Glioblastoma Multiforme accounts for 30% of primary CNS tumors. Standard treatment for GBM is surgery followed by Radiotherapy with or without Chemotherapy. In recent years three dimensional conformal Radiation therapy is being used widely to treat brain tumors rather than using parallel opposed lateral beams to save the normal brain tissue and critical structures. Sixty eight cases of Glioblastoma multiform (GBM) registered from Jan 2003 to June 2007, treated by SRT/IMRT using dynamic micro multi leaf collimator were analyzed for survival and quality of life (QOL). Out of 68 patients 52 were male and 16 were females. Median age of diagnosis was 52 years. Most common site involved was left temporo-parietal lobe (42%). All patients underwent surgical intervention. Only biopsy was done in 9 patients (14%), Decompression was done in 37 patients (53%) and gross total resection was done in 22 patients (33%). Most common presenting symptoms was headache, vomiting with neurological deficit (76%). A dose of 59.4-60 Gy at 1.8-2 Gy per fraction was delivered by SRT/IMRT. Dose was prescribed at 90% to 95 % isodose. 38% patients received concurrent chemo-radiotherapy. We found that the overall median survival was 12 months. The maximum OS was 2 years. Most of the patients developed local recurrence and died due to progressive disease. It was found that outcome was related to the pretreatment KPS of the patient and that there was no significant benefit in Overall Survival (OS). Acute neurological reactions were less with IMRT/SRT. Less supportive measures were required during treatment. Dose to the critical structures such as brain stem, optic nerve and optic chaisma were within the set limits. SRT/IMRT is a good technique of delivering precise dose to lesion and saving normal brain tissue.