The study highlights the critical factors and findings regarding bridge damage susceptibility during typhoons and hurricanes, primarily due to extreme waves, scour, and storm surges. While existing research has extensively studied bridges' responses to either extreme waves or scour individually, their combined effects have not been sufficiently explored. Experiments were conducted on a scaled two-span bridge to examine its behavior under simultaneous wave and scour conditions. Results from these experiments indicate that as scour depth increases, there is a corresponding escalation in displacement of the bridge pier, acceleration of the bearing platform, and strain along the pile foundation. To further investigate these dynamics, fluid-structure interaction analysis was employed, revealing significant insights. Notably, the study found that wave height exerts a substantial influence on wave load. For instance, at a wave height of 6 m, the average peak horizontal wave load on bridge piers was 2.48 times higher than at 3 m wave height. Moreover, local scour was identified as a critical factor reducing the bearing capacity of pile foundations, thereby significantly impacting the bridge's dynamic response to nonlinear waves. Under identical wave conditions, varying scour depths (3 m, 6 m, 9 m, and 12 m) resulted in increases in peak lateral displacements at the pier top compared to non-scouring conditions. The study concludes by emphasizing the increasing risk posed to pile foundations with deeper scour depths, particularly under stronger wave conditions. Consequently, there is a crucial need to enhance the resilience of offshore bridges against these dual hazards through advanced design and protective measures.