Dyslipidemia is a potentially modifiable risk factor in patients with chronic kidney disease (CKD). Information on the safety and efficacy of statins in pediatric CKD is limited. Patients with CKD stage 2-5 and aged 5-18years with low-density lipoprotein cholesterol (LDL-C) > 130mg/dL and/or non-high-density lipoprotein cholesterol (non-HDL-C) > 145mg/dL were enrolled from September 2019 to February 2021. All patients were administered atorvastatin 10mg/day, which was escalated to 20mg/day if LDL-C remained > 100mg/dL and/or non-HDL-C > 120mg/dL at 12weeks. Proportion of patients achieving target lipid levels (LDL-C ≤ 100mg/dL and non-HDL-C ≤ 120mg/dL) and adverse events were assessed at 24weeks. Of 31 patients enrolled, target lipid levels were achieved in 45.2% (95% CI 27.8-63.7%) at 24weeks; 22 patients required dose escalation to 20mg at 12weeks. There was no difference in median lipid level reduction with 10 (n = 9) versus 20mg/day (n = 22, P = 0.3). Higher baseline LDL-C (OR 1.06, 95% CI 1.00-1.11) and older age (OR 36.5, 95% CI 2.57-519.14) were independent predictors of failure to achieve target lipid levels with 10mg/day atorvastatin. None had persistent rise in AST/ALT > 3 times upper normal limit (UNL) or CPK > 10 times UNL. No differences were noted in adverse events due to atorvastatin 10 or 20mg/day. Atorvastatin (10-20mg/day) administered for 24weeks was safe and effectively reduced LDL-C and non-HDL-C in children with CKD stages 2-5. Patients with higher baseline LDL-C required higher doses to achieve the target. A higher resolution version of the Graphical abstract is available as Supplementary information.