles in health and disease. It first covers the dawning phase during which the early pioneers of microglial research discovered cellular entities and already assigned functions to them. Following a recess period, the 1960s brought about a renaissance of active interest, with the development of tools and models-and fundamental notions on microglial contributions to central nervous system (CNS) pathologies. These seminal efforts laid the foundation for the awakening of a sweeping research era beginning in the 1980s and spurred on by a blast of immunological discoveries. Finally, this chapter stresses the advancements in molecular, genetic, and imaging approaches to the study of microglia with the turn of the millennium, enabling insights into virtually all facets of microglial physiology. Moving forward, it is clear that the future holds substantial promise for further discoveries. The next epoch in the history of microglial research has just begun.