Dysfunction In Young Patients Research Articles

The Impact of Disease Duration on Microcirculatory Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes.

This study aimed to evaluate the earliest changes in the structure and function of the peripheral microcirculation using capillaroscopy and transcutaneous oxygen pressure measurement in children and adolescents with type 1 diabetes mellitus at baseline and during post-occlusive reactive hyperemia (PORH) in the function of diabetes duration. Sixty-seven patients with type 1 diabetes mellitus (T1D), aged 8 to 18 years, and twenty-eight age- and sex-matched healthy subjects were included in the analysis. Diabetic patients were divided into subgroups based on median disease duration. The subgroups differed in chronological age, lipid levels, and thyroid hormones. Capillaroscopy was performed twice: at baseline and then again after the PORH test. Transcutaneous oxygen pressure also was recorded under baseline conditions during and after the PORH test. Comparison of capillaroscopy and transcutaneous oxygen pressure parameters at rest and after the PORH showed no statistically significant difference between the subgroups. This remained true after adjusting for variables that differentiated the two subgroups. However, in the group of patients with long-standing diabetes, significant negative correlations were observed between the Coverage value after the PORH test and capillary reactivity with TcPO2_zero (biological zero). Significant positive correlations were also found between distance after the PORH test and TcPO2_zero. The results of our study indicate that in patients with a shorter duration of diabetes, the use of multiple tests provides a better characterization of the structure and function of microcirculation because the onset of dysfunction does not occur at the same time in all the tests.

The Relationship between TNF-a, IL-35, VEGF and Cutaneous Microvascular Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes.

The aim of this study was to analyze the relationship between immunological markers and the dysfunction of cutaneous microcirculation in young patients with type 1 diabetes. The study group consisted of 46 young patients with type 1 diabetes and no associated complications. Microvascular function was assessed with the use of nail fold capillaroscopy before and after implementing post-occlusive reactive hyperemia. This evaluation was then repeated after 12 months. Patients were divided into two subgroups according to their baseline median coverage (defined as the ratio of capillary surface area to surface area of the image area), which was established during the initial exam (coverageBASE). Additionally, the levels of several serum biomarkers, including VEGF, TNF-a and IL-35, were assessed at the time of the initial examination. HbA1c levels obtained at baseline and after a 12-month interval were also obtained. Mean HbA1c levels obtained during the first two years of the course of the disease were also analyzed. Patients with coverageBASE below 16.85% were found to have higher levels of VEGF and TNF-α, as well as higher levels of HbA1c during the first two years following diabetes diagnosis. Our results support the hypothesis that the development of diabetic complications is strongly influenced by metabolic memory and an imbalance of pro- and anti-inflammatory cytokines, regardless of achieving adequate glycemic control.

YouTube is an important resource for hyperhidrosis patients

Background: YouTube is one of the most used information sources. Hyperhidrosis is a disease that needs treatment mostly due to social complaints.
 
 Methods: Search titles ‘Hand sweating, Excessive sweating, Armpit sweating, and Hyperhidrosis’ were searched for separately on YouTube. A total of 400 videos, consisting of 100 under each title, were evaluated. Data such as who uploaded the video, which treatment plan it contained, the upload date, country of upload, duration, number of times watched, and rating were recorded. The Video Power index (VPI) was used to evaluate the popularity of the videos in the study.
 
 Results: The number of views, number of likes, and VPI of the video group with a duration of 232 s or more were found to be significantly higher than the video group with a shorter duration (P =0.001, P =0.000, and P = 0.000). In commercial videos, the rate of videos featuring non-surgical treatment was found to be the highest at92.1%. It was found that the videos containing surgical treatment were older than the videos containing non-surgical treatment (P =0.028).
 
 Conclusion: The internet is an important source of information in diseases such as hyperhidrosis that cause social dysfunction in young patients and the treatment decision is determined entirely by the level of complaint the patient feels. On the YouTube platform, which is one of these sources of information, it was seen that video-assisted thoracoscopic surgery, which is the definitive and permanent treatment of hyperhidrosis, has started to lose its place to alternative methods in recent years.

Correlation of lipid profile with diastolic dysfunction in normotensive young patients under 40 years of age

Background: Diastolic dysfunction in young adults is associated with increased morbidity and mortality. The identification of risk markers associated with diastolic dysfunction could allow for targeted primary prevention efforts. Aims and Objectives: The aim of the study was to study whether dyslipidemia is associated with diastolic dysfunction independent of systemic hypertension in young patients under 40 years of age. Materials and Methods: This was a cross-sectional analytical study done from April 2021 to March 2022 in SSMC and SGMH Rewa (M.P.), 214 normotensive cases under 40 years of age were taken as cases by simple random sampling. Sample size calculated by standard formula with confidence level of 95% and margin of error was <5%. Lipid profiles (S. Triglyceride [TG], S. Cholesterol, and S. low-density lipoprotein [LDL]) of all the patients were checked. 2D echocardiogram of patients was done to check for diastolic dysfunction. All data were compiled and compared with the previous studies. Results: We found that the prevalence of diastolic abnormalities in adults under 40 years of age was 21.9%. It was found that there was significant correlation between dyslipidemia and presence of diastolic dysfunction in patients. Patients with higher than normal levels of S. TG, S. Cholesterols, and S. LDL were found to have more prevalence of diastolic dysfunction then patients with normal levels of S. TG, S. Cholesterols, and S. LDL. Higher grades of diastolic dysfunction were found in patients with dyslipidemia as compared to patients without dyslipidemia. High levels of TG and LDL and even Borderline high levels of LDL can be good predictors of diastolic dysfunction. Conclusion: Dyslipidemia is associated with diastolic dysfunction in young patients even without systemic hypertension.

Contemporary non-invasive methods for the diagnosis of early cardiac dysfunction in young patients with beta-thalassemia major

Thalassemias are a group of inherited disorders, that require regular lifelong blood transfusions, which are vital for the normal development and life of the patients. With time, complications occur due to iron deposition in internal organs with subsequent chronic hemochromatosis development and predominantly affecting the heart, the liver and the endocrine glands. Despite the absence of clinical symptoms in young patients, enough data are supporting the fact that early myocardial iron deposition occurs. This necessitates the introduction of suffi ciently reliable methods and techniques for the detection and follow-up of early heart disorders before the onset of symptoms. Evaluation of myocardial iron deposition by the T2* MRI technique is established as a reliable, non-invasive method with good reproducibility and a low percentage of variability. Echocardiography as a method does not give information concerning the iron deposition in the heart but is easily applicable, safe and widespread for screening and follow up of patients. The use of new technique such as longitudinal strain makes the method almost comparable for the assessment of early subclinical myocardial damage. Although still in the fi eld of research, the identifi cation of specifi c miRNAs associated with cardiac stroke, fi brosis and remodeling is emerging as a new, potential biomarker for myocardial damage that could support the overall cardiovascular assessment of patients. This review will focus on current manifestations of cardiac complications in young patients with beta-thalassemia major, as well as the noninvasive methods for assessing cardiac function described above.  

Erectile dysfunction in young patients and elderly patients by sexual encounter profile: A comparative study.

Demand for erectile dysfunction treatments has increased not only in elderly patients but also in young patients. Reports indicate that frequent causes of erectile dysfunction in Japan are organic disorders in elderly patients and psychogenetic disorders in young patients. We defined patients under the age of 40 as young erectile dysfunction patients, and those over 65 as elderly erectile dysfunction patients. We divided these two groups and conducted a retrospective comparative study based on medical questionnaires. We selected 215 cases of patients under the age of 40, and 176 cases of patients over the age of 65, and created a group of young patients and a group of elderly patients. We implemented the erectile hardness score, Sexual Health Inventory for Men, and sexual encounter profile questions 2 and 3 as the patient's daily clinical journal. The median age of young patients was 36 years, and that of elderly patients was 70 years. With respect to Sexual Health Inventory for Men, the average score was a significantly higher score in the young patients (9.26 vs 7.10, P < 0.001). Concerning erectile hardness score, young patients showed significantly higher scores in erectile hardness score (3.15 vs 2.06, P < 0.001). In terms of sexual encounter profile question 2, 50.9% of young patients responded "yes," but 24.3% of elderly patients responded, thus indicating a significantly higher score in young patients. In terms of sexual encounter profile question 3, 6.1% of young patients responded "yes," and 0.7% of elderly patients responded "yes," indicating a significantly higher in young patients. The results showed that many young patients with erectile dysfunction were able to perform insertion, but were unable to maintain erection.

Correlation analysis of body image level and female sexual dysfunction in young patients with postoperative breast cancer

To determine the relationship between female body image and female sexual dysfunction (FSD) in young patients (20-40 years) with postoperative breast cancer. Using the convenient sampling method, we identified 276 young patients with postoperative breast cancer from June 2017 to 2019 in the Department of Oncology and Radiotherapy of the First Affiliated Hospital of Anhui Medical University to be included in the study. A general situation questionnaire for body image scale (BIS) and female sexual function index (FSFI) scale was used to evaluate the correlation between body image level and the prevalence of FSD in young patients with postoperative breast cancer. The total score for BIS was 10.98 ± 7.19, indicating that patients were moderately dissatisfied with their body image The total prevalence of FSD was 63.41%. Pearson correlation analysis showed a negative correlation between the total score, each dimension score of BIS, total FSD, and the incidence of each dimension disorder (range, r: -0.414 to -0.717, all P values <0.05). There is a negative correlation between the body image level and the prevalence of FSD in young patients with postoperative breast cancer. This suggests that clinical medical workers should develop an intervention plan to improve the body image level of postoperative young breast cancer patients according to the unique physiological and psychological characteristics of these patients while also reducing the prevalence of FSD.

The Large Focal Isolated Chondral Lesion.

Focal chondral defects (FCDs) of the knee can be a debilitating condition that can clinically translate into pain and dysfunction in young patients with high activity demands. Both the understanding of the etiology of FCDs and the surgical management of these chondral defects has exponentially grown in recent years. This is reflected by the number of surgical procedures performed for FCDs, which is now approximately 200,000 annually. This fact is also apparent in the wide variety of available surgical approaches to FCDs. Although simple arthroscopic debridement or microfracture are usually the first line of treatment for smaller lesions, chondral lesions that involve a larger area or depth require restorative procedures such as osteochondral allograft transplantation or other cell-based techniques. Given the prevalence of FCDs and the increased attention on treating these lesions, a comprehensive understanding of management from diagnosis to rehabilitation is imperative for the treating surgeon. This narrative review aims to describe current concepts in the treatment of large FCDs through providing an algorithmic approach to selecting interventions to address these lesions as well as the reported outcomes in the literature.

Speaking of pandemics and vascular walls. From the endothelium to socioeconomic-psychological aspects: an evidence-based approach

This article briefly reviews the pandemics suffered by humankind throughout its history. Additionally, it analyzes the current pandemic caused by a "strange” virus that has generated a new and complex disease. A description of its "new" vascular wall-centered physiopathology (and more specifically from the endothelium) is given. Moreover, the possibility to detect a subclinical endothelial dysfunction in young patients who have shown different susceptibility and lethality indices is considered. Finally, the question “will this pandemic change us or will it help us change?” is attempted to be answered.

EFFECT OF OBESITY ON VENTRICULAR MASS INDEX AND DIASTOLIC DYSFUNCTION IN YOUNG PATIENTS WITH HYPERTENSION

Objective: To investigate the effect of obesity on left ventricular mass index and diastolic dysfunction in young patients with hypertension. Design and method: A total of 166 young patients with hypertension (113 males and 53 females) diagnosed at the Lanzhou University Second Hospital from January 2018 to March 2019 were enrolled, aged 16–44 (34.25 ± 7.085) years old. According to the difference of body mass index (B M I), they were divided into 3 groups: the normal group (18.5 Kg/m2&lt;=B M I &lt; 24 Kg/m2; N = 58), the overweight group (24 Kg/m2&lt;=B M I&lt;28 Kg/m2; N = 62) and the obese group (B M I&gt;=28 Kg/m2; N = 46). Detection of height, weight, 24 h ambulatory blood pressure, fasting blood glucose(F B G), blood lipid, uric acid (U A) and left ventricular structure and diastolic function index were performed. Variance analysis was used to compare the above data between groups, Pearson correlation analysis was used to analyze the influencing factors of ventricular remodeling and diastolic dysfunction. Results: (1) With the increase of B M I,U A (P &lt; 0.05),L VD-s (P &lt; 0.01), L VD-d (P &lt; 0.01),L VS-D (P &lt; 0.01),D (P &lt; 0.01)and L V MI (P &lt; 0.05) all increased in turn, the obese group was significantly higher than the overweight group, but the difference between the normal and the overweight group was not statistically significant (P &gt; 0.05). (2) E/e’ in obese group was higher than that in normal group (P &lt; 0.05) and there was no significant difference between the any other two groups (P &gt; 0.05). (3) In young patients with hypertension: U A was significantly positively correlated with L V D-s, L V D-d, L VS-D, D and L V MI (both P &lt; 0.01 or P &lt; 0.05). (4) In the obese group, U A was positively correlated with E/e’ (P &lt; 0.05), and the correlation was not observed in normal and overweight group (P &gt; 0.05). Conclusions: Among young patients with hypertension, obese patients have higher U A, higher L V M I and more pronounced left ventricular diastolic dysfunction; moreover, U A is independently associated with ventricular remodeling in all subjects but correlates with ventricular diastolic dysfunction only in obese individuals.

Left ventricular diastolic dysfunction is associated with cerebral infarction in young hypertensive patients: A retrospective case-control study.

Studies have indicated that hypertension is associated with the occurrence of acute cerebral infarction (CI) in young patients (18-45 years). However, the association between CI and left ventricular diastolic (LVD) dysfunction in young patients with hypertension has rarely been reported. The purpose of the present study was to investigate the association between LVD dysfunction and acute CI in young patients with hypertension. A total of 92 patients with acute CI who had hypertension were selected as the study group (CI group) and 98 young patients with only hypertension were selected as the control group (non-CI group). Blood pressure measurements, LVD functional assessment and cerebral MRI were performed. The χ² test was used to compare the left ventricular diastolic function between the CI and non-CI groups. The results indicated that LVD function of young patients was associated with hypertension and there was a correlation between the decrease in LVD function and the occurrence of acute CI in young patients with hypertension. The incidence of acute CI was higher in patients with decreased LVD function than in those with normal LVD function. In conclusion, hypertension in the young is associated with decreased LVD function and is a risk factor for diastolic dysfunction of the left ventricle. LVD function may be an independent predictor of acute CI in young patients with hypertension and should be considered by clinicians. By predicting the risk of acute CI in young patients with hypertension, LVD testing may aid in the primary prevention of CI or guide early treatment.

485 - Factors related to early recovery of sexual function after revascularization for post-traumatic arteriogenic erectile dysfunction in young patients

485 - Factors related to early recovery of sexual function after revascularization for post-traumatic arteriogenic erectile dysfunction in young patients

Neuropsychological Impairments in Young Patients With Subclinical Hypothyroidism: A Case Control Study.

Background:There is a lack of clarity about the cognitive dysfunction in young patients with subclinical hypothyroidism (SCH). This study was done to explore the neuropsychological impairments in young patients with SCH and compare them with euthyroid controls.Methods:Patients between 18 and 45 years of age and diagnosed with SCH were recruited. Controls were euthyroid age, gender, and education matched. All the cases and controls underwent a detailed neuropsychological assessment with a battery of tests validated for use in the age groups of 18 to 65 years.Results:Thirty-nine patients with a mean age of 30.3 ± 7.7 years (female:male ratio 12:1) and 23 controls (female:male ratio 21:2) with a mean age of 33.4 ± 7.1 years (P = .24) were included in the study. The mean TSH value was 6.36 ± 1.3 mIU/L and 2.49 ± 1.03 mIU/L in cases and controls, respectively (P < .001). The visual memory delayed recall was impaired, in 48.71% (n = 19) and 21.7% (n = 5) cases and controls, respectively (P = .03). The category fluency test showed impairment in a greater number of cases (35.9%, n = 14) as compared to controls (13%, n = 3; P = .04).Conclusion:This study shows that younger patients with SCH have delayed visual memory recall and category fluency deficits, which are suggestive of dysfunction of the prefrontal cortex and temporal lobe in young SCH patients. These impairments may justify the treatment of young SCH patients with replacement therapy.

The circulating level of miR-122 is a potential risk factor for endothelial dysfunction in young patients with essential hypertension.

MicroRNAs are key molecules involved in the regulation of endothelial function. They are important risk factors and biomarkers for the development of hypertension related to endothelial dysfunction. However, the gene expression patterns associated with hypertension development related to endothelial dysfunction have not been fully elucidated. We conducted a case-control study of 65 patients with essential hypertension (EH) and 61 controls without EH. Plasma levels of miR-122 and its target protein high-affinity cationic amino acid transporter 1 (CAT-1) were measured by qRT-PCR and ELISA, respectively. miR-122 expression in plasma of patients with EH was significantly higher than that of the control group (p = 0.001), while CAT-1 expression in patients with EH was significantly lower than that in the control group (p = 0.018). miR-122 expression in plasma of young patients with EH was significantly higher than that in young people without EH (p = 0.0004), and CAT-1 expression in plasma of young patients with EH was also significantly lower than that of the control group (p = 0.002). CAT-1 expression in the plasma of young participants was significantly higher than that of individuals aged ≥40 years (p = 0.003), whereas miR-122 expression was significantly lower (p = 0.001). We showed that among patients with EH, the high expression of miR-122 contributed to endothelial dysfunction by suppressing the expression of the CAT-1 protein, which led to a decrease in CAT-1 expression in plasma. Therefore, high expression of miR-122 appears to be a risk factor for endothelial dysfunction in EH, especially in younger patients.

Dynamics of quality of dream and cognitive functions for the patients of young age with primary insomnia on background the reception of Sonmelat forte

The aim of the study was to assess the quality of sleep, cognitive functions and the effect of insomnia on work and social adaptation in young patients suffering from primary insomnia (in accordance with the DSM-5 and ICD-10 criteria for insomnia) and their dynamics under the influence of Sonmelate forte.Materials and methods. The study involved 23 patients (mean age – 41,3±2,8 years) with chronic primary insomnia and a duration of insomnia disorders of 7,79±2,4 months. The control group consisted of 20 healthy individuals (mean age 40,6±2,3 years) with no insomnia. In order to treat insomnia, patients took Sonmelate Forte (combination of 5 mg of melatonin immediate and 5 mg of melatonin sustained release) 1 tablet 30 minutes before sleep for 30 days.Results of the study. Chronic primary insomnia in young patients contributes to the development of mild manifestations of cognitive dysfunction in the form of impaired short-term visual and auditory memory, decreased concentration, stability and increased attention depletion, and also contributes to the development of emotional disturbances (anxiety, depression), work and socialmaladjustment. Sonmelat Forte is an effective and safe means of treating chronic primary insomnia in young patients, helping to reduce sleep latency, night and early awakenings, increase night sleep duration and decrease daytime sleepiness, promotes regression of mild cognitive dysfunction in young patients (improvement in short-term visual and auditory memory, attention span), improves the patient’s emotional state and daytime functioning by decreasing daytime oh sleepiness and general fatigue, contributing, thus, to increase the level of social and work adaptation.

Dose-Constraint Model to Predict Neuroendocrine Dysfunction in Young Patients With Brain Tumors: Data From a Prospective Study

PurposeWe report on a possible dose-constraint model to predict long-term neuroendocrine dysfunction after cranial irradiation in children and young adults with benign and low-grade brain tumors treated with stereotactic conformal radiation therapy (RT) in a prospective clinical trial. Methods and materialsPatients treated with stereotactic conformal RT (54 Gy in 30 fractions) were included for analysis if their co-registered planning computed tomography and magnetic resonance imaging scans were available, along with baseline and post-RT endocrine assessment for at least 2 years. The hypothalamus–pituitary axis (HPA) was contoured on the fused computed tomography–magnetic resonance imaging data set. Worsening of endocrine function was defined biochemically as a new onset endocrine deficit or worsening of preexisting endocrine deficit. Dosimetric indices of HPA, extracted using cumulative dose-volume histograms, were correlated with worsening endocrine function using logistic regression analysis. ResultsA total of 51 patients (median age: 13 years; range, 5-25 years) were included. Worsening post-RT endocrine levels were seen in 27 of 51 patients (47%). Growth hormone was the most commonly affected (70%), followed by cortisol (44%), gonadotropin (40%), and thyroxine (7%). The mean of the maximum and minimum doses to HPA was 42.1 Gy and 35.7 Gy, respectively. For patients with worsening endocrine levels, the mean maximum dose to HPA was 46.6 Gy compared with 36.5 Gy in patients with stable functions. The mean minimum dose to HPA was also higher (40.5 Gy vs 29.6 Gy) in patients with endocrine dysfunction. Logistic regression analysis identified the volume of HPA receiving 50% of the prescribed dose as the only statistically significant parameter predicting endocrine dysfunction. A dose of ≥27 Gy to any volume of HPA was associated with a 4-fold increase in risk of endocrine dysfunction (odds ratio: 4.05; 95% confidence interval, 1.07-15.62; P = .038). ConclusionsOur prospective longitudinal study demonstrates the feasibility of HPA avoidance using modern, high-precision, conformal RT techniques and correlates HPA dosimetry with neuroendocrine dysfunction. We suggest restricting HPA doses to <27 Gy to minimize the risk of post-RT neuroendocrine deficits.

Influence of statin therapy on antiphospholipid antibodies and endothelial dysfunction in young patients with coronary artery disease and systemic lupus erythematosus.

IntroductionAntiphospholipid antibodies (aPL) affect atherogenesis and may cause thromboembolism in systemic lupus erythematosus (SLE) and coronary artery disease (CAD). Intensive treatment with statins may reduce inflammation and decrease the number of thrombotic events. That may explain the beneficial effect of statin therapy in SLE and CAD. This study was established to investigate the influence of statin treatment on aPL antibody levels and selected endothelial dysfunction markers in CAD and SLE patients.Material and methodsFifty-eight patients – 40 after coronary revascularization (age 38.9 (27–46), 35 males) and 18 with clinically stable SLE (age 38.8 (18–62), 1 male) – were enrolled in the study. In both groups intensive atorvastatin treatment was administered. At baseline and after 1 year of follow-up serology tests were performed: anticardiolipin antibodies (aCL), anti-β2 glycoprotein I (aβ2GPI), lupus anticoagulant (LA), C-reactive protein (CRP), soluble form of intracellular adhesion molecule-1 (sICAM-1), vWF:Ag.ResultsCoronary artery disease patients in 1 year follow-up revealed a decrease of aβ2GPI IgG and CRP. There was a significant increase in aCL IgG, sICAM-1 and vWF:Ag. In SLE patients aPL levels showed no significant reduction after treatment.ConclusionsIn clinically stable patients IgM and IgG class aβ2GPI levels are higher in CAD than in SLE, whereas IgG class aCL levels are lower. Statin treatment decreases the CRP level in both SLE and CAD patients, while decreasing the aβ2GPI IgG level only in CAD patients.

Evaluation of Early Left Ventricular Dysfunction in Patients with Duchenne Muscular Dystrophy Using Two-Dimensional Speckle Tracking Echocardiography and Tissue Doppler Imaging.

Although progressive cardiac dysfunction is the leading cause of death in patients with Duchenne muscular dystrophy (DMD), their cardiac function measured by conventional echocardiography has been generally interpreted as normal at a young age. We aimed to determine whether two-dimensional speckle tracking echocardiography (STE) or tissue Doppler imaging (TDI) could be used for early identification and detection of cardiac dysfunction in young patients with DMD. Thirteen pediatric patients (mean age, 9.69 ± 2.2years) with DMD and 26 age-matched healthy children (mean age, 9.65 ± 2.2years) were included in the study. All patients were examined via conventional echocardiography, TDI, and STE. Standard echocardiographic measurements of left ventricular (LV) systolic and diastolic function were obtained. Myocardial velocities including peak-systolic and early- and late-diastolic myocardial velocities were calculated in longitudinal direction in the interventricular septum, using TDI. Speckle tracking analyses were performed by acquiring apical four-, three-, and two-chamber views with the highest possible frame rates. Conventional parameters were similar between the two groups, but heart rates were higher in patients with DMD than in controls. The results of LV diastolic function evaluated using TDI showed that annular peak velocity during early diastole (e'; 10.9 ± 1.7 vs. 14.6 ± 1.7cm/s), e'/a' ratio (2.0 ± 0.5 vs. 3.0 ± 0.5), E/e' ratio (9.4 ± 1.4 vs. 7.3 ± 0.8), and myocardial performance index (0.46 ± 0.05 vs. 0.36 ± 0.06) of the mitral septal annulus among patients with DMD differed significantly from those of healthy children. A significant decrease in global longitudinal systolic strain was found in patients with DMD (- 16.6 ± 3.7 vs. - 21.2 ± 2.1), with a marked decrease in the LV basal inferolateral and basal inferior walls. In young patients with DMD who have global normal systolic function, reductions in systolic deformation parameters as well as reduced early diastolic myocardial velocities can be detected particularly in the basal inferolateral LV walls. The prognostic significance of these findings warrants further longitudinal follow-up.

Hemodynamic premises of endothelial dysfunction in young patients with vertebrobasilar insufficiency

According to current interpretations, tonal regulation of major arteries is determined by the degree of endothelial function. Shear stress influence on the vascular endothelium is an important part of vascular physiology. The aim of this study was to evaluate endothelial dysfunction, dependent up on the stage of spondylogenic vertebrobasilar insufficiency using the indicator ISD (systole-diastolic index) in young patients with degenerative-dystrophic lesions of cervical spine. Our results show that there is significant association between the status of the endothelial wall and hemodynamic changes (the growth of the systole-diastolic ratio leads to an increase in vasoconstriction factors in the blood). Raised ET-1 together with increase in ISD in patients with spondylogenic vertebrobasilar insufficiency reflects a hemodynamically dependent link to endothelial dysfunction.

Вивчення напруги зсуву та ендотеліальної дисфункції у пацієнтів молодого віку зі спондилогенною вертебро-базилярною недостатністю

Вивчення напруги зсуву та ендотеліальної дисфункції у пацієнтів молодого віку зі спондилогенною вертебро-базилярною недостатністю