This paper investigates and analyzes the dynamic response of asphalt pavement under pavement-unevenness excitation based on an orthogonal vector function system and efficient DVP (dual variable and position) method. Firstly, starting from the pavement unevenness of the vehicle excitation source, the pavement-unevenness excitation is established by using the filtered white-noise method, and the random load of the vehicle model is obtained by simulation. Then, based on the basic governing equation of the road-surface problem under the random load, the analytical solution of the road-surface mechanical response is obtained by using the orthogonal vector function system and DVP method. The effects of pavement-unevenness grade, vehicle speed, vehicle load, interlayer contact condition, and transverse isotropy on the mechanical response of the road surface are analyzed via the analytical results. The results show that DVP can effectively solve the dynamic response of pavements under the excitation of pavement unevenness; in addition, it can also be applied to certain situations, such as transverse isotropy of materials and interface conditions. The results show that the pavement unevenness does not affect the average stress and strain of each layer but has a significant effect on the peak value and dispersion degree. An increase in vehicle speed causes a peak in strain and a larger coefficient of variation. Poor bonding between interfaces can lead to increased stress and strain at the bottom of the surface layer.