EFFECT OF OBESITY ON VENTRICULAR MASS INDEX AND DIASTOLIC DYSFUNCTION IN YOUNG PATIENTS WITH HYPERTENSION

Abstract

Objective: To investigate the effect of obesity on left ventricular mass index and diastolic dysfunction in young patients with hypertension. Design and method: A total of 166 young patients with hypertension (113 males and 53 females) diagnosed at the Lanzhou University Second Hospital from January 2018 to March 2019 were enrolled, aged 16–44 (34.25 ± 7.085) years old. According to the difference of body mass index (B M I), they were divided into 3 groups: the normal group (18.5 Kg/m2<=B M I < 24 Kg/m2; N = 58), the overweight group (24 Kg/m2<=B M I<28 Kg/m2; N = 62) and the obese group (B M I>=28 Kg/m2; N = 46). Detection of height, weight, 24 h ambulatory blood pressure, fasting blood glucose(F B G), blood lipid, uric acid (U A) and left ventricular structure and diastolic function index were performed. Variance analysis was used to compare the above data between groups, Pearson correlation analysis was used to analyze the influencing factors of ventricular remodeling and diastolic dysfunction. Results: (1) With the increase of B M I,U A (P < 0.05),L VD-s (P < 0.01), L VD-d (P < 0.01),L VS-D (P < 0.01),D (P < 0.01)and L V MI (P < 0.05) all increased in turn, the obese group was significantly higher than the overweight group, but the difference between the normal and the overweight group was not statistically significant (P > 0.05). (2) E/e’ in obese group was higher than that in normal group (P < 0.05) and there was no significant difference between the any other two groups (P > 0.05). (3) In young patients with hypertension: U A was significantly positively correlated with L V D-s, L V D-d, L VS-D, D and L V MI (both P < 0.01 or P < 0.05). (4) In the obese group, U A was positively correlated with E/e’ (P < 0.05), and the correlation was not observed in normal and overweight group (P > 0.05). Conclusions: Among young patients with hypertension, obese patients have higher U A, higher L V M I and more pronounced left ventricular diastolic dysfunction; moreover, U A is independently associated with ventricular remodeling in all subjects but correlates with ventricular diastolic dysfunction only in obese individuals.