Early Days Research Articles

Expressing the Complexities of the Student-Cadaver Relationship Through Visual Artwork.

Many physician assistant (PA) students first encounter death in the earliest days of their training when working with cadavers in the gross anatomy laboratory. Developing a deep knowledge of human anatomy is fundamental to health profession training programs and modern medical practice. Despite decreased laboratory hours and integration of technology and diagnostic imaging into modern anatomy courses, there remains value in the cadaver dissection experience. Medical learners experience diverse and complex feelings toward cadavers; learning to regulate one's personal responses within the anatomy laboratory is a skill that can be extrapolated to clinical practice. Art is one way for students to process their experiences with cadavers, and creating art for cadaver memorial ceremonies is an opportunity for student emotional processing while honoring the lives of their cadaveric teachers. A PA program in New England incorporated student art into a cadaver memorial ceremony, with 4 pieces of artwork and corresponding artist statements from that ceremony included in this piece. The works of art are visually diverse, but there is a shared sentiment in the artist statements of reflection, awe, appreciation, and humanity. Encouraging students to process complex experiences artistically may provide an enduring practice throughout a career in medicine.

Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023.

Social media is a powerful tool in pathology education and professional networking that connects pathologists and pathology trainees from around the world. Twitter (X) appears to be the most popular social media platform pathologists use to share pathology-related content and connect with other pathologists. Although there has been some published research on pathology-related activity on Twitter during short time frames, to date there has not been published research examining pathology-related Twitter activity in totality from its earliest days of activity to recently. To comprehensively evaluate the use of pathology on Twitter (X) during the last 10 years. Pathology-related tweets were systematically scraped from Twitter from January 2012 to January 2023 using pathology hashtags as a surrogate measure for all pathology content on Twitter. COVID-related tweets were approximated by tweets containing the term "COVID." There were 591 812 unique pathology-related tweets identified during the time period, with #pathology being the most common hashtag used and #PathTwitter becoming more popular since 2020. There has been positive annual growth of pathology Twitter, with peaks in use during major pathology conferences. During the initial phases of the COVID-19 pandemic a sustained increase in pathology tweets was observed. Pathology Twitter has grown during the last 10 years and has become increasingly popular for pathology education and networking. With the changing landscape of social media platforms this study provides an understanding of how pathology medical education and professional networking uses of social media are used and evolve over time.

Scanning efficacy of p-Chips implanted in the wing and leg of the Big Brown Bat (Eptesicus fuscus)

Abstract Individual marking techniques are critical for studying animals, especially in the wild. Current marking methods for bats (Order Chiroptera) have practical limitations and some can cause morbidity. We tested the p-Chip (p-Chip Corp.)—a miniaturized, laser light-activated microtransponder—as a prospective marking technique in a captive research colony of Big Brown Bats (Eptesicus fuscus). We assessed long-term readability and postimplantation effects of p-Chips injected subcutaneously above the second metacarpal (wing; n = 30) and the tibia (leg; n = 13 in both locations). Following implantation (Day 0), p-Chips were scanned with a hand-held ID reader (wand) on postimplantation days (PIDs) 1, 8, 15, 22, 32, 60, 74, 81, 88, 95, and over 1 year later (PID 464). For each trial, we recorded: (1) animal handling time; (2) scan time; (3) number of wand flashes; (4) p-Chip visibility; and (5) overall condition of the bat. Average scan times for p-Chips implanted in both the wing and leg increased over the duration of the study; however, the number of wand flashes decreased, suggesting that efficacy of p-Chip recording increased with user experience. Importantly, over 464 days both the visibility and readability of p-Chips in the wing remained high and superior to tags in the leg, establishing the second metacarpal as the preferred implantation site. Observed morbidity and mortality in captive bats with p-Chips was similar to baseline values for bats without these tags. Because scan efficiency on PID 464 was comparable with earlier days, this indicates that p-Chips implanted in the wing may be suitable as a long-term marking method. Our provisional results suggest that p-Chips are viable for extended field testing to see if they are suitable as an effective alternative to traditional methods to mark bats.

Depression in the very young: Implication for the teenage years

While depression is commonly first diagnosed in adolescence, evidence shows that the roots of depression lie in the earliest days of life. Stephanie Thornton looks at the implications for care

Enhanced Sampling in Molecular Dynamics Simulations: How Many MD Snapshots can be Needed to Reproduce the Biological Behavior?

Since its early days in the 19th century, medicinal chemistry has concentrated its efforts on the treatment of diseases, using tools from areas such as chemistry, pharmacology, and molecular biology. The understanding of biological mechanisms and signaling pathways is crucial information for the development of potential agents for the treatment of diseases mainly because they are such complex processes. Given the limitations that the experimental approach presents, computational chemistry is a valuable alternative for the study of these systems and their behavior. Thus, classical molecular dynamics, based on Newton's laws, is considered a technique of great accuracy, when appropriated force fields are used, and provides satisfactory contributions to the scientific community. However, as many configurations are generated in a large MD simulation, methods such as Statistical Inefficiency and Optimal Wavelet Signal Compression Algorithm are great tools that can reduce the number of subsequent QM calculations. Accordingly, this review aims to briefly discuss the importance and relevance of medicinal chemistry allied to computational chemistry as well as to present a case study where, through a molecular dynamics simulation of AMPK protein (50 ns) and explicit solvent (TIP3P model), a minimum number of snapshots necessary to describe the oscillation profile of the protein behavior was proposed. For this purpose, the RMSD calculation, together with the sophisticated OWSCA method was used to propose the minimum number of snapshots.

The High Court’s Prudential Approach to Constitutional Adjudication: When Is It Necessary to Resolve a Constitutional Question?

Despite having a central constitutional function of determining the validity of legislation, the High Court of Australia adopts a variety of principles and doctrines that can result in it declining to resolve constitutional questions. One way this can occur is by only deciding constitutional questions when they are ‘necessary to do justice in the case and to determine the rights of parties’. Although this practice has been followed since the Court’s earliest days, it was only recently labelled the ‘prudential approach’ to resolving constitutional questions by the plurality in Mineralogy Pty Ltd v Western Australia. This article seeks to identify the different ways in which the prudential approach can be followed and why the High Court adopts the practice. It will then turn to analyse the High Court’s adherence to the practice during the tenure of Kiefel CJ, arguing that the Court’s application would benefit from greater clarity and consistency.

Nostalgia and Stories of Early Arrival Amongst the Turkish Diaspora in Broadmeadows

This article discusses how Turkish people in the suburb of Broadmeadows in Melbourne, Australia, construct nostalgia for their earlier days as migrants. Furthermore, it highlights the didactic and ethical role this nostalgia plays within the Turkish community. Turkish migrants began to manifest nostalgia for the earlier days in Australia after the dream of returning to the homeland began to wane. This nostalgia presents an image of the ideal Turk to the younger generations in Australia and therefore helps to preserve the Turkish identity. This nostalgia also enables Turks to distance themselves from negative images of the contemporary homeland, allowing them to present themselves as authentic Turks; it also helps Turkish Australians to cope with their economic marginality in Australia. Nostalgia for the early days in Australia therefore has many purposes for Turkish Australians today.

Memories of a young student: the early days of splicing regulation with François Gros.

I joined the laboratory of François Gros as a young student in the mid-1980s and worked on the characterization of the -tropomyosin gene in chicken and the regulation of alternative splicing of its transcript, under the supervision of Marc Fiszman. In particular, I was interested in how secondary structures of the RNA influence the recognition of exons specifically used in muscle cells. I will recall a few memories on how interacting with François on this project shaped my perception of the scientific process and of the relationships between models and data. Later I worked on many aspects of RNA biology, from transcription to mRNP biogenesis and non-coding RNAs.

Response of cucumber cultivars to organomineral fertilizer rate in rainforest savannah

Organomineral fertilizer is used to improve and ameliorate the supply of nutrients in soils. Right and adequate application of fertilizers are determinants of its nutrient supply efficiency, which in turn enhances the vegetative growth and yield of cucumber. Field experiments were conducted at the Research Farm of the Federal University of Agriculture, Abeokuta, Nigeria, to assess the effects of variety and rate of organomineral fertilizer on cucumber growth and yield. Trials were conducted from June to August 2019 and repeated from September to November 2019. The cultivars were Poinsett, Greengo, and Monalisa. The rates of organomineral fertilizer were 0, 2.5, or 5.0 tons. ha−1. The treatments were replicated three times. Cucumber vegetative characters, yield, and yield components were studied. ‘Greengo’ produced the most leaves, followed by ‘Monalisa’; ‘Poinsett’ produced the least. Application of 5.0 tons. ha−1 organomineral fertilizer produced the longest vines and fruits. ‘Greengo’ had the earliest days to 50% flowering, followed by ‘Monalisa’; ‘Poinsett’ had the most days to 50% flowering. Plants treated with an application of 5.0 tons. ha−1 organomineral fertilizer attained 50% flowering in 29 days, but in 30 days with an application of 2.5 tons. ha−1 organomineral fertilizer; the control treatment attained 50% flowering in 33 days. Application of 5.0 tons. ha−1 organomineral fertilizer produced the longest fruits, thicker fruit diameter, and highest fruit yield compared with 2.5 and 0 tons. ha−1 of organomineral fertilizer treatments. The Greengo variety with application of 5.0 tons. ha−1 of organomineral fertilizer is recommended for optimum growth and yield in south western Nigeria.

Keterlibatan Santri dalam Persepsi Wacana Tiongkok

Santris who have had the opportunity to go to China then face some contemplation, questions, and curiosity about what is really going on in the relationship between the two countries. Not all but some of them try to trace the substance and variations of Indonesians’ perceptions of China in the past. It’s like a philosophical romance where a child migrates to a foreign land but because of their migration, they become curious about their hometown. In scientific language, they try to slowly trace the existence of negative perceptions of China. They even unconsciously dismantle, although not frontally, the bad and negative image. Following Hong Liu’s (2015) opinion on the Chinese Metaphor, where China is used as a metaphor to express a sense of anxiety over domestic politics that is not going according to ideals, then, the santri are trying to dismantle the conflicting perceptions and narratives about China. For Indonesians, especially natives, Tiongkok as a nation-state is respected as a model country where leaders set an example so that the masses can work closely together. How the Chinese metaphor expresses the mood of the general public and anchors political and cultural thought in the early days of Indonesia as a country. Hong Liu even provides historical information that China for some Indonesian political elites was once used as an alternative form of modernity to the conception and practice of government politics that at that time still followed and emulated Western-derived systems and institutions. This study tries to apply a transnational approach to provide new insights into modern Asian History and regional transformation. 

Teenagers: A Social Media Threat Vector

Social media has grown significantly since the early days.  During this time, social media has grown to be a mainstay in most teenagers’ lives.  Whether they are on Facebook, Snapchat, X (formerly Twitter), or TikTok, teenagers have fully integrated social media into their lives.  Teens tend to post the ins and outs of their lives, sharing sensitive information about themselves to people they know, but also to strangers.  Although social media can be used for good, it can also be used by nefarious threat actors to take advantage of teenagers.  Social engineers count on their subject's desire to increase the number of virtual connections, which may increase the endorphin response received when they get “likes”.  As such, social engineers create targeting accounts and then try to get as many people to accept them as possible.  This increased footprint levitates the chances of a successful social engineering attack.  Add to this, when someone shares an abundance of information about themselves, social engineers use this information to target individuals with spear phishing attacks.  To further exacerbate the situation, social media uses algorithms to target its users and feed them with a significant amount of information that is not always vetted as being truthful.  When someone is influenced by disinformation, it increases their susceptibility by taking away their desire to verify the truth, but rather accept that what they are being told is the truth.  This case study examines the dynamics associated with teenagers and their susceptibility to becoming a victim of cybercrime and how social media perpetuates this situation.

Nostalgia and Stories of Early Arrival

This article will discuss how Turkish people in the suburb of Broadmeadows in Melbourne, Australia, construct nostalgia for their earlier days as migrants. Further, it will highlight the didactic and ethical role this nostalgia plays within the Turkish community. Turkish migrants began to manifest nostalgia for the earlier days in Australia after the dream of returning to the homeland began to wane. This nostalgia presents an image of the ideal Turk to the younger generations in Australia and therefore helps to preserve the Turkish identity. This nostalgia also enables Turks to distance themselves from negative images of the contemporary homeland, allowing them to present themselves as authentic Turks; it also helps Turkish Australians to cope with their economic marginality in Australia. Nostalgia for the early days in Australia therefore has many purposes for Turkish Australians today.

Transnational networks of human resources and knowledge in East Asia: a case study of Taiwan merchant Wang Xuenong (1870–1915) and his trading company

Abstract Taiwan is an island and trade has always been the locomotive of its economic development. From the 1620s to the 1960s, cane sugar was Taiwan's most representative export commodity. Yet little attention has been paid to the business strategies of sugar traders and the changes in their thinking. How did the Takow (Kaohsiung) merchants who first went to Japan and Hong Kong to conduct cross-border trade in person learn about international trade and build a network of human resources that crossed borders, especially after the 1870s? And how did they face the great changes of an era in which tradition and modernity were intertwined, so that, following the regime transfer in the 1890s from the Qing Dynasty to the Japanese empire, they were able to expand their business territory and become major sugar merchants in southern Taiwan? This article examines the career of Wang Xuenong—a well-known sugar merchant in Taiwan during the Meiji period (1868–1912). It attempts to explain, from the perspective of cross-cultural knowledge transfer and human resource strategies, why and how sugar merchants such as Wang, who had gone to Japan in the early years of the Meiji Restoration for purposes of cross-border trade, introduced a trading company system that incorporated a mixture of East Asian and Western elements. It further investigates how they expanded their business from the sugar trade into a wider commercial domain that included mechanical rice milling and steamship transport. Finally, it looks at how their actions affected a transformation of Taiwan's commercial culture from the late Qing Dynasty to the early days of Japanese rule, and the historical significance of these changes in Taiwan's transitions towards industrialisation and modernisation.

Impact of Risk-Based therapy on late morbidity and mortality in neuroblastoma survivors: a report from the childhood cancer survivor study.

Early efforts at risk-adapted therapy for neuroblastoma are predicted to result in differential late effects; the magnitude of these differences have not been well-described. Late mortality, subsequent malignant neoplasms (SMN), and severe/life-threatening chronic health conditions (CHCs), graded according to CTCAE v4.03, were assessed among 5-year CCSS survivors of neuroblastoma diagnosed 1987-1999. Using age, stage at diagnosis, and treatment, survivors were classified into risk groups (low [n = 425]; intermediate [n = 252]; high [n = 245]). Standardized mortality ratios (SMR) and standardized incidence ratios (SIR) of SMNs were compared to matched population controls. Cox regression models estimated hazard ratios (HR) and 95% confidence intervals (CI) for CHC compared to 1,029 CCSS siblings. Among survivors (49.8% male; median age 21 years, range 7-42; median follow-up 19.3 years, range 5-29.9), 80% with low-risk disease were treated with surgery alone, while 79.1% with high-risk disease received surgery, radiation, chemotherapy ± autologous stem cell transplant (ASCT). All-cause mortality was elevated across risk groups (SMRhigh=27.7 [21.4-35.8]; SMRintermediate=3.3 [1.7-6.5]; SMRlow=2.8 [1.7-4.8]). SMN risk was increased among high- and intermediate-risk survivors (SIRhigh=28.0 [18.5-42.3]; SIRintermediate=3.7 [1.2-11.3]), but did not differ from the US population for survivors of low-risk disease. Compared to siblings, survivors had an increased risk of grade 3-5 CHCs, particularly among those with high-risk disease (HRhigh=16.1 [11.2-23.2]; HRintermediate=6.3 [3.8-10.5]; HRlow=1.8 [1.1-3.1]). Survivors of high-risk disease treated in the early days of risk stratification carry a markedly elevated burden of late recurrence, SMN, and organ-related multi-morbidity, while survivors of low/intermediate-risk disease have a modest risk of late adverse outcomes.

The Smallpox Chiefs: Bioterrorism and the Exercise of Power in the Pacific Northwest

Abstract Although there has been much writing and speculation on the deliberate use of smallpox as a tool of genocide, this article documents the use of the bluff threat of spreading smallpox as a tool of power and manipulation in the early days of European trade and settlement in the Pacific Northwest. By documenting ten cases when a bluff threat was used, the article argues that it was a common strategy of Europeans when they felt threatened or thwarted. Because it was compatible with existing Indigenous beliefs about the spread of disease, it was highly credible and was occasionally used by Indigenous people to manipulate others. While Europeans in this era did not actually have the power to control smallpox, the fact that outbreaks of the disease often occurred following a threat to spread it gave credence to the threat and to today’s widespread belief that some or all of the epidemics were deliberate genocide. Recognizing bluff threat bioterrorism as a tool in the newcomer’s arsenal is essential to understanding how the heavily outnumbered and out-gunned newcomers were so often able to manipulate Indigenous people and then establish the settlements that eventually evolved into full scale colonial occupations of Indigenous territory.

Evolution of Colombia’s market for manufactured products of the wood industry

A detailed exploration of the development of Colombia's market for manufactured products of the wood industry since its early days, with an analytical focus on the period 1970-2021, is presented. The examination of early days draws upon historical information, wood industry-specific statistics derived from Colombia’s Annual Manufacturing Survey and industrial census, and data from the National Accounts of Colombia (NAC), which offers insightful understanding of the market dynamics up to the end of the 1960s. For 1970 to 2021 comprehensive consolidated data derived from the Supply and Use Tables of the NAC and other sources provides the base for an in-depth examining of the market aspects such as quantities of supply (national production), demand, and the components of demand – including domestic consumption, exports, and imports. The exploration reveals a significant shift in the manufactured products of the wood industry market’s dynamics, transitioning from a primarily domestic consuming and export-driven one to a market increasingly reliant on imports to satisfy domestic consumption. Critical factors contributing to this shift are identified, highlighting Colombian forest resource depletion and inadequate nation’s wood industry development. The paper synthesizes historical data to articulate the interplay between economic policies and market outcomes, culminating in a discernible need for strategic industry modernization. Furthermore, it offers comprehensive and detailed information, facilitating a thorough understanding of all market aspects without necessitating consultation of additional sources.

Statistical indices of masculinity-femininity: A theoretical and practical framework.

Statistical indices of masculinity-femininity (M-F) summarize multivariate profiles of sex-related traits as positions on a single continuum of individual differences, from masculine to feminine. This approach goes back to the early days of sex differences research; however, a systematic discussion of alternative M-F indices (including their meaning, their mutual relations, and their psychometric properties) has been lacking. In this paper I present an integrative theoretical framework for the statistical assessment of masculinity-femininity, and provide practical guidance to researchers who wish to apply these methods to their data. I describe four basic types of M-F indices: sex-directionality, sex-typicality, sex-probability, and sex-centrality. I examine their similarities and differences in detail, and consider alternative ways of computing them. Next, I discuss the impact of measurement error on the validity of these indices, and outline some potential remedies. Finally, I illustrate the concepts presented in the paper with a selection of real-world datasets on body morphology, brain morphology, and personality. An R function is available to easily calculate multiple M-F indices from empirical data (with or without correction for measurement error) and draw summary plots of their individual and joint distributions.

AN ANALYSIS OF THE MYTHICAL PATTERNS IN ULYSSES FROM THE PERSPECTIVE OF ARCHETYPE THEORY

As one of the important creative themes of modern literature, mythology is constantly reiterated in the writings of modern writers. Through retelling, we can travel through the time tunnel and feel the poetic wisdom of our ancestors. The inherent characteristic of myth is symbolism, and at the same time, it has strong metaphor and inclusiveness, which has opened up an almost infinite space of meaning for modern writers. Mythology provides rich prototype resources for the plot structure framework of narrative works, and expresses the writer's unique creative perspective and aesthetic awareness. James Joyce was an outstanding modern novelist in the West in the 20th century, and he created unique mythological novels. Ulysses adopts the mythological prototype structure and uses the theme of the ancient hero Odysseus returning home, echoing the deep meaning of modern people's search for a spiritual home. This paper uses the theory of myth-prototype criticism and combines the theory of collective unconsciousness to explore the creation mode of Ulysses from the perspective of mythic archetype criticism, to explain how ancient myths and modern writers have a spiritual fit, and to further feel the uniqueness of Joyce's novels. Some artistic charm and the practical significance brought by Ulysses. Our era needs the spirit of exploration and courage left over from the early days of human society, and the connotation of archetypal criticism has positive ideological value to this day.

(105) Arab Patient and Partner Satisfaction Following Malleable Penile Prosthesis Implantation in North Africa and the Middle East

Abstract Introduction Due to the sensitivity of the topic of penile implants for the treatment of refractory erectile dysfunction (ED) in the Middle East and North Africa region, a scarce body of related research is available. Objective We aimed at investigating the levels of patient and partner satisfaction after malleable penile prosthesis implantation among the Arab population and its dynamics during and after the first 6 months of surgery. Methods This was a prospective 6-month follow-up study of 120 patients undergoing malleable penile prosthesis implantation at our unit by a single surgeon. Three telephone encounters were conducted for each couple at 1 month, 3 months, and 6 months postoperative (PO). We utilized our validated Arabic version of the Modified Erectile Dysfunction Inventory of Treatment Satisfaction (AM-EDITS). During the 1st first encounter, we inquired about the general patient perioperative experience, starting from preoperative counseling till the first month after surgery. The 2nd and 3rd encounters focused on patient and partner satisfaction after implant utilization. Results The average ages of the men and their partners were 54.7±8.4 and 32.9±4.6 years, respectively. Levels of anxiety decreased in over 82% of the men in our study upon receiving proper preoperative counseling. Almost all of the patients were happy (96%) with their early PO days with over 50% of them exceeding their expectations. After 3 months, 82.5% of the men were satisfied, describing their erections to be 80% close to natural. Of the 92.5% satisfied partners at 3 months, nearly 80% were highly satisfied. Over 93% of them reported feeling sexually desirable by their husbands. As opposed to the significant rise in men’s overall satisfaction and AM-EDITS index by 11.6% and 5.2 ± 0.8% (P < 0.001), respectively after 6 months PO, partners demonstrated a 12.4% and 5.9 ± 0.8 decline (P < 0.001), respectively, compared to the 3 months follow up. Conclusions Malleable penile implants still represent a good quality-of-life treatment option for middle to low-income countries. Time has a positive effect on Arab men’s PO satisfaction as opposed to their partners’. The explanation behind these findings should be investigated in further studies. A proper understanding of the dynamics of patient and partner satisfaction over time may be useful for proper perioperative counseling of both parties to ensure their sustainable satisfaction. Disclosure No.

History of pain around the lumbopelvic region during perinatal period: a prospective cohort study.

Many women experience pain around the low back and pelvic girdle during/after pregnancy. These pains have different risk factors and require independent management strategies. Therefore, an epidemiological database is required to understand when each type of pain occurs, and how serious it could be. Thus, the history of pain in the lumbopelvic region throughout the perinatal period was investigated. The information of 170 women recruited at the obstetrics and gynecology clinics in Japan was collected at 12, 24, 30, and 36weeks of pregnancy, in the early days after childbirth, and one month after childbirth. The presence and severity of sacroiliac joint pain, pubic pain, groin pain, and low back pain were assessed using a numerical rating scale. Descriptive statistics were used to determine changes in the prevalence of pain. In addition, the change in the severity of each type of pain was observed through descriptive statistics, by including only those who had pain. The sacroiliac joint pain showed a twofold increase from 12 to 24weeks, while the pubic pain suddenly increased after 24weeks. The severity of pubic and groin pain increased sharply during pregnancy. Regarding low back pain, the change in the severity was lesser than the other pains. The sacroiliac joint pain was the highest among the four pains during pregnancy. Each type of pain had a different incidence rate and a different time of onset and aggravation. These results help women and health professionals to manage, and prevent these harmful symptoms.