Crystallization Kinetics Research Articles

Simultaneous Water Sorption and Crystallization in ASDs 2: Modeling Long-Term Stabilities.

The physical stability of amorphous solid dispersions (ASDs) is a major topic in the formulation research of oral dosage forms. To minimize the effort of investigating the long-term stability using cost- and time-consuming experiments, we developed a thermodynamic and kinetic modeling framework to predict and understand the crystallization kinetics of ASDs during long-term storage below the glass transition. Since crystallization of the active phrarmaceutical ingredients (APIs) in ASDs largely depends on the amount of water absorbed by the ASDs, water-sorption kinetics and API-crystallization kinetics were considered simultaneously. The developed modeling approach allows prediction of the time evolution of viscosity, supersaturation, and crystallinity as a function of drug load, relative humidity, and temperature. It was applied and evaluated against two-year-lasting crystallization experiments of ASDs containing nifedipine and copovidone or HPMCAS measured in part I of this work. We could show that the proposed modeling approach is able to describe the interplay between water sorption and API crystallization and to predict long-term stabilities of ASDs just based on short-term measurements. Most importantly, it enables explaining and understanding the reasons for different and sometimes even unexpected crystallization behaviors of ASDs.

Decoupling Nucleation and Growth in Fast Crystallization of Phase Change Materials

AbstractDisentangling nucleation and growth in materials that crystallize on the nanosecond time scale is experimentally quite challenging since the relevant processes also take place on very small, i.e., sub‐micrometer length scales. Phase change materials are bad glass formers, which often crystallize rapidly. Here systematic changes in crystallization kinetics are shown in pseudo‐binary compounds of GeTe and Sb2Te3 and related solids subjected to short laser pulses. Upon systematic changes in stoichiometry, the speed of crystallization changes by three orders of magnitude concomitantly with pronounced changes in stochasticity. Resolving individual grains with electron backscatter diffraction (EBSD) permits to disentangle of the process of nucleation and growth. From these experiments, supported by multiphysics simulations of crystallization, it can be concluded that high crystallization speeds with small stochasticity characterize phase change materials with fast nucleation, while compounds that nucleate slowly crystallize much more stochastically.

Crystallisation Dynamics in Large-Scale Extrusion Additive Manufacturing: An Analysis with and without Temperature Modification.

Large-Scale Material Extrusion (LS-MEX) is increasingly being used in small-scale production and prototyping due to its ability to create components in new temporal and spatial dimensions. However, the use of this manufacturing process poses microscopic and macroscopic challenges not encountered in previous small-scale production systems. These challenges arise primarily from the prolonged retention of heat in the material, which leads to insufficient strength in the extruded strands at the macrostructural level. As a result, the component can collapse, a phenomenon known as 'slumping'. Thermal energy also influences microstructural changes, such as crystallisation kinetics, which affect properties such as the strength and stiffness of the final product. The duration and dynamics of thermal energy are influenced by manufacturing parameters and the possible use of additional peripheral equipment, which affects component quality. In this study, the influence of thermal energy on structural processes through simulations of polyamide 6 with 40% carbon fibres (PA6 wt.%40 CF) is investigated. The results show that by adjusting the process parameters and using modification units, the thermal profile of the material can be accurately controlled, which allows the microstructural processes to be precisely controlled. This leads to the targeted modification of the macroscopic material properties. The focus of this work is on the combination of numerical simulations of the LS-MEX process with semi-empirical methods for the analysis of crystallisation processes. The application of the Nakamura model, which is used throughout similar investigations, allows a detailed description and prediction of the crystallisation kinetics during the manufacturing process. The study shows that the absolute degree of crystallisation can be determined with simplified assumptions using a combination of thermal simulations and semi-empirical approaches. It was found that the absolute degree of crystallisation increases from the outer interface of the strand to the print bed across the cross-section. This can be attributed to the specific thermal boundary conditions and the resulting temperature profiles at different points.

Photopolymerizable semi-crystalline polymers for thermally reversible, 3D printable cast molds

ObjectivesThis study demonstrates the use of photopolymerization to create semi-crystalline linear polymers suitable for thermally reversible materials in dental cast moldings produced from 3D printing. MethodsAn aromatic diallyl, aliphatic dithiol chain extender, and monofunctional thiol were used in a photoinitiated system. The photopolymerization and crystallization kinetics as a function of chemistry and temperature were investigated using spectroscopy and calorimetry. These insights were used to realize vat photopolymerization-based 3D printing of functional objects that could be remotely melted and thereby removed using induction heating. ResultsThe addition of monothiol was shown to decrease the polymer molecular weight which correspondingly increased the crystallization rate. Photopolymerization kinetics are independent of temperature while crystallization was slowed as the temperature approaches the melting point of the materials. Through inclusion of chromium oxide, semicrystalline materials could be melted through induction heating. These materials were implemented in vat photopolymerization 3D printing to realize high-resolution objects that could be used as releasable dental molds following printing and induction heating. SignificanceThis work demonstrates a proof-of-concept methodology to realize directly printable, thermally reversible semicrystalline materials for potential use as dental molding materials.

Flash melting amorphous ice.

Water can be vitrified if it is cooled at high rates, which makes it possible to outrun crystallization in so-called no man's land, a range of deeply supercooled temperatures where water crystallizes rapidly. Here, we study the reverse process in pure water samples by flash melting amorphous ice with microsecond laser pulses. Time-resolved electron diffraction reveals that the sample transiently crystallizes despite a heating rate of more than 5 × 106 K/s, even though under the same conditions, vitrification can be achieved with a similar cooling rate of 107 K/s. Moreover, we observe different crystallization kinetics for amorphous solid water and hyperquenched glassy water. These experiments open up new avenues for elucidating the crystallization mechanism of water and studying its dynamics in no man's land. They also add important insights into the laser melting and revitrification processes that are integral to the emerging field of microsecond time-resolved cryo-electron microscopy.

The Application of Crystallization Kinetics in Optimizing Morphology of Active Layer in Non-Fullerene Solar Cells

Organic photovoltaics (OPVs) have attracted widespread attention and became an important member of clean energy. Recently, their power conversion efficiency (PCE) has surpassed 19%. As is well known, the morphology of the active layer in OPVs crucially influences the PCE. In consideration of the intricate interactions between the donor molecules and acceptor molecules, the precise control of the morphology of the active layer is extremely challenging. Hence, it is urgent to develop effective methods to fabricate the hierarchical structure of the active layer. One significant driving force for the morphological evolution of the active layer is crystallization. Therefore, regulating the crystallization kinetics is an effective strategy for morphology control. In this review, we present the kinetic strategies recently developed to highlight their significance and effectiveness in morphology control. By applying these kinetic strategies, the hierarchical structure, including phase separation, domain size, crystallinity, and molecular orientation of the active layer can be optimized in different blend systems, leading to an improved PCE of OPVs. The outcomes set the stage for future advancements in device performance.

Continuous Crystallization Kinetics of Cefradine in a Mixed Suspension Mixed Product Removal System

Continuous Crystallization Kinetics of Cefradine in a Mixed Suspension Mixed Product Removal System

Flexible and rigid block copolymers from recyclable polyesters

The paper addresses a study on the thermoplastic elastomers (TPE) that can be synthesized using monomers retrieved from the chemically recycled semi-aromatic polyesters, such as terephthalic acid from low value stream recyclable polyethylene terephthalate (rPET). In contrast to PET, because of their physical and mechanical properties, TPEs are often used as an engineering polymer in automotive and consumer goods. The understanding of the crystallization and phase behavior of these materials is crucial to fine-tune the molecular structure and properties. We explore the interplay between the crystallization and phase separation in these materials by performing experiments on model thermoplastic elastomers consisting of polybutylene terephthalate (PBT) and polytetrahydrofuran (PTHF). A common denominator in the synthesis of PBT is terephthalic acid that can be obtained from Dimethyl Terephthalate (DMT) or recycling used PET. We show that by varying the compositions and block length of different blocks, in PBT-PTHF block copolymers, morphological variations from spherulites to dendrites can be induced, which could be captured using optical microscopy. By performing rheological and small angle X-ray scattering studies, we correlate these morphological variations at microscopic length scales, to the chain architecture at nanometer length scales. Our observations reveal that at the higher rigid PBT content, the process of phase separation strongly influences the crystallization kinetics that promotes the lamellar structure of the semi-crystalline polymer, observed at room temperature. On the other hand, in the presence of higher soft block content, the crystal growth occurs with minimal influence of the microphase separation. In broader generality, no morphological differences in the TPEs synthesized using the terephthalic acid from rPET are found. However, when the monomer from rPET is used, enhancement in crystallization rate occurs in the TPEs having similar molar mass and molecular configuration. We attribute the enhanced crystallization rate to the catalyst residues present in the terephthalic acid obtained fom rPET.

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives.

The last few decades have witnessed significant advances in the development of polymeric-based foam materials. These materials find several practical applications in our daily lives due to their characteristic properties such as low density, thermal insulation, and porosity, which are important in packaging, in building construction, and in biomedical applications, respectively. The first foams with practical applications used polymeric materials of petrochemical origin. However, due to growing environmental concerns, considerable efforts have been made to replace some of these materials with biodegradable polymers. Foam processing has evolved greatly in recent years due to improvements in existing techniques, such as the use of supercritical fluids in extrusion foaming and foam injection moulding, as well as the advent or adaptation of existing techniques to produce foams, as in the case of the combination between additive manufacturing and foam technology. The use of supercritical CO2 is especially advantageous in the production of porous structures for biomedical applications, as CO2 is chemically inert and non-toxic; in addition, it allows for an easy tailoring of the pore structure through processing conditions. Biodegradable polymeric materials, despite their enormous advantages over petroleum-based materials, present some difficulties regarding their potential use in foaming, such as poor melt strength, slow crystallization rate, poor processability, low service temperature, low toughness, and high brittleness, which limits their field of application. Several strategies were developed to improve the melt strength, including the change in monomer composition and the use of chemical modifiers and chain extenders to extend the chain length or create a branched molecular structure, to increase the molecular weight and the viscosity of the polymer. The use of additives or fillers is also commonly used, as fillers can improve crystallization kinetics by acting as crystal-nucleating agents. Alternatively, biodegradable polymers can be blended with other biodegradable polymers to combine certain properties and to counteract certain limitations. This work therefore aims to provide the latest advances regarding the foaming of biodegradable polymers. It covers the main foaming techniques and their advances and reviews the uses of biodegradable polymers in foaming, focusing on the chemical changes of polymers that improve their foaming ability. Finally, the challenges as well as the main opportunities presented reinforce the market potential of the biodegradable polymer foam materials.

Improvement of Photovoltaic Performance of Perovskite Solar Cells by Synergistic Modulation of SnO2 and Perovskite via Interfacial Modification.

In the past decade, perovskite solar cell (PSC) photoelectric conversion efficiency has advanced significantly, and tin dioxide (SnO2) has been extensively used as the electron transport layer (ETL). Due to its high electron mobility, strong chemical stability, energy level matching with perovskite, and easy low-temperature fabrication, SnO2 is one of the most effective ETL materials. However, the SnO2 material as an ETL has its limitations. For example, SnO2 films prepared by low-temperature spin-coating contain a large number of oxygen vacancies, resulting in energy loss and high open-circuit voltage (VOC) loss. In addition, the crystal quality of perovskites is closely related to the substrate, and the disordered crystal orientation will lead to ion migration, resulting in a large number of uncoordinated Pb2+ defects. Therefore, interface optimization is essential to improve the efficiency and stability of the PSC. In this work, 2-(5-chloro-2-benzotriazolyl)-6-tert-butyl-p-cresol (CBTBC) was introduced for ETL modification. On the one hand, the hydroxyl group of CBTBC forms a Lewis mixture with the Sn atom, which reduces the oxygen vacancy defect and prevents nonradiative recombination. On the other hand, the SnO2/CBTBC interface can effectively improve the crystal orientation of perovskite by influencing the crystallization kinetics of perovskite, and the nitrogen element in CBTBC can effectively passivate the uncoordinated Pb2+ defects at the SnO2/perovskite interface. Finally, the prevailing PCE of PSC (1.68 eV) modified by CBTBC was 20.34% (VOC = 1.214 V, JSC = 20.49 mA/cm2, FF = 82.49%).

Influence of nano-CuO modification on crystallization behavior and surface characteristics of P2O5 containing Li2O-ZnO-B2O3-SiO2 glass-ceramics

This paper investigates the impact of nano-CuO addition on the crystallization process and surface properties of phosphate containing lithium zinc borosilicate glass-ceramic coatings. A comprehensive analysis was performed using diverse thermal, structural, and morphological techniques such as hot stage microscope, differential thermal analysis, X-ray diffraction analysis and scanning electron microscopy. Thermal analysis revealed a glass transition temperature of 478.5 °C and a crystallization onset temperature of 595.6 °C. The coefficient of thermal expansion was measured to be 8.94 × 10−6.°C−1. Viscosity measurements indicated a significant decrease in viscosity with increasing temperature, following the Vogel-Fulcher-Tammann equation. Kinetic studies revealed an activation energy of 11.36 kJ/mol for the crystallization process, suggesting potential kinetic hindrance for the reference glass-ceramic coating. X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses confirmed the formation of a crystalline phases of Li2ZnSiO4 and Li3PO4 at crystallization temperatures above 750 °C. Nano-CuO addition was found to promote crystal formation and increase the inter-crystal spacing according to the SEM analysis. Optical microscopy and 3D surface analysis revealed that nano-CuO addition refined surface texture and reduced the surface roughness of the glass-ceramic coatings at varying crystallization temperatures of 750, 800 and 850 °C. Moreover, contact angle measurements indicated that nano-CuO addition decreased the wetting angle of the coatings around 62 %, suggesting improved hydrophilicity. The findings suggest that nano-CuO addition can enhance the crystallization kinetics and improve the surface quality and hydrophilicity of glass-ceramic coatings.

Accelerated stability modeling of recrystallization from amorphous solid Dispersions: A Griseofulvin/HPMC-AS case study

Amorphous solid dispersions (ASDs) represent an important approach for enhancing oral bioavailability for poorly water soluble compounds; however, assuring that these ASDs do not recrystallize to a significant extent during storage can be time-consuming. Therefore, various efforts have been undertaken to predict ASD crystallization levels with kinetic models. However, only limited success has been achieved due to limits on crystal content quantification methods and the complexity of crystallization kinetics. To increase the prediction accuracy, the accelerated stability assessment program (ASAP), employing isoconversion (time to hit a specification limit) and a modified Arrhenius approach, are employed here for predictive shelf-life modeling. In the current study, a model ASD was prepared by spray drying griseofulvin and HPMC-AS-LF. This ASD was stressed under a designed combinations of temperature, relative humidity and time with the conditions set to ensure stressing was carried out below the glass transition temperature (Tg) of the ASD. Crystal content quantification method by X-ray powder diffraction (XRPD) with sufficient sensitivity was developed and employed for stressed ASD. Crystallization modeling of the griseofulvin ASD using ASAPprime® demonstrated good agreement with long-term (40 °C/75 %RH) crystallinity levels and support the use of this type of accelerated stability studies for further improving ASD shelf-life prediction accuracy.

Synthesis, Structure and (Photo)Catalytic Behavior of Ce-MOFs Containing Perfluoroalkylcarboxylate Linkers: Experimental and Theoretical Insights.

Cerium-based Metal-Organic frameworks (Ce-MOFs) are attracting increasing interest due to their similar structural features to zirconium MOFs. The redox behavior of Ce(III/IV) adds a range of properties to the compounds. Recently, perfluorinated linkers have been used in the synthesis of MOFs to introduce new characteristic into the structure. We report the synthesis and structural characterization of Ce(IV)-based MOFs constructed using two perfluorinated alkyl linkers. Their structure, based on hexanuclear Ce6O4(OH)4 12+ clusters linked to each other by the dicarboxylate ions, has been solved ab-initio from X-ray powder diffraction data and refined by the Rietveld method. The crystallization kinetics and the MOF formation mechanism was also invesitigated by Synchrotron radiation with XAS spectroscopies (EXAFS and XANES). The MOFs present the same fcu cubic topology as observed in MOF-801 and UiO-66, and they showed good stability in water at different pH conditions. The electronic structure of these MOFs has been studied by DFT calculations in order to obtain insights into the density of states structure of the reported compounds, resulting in band gaps in the range of 2.8-3.1 eV. Their catalytic properties were tested both thermally and under visible light irradiation for the degradation of methyl orange (MO) dye.

Synthesis of MPEG-b-PLLA Diblock Copolymers and Their Crystallization Performance with PDLA and PLLA Composite Films.

Methoxy poly(ethylene glycol)-block-poly(L-lactide) (MPEG-b-PLLA) has a wide range of applications in pharmaceuticals and biology, and its structure and morphology have been thoroughly studied. In the experiment, we synthesized MPEG-b-PLLA with different block lengths using the principle of ring-opening polymerization by controlling the amount of lactic acid added. The thermodynamic properties of copolymers and the crystallization properties of blends were studied separately. The crystallization kinetics of PDLA/MPEG-b-PLA and PLLA/MPEG-b-PLA composite films were studied using differential scanning calorimetry (DSC). The results indicate that the crystallization kinetics of composite films are closely related to the amount of block addition. The crystallinity of the sample first increases and then decreases with an increase in MPEG-b-PLLA content. These results were also confirmed in polarized optical microscope (POM) and wide-angle X-ray diffraction (WAXD) tests. When 3% MPEG-b-PLLA was added to the PDLA matrix, the blend exhibited the strongest crystallization performance.

Argon nonthermal plasma etching of poly(L-lactic acid) films: Tunning the local surface degradation and hydrolytic degradation rate

Plasma technology is widely used in the industry for the surface modification of polymeric materials, improving the adhesion of paints in polymeric packaging and cellular adhesion on polymers' surfaces without using hazardous chemicals. Plasma etching is a fast way to modify polymers, creating new nanostructure surfaces and adding chemical groups for new applications like antimicrobial surfaces. Poly(L-lactic acid) (PLLA) is a biodegradable polymer with exciting properties for biomedical, tissue engineering, food packaging, and other applications. In many cases, these products must undergo plasma surface treatments to meet the technical requirements of their function. Herein, we evaluated the effects of surface modification of PLLA using Argon nonthermal plasma etching. The results from Gel Permeation Chromatography (GPC), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), X-ray Excited Photoelectron Spectroscopy (XPS), and Matrix-assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF-MS) show that increasing the plasma exposure time causes an enhancement in bulk and local surface degradation, crystallization kinetics and susceptibility to hydrolytic degradation for PLLA. Atomic Force Microscopy (AFM) show that the PLLA films present the highest surface roughness after 60 s of plasma etching times. Our findings suggest that plasma etching can be a suitable tool to adjust the polymer degradation rate to design intracorporeal devices with controlled degradation kinetics.

A radiochemical lab-on-a-chip paired with computer vision to unlock the crystallization kinetics of (Ba,Ra)SO4

(Ra,Ba)SO4 solid solutions are commonly encountered as problematic scales in subsurface energy-related applications, e.g., geothermal systems, hydraulic fracturing, conventional oil and gas, etc. Despite its relevance, its crystallization kinetics were never determined because of radium (226), high radioactivity (3.7 × 1010 Bq g−1), and utilization in contemporary research, therefore constrained to trace amounts (< 10−8 M) with the composition of BaxRa1-xSO4 commonly restricted to x > 0.99. What if lab-on-a-chip technology could create new opportunities, enabling the study of highly radioactive radium beyond traces to access new information? In this work, we developed a lab-on-a-chip experiment paired with computer vision to evaluate the crystal growth rate of (Ba,Ra)SO4 solid solutions. The computer vision algorithm enhances experimental throughput, yielding robust statistical insights and further advancing the efficiency of such experiments. The 3D analysis results of the precipitated crystals using confocal Raman spectroscopy suggested that {210} faces grew twice as fast as {001} faces, mirroring a common observation reported for pure barite. The crystal growth rate of (Ba0.5Ra0.5)SO4 follows a second-order reaction with a kinetic constant equal to (1.23 ± 0.09) × 10−10 mol m−2 s−1.

Small Molecule Regulatory Strategy for Inorganic Perovskite Solar Cells with 368 mV of VOC Deficit and its Application in Tandem Devices

AbstractTandem solar cells combining perovskite and silicon have witnessed rapid development in recent years. However, the top cell, utilizing wide‐bandgap perovskite as absorbers generally suffer significant open‐circuit voltage (VOC) deficit, particularly for inorganic perovskite, which poses a considerable obstacle to enhancing the power conversion efficiency (PCE). Here, a modulation strategy by using 2,6‐pyridinedicarboxamide (PC), the crystallization kinetics of inorganic perovskite film can be effectively regulated, specifically manifested as a relatively longer annealing time in the air, resulting in sufficient growth for the inorganic perovskite grains. Additionally, PC can effectively in situ passivate uncoordinated Pb2+, suppressing the non‐radiative recombination of charge carriers. Eventually, a record PCE of 22.07% is achieved based on n–i–p inorganic perovskite solar cells (IPSCs), which also demonstrate the highest VOC above 1.34 V (1.71 eV of bandgap). More importantly, the unencapsulated IPSCs show enhanced thermal stability and photostability. Furthermore, the n–i–p IPSCs are also applied to inorganic perovskite/silicon tandem solar cells (IPTSCs), a PCE of 27.27% and an impressive VOC of 2.024 V are obtained.

Distinct Crystallization Pathways of Polyoxymethylene in Methanol System

Recrystallization of polyoxymethylene (POM) in solvent is an effective post-treatment method for manufacturing a better POM product. Herein, the crystallization process of POM in methanol was investigated with the use of a series of equipment. The results reveal that POM crystallization in methanol yields two kinds of particle morphologies, including small particles with lamellar structures branching and growing in all directions and large particles resulting from melt agglomeration. The mechanism of POM crystallization in methanol with two distinct pathways was proposed, in which solution cooling crystallization of POM at higher temperature yields small particles while melt crystallization yields large particles. Furthermore, both non-isothermal and isothermal crystallization kinetics of POM were determined. The Avrami equation was employed to derive the crystallization rate constant via data fitting. The activation energy of crystallization was then obtained using the Arrhenius formula. The kinetics suggest that recrystallization of POM in methanol may dissolve and remove substances hindering raw material crystallization, achieving a faster crystallization rate for products.

Effect of Nano Spinel Ferrites Co0.9Cu0.1Fe2O4 on Non-Isothermal Cold Crystallization Behaviours and Kinetics of Its Composites with Polylactic Acid.

Nanoparticles of spinel ferrites with a composition of Co0.9Cu0.1Fe2O4 (AM NPs) were effectively synthesized via a hydrothermal route. The structure of ferrite nanoparticles was characterized with X-ray diffraction, which showed a single cubic spinel phase. Energy-dispersive X-ray (EDX) spectroscopy and field emission-scanning electron microscopy (FE-SEM) were employed to analyse elemental composition and surface morphology, respectively. Moreover, the effects of the Co0.9Cu0.1Fe2O4 on the morphology of [PLA = polylactic acid] nanocomposites were examined through polarized light optical microscopy (POM) and X-ray diffraction (XRD). The thermal behaviours for tested samples were studied through [DSC = differential scanning calorimetry] and [TGA = thermal gravimetric analysis]. A great number of minor PLA spherulites were detected using POM in the presence of the Co0.9Cu0.1Fe2O4 ceramic magnetic nanoparticles (AM), increasing with AM nanoparticle contents. X-ray diffraction (XRD) analysis showed that the presence of nanoparticles led to an increase in the intensity of diffraction peaks. The DSC findings implied that the crystallization behaviours for the efficient PLA as well as its nanocomposites were affected by the addition of AM nanoparticles. They act as efficient nucleating agents because they shift the temperature of crystallization to a lower value. The Avrami models were used to analyse kinetics data. The experimental data were well described using the Avrami method for all samples tested. The addition of AM to the PLA matrix resulted in a decrease in the crystallization half-time t1/2 values, indicating a faster crystallization rate. TGA data showed that the occurrence of AM nanoparticles decreased the thermal stability of PLA.

A new experimental setup for combined fast differential scanning calorimetry and X-ray photon correlation spectroscopy.

Synchrotron-radiation-based techniques are a powerful tool for the investigation of materials. In particular, the availability of highly brilliant sources has opened the possibility to develop techniques sensitive to dynamics at the atomic scale such as X-ray photon correlation spectroscopy (XPCS). XPCS is particularly relevant in the study of glasses, which have been often investigated at the macroscopic scale by, for example, differential scanning calorimetry. Here, we show how to adapt a Flash calorimeter to combine XPCS and calorimetric scans. This setup paves the way to novel experiments requiring dynamical and thermodynamic information, ranging from the study of the crystallization kinetics to the study of the glass transition in systems that can be vitrified thanks to the high cooling rates reachable with an ultrafast calorimeter.