The blending of Internet technologies and traditional business concerns impacts all industries and is the latest phase in the ongoing evolution of business. In this changing business environment, the most successful companies are those that leverage their investment in Web-based technologies by implementing e-business solutions supported by sound existing infrastructures based on well-functioning Enterprise Resource Planning (ERP) systems. Companies must also forge tighter links in the supply chain, from raw materials to customers and have increasingly turned to the Internet and Web-based technologies to do so. This paper presents a framework for understanding e-business opportunities within the context of a traditional enterprise and its infrastructure and examines the evolving relationship between e-business and ERP. These developments are moving businesses toward the concept of e-Supply Chain to achieve true supply chain integration. The issues and challenges faced by organizations in moving to such a complete e-business environment are discussed and suggestions are offered for businesses to navigate this challenging transformation.