Dysentery Vaccine Research Articles

AGGLUTINATION REACTIONS IN RABBITS FOLLOWING ORAL VACCINATION WITH BACILLUS DYSENTERIAE

Considerable work has been done in recent years on protection against bacillary dysentery by the oral administration of dysentery vaccines. Enlows¹gives a review of the literature, much of it indicating that some immunity at least is afforded by the ingestion of killed dysentery bacilli. The greater part of the work has been done with the Shiga type of organism, as it is the chief type causing serious dysentery in adults. In children in this country, however, the Shiga bacillus is found only in a small percentage of the cases as compared with those caused by the several strains of the Flexner dysentery organism. It was suggested to us that before any attempt was made to determine the efficacy of feeding a killed Flexner vaccine to children its ability to produce antibodies in rabbits should be tested by feeding them the vaccine. This work was therefore undertaken to determine,

On the Cocto-Immunogen of the Dysentery Bacillus (Shiga Type)

Abstract I. Introduction. Since the publication on “Cocto-precipitinogen and cocto-immunogen” by one of us, Torikata, in 1917 (1), the experiments have been repeated with various bacterial organisms by many investigators. But no one has yet repeated the experiments with regard to dysentery, except Boku (10), who successfully immunized rabbits with cocto-immunogen of the Shiga dysentery bacillus in order to obtain dysentery agglutinating serum. This was the reason that prompted us to undertake the present study. It is a well known fact that the dysentery vaccine or raw toxin is so extremely strong that it can not be used for immunizing human beings or laboratory animals, such as rabbits. Our primary object was to find out whether or not the cocto-immunogen can be used more advantageously to immunize rabbits and at the same time to test the value of the cocto-immunogen as such.

Vaccine therapy for bacillary dysentery per os

The authors were convinced that application of dysentery vaccine in doses even up to 600 billion per day per person for 6-8 days is completely harmless. To get a good therapeutic result the vaccine should be used as early as possible - in the first day of the disease.

IMMUNIZATION OF CHILDREN AGAINST FLEXNER DYSENTERY

In spite of all the precautionary methods, it is difficult to prevent the spread of bacillary dysentery in institutions for young children. If immunity to this disease could be produced, a material reduction in the morbidity and mortality of such institutions during the summer months would result. Many workers¹have shown by experiments on animals and men that protection against dysentery can be conferred by the use of vaccines. Shiga,²Gibson,³Vincent⁴and Csernel⁵have been successful by the subcutaneous administration of vaccines in lowering materially the incidence and mortality of the disease in certain epidemics. Their results indicate that protection is not conferred by dysentery vaccines in all cases. Among a large group of inoculated persons there are always certain ones who never develop immune bodies. From five days to three weeks must elapse before agglutinins are produced in most instances. The duration of

Preliminary Experiments with a View to the Preparation of a Non-Toxic Dysentery Vaccine

Preliminary Experiments with a View to the Preparation of a Non-Toxic Dysentery Vaccine