Climate variability significantly impacts plant growth, making it crucial to monitor ecosystem performance for optimal carbon sequestration, especially in the context of rising atmospheric CO2 levels. Net Primary Productivity (NPP), which measures the net carbon flux between the atmosphere and plants, serves as a key indicator. This study uses the CASA (Carnegie–Ames–Stanford Approach) model, a radiation use efficiency method, to assess the spatio-temporal dynamics of NPP in Togo from 1987 to 2022 and its climatic drivers. The average annual NPP over 36 years is 4565.31 Kg C ha−1, with notable extremes in 2017 (6312.26 Kg C ha−1) and 1996 (3394.29 Kg C ha−1). Productivity in natural formations increased between 2000 and 2022. While climate change and land use negatively affect Total Production (PT) from 2000 to 2022, they individually enhance NPP variation (58.28% and 188.63%, respectively). NPP shows a strong positive correlation with light use efficiency (r2 = 0.75) and a moderate one with actual evapotranspiration (r2 = 0.43). Precipitation and potential evapotranspiration have weaker correlations (r2 = 0.20; 0.10), and temperature shows almost none (r2 = 0.05). These findings contribute to understanding ecosystem performance, supporting Togo’s climate commitments.