The present study deals with a major summertime dust storm event that occurred over the Arabian Desert, Saudi Arabia (SA), and the United Arab Emirates (UAE) and spread to Pakistan, the Arabian Sea, and Western India (in particular over Alibaug and Pune), using multi-satellite- and ground-based measurements. Analysis of the aerosol parameters retrieved over Alibaug and Pune from the ground-based MICROTOPS-II Sunphotometer, seven Aeronet Robotic Network (AERONET) stations, including Pune, and satellite (Moderate-resolution Imaging Spectroradiometer (MODIS)) and Ozone Monitoring Instrument ((OMI-Aura)) measurements shows significant changes on dusty days as compared with non-dusty days prior to and after the dust storm event. A large increase in aerosol optical depths (AODs) and decrease in Angstrom exponent (AE, α440-870 nm), showing the presence of a larger fraction of coarser particles comparable to those of other intense dust outbreak episodes worldwide, have been found at all these sites during the dust storm event. Higher observed AODs are considered to be the combined effect of desert dust and burning biomass/biofuel-induced aerosols. AERONET-retrieved mean aerosol volume size distributions (AVSDs) on non-dusty and dusty days are bimodal in nature at the stations of Pune, Kanpur, Jaipur, Karachi, and Lahore, while at the stations of KAUST_Campus (SA) and Mezaira (UAE), AVSDs are monomodal. This indicates that at the first five stations, the aerosol system is a complex mixture of fine- and coarse-mode aerosols with coarse mode exerting a strong influence on the system. Dust-induced turbid conditions triggered significant extinction of 30–40%, in shortwave (SW) global solar irradiance, resulting in an increase of 57% and 74% in aerosol direct radiative forcing (ADRF) at Alibaug and Pune, respectively, causing perturbation in the radiation budget. The space-borne Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO)-retrieved aerosol vertical profiles reveal the presence of polluted dust (a mixture of fine- and coarse-mode aerosols), corroborating well with the aerosol behaviour captured by the MICROTOPS/AERONET measurements and MODIS retrievals over the study areas. The Dust Regional Atmospheric Model (BSC-DREAM8b) predictions are also found to be consistent with satellite retrievals, implying the ability of the model to monitor dust transport over the study region.