Evaluation of the effect of the clodronate therapy on the dynamics of chronic pain syndrome and on the quality of life of patients with breast cancer with metastatic lesions of bones after previous treatment with drug containing zoledronic acid. Topicality: Breast cancer is characterized by tendency to early metastasize: about 6% of patients already at diagnosis have metastatic form of the disease. The most frequent targets are the bones: for the frequency of bone metastasis, breast cancer is on the second place among malignant tumors and for the specific weight on the first place [1, 2, 3, 4]. On the early stages, metastatic bone lesions can be asymptomatic.