State Of Dynamic Equilibrium Research Articles

Self-Inhibition Phenomena in Cu3Pt Oxidation by CO2.

This study investigates the oxidation behavior of Cu3Pt(100) in CO2 using a combination of ambient-pressure X-ray photoelectron spectroscopy, mass spectroscopy, and density functional theory modeling. Our in situ measurements reveal the simultaneous oxidation and reduction of Cu2O due to the opposing effects of atomic oxygen and CO generated from dissociative CO2 adsorption, leading to a dynamic equilibrium state of simultaneously occurring redox reactions. Complementary atomistic calculations elucidate the inhibitory effects of subsurface Pt enrichment and the counteracting roles of CO2 and CO in surface oxidation and reduction. These results provide mechanistic insights into the dissociative pathway of CO2 molecules and dynamic evolution of surface composition and reactivity of Cu-based alloy catalysts in CO2-rich environments, with broader implications for tuning gas-surface reactions by manipulating gas reactants or solid surface composition.

Microstructure and strength of cold-drawn large strain Fe35Ni35Cr20Mn10 high-entropy alloy

The Fe35Ni35Cr20Mn10 high-entropy alloy wires can achieve a large strain of 8.73 and a section reduction ratio of 99.98 %,and possess a high strength of 1868 MPa via traditional wire drawing. The microstructure evolution and mechanical properties of cold-drawn Fe35Ni35Cr20Mn10 high-entropy alloy are characterized by microstructure observation and tensile test. The results showed that The Fe35Ni35Cr20Mn10 HEA has excellent plastic forming capacity and excellent phase stability during plastic deformation. The Fe35Ni35Cr20Mn10 HEA has excellent continuous drawing ability, the main deformation mechanism is the plane slip and cross slip of the dislocation and the dynamic recovery of the sublamellar layer make the lamellar structure maintain a dynamic equilibrium state, and the lamellar thickness is basically unchanged to support the continuous plastic deformation under high strain conditions. The dynamic balance of coarsening and refining of lamellar structure in the process of plastic deformation is mainly due to the merging of HEA lamellar caused by the movement of trigeminal node induced by strain. Texture evolution showed that the <111> and <100> fiber textures were the stable texture component and the texture component content remained unchanged even under further increased strain. The Fe35Ni35Cr20Mn10 high-entropy alloy wire with high strain of 8.73 possesses excellent strength, and its tensile strength is 1868 MPa at room temperature, which has the largest strain. The dislocations proliferation, lamellar structure refinement and texture strengthening lead to high strength of the Fe35Ni35Cr20Mn10 high-entropy alloy wire.

Quantifying the Temperature Dependence of the Multi-Species, Multi-Reaction Model. Part 1: Parameterization for a Meso-Carbon Micro-Bead Graphite

In this work, the temperature impact on the Multi-Species, Multi-Reaction (MSMR) model is studied. This is accomplished by acquiring data from slow rate lithiation and delithiation of a meso-carbon micro-bead (MCMB) graphite. The MSMR model is used to simulate linear-sweep voltammetry data of a porous electrode composed of graphite, and because the electrode is close to a state of dynamic equilibrium, the peaks in the differential voltage spectroscopy plot can be analyzed. Through this analysis, the temperature impact on the total fraction of available host sites in a particular MSMR gallery (Xj), the impact on the reference potential (U°j), and the impact on the parameter detailing the deviation from Nernstian behavior (ω j) can be found. This is the first time the temperature dependence of the MSMR parameters have been experimentally analyzed. In Part 2, the impact of the temperature dependence of the MSMR parameters on the entropy coefficient of an intercalation material will be studied.

Integration of vacuum UV/peroxydisulfate and reductive processes for the thorough defluorination of 8:3 fluorotelomer carboxylates: The critical contribution of preoxidation

Fluorotelomers have been systematically developed in bulk quantities and extensively applied in the fluoropolymer industry. Reductive treatments of fluorotelomers are different from those of perfluoroalkyl substances. In this study, vacuum UV/peroxydisulfate (VUV/PDS) was used for the first time to preoxidize 8:3 fluorotelomer carboxylates (8:3FTCA). Subsequently, it was integrated with the VUV/sulfite/iodide reductive process to accomplish the comprehensive defluorination of the oxidized products. The performance and mechanisms of 8:3FTCA degradation in the preoxidation process were mainly explored. pH values from 6.0 to 8.0 were conducive to 8:3FTCA decomposition. Hydrogen peroxide, hydroxyl radical (•OH), and hydroperoxyl radical (HO2•) were observed to be in a dynamic equilibrium state of mutual transformation, and the contributions of •OH and HO2• were 76.8 % and 17.4 %, respectively. The investigation of the influences of background water matrices demonstrated minimal adverse effects of sulfate and chloride, whereas bicarbonate, carbonate, and natural organic matter exhibited inhibitory effects. The degradation pathways of 8:3FTCA were speculated through density functional theory calculation and intermediate identification. The Ecological Structure–Activity Relationships simulation showed that VUV/PDS preoxidation decreased the aquatic toxicity of 8:3FTCA. These findings provide valuable insights for addressing challenges associated with fluorotelomer carboxylates.

Enhanced Extracellular Electron Transfer in Magnetite-Mediated Anaerobic Oxidation of Methane Coupled to Humic Substances Reduction: The Pivotal Role of Membrane-Bound Electron Transfer Proteins.

Humic substances are organic substances prevalent in various natural environments, such as wetlands, which are globally important sources of methane (CH4) emissions. Extracellular electron transfer (EET)-mediated anaerobic oxidation of methane (AOM)-coupled with humic substances reduction plays an important role in the reduction of methane emissions from wetlands, where magnetite is prevalent. However, little is known about the magnetite-mediated EET mechanisms in AOM-coupled humic substances reduction. This study shows that magnetite promotes the reduction of the AOM-coupled humic substances model compound, anthraquinone-2,6-disulfonate (AQDS). 13CH4 labeling experiments further indicated that AOM-coupled AQDS reduction occurred, and acetate was an intermediate product of AOM. Moreover, 13CH313COONa labeling experiments showed that AOM-generated acetate can be continuously reduced to methane in a state of dynamic equilibrium. In the presence of magnetite, the EET capacity of the microbial community increased, and Methanosarcina played a key role in the AOM-coupled AQDS reduction. Pure culture experiments showed that Methanosarcina barkeri can independently perform AOM-coupled AQDS reduction and that magnetite increased its surface protein redox activity. The metatranscriptomic results indicated that magnetite increased the expression of membrane-bound proteins involved in energy metabolism and electron transfer in M. barkeri, thereby increasing the EET capacity. This phenomenon potentially elucidates the rationale as to why magnetite promoted AOM-coupled AQDS reduction.

Regime Shift to Hyperturbid Conditions in the Loire Estuary: Overview of Observations and Model Analysis of Physical Mechanisms

AbstractThe Loire estuary (France) was extensively deepened during the 20th century. Coincidentally, suspended sediment concentrations increased drastically from ∼0.1 g/l to ∼1–5 g/l at the surface and the estuarine turbidity maximum (ETM) moved upstream. In this study we, for the first time, brought together a century of observations of estuary bed level, tidal amplitude, and sediment concentration to demonstrate these large changes. Next, we analyzed a minimal set of physical mechanisms that explain the dramatic increase in sediment concentration. To this end, we used the iFlow model representing dynamic equilibrium conditions in the Loire. Novel in the model is that it dynamically resolves salt stratification and corresponding damping of turbulence. For conditions representing the year 2000, high sediment concentrations were found with satisfactory correspondence to observations. Low sediment concentrations were found when using the year 1900 bed level but keeping all other model parameters the same. Varying the bed level gradually between these two extremes, the equilibrium solution suddenly increases for intermediate bed level, constituting an abrupt regime shift. Robustness of this result was established in an extensive sensitivity study featuring 13,200 model experiments. The regime shift is enabled by a feedback between increasing sediment concentration, reducing turbulence due to sediment and salt stratification, and increasing sediment importing capacity of the estuary. The essential sediment importing mechanisms in this feedback are related to the tidal asymmetry and gravitational circulation. This is the first time gravitational circulation and salt stratification are shown to be important factors in a transition to hyperturbidity.

Morphological response of gravel bed rivers near a knickpoint: Effect of bars on dynamic equilibrium river profile

AbstractGeomorphological evolution is one of the main factors that increases flood damage in small or medium rivers located in upstream river reaches. These types of flood damage have been increasing at knickpoints where the riverbed slope and river width change abruptly and are likely to cause non‐equilibrium conditions for sediment transport during floods. Therefore, it is important to understand the non‐equilibrium morphological response at the knickpoint and the resulting new dynamic equilibrium state under given external forces. The effects of two‐dimensional (2D) morphological features on the dynamic equilibrium riverbed profile, however, have not been specifically studied because the methods currently in use for calculating equilibrium profiles are based on zero‐ or one‐dimensional (0D or 1D) modeling. Here, we perform numerical calculations using the 2D morphodynamic model iRIC‐Nays2DH to clarify the dynamic equilibrium profile and the process of reaching a dynamic equilibrium state. We also use an existing 1D model to show the 2D effect in the dynamic equilibrium state. To understand this, we set up three channels: slope transition point, width transition point, and both the slope and width transition point. 1D results show a constant slope profile in channels with constant width and upward‐convex profiles in channels with width expansion at the equilibrium state, owing to the adjustment of the difference in sediment transport volume in the two reaches with different widths by changing the slopes. In contrast, the 2D results show that the alternate bars create a small autogenic knickpoint even in the straight channel and significantly dampen sediment deposition at the width expansion point, as seen in the 1D model result. This was because the bars' shape increased the volume of sediment transport because the shape of the bars concentrated flow. These results suggest that 2D morphological features, such as fluvial bars, play a significant role in the equilibrium riverbed profile.

К оценке геодинамической устойчивости геосфер Земли

The Earth, as a system, is characterized by certain average state parameters (density, temperature). These parameters cannot but depend on similar states of internal geospheres (subsystems), which follow the unified law of increasing entropy of the cooling Earth from the center in the direction of the Earth's radius. As a model for assessing the dynamic stability of the Earth's internal geospheres relative to each other, the principle of the golden proportion (golden section) was used with the given parameters of density, temperature, power of the geospheres to the extreme ratios of their states at points (0.618; 1.618; 2.618), which determine the conditions for the stable dynamic equilibrium of the compared parameters of geospheres. And if these relations satisfied the known theoretical, model, geophysical data, then the conclusion was made that the geospheres in the compared parameter relations were in a state close to a stable dynamic equilibrium of the exchange of matter and energy between them. Otherwise, it was recognized that the compared geospheres of the Earth were in a state of either unstable dynamic equilibrium with an assessment of the level of this deviation from the golden numbers, or the known values of the density and temperature of the geospheres, as well as their structure, should be subject to clarification. Average model estimates of the parameters of the Earth's internal geospheres reach a stable dynamic equilibrium at a level of deviation from the golden numbers of up to 2.72 %. This allows estimating the model duration of the modern geological activity of the Earth for another 124 million years until the formation of a new state of the existing continents. The instability of the dynamic equilibrium of density and temperature of matter is established at the boundaries: continental and oceanic crust; oceanic crust and Golitsin layer; at the boundary between the outer part of the Earth's core and the lower mantle; inside the Earth's core at the level of identified transition zones in the four-layer core model. The presence of spheres with a high core density from 16.05 to 26.45 g/cm3 suggests the stratification of its central part into essentially gold and platinoid. The presence of instability boundaries in the dynamic state of geospheres is in good agreement with the concept of plate tectonics and with the depths of plume origin. It can be assumed that the relative equilibrium of the internal structure of the Earth will continue for about 124 million years until the beginning of the formation of a new Pangea Proxima, which, according to Cristofor Scotese, will arise in 200 million years.

Experimental study on granule trajectory tracking for the EPB shield tunneling in sandy cobble stratum

An investigation into the movement characteristics of granules during Earth Pressure Balance (EPB) shield tunneling contributes significantly to understanding the interaction between the shield machine and the soil. This understanding also enables researchers to gain deeper insights into the cutting and guiding effects of the shield cutterhead on the soil, thus providing a scientific basis for optimizing shield tunneling parameters and cutterhead designs. To achieve this, indoor model shield tunneling experiments were conducted using independently developed shield tunneling equipment and spatial positioning devices developed by our research group. The research investigated the spatial movement trajectories, radial diffusion, and axial movement characteristics of granules at the face subjected to the action of a spoke-type cutterhead. Furthermore, the study proposes the use of average diffusion degree and movement rates of granules as metrics for evaluating the cutting and steering performance of the cutterhead. The influence of cutterhead rotational speed and advance rate on the movement characteristics of granules was further explored based on these two indicators. The study’s findings reveal the following: (1) Granules at the face predominantly exhibit a spiral movement trajectory when the EPB shield tunneling machine operates in a dynamic equilibrium state. (2) The cutting and steering performance of the cutterhead’s various areas is enhanced progressively from the center to the outer edge, as evidenced by a gradual decrease in the average diffusion degree of granules and an increase in the average axial movement rate (AMR). (3) The AMR and average diffusion degree of granules are influenced by both the rotational speed of the cutterhead and the advance rate of the shield machine. Optimal matching of the rotational speed and advance rate maximizes the average AMR of granules, minimizes the average diffusion degree, reduces the torque on the cutterhead to its lowest point, and consequently, optimizes the efficiency of shield tunneling. This research presents a novel perspective and methodology for understanding the movement characteristics of granules during shield tunneling operations. The outcomes of this study provide valuable insights for the structural design of shield machine cutterheads and the optimization of tunneling parameters.

Effect of phosphorus and zinc application on zinc transformation and phyto-availability of zinc fraction in rice soil

Application of high dose of phosphorus (P) changes the soil chemical properties which may lead to redistribution of Zn fractions in soil. A field experiment was conducted to study the effect of added zinc (Zn) and P on Zn transformations in a New Alluvial soil (Aeric Haplaquept), together with dry matter yield and Zn uptake by rice plants. The treatments included four levels of P (0, 40, 60, and 80 kg ha−1) and three levels of Zn (0, 5, and 10 kg ha−1). Although P application increased the dry matter yield of rice, Zn concentration and uptake was decreased significantly at higher dose of P application. Application of P caused a decrease in all the fractions of soil Zn except amorphous and crystalline Fe-oxide bound zinc. The order of preponderance of different zinc fractions followed the order, water soluble plus exchangeable (WE-Zn) < carbonate bound (Car-Zn) < organically bound (Org-Zn) < manganese oxide (MnOx-Zn) < crystalline sesquioxide (CFeOx-Zn) < amorphous sesquioxide (AFeOx-Zn) < residual Zn (Res-Zn). Residual Zn was the most dominant form of Zn, contributing about 69.07% to total Zn. Correlation data indicated that those fractions are in a state of dynamic equilibrium among different fractions and governs the plant-available Zn in soil. Path coefficient analysis of different Zn-fractions with Zn-uptake in rice plant showed that among the all pools of Zn, Org-Zn fraction plays the most vital role in contributing to Zn uptake by plants.

Modulation of Microbiota and its Impact on Depression

Gut microbial flora is the largest micro-ecosystem in the human body, it is symbiotically associated with the host; and maintains normal physiological processes in a dynamic equilibrium state. A plethora of evidence supports that gut microbial flora influences the neurotransmitters of the central nervous system. This gut flora influences cognitive function, anxiety, depression; and mood disorders as they are capable of synthesizing neurotransmitters in the nervous system. Therefore intake of probiotics influences gut microbiome; and depression. The versatility and number of gut microbial flora varies individually, so the content of common gut microbes may affect the neurotransmitters, manipulating the gut microbiota with probiotics offers a novel approach to treat brain disorders such as depression via GUT-BRAIN AXIS. The present review outlines the aspect of such alterations and how modulation of gut microbiota influences depression.

Historic channel dynamics of a highly developed dryland river

AbstractUnderstanding how river systems adjust to hydrologic alterations is critical to sustainable river management. Remote sensing and geographic information systems (GIS) provide a reliable and cost‐effective approach to studying river adjustment, including the possible attainment of dynamic equilibrium. We used this approach to study the highly managed lower South Platte River in northeastern Colorado, USA. We assessed the active channel (inclusive of open water, sand bars and adjacent sparsely vegetated areas) in three 30 km study sections, using General Land Office (GLO) maps circa 1870, and a time series of eight sets of aerial photographs from 1941 to 2015. In the GLO surveys, the active channel was 72–80% larger and 65–85% wider than in the later aerial photographs. Mean daily discharge in the prior photo interval was the strongest hydrologic predictor of channel area, while mean June daily discharge was the strongest predictor of channel width. Maximum daily discharge was the only significant predictor of lateral movement of the main channel. The highest rates of channel movement occurred when the primary channel switched locations to occupy a pre‐existing secondary channel. An average of 17% of the total active channel area was persistent, defined as consisting of channels at ≥7 of the eight photo years, and there was a narrow, persistent active channel throughout 68–72% of the length of each section. Thus, the location of the river has been stable since 1941, though flanking the channel location were areas of the active channel that were more temporally dynamic. After 1956, the post‐development lower South Platte River channel planform achieved a state of dynamic equilibrium, fluctuating thereafter within a relatively narrow range of values. As conditions in the basin change in the future due to increased municipal and industrial water demand and climate change, we can expect the river to also change.

Light induced self-assembly of one-dimensional PT-symmetric optical system exhibiting pulling force

Light induced self-assembly’s non-contact and non-invasive nature, along with its versatility and dynamic assembly capabilities, make it particularly well-suited for the self-organization of particles. Previous self-assembly configurations are either in a static equilibrium state or in a dynamic equilibrium state driven by a pushing force. In this study, we introduce a one-dimensional parity-time symmetric (PT-symmetric) multilayer optical system consisting of balanced gain and loss, enabling the generation of a total pulling force on the structure. By conducting molecular dynamics simulations, we achieve the self-organized structure exhibiting pulling force. Furthermore, by reversing the direction of the incident light, we realized pushing force induced binding. The stability of the bound structure is also analyzed using linear stability analysis. Additionally, the light induced self-assembly exhibiting pulling and pushing force is achieved in the one-dimensional multilayer system with unbalanced gain and loss. This work provides an additional degree of freedom in the self-organization of particles.

Three-dimensional tunnel face stability using a new heterogeneous dynamic filter cake

In slurry-shield tunnelling, a heterogeneous dynamic filter cake occurs due to the interaction between slurry infiltrating and tool cutting, whose influence on tunnel face stability is not fully plumbed. Thus, a numerically based-limit analysis framework is proposed to assess the tunnel face stability considering a heterogeneous dynamic filter cake. The numerical model with a heterogeneous dynamic filter cake, which has spatio-temporally variable permeability coefficients according to cutter layouts, is built for solving a transient seepage flow. Numerically obtained seepage flow results are further incorporated into the 3D rotational failure mechanism, so as to give an upper-bound estimation on the tunnel face safety factor and the slurry pressure transfer efficiency. The proposed method is validated by comparing with previous studies regarding the slurry pressure drop, slurry pressure transfer efficiency, and tunnel face safety factors. Parametric analyses are performed to examine the excess pore pressure distributions at the filter cake-soil interface, and discuss the influences of cutterhead rotation and excess slurry pressures on the tunnel face stability. The results show that the defined three-dimensional pressure transfer efficiency is between the one-dimensional and the two-dimensional solutions published previously; the tunnel face stability reduces as cutterhead rotating and finally reaches a dynamic equilibrium state.

Cysteine‐Based Dynamic Self‐Assembly and Their Importance in the Origins of Life

AbstractThe knowledge regarding the origins of life from inanimate materials is still elusive. It was proposed that biological building blocks evolved from the inorganic substances present in the early earth conditions. However, the process by which chemistry can be converted into biology has not yet been achieved in the laboratory. The artificial system in the out‐of‐equilibrium state must maintain a few critical features of life, like compartmentalization, metabolism, and replication, to be considered alive. In this direction, working with cysteine (Cys)‐based molecules is strategic to understand the life evolution process. The presence of the sulphydryl (−SH) group in the Cys‐residue can build a dynamic equilibrium state through disulfide redox chemistry under the proper guidance of oxidizing and reducing agents. In this review article, our primary focus is to discuss the Cys‐containing short‐peptide‐based self‐assembly and disassembly processes. The formation of disulfide bonds sometimes helps in the self‐assembly process and gelation, but the reverse is also true in some cases. In the later part of this article, we cover the fact that these sulphydryl‐based systems have shown their adaptability to mimic different life‐essential criteria to participate in Darwinian evolution.

Research Progress on Inhibition of Osteoclast Differentiation by Traditional Chinese Medicine

Background: Bone tissue undergoes continuous remodeling to maintain a steady state of bone equilibrium. During this process, osteoblasts actively stimulate bone formation, while osteoclasts continuously engage in bone resorption. The dynamic equilibrium between bone formation and bone resorption is crucial for maintaining bone structure. In a healthy human skeletal structure, the two components are constantly in a state of benign dynamic equilibrium. However, due to factors such as aging, trauma, bone diseases, and other influences, the activity of osteoblasts decreases while the activity of osteoclasts increases. This disrupts the dynamic equilibrium, leading to a decrease in bone metabolism. As a result, bone resorption gradually surpasses bone production, making it challenging to maintain a normal amount of bone mass. The effectiveness of traditional Chinese medicine in treating bone-related disorders is extraordinary, and its molecular biological mechanism has become a widely discussed subject. Objectives: This study aims to unravel the classical signaling pathways and potential targets involved in the effects of traditional Chinese medicine on osteoclast differentiation, and to provide evidence for its clinical efficacy. Methodology: The main keywords chosen for this study were “Traditional Chinese Medicine (TCM)”, “osteoclast differentiation”, “natural plant”, and “medicinal plant”. To gather relevant literature, we utilized multiple online search engines, including PubMed, Web of Science, and CNKI, as well as other publication resources. Results: The results indicated that Traditional Chinese Medicine (TCM) can modulate signaling pathways, including NF-κB, MAPKs, STATs, and Wnt/β-catenin pathways., to influence osteoclast differentiation. This modulation involves maintaining the balance of inflammatory interactions, inhibiting oxidative stress. Conclusion: The impact of traditional Chinese medicine on osteoclast differentiation is reflected on multiple levels and through various pathways. Future research is envisioned to delve deeper from the perspective of precision-targeted therapy, aiming to provide insights for identifying the core targets of traditional Chinese medicine in treating orthopedic diseases.

The Energetics of the Lagrangian Evolution of Tropical Convective Systems

Abstract The convective life cycle is often conceptualized to progress from congestus to deep convection and develop further to stratiform anvil clouds, accompanied by a systematic change in the vertical structure of vertical motion. This archetype scenario has been developed largely from the Eulerian viewpoint, and it has yet to be explored whether the same life cycle emerges itself in a moving system tracked in the Lagrangian manner. To address this question, Lagrangian tracking is applied to tropical convective systems in combination with a thermodynamic budget analysis forced by satellite-retrieved precipitation and radiation. A new method is devised to characterize the vertical motion profiles in terms of the column import or export of moisture and moist static energy (MSE). The bottom-heavy, midheavy, and top-heavy regimes are identified for every 1° × 1° grid pixel accompanying tracked precipitation systems, making use of the diagnosed column export/import of moisture and MSE. The major findings are as follows. The Lagrangian evolution of convective systems is dominated by a state of dynamic equilibrium among different convective regimes rather than a monotonic progress from one regime to the next. The transition from the bottom-heavy to midheavy regimes is fed with intensifying precipitation presumably owing to a negative gross moist stability (GMS) of the bottom-heavy regime, whereas the transition from the midheavy to top-heavy regimes dissipates the system. The bottom-heavy to midheavy transition takes a relaxation time of about 5 h in the equilibrating processes, whereas the relaxation time is estimated as roughly 20 h concerning the midheavy to top-heavy transition.

Rational preference knowledge influence on the evolutionary equilibrium of carbon reduction negotiation: An exploration based on timed petri net

In the digital economy age, carbon emission reduction is perhaps the most crucial contribution affecting national activities and international negotiations. In a potential carbon reduction conflict, a rational participant expects to select a suitable strategic opinion to reach another state with improved benefit. Participants’ preferences reflect their priority ranking on multiple possible conflict solutions, directly determining the evolutionary direction and equilibrium solutions. Referring to the potential carbon reduction conflicts, Timed Petri Net for Conflict Analysis (TPNCA) is proposed as a graphical tool to explore participants’ rational preferences, state transformation, and conflict evolutionary equilibrium. The generation rule of TPNCA is designed according to carbon reduction co-operators’ rational preference knowledge. From the long-term perspective, dynamic unilateral improvement is proposed to reflect decision-makers’ strategic initiative willingness to reach end nodes. Dynamic equilibrium conditions are conducted to determine the final stability state for a conflict. This study reveals how participants’ preference knowledge and time constraints influence conflict evolutionary and dynamic equilibria. Climate group should positively engage in carbon reduction negotiations and flexibly adjust national tasks, according to real-time carbon reduction contributions. This study (1) reveals the influence of preference knowledge on conflict evolution, (2) explores the role of time constraints in determining a terminated node, (3) proposes dynamic equilibrium from the long-term perspective, and (4) helps guide participants’ strategic decision-making for mutually solving carbon reduction.

Ассимиляционный потенциал природы и территорий: нетривиальные следствия управления устойчивым эколого-экономическим развитием

Ecological-economic systems, which are in a state of unstable dynamic equilibrium under the influence of natural and anthropogenic factors, strive for sustainability if human economic activity is able to maintain the assimilation potential at the level of reproduction of natural resources and environmental quality by devoting part of the income to the environmental agenda. Within the framework of the law of balanced environmental management T=1.618·t·a, sustainable environmental and economic development is achieved by allocating funds at the level (t) of the GDP growth rate (T) to the environmental agenda for the regions. The value of the ecological situation coefficient (ESC) in the law of balanced environmental management for the Russian Federation varies around the golden numbers 0.618, 1.618, 2.618, depending on the level of economic development in the biosphere, artificial maintenance of the quality of the environment in it, as well as in the future possibility of terraforming the solar planets systems. An indicator of sustainable, harmonious environmental and economic development is a linear relationship between the assimilation potential (a) and the EES at the level of golden numbers 0.618, 1.618, 2.618. In this case, sustainable environmental and economic development can be achieved in any environmental condition as long as balance is maintained between the rate of economic growth and allocations of funds for the restoration of the assimilation function of nature. But they must be directed to the environmental agenda in strict accordance with the golden proportion relative to the main directions of environmental activities, even in conditions of transformed (converted) nature, and in the near future, in conditions of terraforming. However, then all development costs will go exclusively to maintaining the habitat in multiples of the golden numbers of 1.618 and 2.618 in the coefficient of the law of balanced environmental management.

Abstract 2532: Deciphering multiple protein complexes in BCL2 family to measure apoptotic dependencies in acute myeloid leukemia

Abstract The BCL2 protein family controls apoptosis by shifting the dynamic equilibrium state of complex formation. BH3 mimetics disrupt this balance by disturbing the interaction of a specific anti-apoptotic protein, leading to the initiation of apoptosis. However, relying solely on molecular data for the specific anti-apoptotic protein can be challenging due to the functional redundancy within the BCL2 protein family and their complex interaction network. Therefore, comprehensive profiling information considering protein complexes is essential to determine apoptotic dependencies, particularly in a clinical context. In this study, we adapted a Single-molecule Protein Interaction Detection (SPID) platform that can assess levels of protein complexes in a quantitative manner. Out of the 47 metrics included in our Apoptosis Signaling 47 panel, we utilized 22 assays to measure apoptosis dependencies in acute myeloid leukemia (AML) cells obtained from 32 patients. By combining these metrics, we developed a predictive model for the ex vivo response to ABT-199 treatment, focusing on three key biomarkers: BCL2-BAX complex, BCL2-BIM binding potential, and BCLxl-BAK level. From a receiver operating curve (ROC) analysis, the model exhibited high accuracy with a value of 0.94 area under the curve (AUC). We further validated our model by comparing the predicted response to the therapeutic outcomes in 10 AML patients according to the 2017 ELN guidelines, and achieved 100% sensitivity (4 out of 4 identified correctly) and 83.3% specificity (5 out of 6 identified correctly). Overall, our platform provides an effective method to explore apoptosis dependencies in clinical samples based on the information regarding protein complexes within the BCL2 protein family. Three key molecular biomarkers can be translated into a gauge for predicting therapeutic outcomes of BH3 mimetics, suggesting an improvement of precision medicine in AML treatment. Citation Format: Hongwon Lee, Changju Chun, Byungsan Choi, Saem Hong, Yunseo Lee, Youngil Koh, Tae-Young Yoon. Deciphering multiple protein complexes in BCL2 family to measure apoptotic dependencies in acute myeloid leukemia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2532.