Passive isolation flap valves are relatively simple devices widely used in the process industries. However, as with any explosion mitigation technique, they work only within well-defined conditions, and the underlying physics makes any prediction difficult. The current paper presents new methods and findings, which rely on experiments on passive flap valves tested on 0.7 to 10 m3 vessels with 100 to 800 mm pipes. This study considers the simple configuration of a flap valve connected to a vented vessel-straight duct arrangement. The explosion in the vessel triggers the closure of the initially opened flap valve and should be effective within a short delay to prevent the flame from passing. The explosion in the vessel drives both the fluid flow in the pipes and the flap valve closing duration. The sudden closing of the pipe induces a complex fluid flow, including significant pressure and velocity fluctuations around the flap valve and a backflow towards the vessel. The commonly used empirical laws, such as those displayed in the EN standards on dust explosions, do not account for these fluid-structure interactions. A hybrid code has been developed to describe the fluid flow throughout the assembly. This code combines an integral model for the vessel and flap explosions, a 1D Eulerian method relying on a MacCormack scheme for the pipes, and a damped pendulum model for the flap solved using an RK4 scheme. The model results compare satisfyingly well with experimental results. The discussion focuses on analysing the problem's physics, from which design engineering rules are derived.