Early Time Research Articles

Persistent angina following revascularization for chronic coronary syndromes: a systematic review and meta-analysis of randomized controlled trials

Abstract Introduction Recent randomized clinical trials (RCTs) have demonstrated that revascularization plus optimal medical therapy for patients with chronic coronary syndromes (CCS) results in greater reduction in angina than medical therapy alone. However, the frequency of persistent angina following revascularization for CCS is not well understood. Purpose To quantify the frequency of persistent angina following revascularization in contemporary RCTs of revascularization plus medical therapy vs. medical therapy alone among patients with CCS. Methods A literature search through January of 2024 was conducted in PubMed and Cochrane Central Register of Controlled Trials for contemporary RCTs reporting angina frequency following randomization to revascularization plus medical therapy vs. medical therapy alone. The primary outcome of interest was the frequency of persistent angina in the revascularization arms of these studies at early (3-12 months) and late (3-5 years) time points. A random effects model was used to combine results from individual studies. Results From a total of 5287 citations, the search yielded 7 RCTs that met inclusion criteria. These studies randomized 5719 patients to an invasive or revascularization strategy. Revascularization was exclusively by percutaneous coronary intervention (PCI) in 4 studies and by coronary artery bypass grafting or PCI in 3 studies. At the early time point, the combined frequency of persistent angina was 39.6% (95% CI: 30.6-49.4). For the two blinded, sham-controlled studies, the rate of persistent angina was significantly greater at 67.2% (95%CI: 54.9-77.4) compared to 30.5% (95% CI: 23.1-39) in the unblinded studies (P<0.001). In the 5 studies with 3-5 years of follow-up, the frequency of persistent angina was 33.3% (95% CI: 19.2-51.2). Conclusion Persistent angina is common after revascularization for CCS and suggests alternative causes and treatments of residual angina should be considered.

Did the Buddha Teach to Be Called ‘Buddha’?―Focusing on the Meaning of Brāhmaṇa and How Buddhist Authors (re)Formulated His Words to Praise Him―

The attainment of enlightenment by Gautama Buddha is the very beginning of Buddhism as a religious phenomenon. Because of his attainment of enlightenment, he has been remembered as Buddha for centuries, even though it is uncertain whether buddha was the preferred title to remember him by from the earliest times. Previous scholarship has demonstrated that the term buddha was a common noun in the Indian religious context, and it was also employed to refer to his higher disciples. The verses of the Suttanipāta represent a complex corpus rich in many fundamental concepts common to Jain religious thought. Many epithets were introduced by Buddhists to praise their monastic founder as Jains do. Among them, buddha does not seem to be the preferred one among them. Contrarily, by redefining brāhmaṇa, Buddhists participate in the ascetic discourse of praising their master as the one who deserves to be regarded as that ideal. This paper argues that Buddhists advocated their master as a brāhmaṇa, a title that is not only consistent with the teachings of Jains but also one that may have preceded the popularity of Buddha as his most memorable title.

A Machine Learning Approach to Identifying Risk Factors for Long COVID-19

Long-term sequelae of coronavirus disease 2019 (COVID-19) infection are common and can have debilitating consequences. There is a need to understand risk factors for Long COVID-19 to give impetus to the development of targeted yet holistic clinical and public health interventions to reduce its associated healthcare and economic burden. Given the large number and variety of predictors implicated spanning health-related and sociodemographic factors, machine learning becomes a valuable tool. As such, this study aims to employ machine learning to produce an algorithm to predict Long COVID-19 risk, and thereby identify key predisposing factors. Longitudinal cohort data were sourced from the UK’s “Understanding Society: COVID-19 Study” (n = 601 participants with past symptomatic COVID-19 infection confirmed by serology testing). The random forest classification algorithm demonstrated good overall performance with 97.4% sensitivity and modest specificity (65.4%). Significant risk factors included early timing of acute COVID-19 infection in the pandemic, greater number of hours worked per week, older age and financial insecurity. Loneliness and having uncommon health conditions were associated with lower risk. Sensitivity analysis suggested that COVID-19 vaccination is also associated with lower risk, and asthma with an increased risk. The results are discussed with emphasis on evaluating the value of machine learning; potential clinical utility; and some benefits and limitations of machine learning for health science researchers given its availability in commonly used statistical software.

Time dependent changes in protein expression induced by intermittent theta burst stimulation in a cell line.

Intermittent Theta Burst Stimulation (iTBS), a non-invasive brain stimulation technique, is recognized for its ability to modulate cortical neuronal activity. However, its effects over time and the dynamics following stimulation are less well understood. Understanding the temporal dynamics of iTBS effects is essential for optimizing the timing and frequency of stimulation in therapeutic applications. This study investigated the temporal changes in protein expression induced by iTBS in Neuro-2a cells. We analyzed protein expression in retinoic acid-differentiated Neuro-2a cells at multiple time points - 0.5, 3, 6, 12, and 24 hours post-iTBS - using Western blot and immunocytochemistry techniques. Our findings reveal a significant early increase in neurotransmitter receptor subunits, neurotrophic factors, and cytoskeletal proteins within the first 0.5 hour following iTBS. Notably, proteins such as mGLuR1, NMDAR1, GABBR2, and β-tubulin III showed substantial increase in expression. However, the effects of iTBS on protein expression was not sustained at later timepoints. Our results suggest that iTBS can transiently alter the expression of specific proteins in Neuro-2a cells. Future research should investigate the potential benefits of repeated stimulations within the early time window to refine iTBS interventions, potentially expanding their research and clinical applications.

Blood-brain barrier profile pretreatment is associated with hemorrhagic transformation after endovascular reperfusion.

While advances in endovascular thrombectomy (EVT) have led to high reperfusion rates, most patients treated with EVT do not avoid disability. Post-reperfusion hemorrhagic transformation (HT) is a potential target for improving outcomes. This study examined pretreatment blood-brain barrier (BBB) disruption in tissue that would subsequently become part of the final infarct to evaluate its role in post-EVT HT. This post hoc analysis of the FRAME study, which enrolled patients with anterior large vessel occlusion who received EVT within 6 hours of onset, included patients if they had successful pretreatment MRI perfusion weighted imaging (PWI) and underwent successful EVT. BBB disruption was measured as the percent signal change due to gadolinium leakage on the PWI source images prior to thrombectomy. Mean permeability derangement (MPD) was defined as the average of all voxels in the stroke core that are two standard deviations above normal. The primary outcome was hemorrhagic transformation with parenchymal hematoma (PH). In total, 164 patients were included; mean age was 71 and 48% were female. PH occurred in 57 patients. Median MPD was 13.5% for patients with PH versus 3.6% for patients without (p < 0.0001). Elevated MPD was independently associated with PH with a 20% increased risk of PH for each 5% increase in MPD (OR 1.206; 95% CI 1.037:1.405; p = 0.0147, adjusted for NIHSS and procedure duration). Even in patients who are successfully recanalized in an early time window, pretreatment BBB disruption in regions that go on to infarct is associated with an increased risk of post-EVT HT.

Mesiri: Mephisto Early Supernovae Ia Rapid Identifier

The early time observations of Type Ia supernovae (SNe Ia) play a crucial role in investigating and resolving longstanding questions about progenitor stars and the explosion mechanisms of these events. Colors of supernovae (SNe) in the initial days after the explosion can help differentiate between different types of SNe. However, the use of true color information to identify SNe Ia at the early-time explosion is still in its infancy. The Multi-channel Photometric Survey Telescope (Mephisto) is a photometric survey telescope equipped with three CCD cameras, capable of simultaneously imaging the same patch of sky in three bands (u, g, i or v, r, z), yielding real-time colors of astronomical objects. In this paper, we introduce a new time-series classification tool named Mephisto Early Supernovae Ia Rapid Identifier (Mesiri), which, for the first time, utilizes real-time color information to distinguish early-time SNe Ia from core-collapse supernovae. Mesiri is based on the deep learning approach and can achieve an accuracy of 96.75% ± 0.79%, and AUC of 98.87% ± 0.53% in case of single epoch random observation before the peak brightness. These values reach towards perfectness if additional data points on several night observations are considered. The classification with real-time color significantly outperforms that with pseudo-color, especially at the early time, i.e., with only a few points of observations. The BiLSTM architecture shows the best performance compared to others that have been tested in this work.

Role of Oxide-Derived Cu on the Initial Elementary Reaction Intermediate During Catalytic CO2 Reduction.

The catalytic role of oxide-derived Cu (OD-Cu) in promoting CO2 reduction (CO2R) to C2+ products has been appreciated for decades. However, the dynamic evolution of the surface oxidation states, together with their real correlation to the binding of reaction intermediates, remains unclear due to technical challenges. Here, we show the time-resolved spectroscopic signatures of key OD-Cu-CO2•- intermediates during catalytic CO2 reduction through one electron transfer from nanoseconds to seconds time scale. We generated the initial intermediate CO2•- radicals in the bulk solution and monitored the interfacial reaction kinetics with well-defined OD-Cu (Cu(0), Cu(I), and Cu(II)) nanoparticles. Combined with molecular simulations, transient absorption profiles analysis reveals that Cu(I) induced a faster CO2•- radical coupling reaction than Cu(0), whereas Cu(II) is only reduced to Cu(I) by the CO2•- radical. Furthermore, the newly developed multistep cumulative pulse methodology uncovered the transition in chemical states of mixed OD-Cu during radical coupling reactions. This pulse radiolysis study provides compelling evidence for the beneficial role of subsurface oxides in early time catalytic CO2 transformation.

The impact of viral respiratory infection on surgical outcome of cavopulmonary shunt.

Undetected respiratory infections may adversely affect the intrapulmonary resistance after Stage 2 or Stage 3 Fontan palliation. A few studies describe a higher risk for viral pneumonia during respiratory virus season, but none of them have focused on the effect of symptomatic viral pneumonia on in-hospital clinical course after bidirectional Glenn shunt. We analysed 77 patients who underwent bidirectional Glenn shunt surgery. Six patients were detected with pneumonia and proof of viral ribonucleic acid in tracheal mucus in the very early postoperative time. We compared them retrospectively to the remaining 71 patients regarding preoperative inflammatory signs, mortality, paediatric ICU length of stay, and ventilation time. The infection rate was not seasonal dependent. Ventilation time was significantly elongated in the pneumonia group (558 h ± 634 vs. 8.7 h ± 1.9; p < 0.0001) and so was the paediatric ICU length of stay (29 days ± 26 vs. 3 days±1; p = 0.007). Significantly more patients in the pneumonia group required extracorporeal cardiac life support postoperatively. The mortality was significantly increased in patients with pneumonia. Even subclinical viral pneumonia may cause ventilation-to-perfusion mismatch by raising intrapulmonary resistance. Recorded parameters of postoperative paediatric ICU therapy showed a significant impact of a viral pneumonia on patients after bidirectional Glenn shunt. The respiratory syncytial virus vaccination does not protect these patients from infection with other respiratory viruses. The focus should be put on preoperative diagnosis of pulmonary infections in the vulnerable group of patients with univentricular hearts.

Dynamics of transcription-coupled repair of cyclobutane pyrimidine dimers and (6-4) photoproducts in Escherichia coli

DNA repair processes modulate genotoxicity, mutagenesis, and adaption. Nucleotide excision repair removes bulky DNA damage, and in Escherichia coli, basal excision repair, carried out by UvrA, B, C, and D, with DNA PolI and DNA ligase, occurs genome-wide. In transcription-coupled repair (TCR), the Mfd protein targets template strand (TS) lesions that block RNA polymerase for accelerated repair by the basal repair enzymes. Accelerated repair is also seen with particular adducts. Notably, of the two major UV photoproducts, basal repair of (6-4) photoproducts [(6-4)PPs] is about 10× faster than repair of cyclobutane pyrimidine dimers (CPDs). To better understand repair prioritization in E. coli, we used XR-seq to measure TCR of UV photoproducts genome-wide. With CPDs, we found that TCR occurred at early time points, increased with transcription level, and was Mfd dependent; later, with completion of TS repair, nontranscribed strand (NTS) repair predominated. With (6-4)PP, when analyzing all genes, TCR was not observed; in fact, among the most highly transcribed genes, slightly more repair of (6-4)PPs in the NTS was evident. Thus, the very rapid basal repair of (6-4)PP in the NTS was faster than TCR of (6-4)PPs in the TS. Overall, TCR is of limited importance in (6-4)PP repair, and TCR of CPDs is limited to the TS of more highly transcribed genes. These results are consistent with the significant role of Mfd in mutagenesis and the modest effect of mfd deletion on UV survival and bear upon the response of E. coli to bulky DNA damage.

Successful 24-hour discharge for total knee arthroplasty: importance of timing of surgery and physiotherapy in enhanced recovery after surgery protocol.

The current literature is mixed on which patient factors, if any, predict the rate of successful discharge within 24 h of enhanced recovery after surgery (ERAS) total knee arthroplasty (TKA). This study aimed to investigate the influence of timing of surgery and physiotherapy on the rate of successful 24-h discharge. All 342 patients who underwent ERAS day surgery TKA from August 2020 to July 2021 were followed up prospectively. Patient characteristics and postoperative outcomes, such as number of physiotherapy sessions required before clearance for home, time taken after surgery to ambulate >10 m and length of stay (LOS), were recorded. Patients were grouped based on surgical end time (morning/afternoon/ evening) and time of physiotherapy review (morning/afternoon/evening/morning after). Patients successfully passed ERAS day surgery protocol if they were discharged within 24 h. With regard to the timing of operation, the morning group had the shortest LOS (P = 0.001) and a higher ERAS day surgery pass rate than the afternoon group (P = 0.016). With regard to the timing of physiotherapy, the afternoon group took the shortest time to ambulate >10 m (P < 0.001), had the shortest LOS (P < 0.001) and had a higher ERAS day surgery pass rate as compared to the morning after the operation group (P = 0.005). Patients who ended their operations in the morning and received physiotherapy review in the same afternoon were the most likely to be discharged within 24 h due to early ambulation and adequate time for spinal anaesthesia to wear off.

Sleep timing and the prevalence of hypertension in middle-aged and older populations: the sleep heart health study

ObjectivesSleep characteristics such as duration, continuity, and irregularity are associated with the risk of hypertension. This study aimed to investigate the association between sleep timing (including bedtime, wake-up time, and sleep midpoint) and the prevalence of hypertension.MethodsParticipants were selected from the Sleep Heart Health Study (n = 5504). Bedtime and wake-up times were assessed using sleep habit questionnaires. The sleep midpoint was calculated as the halfway point between the bedtime and wake-up time. Restricted cubic splines and logistic regression analyses were performed to explore the association between sleep timing and hypertension.ResultsA significant nonlinear association was observed between bedtime (Poverall<0.001; Pnonlinear<0.001), wake-up time (Poverall=0.024; Pnonlinear=0.076), sleep midpoint (Poverall=0.002; Pnonlinear=0.005), and the prevalence of hypertension after adjusting for potential confounders. Multivariable logistic regression showed that both late (> 12:00AM and 23:01PM to 12:00AM) and early (≤ 22:00PM) bedtimes were associated with an increased risk of hypertension compared to bedtimes between 22:01PM and 23:00PM. In addition, individuals with late (> 7:00AM) and early (≤ 5:00AM) wake-up times had a higher prevalence of hypertension than those with wake-up times ranging between 5:01AM and 6:00AM. Delaying the sleep midpoint (> 3:00AM) was also associated with an increased risk of hypertension. Furthermore, no significant interaction effect was found in the subgroup analyses stratified by age, sex, or apnea-hypopnea index.ConclusionsOur findings identified a nonlinear association between sleep timing and hypertension. Individuals with both early and late sleep timing had a high prevalence of hypertension.

The Cibarco anticline of the northernmost San Jacinto fold belt: Possible influence of mud diapirism on the Neogene to the recent evolution of the structure where the first oil and gas wells were drilled in Colombia

The Cibarco anticline, located in the northwestern South American convergent margin, is a long (approximately 40 km) and narrow (2.5 km wide), south-southwest–north-northeast-trending structure that separates two much wider depocenters, the Tubará-Juan de Acosta depocenter (approximately 20 km wide) to the west, and the Sabanalarga syncline (approximately 11 km wide) to the east. Detailed geologic surface mapping and subsurface seismic interpretation suggest that the formation and evolution of the Cibarco anticline have been strongly influenced by mud diapirism, which has been focused along a west-southwest–east-northeast-trending, inverted pre-Oligocene extensional fault. Seismic interpretation and outcrop analyses also confirmed that the source of mobile shales is the Upper Oligocene marlstones of the Lower Ciénaga de Oro Formation. We suggest that the main mechanism that caused the overpressures that triggered and controlled shale mobilization was disequilibrium compaction related to the sedimentary loading of impermeable seals and the shortening and inversion of pre-Oligocene extensional faults. Growth strata indicate that the Upper Oligocene mud started moving in Early Miocene times during the deposition of the thick Porquero mudstones, and it stopped migrating in Latest Miocene times. After an uplift and erosion event, mud diapirism remained inactive in the Early Miocene, and it was then reactivated in Late Pliocene times. Slight mud migration focused on the inverted fault continued throughout the Pleistocene and to the present. Today, the slight mud migration to the surface is observed in volcanoes located in the northern strand of the Cibarco anticline, although the rest of the anticline has become welded. Our new interpretations, carried out more than a century after the first hydrocarbon exploration activities began in Colombia, will hopefully allow us to increase our understanding of shale tectonics, petroleum systems, and plays in this portion of the convergent margin.

Facade Design and the Outdoor Acoustic Environment: A Case Study at Batna 1 University

The relationship between architectural design and outdoor acoustic environments remains underexplored, particularly in educational spaces where noise levels impact comfort and usability. This study investigates the impact of building facade height on the outdoor acoustic environment in university courtyards. Acoustic measurements were conducted in two courtyards at Batna 1 University, each surrounded by buildings with distinct facade heights. Key acoustic parameters, including reverberation time (RT), early decay time (EDT), rapid speech transmission index (RaSTI), Definition (D50), and sound pressure level (SPL) attenuation were evaluated at specified source-receiver distances. The results reveal a strong correlation between RT20 and distance at higher frequencies due to building facade reflections, while lower frequencies are more influenced by geometric configuration and material absorption properties. The results demonstrate that RT and EDT increase logarithmically or polynomially with distance, especially at higher frequencies (2000–4000 Hz), due to the decrease in direct sound energy and increase in reflected sound amplitude. Taller building facades lead to longer RT and EDT values compared to lower heights. D50 and RaSTI decrease polynomially with increasing source–receiver distance, with lower values observed in the courtyard with taller facades, indicating reduced speech clarity. The SPL attenuation is influenced by surrounding geometry, with the least reduction in the courtyard with lower facade heights, followed by the taller facade courtyard, contrasting with semi-free field conditions. These findings highlight the significant role of building facade height and architectural elements in shaping the acoustic characteristics of outdoor spaces, providing valuable insights for designing acoustically comfortable urban environments, particularly in educational settings.

Door-in-Door-Out Times at Referring Hospitals and Outcomes from Hemorrhagic Stroke

Interhospital transfer is often required in the care of patients with hemorrhagic stroke. Guidelines recommend a door-in-door-out (DIDO) time of ≤120 minutes at the transferring emergency department (ED); however, it is unknown whether DIDO times are related to clinical outcomes of hemorrhagic stroke. Retrospective, observational cohort study using US registry data from Get With The Guidelines-Stroke participating hospitals. Patients include those aged ≥18 years with intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH) who were transferred from the ED to a Get With The Guidelines participating receiving hospital from January 1, 2019, to July 31, 2022. The primary outcome was ordinal discharge modified Rankin scale (mRS) score and secondary outcomes included dichotomous discharge mRS, ability to ambulate independently at discharge, and inhospital mortality at the receiving hospital. In all, 19,708 ICH and 7,757 patients with SAH were included. For patients with ICH, an increasing DIDO time was associated with greater odds of mRS 0 to 3 versus 4 to 6 at discharge in the unadjusted analyses (DIDO 91 to 180 minutes, odds ratio [OR] 1.15 [1.04 to 1.27]; DIDO 181 to 270 minutes, OR 1.51 [1.33, 1.71]; DIDO >270 minutes, OR 1.83 [1.58, 2.11]; versus DIDO ≤90 minutes). In the adjusted analyses, no associations were observed. Similar results were seen for mRS at discharge in patients with SAH. In both patients with ICH and SAH, longer DIDO times were associated with greater odds of independent ambulation at discharge and lower odds of inhospital mortality in the unadjusted analyses. After adjustment, the effect sizes of these associations were reduced, with some of the results based on quartiles becoming statistically nonsignificant. These findings suggest that EDs currently expedite the transfer of the sickest patients; however, prospective studies and more granular data are needed to understand the impact of early treatment and timing of transfer for patients with hemorrhagic stroke.

Evolution of Semiconvective Staircases in Rotating Flows: Consequences for Fuzzy Cores in Giant Planets

Recent observational constraints on the internal structure of Jupiter and Saturn suggest that these planets have “fuzzy” cores, i.e., gradients of the concentration of heavy elements that might span a large fraction of the planet’s radius. These cores could be composed of a semiconvective staircase, i.e., multiple convective layers separated by diffusive interfaces arising from double-diffusive instabilities. However, to date, no study has demonstrated how such staircases can avoid layer mergers and persist over evolutionary timescales. In fact, previous work has found that these mergers occur rapidly, leading to only a single convective layer. Using 3D simulations, we demonstrate that rotation prolongs the lifetime of a convective staircase by increasing the timescale for both layer merger and erosion of the interface between the final two layers. We present an analytic model for the erosion phase, predicting that rotation increases the erosion time by a factor of approximately Ro−1/2, where Ro is the Rossby number of the convective flows (the ratio of the rotation period to the convective turnover time). For Jovian conditions at early times after formation (when convection is vigorous enough to mix a large fraction of the planet), we find the erosion time to be roughly 109 yr in the nonrotating case and 1011 yr in the rotating case. If these timescales are confirmed with a larger suite of numerical simulations, the existence of convective staircases within the deep interiors of giant planets is a strong possibility, and rotation could be an important factor in the preservation of their fuzzy cores.

Radial properties of dust in galaxies: Comparison between observations and isolated galaxy simulations

We study the importance of several processes that influence the evolution of dust and its grain size distribution on spatially resolved scales in nearby galaxies. Here, we compiled several multi-wavelength observations for the nearby galaxies NGC\,628 (M74), NGC\,5457 (M101), NGC\,598 (M33), and NGC 300. We applied spatially resolved spectral energy distribution (SED) fitting to the latest iteration of infrared data to get constraints on the galaxy dust masses and the small-to-large grain abundance ratio (SLR). We separated each galaxy into radial rings and obtained the radial profiles of the properties mentioned above. For comparison, we took the radial profiles of the stellar mass and gas mass surface density for NGC\,628 combined with its metallicity gradient in the literature to calibrate a single-galaxy simulation using the GADGET4-OSAKA code. The simulations include a parametrization to separate the dense and diffuse phases of the ISM where different dust-evolution mechanisms are in action. We find that our simulation can reproduce the radial profile of dust mass surface density but overestimates the SLR in NGC\,628. Changing the dust-accretion timescale has little impact on the dust mass or SLR, as most of the available metals are accreted onto dust grains at early times ($&lt;3$\,Gyr), except in the outer regions of the galaxy where the metallicity is below $2 $. This suggests we can only constrain the accretion timescale of galaxies at extremely low metallicities where accretion still competes with other mechanisms controlling the dust budget. The overestimation of the SLR likely results from (i) overly efficient shattering processes in the diffuse interstellar medium (ISM), which were calibrated to reproduce Milky Way-type galaxies and/or (ii) our use of a diffuse and dense gas density subgrid model that does not entirely capture the intricacies of the small-scale structure present in NGC\,628. We conclude that future modeling efforts will need to focus on improving the subgrid recipes to mimic the multi-phase gas distribution in galaxies before the efficiency of dust evolution processes can be calibrated for galaxies other than the Milky Way.

Early time wetting kinetics in surface-directed spinodal decomposition for off-critical quenches: A molecular dynamics study.

We present results from the molecular dynamics simulation of surface-directed spinodal decomposition in binary fluid mixtures (A + B) with off-critical compositions. The aim is to elucidate the role of composition ratio in the early time wetting kinetics under the influence of long-range surface potential. In our simulations, the attractive part of surface potential varies as V(z) = -ϵa/zn, with ϵa being the surface-potential strength. The surface prefers the "A" species to form the wetting layer. Its thickness [R1(t)] for the majority wetting (number of A-type particles [NA] > number of B-type particles [NB]) grows as a power-law with an exponent of 1/(n + 2). This is consistent with the early time kinetics in the form of potential-dependent growth present in the Puri-Binder model. However, for minority wetting (NA < NB), the growth exponent in R1(t) is less than 1/(n + 2). Furthermore, on decreasing the field strength ϵa, we recover 1/(n + 2) for a minority wetting case. We provide phenomenological arguments to explain the early time wetting kinetics for both cases.

Acoustic Analysis of the Masjid at Necmettin Erbakan University Köyceğiz Campus in Konya

In this study, the passive acoustic performance of Necmettin Erbakan University Köyceğiz Campus Masjid was investigated. Designed as the largest masjid of the city with a capacity of 15,000 people and a volume of 43,200 m3, the masjid, which has traces of Seljuk, Ottoman and Modern architecture. is built as a complex at a location overlooking the city in the Meram District of Konya City, Turkiye. The aim of the study is to determine the acoustic comfort conditions by considering all the activities in the masjids as a whole. Within the scope of the study, the acoustic performance of the masjid was evaluated by determining different source and receiver points for each mode of activity. As a method, the chosen masjid was simulated with ODEON Room Acoustics Software Ver. 14.04 software. Objective room acoustic parameters were analysed in three groups. These are sound energy ratio parameters (reverberation time (RT), early decay time (EDT), clarity (C50, C80), lateral fraction (LF80)), speech intelligibility parameters (definition (D50), speech transmission index (STI)) and sound strength parameters (strength (G)). The results obtained were compared with precedent studies in the literature. In comparison with the acoustic values obtained in other masjid/mosque buildings, it was reported that, while the speech intelligibility of other masjids/mosques was at a satisfactory level, the masjid under consideration was at a poor level in both fully occupied and unoccupied conditions. In the analysis made for reverberation time, it was seen that the masjid discussed in this study showed similar characteristics to other masjids/mosques globally. As a result, it was determined that the dimensions of the surfaces forming the mihrab, the minbar design and the depths of the mahfil overhangs are effective regarding the acoustics of the masjid, and the design of curved surfaces should be carried out in a way that does not cause focusing problems. In addition, suggestions that can give guidelines to modern masjid designs have been put forward.

Лепная посуда могильника Алмалык-Дере

The article describes the molded dishes of the burial ground of the 4th-7th centuries. AD Almalyk-dere, located in the South-Western Crimea. A comparative typological analysis of this group of archaeological finds, in general, demonstrates its general cultural unity with molded dishes from other Crimean burial grounds of the late Roman and early medieval times, with the presence of certain differences. Common features are manifested in the technique and technology of production of stucco products, as well as in the composition and structure of the ceramic complex, and differences are in the morphology and ornamentation of vessels. The study of Almalyk molded dishes allows us to say that the emergence of the burial ground is associated with the arrival of a group of new population in southwestern Taurica, consisting of the numerically predominant Alans, as well as Germans and, obviously, some part of the Bosporans and late Scythians.

Dysregulated proinflammatory cytokines and immune-related miRNAs in ASK cells exposed to 17⍺-Ethynyl estradiol and 4-nonylphenol

Endocrine Disruptor Compounds (EDCs) in the aquatic environment have acquired pronounced relevance due to their toxic effect on the aquatic flora and fauna. Xenoestrogens are EDCs that possess estrogenic activity and, thus, disrupt normal estrogen signaling, affecting different functions, such as immune system processes. Two relevant xenoestrogens discarded into fresh and seawater are 4-nonylphenol (NP) and 17⍺-Ethynyl Estradiol (EE2). Considering that the piscicultures of Salmo salar can be located at sites of potential exposure to xenoestrogen-containing effluxes, it is crucial to understand the effect of xenoestrogens on the immune response and its possible molecular mechanism in this species. Our studies reveal an increase in the expression of the receptor era and erb at early times of exposure, a disrupted expression of pro-inflammatory cytokines (il1b and tnfa), an upregulation of ssa-miR-146a-5p, ssa-miR-125 b-5p, and downregulation of ssa-miR-145–5p in ASK cells exposed to estrogen and xenoestrogen, could potentially lead to new strategies for mitigating the effects of xenoestrogens on Salmo salar immune response.