A national e-commerce demonstration city is a city with a relatively popular application of e-commerce and a high annual e-commerce transaction volume, with the aim of reducing energy consumption and developing a green economy. It is an attempt by China to actively explore a unique modernization path with Chinese characteristics. We believe that in the new era, the transformation of urban e-commerce can increase innovation vitality, create more opportunities for people to achieve prosperity, and become an important new practical approach to promote common prosperity. Based on the policy experiment of national e-commerce demonstration city pilot construction as the main entry point of the project, this paper explores the process and development facts of China's innovation policy pilot construction, combines theoretical and empirical analysis, and uses multidimensional data and multiple econometrics methods to analyze and evaluate the innovation vitality of urban e-commerce transformation region influenced by mechanism and policy. Our research finds that the transformation of urban e-commerce plays a crucial role in activating urban innovation vitality and enhancing the market drivers of innovation vitality. We must unwaveringly consolidate and develop the public sector of the economy and expand financing and market access mechanisms, which will help to enhance innovation vitality and gradually improve the ability of market participants to achieve prosperity, thus facilitating the exploration and realization of the road to common prosperity.