Early Weight Research Articles

Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants: a secondary analysis of the PEPaNIC trial

Neonates and infants surviving critical illness show impaired growth during critical illness and are at risk for later neuropsychological impairments. Early identification of individuals most at risk is needed to provide tailored long-term follow-up and care. The research question is whether early growth during hospitalization is associated with growth and neuropsychological outcomes in neonates and infants after pediatric intensive care unit admission (PICU). This is a secondary analysis of the PEPaNIC trial. Weight measurements upon PICU admission, at PICU discharge, at hospital discharge, at 2- and 4-year follow-up, and of different subgroups were compared using (paired) t-tests. Multiple linear regression analyses were performed to investigate the association between early growth in weight measures and neuropsychological outcomes at 4-year follow-up. One hundred twenty-one infants were included, and median age upon admission was 21 days. Growth in weight per week was less than the age-appropriate norm, resulting in a decrease in weight-for-age Z-score during hospitalization. Weight is normalized at 2- and 4-year follow-up. Weight gain in kilograms per week and change in weight Z-score were not associated with neurodevelopmental outcome measures at 4-year follow-up. Lower weight-for-age Z-score at PICU admission and at hospital discharge was associated only with lower weight and height Z-scores at 4-year follow-up.Conclusion: Growth in weight during hospital stay of young survivors of critical illness is impaired. Worse early growth in weight is associated with lower weight and height but not with neuropsychological outcomes at 4-year follow-up.What is Known:• Critically ill neonates and infants show impaired early growth during admission and are at risk for later neuropsychological impairments.• Unraveling the association between early growth and later neuropsychological impairments is crucial since the first year of life is critical for brain development.What is New:• Critically ill neonates and infants had age appropriate weight measures at 4-year follow-up.• Poor growth in weight during hospital stay was not associated with poorer cognitive, emotional, or behavioral functioning four years after critical illness.

Functional analysis of ZmG6PE reveals its role in responses to low-phosphorus stress and regulation of grain yield in maize.

A previous metabolomic and genome-wide association analysis of maize screened a glucose-6-phosphate 1-epimerase (ZmG6PE) gene, which responds to low-phosphorus (LP) stress and regulates yield in maize's recombinant inbred lines (RILs). However, the relationship of ZmG6PE with phosphorus and yield remained elusive. This study aimed to elucidate the underlying response mechanism of the ZmG6PE gene to LP stress and its consequential impact on maize yield. The analysis indicated that ZmG6PE required the Aldose_epim conserved domain to maintain enzyme activity and localized in the nucleus and cell membrane. The zmg6pe mutants showed decreased biomass and sugar contents but had increased starch content in leaves under LP stress conditions. Combined transcriptome and metabolome analysis showed that LP stress activated plant immune regulation in response to the LP stress through carbon metabolism, amino acid metabolism, and fatty acid metabolism. Notably, LP stress significantly reduced the synthesis of glucose-1-phosphate, mannose-6-phosphate, and β-alanine-related metabolites and changed the expression of related genes. ZmG6PE regulates LP stress by mediating the expression of ZmSPX6 and ZmPHT1.13. Overall, this study revealed that ZmG6PE affected the number of grains per ear, ear thickness, and ear weight under LP stress, indicating that ZmG6PE participates in the phosphate signaling pathway and affects maize yield-related traits through balancing carbohydrates homeostasis.

Genetic and morphological diversity of various corn lines for the determination of waxy corn (Zea mays var. ceratina) parents

Abstract. Pangestu DA, Sutjahjo SH, Ritonga AW. 2023. Genetic and morphological diversity of various corn lines for the determination of waxy corn (Zea mays var. ceratina) parents. Biodiversitas 24: 5643-5652. Genetic diversity is the first step in plant breeding programs. Information about genetic diversity is essential for commodity development to run well, and crop improvement can be more focused. This study aimed to evaluate the genetic diversity and performance of various genotypes of waxy corn. A total of 18 genotypes of waxy corn were grown using a randomized complete block design with three replications. Analysis of variance, estimation of the genetic parameters, broad-sense heritability, genotypic and phenotypic coefficient of variances, and cluster analysis were carried out in this study. The results showed differences in qualitative and quantitative characters between the genotypes of the tested waxy corn. The characters of plant height, ear height, stem diameter, number of leaves, tassel length, ear weight, and number of seeds per row had a high heritability and genetic coefficient of variance. This result indicates that those traits have a high variability among genotypes. Cluster analysis based on qualitative and quantitative characters divided 18 genotypes of waxy corn into three main clusters with similarity 18.34%. The main characteristics that divide the 3 clusters include ear weight with husk, ear length, ear length with kernels, stem diameter, plant height, and ear height. Based on the cluster analysis results, it was suspected that the F1 hybrid resulting from crossing genotypes JPM-1-5-9 with JPS-13-6-5-5 was a hybrid that could produce the best ear character.

Efficacy of Cal-Cemex as bone substitute for tibial plateau fractures

BackgroundVarious factors influence treatment and outcomes in tibial plateau fractures. Bone defects are among them. Many materials have been proposed to address this problem: allograft, bone–cements and various bone substitutes (BSM). Cal-Cemex (β-tricalciophosphate and polymethylmethacrylate) is a new hybrid bi-component BSM. A retrospective multicenter study was conducted based on the clinical experience of three European Hospitals, to demonstrate its clinical effectiveness, versatility and safety.Materials and MethodsFrom December 2016 to March 2022, 45 displaced tibial plateau fractures were treated with internal fixation and augmentation using Cal-Cemex. The average age was 55.9 years. According to Schatzker classification, we included 13 type II, 24 type III, 3 type V and 4 type VI fractures. The postoperative follow-up (FU) consisted of clinical and radiological examinations at 6 and 12 weeks and 1 year after surgery. A CT scan was performed preoperatively and 1 year after surgery. Full weight bearing was permitted after less than 6 weeks. Clinical data were collected from patient charts, while functional data were evaluated using the Rasmussen knee function score, the KOOS score and the Hospital for Special Surgery knee rating score (HSS), to evaluate the range of motion, axis and functionality of the knee.ResultsThe average FU was 42.8 months. CT scans taken at 1 year demonstrated a good surface osteointegration without radiolucent lines or osteolysis with good evidence of interdigitation and even bone ingrowth. At 1-year FU, the mean Rasmussen score was 24.7, the mean KOOS score was 90.7 and the mean HSS was 89.9 and the average full weight-bearing period 34.9. No patients had hardware failure or fracture secondary displacement.DiscussionCal-Cemex combines biological features and good mechanical performances. It guarantees biocompatibility and osteoconductivity, although it is not fully reabsorbable; β-tricalciophosphate component gives macro- and microporosity that allow fluids to penetrate inside the material, to stimulate bone ingrowth.ConclusionsThe study suggests that Cal-Cemex is an option for tibial plateau fractures, where augmentation and support are necessary for early full weight bearing. The absence of major complications, ease of application, the possibility to cut and perforate this material support its extensive use in bone augmentation for trauma cases.

Class III Obesity Is Associated with Worse Overall Survival in Previously Untreated Younger Patients with Acute Myeloid Leukemia Enrolled on SWOG 1203

Mohamed Sorror and Mary-Elizabeth Percival contributed equally to this project. Introduction: There has been inconsistent evidence supporting the association between obesity and outcomes in patients with newly diagnosed acute myeloid leukemia (AML). Prior studies have studied obesity as defined by body mass index (BMI) ≥ 30. However, this general definition of obesity can be further subdivided into class I obesity (BMI 30 to <35), class II obesity (BMI 35 to <40) and class 3 obesity (BMI ≥40). Given the high prevalence of obesity in the United States (41.9%; with class III obesity 9.2%), distinctions in degree of obesity may be associated with outcomes for patients with AML (Stierman et al, 2021). We were interested in studying outcomes in patients with AML stratified by class I, class II and class III obesity after induction chemotherapy and allogeneic hematopoietic cell transplant (HCT). Identification of at-risk patient populations could aid in design of future interventions. Methods: We retrospectively reviewed a group of 738 previously untreated subjects with AML randomized to daunorubicin and cytarabine (DA), idarubicin and cytarabine (IA), and IA with vorinostat as part of clinical trial SWOG 1203, conducted by the SWOG Cancer Research Network between 2012 and 2015. Subjects with adverse risk cytogenetics were recommended to receive HCT in their first complete remission (CR1); subjects with intermediate risk cytogenetics were selected for HCT in CR1 per local institutional standards. Nine patients who did not receive protocol therapy or had missing BMI were excluded (final cohort 729 patients). Early death was defined as death within 56 days of induction chemotherapy. Multivariable time-dependent Cox regression model and Fisher's exact test were used for analysis of overall survival (OS). HCT in first complete remission (CR1) was included as a time-dependent covariate. Results: The median age was 49 years (range, 18 to 60), 51% were male, 90% had de novo disease, and 88% had a performance status (PS) of 0-1 (Table 1). Among these patients, 1% (n=9) were underweight, 25% (n=182) were normal weight, 31% (n=225) were overweight, 20% (n=145) had class I obesity, 11% (n= 82) had class II obesity and 12% (n= 86) had class III obesity. There was no difference in the rate of achieving composite CR (CR with or without count recovery) between different weight categories (p=0.17). There was no clear trend in early death rate by weight (underweight: 11%; normal weight: 4%; overweight: 6%;class I obesity: 7%; class II obesity: 4%; class III obesity: 17%), though class III obesity had a significantly higher early death rate as compared to all the other groups combined (p=0.004). In multivariable Cox regression analyses, class III obesity was significantly associated with worse OS when compared to normal weight (hazard ratio (HR) 2.56, 95% confidence interval (CI) 1.68-3.90; p<0.001); though not statistically significant, we identified a trend towards worse OS for patients with class I (HR 1.40, 95% CI 0.95-2.06; p=0.09) and class II obesity (HR 1.48, 95% CI 0.95-2.31; p=0.09) (Figure 1). Other co-variates with a significant association with OS included age (HR 1.03, 95% CI 1.01-1.04; p<0.001), intermediate cytogenetic risk (HR 2.45, 95% CI 1.33-4.51; p=0.004), and adverse cytogenetic risk (HR 5.86, CI 3.10-11.06; p<0.001). HCT during CR1 was not found to be significantly associated with OS (HR 0.88, CI 0.67-1.15; p=0.3). No significant difference was identified in time to HCT based on BMI category. In patients who underwent HCT during CR1, class III obesity (HR 2.32, 95% CI 1.22-4.43; p=0.01) and older age (HR 1.02, 95% CI 1.00-1.04; p=0.01) were significantly associated with worse OS; in contrast no significant association was identified between OS and class I obesity (HR 1.30, 95% CI 0.77-2.20;p=0.32), while a higher HR and a trend existed for class II obesity (HR 1.76, 95% CI 0.97-3.17; p=0.06). Conclusions: Our retrospective analysis suggests that among newly diagnosed younger patients with AML, those with class III obesity are at increased risk of early death and shorter overall survival. Future directions include assessing lean body mass in addition to BMI in patients with newly diagnosed AML, as sarcopenic obesity is known to portend poor outcomes. Identifying this at-risk patient population may help guide future investigation of early weight management interventions in patients with newly diagnosed AML.

Some Genetic Parameters of Double Crosses under Different Planting Dates Suitable to the Middle Region of Iraq

With the aim of estimating some genetic parameters of double crosses at sowing dates appropriate to the fall season in the middle region of Iraq, a field experiment was conducted in the fields of the College of Agricultural Engineering Sciences - University of Baghdad - Al-Jadriya for the fall season 2022 using superior double crosses of maize were chosen from fifteen double crosses. It was obtained from the crossing of ten single crosses resulting from the crossing of five inbred lines (1=ZM43WIZE, 2=ZM60, 3= ZM49W3E, 4=ZM19, 5=CDCN5) by the half-dialle crossing method. Hybrids (3×5)(1×4),(3×5)(1×2),(2×4)(1×5), (4×5)(1×2), and (2×3)(1×4), compared it with the synthetic cultivar IPPA 5012 and tested it under three planting dates:1st July, 15th July and 1st August. The Randomized Complete Block Design (RCBD) was used with four replicates. The traits were studied: tassling, silking, plant height, ear height, number of leaves, leaf area, ear length, ear diameter, number of rows, number of grains per row, number of grains in a row, number of ears, average grain weight, dry matter weight, physiological maturity, ear weight, plant growth rate, individual plant yield, unit area yield, and. harvest Index. The results of the genetic analysis showed that the value of the standard error was low in all traits except for leaf area, number of plant seeds, and in the three dates, and the values of the coefficient of variation (C.V) on1st July were less than 20 in all traits except for individual plant yield, area unit yield, harvest index, and time. 15 th July and 1st August were also less than 20, and the values of genetic variance at the date of 1st July were greater than the values of environmental variance in most of the studied traits, except for ear height, ear length, ear diameter, number of rows, and ear weight. The ratio of genetic variation to environmental variation, as it was less than 1, and it had P.C.V values higher than G.C.V.The number of grains in the row, the weight of the dry matter, the physiological maturity and the plant growth rate due to the high genetic variance for it and the values of the ratio of genetic to environmental variance and then the high heritability values for it and on the date 1st August and the values of the genetic variance were greater than the values of the environmental variance in most of the studied traits.

Early adulthood weight change, midlife “Life’s essential 8” health status and risk of cardiometabolic diseases: a chinese nationwide cohort study

BackgroundThe association between weight change during early adulthood and cardiometabolic diseases remains uncertain in Chinese population. Whether the association varies with comprehensive cardiovascular health (CVH) in midlife assessed by “Life’s Essential 8” has not been characterized. We aim to examine the associations of early adulthood weight change and midlife “Life’s Essential 8” CVH status with cardiometabolic outcomes in a Chinese cohort.MethodsThe study participants were from the China Cardiometabolic Disease and Cancer Cohort (4 C) Study. This analysis included 72,610 middle-aged and older participants followed for a median of 3.6 years. At baseline, the participants recalled body weight at age 20 and 40 years, and we calculated change in weight and BMI between 20 and 40 years of age. Health behaviors information in “Life’s Essential 8” was collected by questionnaire, and health factors were measured in the study center. During follow-up, we ascertained incident cardiovascular events based on medical records, and diagnosed incident diabetes according to the American Diabetes Association 2010 criteria.Results72,610 study participants were included with a mean age of 56.0 ± 8.8 years and 29% of them were males. Weight gain of more than 10 kg between 20 and 40 years of age was associated with 22% increased risk of incident cardiovascular events (HR: 1.22; 95%CI: 1.04–1.43) and 38% increased risk of diabetes (HR: 1.38; 95%CI: 1.25–1.53) compared to stable weight. Besides, the association of weight gain more than 10 kg in early adulthood with cardiometabolic risk was even stronger in those with low CVH score in midlife (HR: 2.44; 95%CI: 2.01–2.97 for incident cardiovascular events; HR: 2.20; 95%CI: 1.90–2.55 for incident diabetes) or with few ideal cardiovascular health metrics in midlife.ConclusionsOur study indicated that weight gain in early adulthood was associated with significantly increased risk of cardiometabolic diseases. And the association could be stronger in those with poor CVH profiles in midlife. These findings confirmed the significance of weight management during early adulthood and suggested that individuals who experienced substantial weight gain in early life should be encouraged to maintain good CVH status in Chinese population.

CORRELATION AND PATH ANALYSES IN F4 SEGREGATING POPULATIONS OF BREAD WHEAT FOR GRAIN YIELD AND ITS ATTRIBUTES

Wheat breeders focus on enhancing the production potential of bread wheat by creating new varieties with acceptable genetic makeup to combat the pressure of rising human population consumption. Research to resolve this issue transpired during the Rabi of November 2021– April 2022 at the Lovely Professional University, Punjab, India. Developing the field trial used an augmented block design, 45 F4 segregating population genotypes, and five checks. Data on characteristics, such as days to 50% flowering, days to maturity, number of productive tillers, plant height, ear length, and weight, number of spikelets ear-1 and grains ear-1, 1000 grain weight, grain yield plant-1, biological yield, harvest index, and chlorophyll index underwent assessment. Highly significant variations between the genotypes for all the traits had the analysis of variance determining these, except 1000 grain weight and chlorophyll index in the treatment test and the test versus check. In this study, the harvest index, biological yield plant-1, and grain yield plant-1 are all higher for the phenotypic and genotypic coefficient of variances (PCV, GCV). The genetic advancement and heritability are highest for days to maturity, ear weight, number of grains ear-1, biological yield plant-1, grain yield plant-1, and harvest index. Studies on the relationships between various traits divulged that the number of productive tillers and harvest index had a positive, strong link and a direct effect with grain yield plant-1. These findings support the application of genetic modification to increase seed yield in bread wheat.

EFFECT OF DIFFERENCES IN PLANTING DISTANCE ON GROWTH AND YIELD OF Zea mays in RED-YELLOW PODZOLIC SOIL

The problem that occurs in efforts to increase zea mays production is low land productivity, especially for red-yellow podzolic soil types. Setting plant spacing is an important factor to increase crop production easily and not increase production costs. Increasing the plant population per unit area can increase yields, but if the plant population continues to be increased, the yield will actually decrease. The aim of this research was to determine the response of growth and production of Zea mays to plant spacing treatments and to determine the correct planting distance with a high growth and production response. This research used a Randomized Block Design with 4 treatments, namely: P1 = planting distance 100 x 20 cm; P2 = planting distance 80 x 20 cm; P3 = planting distance 60 x 20 cm; and P4 = planting distance 40 x 20 cm; and repeated 3 times. Observation variables included plant height, ear weight, ear diameter, ear length, and sweetness level. The data analysis used was analysis of variance to determine whether the treatments were significantly different or not and continued with the LSD test with a significance level of 5%. The research results showed that differences in the planting distance of Zea mays on red-yellow podzolic soil had an effect on plant height, cob weight without corn husks, cob weight with corn husks, and cob length. Treatments P1 and P2 were the best treatments for the variables plant height, cob weight without corn husks, and cob weight with corn husks. Meanwhile, for the cob length variable, the best treatment is the P1 treatment.

Influence of Different Sowing Dates and Nutrient Management on Dry Matter Accumulation and Correlation Study for Grain Yield of Wheat (Triticum aestivum. L.)

A field experiment was carried out during the rabi season of 2020-21 in the Instructional farm of Barrister Thakur Chhedilal College of Agriculture and Research Station, Bilaspur, Chhattisgarh, to study the “Influenced of different sowing date and nutrient management on dry matter accumulation and Correlation and regression equations for grain yield of wheat (Triticum aestivum. L.)”. The experiment was laid out in split plot design with three replications with keeping four sowing dates viz., D1 (25th October), D2 (5th November), D3 (15th November) and D4 (25th November) as main plot and three fertilizer rates viz., NM1 (RFD), NM2 (150% RFD + FYM 15 t ha-1) and NM3 (150% RFD + FYM 15 t ha-1 + Growth regulators) as sub plot treatments. The crop sown on 5th November and NM3 (150% RFD + FYM 15 t ha-1 + Growth regulators) was significantly influenced by higher dry matter accumulation, CGR, RGR. Results revealed that, the maximum growth i.e. (higher dry matter accumulation, CGR and RGR), yield attributes (weight of grains per ear and test weight) and yield (grain yield) of wheat crop sown on 5th November as compared to other sowing dates. Among the fertilizer rates, maximum growth i.e. (dry matter accumulation, CGR and RGR), yield parameters (weight of grains ear-1 and test weight) were recorded the treatment NM3 (150% RFD + FYM 15 t ha-1 + Growth regulators), which was at par with NM2 (150% RFD + FYM 15 t ha-1). The data revealed that grain yield of wheat was significantly and positively correlated with biomass yield, test weight, number of grain ear-1 head, spike length, grain weight ear-1 head.

Calcaneoplasty with radiofrequency cementing following balloon reduction

The standard surgical procedure for complex calcaneal fractures is open reduction, internal reduction and internal stable angle plate osteosynthesis via alateral approach. More recently, options for minimally invasive and percutaneous surgical strategies have been presented [4, 7]. As a possible procedural alternative for acovered, surgical treatment of calcaneal fractures, calcaneoplasty is discussed and applied in this context [5]. In this case series of five complex calcaneal fractures presented here, aballoon catheter was used for percutaneous reduction to restore the alignment of the calcaneus.This was followed by placement of PMMA cement in radiofrequency application and osteosynthesis using percutaneous cannulated screws. This Vicenti technique allows stable reduction and retention with early partial weight bearing with an overall low complication rate [17].

Physiological and Agronomic Characteristics of Alternative Black Barley Genotypes (Hordeum vulgare var. nigricans and H. v. var. rimpaui) under Different Hydrothermal Conditions of the Growing Seasons

Black-seeded barley can be a valuable raw material for functional food. However, its restoration to cropping should be preceded by the identification of the characteristics determining productivity. The field study was conducted to identify specific parameters of the black-seeded barley genotypes (Hordeum vulgare var. nigricans and H. v. var. rimpaui) and compare them with common barley (H. vulgare) under the different hydrothermal conditions of the two growing seasons of 2021 and 2022. Our research has shown that each genotype has a set of specific characteristics that best describe it at a given developmental stage. H. v. rimpaui was well characterized by chlorophyll fluorescence parameters such as FV/FM, FV/F0, and PIABS at the seedling stage and H. v. nigricans by FV/FM and FV/F0 at the flag leaf stage. Moreover, H. v. var. rimpaui was distinguished by a high biomass of shoot (726 g m−2) and straw yield (5.04 t ha−1) but H. v. var. nigricans by a high number of sterile generative tillers (103 m−2 in the dry year 2022). Further research should focus on the response of black-seeded barley genotypes to abiotic stresses, while in agronomic practice, efforts should be made to increase the number of grains per ear and 1000-grain weight.

Circular frame fixation of complex tibial plateau fractures in the elderly: Functional and radiological outcomes for Schatzker V and VI type fractures

Tibial plateau fracture fixation in the elderly poses a unique challenge due to poor bone stock, comminution and co-morbidities. There is limited evidence available in older patients sustaining multiple column Schatzker type V and VI injuries. In our institutions these injuries have traditionally been managed with circular frame fixation, often augmented with cross knee frame extension, internal screw fixation +/- bone graft substitutes. This study has reviewed the over 60-year-old cohort to better understand this complex injury. MethodsElectronic fracture databases were queried for ‘tibial plateau fracture’ and ‘Ilizarov frame’ between July 2009 and 2019. Inclusion criteria; age >60 years; CT identified multiple column (Schatzker V or VI) injuries; Ilizarov fixation; adequate follow-up data. Patient demographics, fixation technique, time to frame removal, residual radiological tibial deformity, joint incongruity, significant peri‑operative complications and progression to salvage TKA were reported. Results35 patients >60 years were treated with Ilizarov frame techniques for multiple column injuries. 84 % were female. Average age was 68 (62–81) with a follow-up of 6.6 years (2.3–11.3). 33 of the 35 patients investigated for osteoporosis had evidence of decreased bone mass (94 %). 94 % were Schatzker VI injuries. 22 cases required cross knee extension with a frame duration 155 days (range 103–317). Those without had a frame duration 128 days (range 93–212). 20 cases had a combined internal/external fixation technique and 9 cases required allograft or bone substitute. There was one case of non-union requiring salvage to constrained TKA. Three cases (9 %) of metalwork removal, two for prominent metalwork and one for deep infection. There were no VTE events and there was 0 % mortality in the two post-operative years. Oxford knee scores and SF-12 scores demonstrate that minimal residual deformities in the coronal and sagittal planes following frame removal are tolerated well within this age group. This study demonstrates Ilizarov techniques are highly successful at permitting early weight bearing and achieving union with associated low morbidity rates in an older population.

LOW RISK OF DELAYED TALAR SHIFT IN STABLE WEBER B FRACTURES MANAGED WITH A FUNCTIONAL BRACING PROTOCOL WITH EARLY WEIGHT BEARING

Stable Weber B fractures are typically treated non-operatively without complications but require close monitoring due to concerns over potential medial deltoid ligament injuries and the risk of delayed talar shift. Following recent evidence suggesting this is unlikely, a functional protocol with early weight bearing was introduced at Glasgow Royal Infirmary (GRI) following a pilot audit.This study aims to evaluate the risk of delayed talar shift in isolated Weber B fractures managed with functional bracing and early weight-bearing, particularly if signs of medial ligament injury are present.We conducted a retrospective review of 148 patients with isolated Weber B fractures without talar shift at presentation that were reviewed at the virtual fracture clinic at our institution between July 2019 and June 2020. The primary outcome was the incidence of delayed talar shift. Secondary outcomes were other complications and adherence to protocol.48 patients had medial signs present and of these 1 (2%) showed possible talar shift on X-rays at 4 weeks, and was kept under review. This patient had a normal medial clear space at 3 months. No patients with medial signs not documented (n=19) or not present (n=81) had delayed talar shift. 10% of patients (n=15) had at least 1 complication: delayed union (n=2); non-union (n=3); ongoing pain (n=14).Functional bracing with early weight-bearing is a safe, effective protocol for managing isolated Weber B fractures without initial talar shift. This study concludes that the risk of delayed talar shift is low in all patients, with or without medial signs.

Doses and application timing of boron on the agronomic characteristics of corn

Corn cultivation holds great economic importance in Brazil, as it is grown throughout the country, covering approximately 21.5 million hectares annually, with a production of 113 million tons in the 2021/2022 harvest. However, crop production is directly linked to plant nutrition, and boron (B) is one of the essential micronutrients for plant development. Its deficiency imposes limitations on Brazilian agricultural crops. Therefore, the objective of this study was to evaluate the vegetative and productive characteristics of corn in response to the application of different doses of boron at different application timings. The experimental design used was completely randomized, in a 3x5 factorial scheme, with 4 replications, consisting of the combination of 5 doses of B (0, 0.5, 1, 2, and 4 kg ha-1) applied in the sowing furrow and at the V4 and V7 phenological stages. Plant height, first ear insertion height, stem diameter, number of rows per ear, number of grains per row, number of grains per ear, ear weight, grain weight per plant, and 100-grain weight were evaluated. No significant differences were observed between the doses and/or timing of boron application in the hybrid corn used in this study.

HIP DISLOCATION, ANATOMICAL DESCRIPTION, EPIDEMIOLOGY, MECHANISMS OF ACTION, CLASSIFICATION, CLINICAL PRESENTATION, IMAGING PRESENTATION, TREATMENT, COMPLICATIONS AND DISLOCATION AFTER TOTAL HIP REPLACEMENT

Introduction: Traumatic hip dislocation is an uncommon injury, approximately making up 2 to 5% of all dislocations generated by high-energy trauma. This type of dislocation can be pure or related to other injuries or alterations such as fracture of the femoral head, femoral neck or acetabulum. Objective: to detail the current information related to hip dislocation, anatomical description, epidemiology, mechanisms of action, classification, clinical presentation, imaging presentation, treatment, complications and dislocation after total hip replacement. Methodology: a total of 30 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 21 bibliographies were used because the other articles were not relevant to this study. The sources of information were PubMed, SciELO, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: hip dislocation, proximal femur, femoroacetabular dislocation, prosthetic dislocation. Results: Anterior dislocations account for 10% to 15% of traumatic hip dislocations, with the remainder being assigned to posterior dislocations. The incidence of osteonecrosis of the femoral head is between 2% to 17% of individuals, while 16% form post-traumatic osteoarthritis. The sciatic nerve is affected in about 10% to 20% of posterior dislocations. There is no correlation between early weight bearing and osteonecrosis. Dislocation of the total hip endoprosthesis is observed in about 2% of individuals within one year after surgery. There are dislocation rates of up to 28% following revision and implant exchange surgeries. Conclusions: The capsular ligaments of the hip joint (iliofemoral, ischiofemoral, and pubofemoral) act very importantly in the functional mobility and stability of the joint. Hip dislocations are caused by high-energy trauma, such as traffic accidents, which are becoming more common due to the increase of these. Posterior dislocations are more common compared to anterior hip dislocations. A complete and thorough trauma evaluation is important in the clinical assessment. Those with a posterior dislocation of the hip show marked pain and the hip in flexion, internal rotation and adduction. Those with an anterior dislocation remain with the hip in marked external rotation, slight flexion and abduction. The importance of an anteroposterior projection of the pelvis and a cross lateral projection of the injured hip is emphasized. Treatment may be closed or open reduction depending on the circumstances, clinical situation and associated injuries. Complications such as osteonecrosis may be associated with the time of evolution. The treatment of instability following total hip replacement should follow a standardized algorithm. KEY WORDS: dislocation, hip, femur, acetabulum, prosthesis.

Institutions, Gender, and Net Nutrition during Economic Development: The United States from 1860s–1930s

Gender-based institutions influence resource allocation within the household and when other measures for economic welfare are scarce or unreliable, the use of biological measures are now standard in economics. This study uses late nineteenth and early twentieth century BMI, statures, and weight to assess how net nutrition accumulated to women and men during U.S. economic development. Throughout the late nineteenth and early twentieth centuries, female and male BMIs, statures, and weight remained constant over time. Unskilled laborers’ BMIs were higher, their statures were taller, and their weights heavier than workers in other occupations. Women and men from the Northeast and Middle Atlantic had higher BMIs and shorter statures, while their counterparts from the South were taller and had lower BMIs, indicating that it was superior Southern cumulative net nutrition associated with lower BMIs

Four-Leg Sustained Dynamic Compression Staple and Screw Generates Superior Lapidus Construct as Compared to Plate and Screw: A Biomechanical Study

Category: Ankle; Basic Sciences/Biologics Introduction/Purpose: Lapidus procedures are frequently used to treat moderate to severe hallux valgus in the setting of first tarsometatarsal instability or arthritis. The push for early weightbearing can lead to nonunion rates reaching 12%. A growing number of surgeons are utilizing orthopedic staples manufactured from NiTiNOL in foot and ankle arthrodesis procedures. These staples are inserted in an “open expanded” state which enables application of sustained dynamic compression (SDC) between bony segments, which can persist even when challenged with joint settling / bony resorption. The biomechanical performance of these devices has not been quantified in the setting of Lapidus procedures. This study determined the optimum SDC staple construct during Lapidus procedures, and to compare their performance to traditional plate and screw construct in an established model. Methods: Lapidus procedures were performed on synthetic bone replicates (Sawbones) using three SDC staple constructs and one static device construct: (1) dorsal four-leg inline SDC staple, (2) dorsal four-leg inline SDC staple with medial two-leg SDC staple (3) dorsal four-leg inline SDC staple with plantar medial-distal to lateral-proximal cannulated screw and (4) dorsomedial plate and distal dorsal to proximal plantar cannulated screw (FigA). Samples underwent four-point bending with calibrated servo- hydraulic machine (MTS). Max load and construct stiffness was calculated. Interfragmentary contact force, area, and pressure was measured with pressure sensor (Tekscan) and joint plantar gap measurements were completed with 3D motion capture system (Motion Analysis). Testing consisted of stepwise loading to 1, 2, and 3mm of crosshead displacement. For brevity, only data from 3mm displacement test are included herein. Data were analyzed with one-way ANOVA with Dunnett’s post hoc test (N=5/group). Results: The four-leg inline staple + two-leg staple and the four-leg inline staple + screw groups exhibited a 2.5x (p=0.03) and 7.5x (p <.001) increase in joint contact force as compared to the plate + screw group, respectively (FigB). The four-leg inline staple + two-leg staple and the four-leg inline staple + screw groups demonstrated a 3.5x (p=0.002) and 6.6x (p <.001) increase in joint contact area as compared to the plate + screw group, respectively (FigC). The four-leg inline staple + screw group exhibited a 65.1% reduction in plantar gap as compared to the plate + screw group (p=.039, FigD). Conclusion: The four-leg inline staple + screw group exhibited the optimal Lapidus construct biomechanical properties (greatest joint contact force, greatest joint contact area, and least plantar gap). The biomechanical testing performed herein was undertaken to simulate loading akin to early post-operative weight bearing. These data highlight the ability of the four-leg SDC NiTiNOL staple in combination with a static screw to provide meaningfully increased joint compression, uniformity of joint compression, and decreased construct motion as compared to the standard plate + screw construct that is frequently used clinically.

S4303 It's All in the Rib: A Rare Cause of Early Satiety and Weight Loss

S4303 It's All in the Rib: A Rare Cause of Early Satiety and Weight Loss

Immediate Weight Bearing after Modified-Brostrom Reconstruction: A Retrospective Review of an Accelerated Rehab Protocol

Category: Ankle; Sports Introduction/Purpose: Majority of injuries to the anterior talofibular ligament (ATFL) will go on to heal with non-operative management. Nearly a third of these injuries, however, will go on to develop chronic pain and instability; in these cases, operative reconstruction is indicated. An anatomic modified Broström reconstruction has replaced a traditional tenodesis as the standard of care. This reconstruction is often limited by damage to the native tissue and the time required for ligamentous healing, restricting the benefits of early weight bearing. In order to maximize the benefits of early range-of-motion exercises and weight bearing while protecting the repair, a suture-tape augmented Broström procedure has been suggested. We hypothesized that a suture-tape augmented Broström procedure would allow early weightbearing while preventing early failure. Methods: A retrospective chart review of patients who underwent a suture-tape augmented Broström procedure from August, 2020 to January, 2023 was conducted. Our inclusion criteria consisted of MRI confirmation of ATFL injury, a positive anterior drawer, failure of non-operative management, and post-operative physical exam consisting of a single leg hop and single leg heel raise at six weeks. Patients who had concomitant cartilage injuries with allograft repair, posterior arthroscopic debridement, peroneal tendon repair, syndesmosis repair, or calcaneal osteotomies were excluded. All patients participated in our accelerated rehab protocol which included immediate post-operative weightbearing as tolerated (WBAT) in a boot for two weeks followed by WBAT in an ankle brace for four weeks. Physical therapy was initiated two weeks post-op. Our primary outcome was the ability of patients to perform a single leg hop and single leg heel rise at six weeks. Secondary outcomes included visual analog scores (VAS) and post-operative complications. Results: 128 patients met our inclusion criteria. Our mean follow up was 11 (range, 6-52) weeks. At 6 weeks postoperatively, 88 (90%) of the patients asked could perform a single-leg heel raise and 73 (80%) of the patients asked could perform a single-leg hop. The average VAS at the final follow up visit was 1.03+1.9 (range, 0-8). No patients required a revision surgery. Post-operative complications were peroneal or sural neuritis (6 patients) and persistent pain (4 patients). There was no difference in primary and secondary outcomes in patients who had concomitant cartilage injuries not treated with grafting. Male patients were more likely to be able to complete a single leg hop at 6 weeks postoperatively (p = .04). No difference was found amongst other demographic factors. Conclusion: This study demonstrated that a modified-Broström procedure with suture-tape augmentation allowed for immediate weight bearing without reconstruction failure. The vast majority of patients had an excellent functional outcome at six weeks post- operative with minimal complications being recorded. There were no cases of revision surgery, DVTs, post-operative infections, and no patients reported residual instability.