In order to further understand the impact of tip air injection on compressor stability under circumferential pressure distortion, a series of experimental studies on tip air injection under uniform and circumferential distortion were conducted on a low-speed single rotor axial flow compressor. The unsteady measurements were carried out by use of microsensors and strain gauges bonded on the rotor blade surfaces, and a collection of dynamic pressure sensors installed on the casing wall. Results indicate that with the increase in the injected momentum ratio, the load at the leading edge near the rotor blade tip obviously decreases, thereby delaying the stall. By comparing the pressure distribution on the rotor blade surface under different injected momentum ratios, tip air injection can effectively suppress flow separation at the blade tip to enhance flow capability. In addition, it can also weaken the fluctuation of tip leakage flow and reduce the dynamic stress similar to natural vibration near the blade root both in stationary and rotating coordinate systems. Under the condition of inlet circumferential distortion, tip air injection can significantly reduce the load at the distorted region and suppress the low-frequency disturbances measured on the rotor blade surface caused by inlet distortion. In addition, the dynamic stress near the blade root can also be effectively reduced by tip air injection. It implies that tip air injection can both extend the stall margin and reduce blade vibration when suffering from circumferential distortion; thus, the compressor can safely operate.