Duration Of Rest Period Research Articles

Relationship between perceptual and mechanical markers of fatigue during bench press and bench pull exercises: impact of inter-set rest period length.

This study aimed to explore whether the relationship between perceptual (rating of perceived exertion; RPE) and mechanical (maximal number of repetitions completed [MNR], fastest set velocity, and mean velocity decline) variables is affected by the length of inter-set rest periods during resistance training sets not leading to failure. Twenty-three physically active individuals (15 men and eight women) randomly completed 12 testing sessions resulting from the combination of two exercises (bench press and bench pull), three inter-set rest protocols (1, 3, and 5 min), and two minimal velocity thresholds (farther from muscular failure [MVT0.45 for bench press and MVT0.65 for bench pull] and closer to muscular failure [MVT0.35 for bench press and MVT0.55 for bench pull]). The duration of inter-set rest periods did not have a significant impact on RPE values (p ranged from 0.061 to 0.951). Higher proximities to failure, indicated by lower MVTs, were associated with increased RPE values (p < 0.05 in 19 out of 24 comparisons). Moreover, as the number of sets increased, an upward trend in RPE values was observed (p < 0.05 in seven out of 12 comparisons). Finally, while acknowledging some inconsistencies, it was generally observed that higher magnitudes of the mechanical variables, especially MNR (rs < -0.55 in three out of four comparisons), were associated with lower RPE values. These results, which were comparable for the bench press and bench pull exercises, suggest that post-set RPE values are affected by the fatigue experienced at both the beginning and end of the set.

Acute effects of different rest period durations after warm-up and dynamic stretching on endurance running performance in male runners

Acute effects of different rest period durations after warm-up and dynamic stretching on endurance running performance in male runners

Timing of Surgery and Pathologic Complete Response (pCR) after Completing Total Neoadjuvant Therapy for Rectal Adenocarcinoma: A Retrospective Study of the National Cancer Database

Total neoadjuvant therapy (TNT) is a treatment strategy for rectal cancer that includes a course of multiagent chemotherapy and a separate course of radiation +/- concurrent chemotherapy before definitive surgery. The use of TNT has increased in recent years and carries the potential for improved sphincter preservation and a significant risk reduction of locoregional recurrence. However, the influence of rest period from end of radiation to surgery after TNT is unclear. The objective of this study was to evaluate the relationship between rest period and pCR using data from the National Cancer Database. We hypothesized that longer duration of rest period before surgery will be positively associated with pCR. Patients aged 18 years and older diagnosed with primary rectal cancer between 2016 and 2020, who underwent an NCCN-recommended TNT regimen followed by definitive surgery at a Commission on Cancer-accredited facility were retrospectively analyzed in the current study. We included 5,997 patients who met the following inclusion criteria: clinical stage T2 and above, any N stage, M0, adenocarcinoma histology, and not receiving any adjuvant therapy. Logistic regression methods were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between duration of rest period and pCR. Restricted cubic splines were used to evaluate potential non-linear relationship between duration of rest period and pCR. The median age of the study sample was 57 years old (interquartile range: 49 - 65), with majority of them being males (62.3%) and reporting Non-Hispanic White race and ethnicity (75.5%). The overall pCR rate was 18.6%. The majority received long-course radiation (76.7%) and induction chemotherapy (86.3%). In multivariable adjusted models, there was a non-linear relationship between duration of rest period and pCR (p = 0.036). Rest periods of 8-24 weeks were significantly associated with elevated odds of pCR with the odds highest at 14 weeks (OR = 2.86, 95% CI: 1.20 - 6.84) when compared to rest periods of less than a week. There was no difference in pCR between long-course vs. short course radiation and no difference between those who received induction chemotherapy vs. consolidative chemotherapy. Although the rest period is inherently longer when radiation therapy precedes consolidative chemotherapy, the order of chemotherapy to radiation itself did not impact pCR but rather the duration of rest period. These data demonstrate an ideal window for surgery to achieve pCR in rectal cancer in the TNT era and the need for further prospective investigations of optimal rest period before surgery to achieve maximal pCR with homogenous TNT treatment regimens.

Unraveling capacity fading in lithium-ion batteries using advanced cyclic tests: A real-world approach

Battery lifespan estimation is essential for effective battery management systems, aiding users and manufacturers in strategic planning. However, accurately estimating battery capacity is complex, owing to diverse capacity fading phenomena tied to factors such as temperature, charge-discharge rate, and rest period duration. In this work, we present an innovative approach that integrates real-world driving behaviors into cyclic testing. Unlike conventional methods that lack rest periods and involve fixed charge-discharge rates, our approach involves 1000 unique test cycles tailored to specific objectives and applications, capturing the nuanced effects of temperature, charge-discharge rate, and rest duration on capacity fading. This yields comprehensive insights into cell-level battery degradation, unveiling growth patterns of the solid electrolyte interface (SEI) layer and lithium plating, influenced by cyclic test parameters. The results yield critical empirical relations for evaluating capacity fading under specific testing conditions.

Manipulating the Rapid Consolidation Periods in a Learning Task Affects General Skills More than Statistical Learning and Changes the Dynamics of Learning.

Memory consolidation processes have traditionally been investigated from the perspective of hours or days. However, recent developments in memory research have shown that memory consolidation processes could occur even within seconds, possibly because of the neural replay of just practiced memory traces during short breaks. Here, we investigate this rapid form of consolidation during statistical learning. We aim to answer (1) whether this rapid consolidation occurs in implicit statistical learning and general skill learning, and (2) whether the duration of rest periods affects these two learning types differently. Human participants performed a widely used statistical learning task-the alternating serial reaction time (ASRT) task-that enables us to measure implicit statistical and general skill learning separately. The ASRT task consisted of 25 learning blocks with a rest period between the blocks. In a between-subjects design, the length of the rest periods was fixed at 15 or 30 s, or the participants could control the length themselves. We found that the duration of rest periods does not affect the amount of statistical knowledge acquired but does change the dynamics of learning. Shorter rest periods led to better learning during the learning blocks, whereas longer rest periods promoted learning also in the between-block rest periods, possibly because of the higher amount of replay. Moreover, we found weaker general skill learning in the self-paced group than in the fixed rest period groups. These results suggest that distinct learning processes are differently affected by the duration of short rest periods.

The Misuse of “Workload” in Sports Science and Possible Solutions

ABSTRACT Because of fundamental mechanical misconceptions, workload is a contested and nonsensical term that has been erroneously used in sports science literature. When the term workload is used, readers may interpret the term to mean: (a) load, referring to the weight force of an object, or an external or internal force, applied in a specified direction and, when using the International System of Units (SI), the outcome measure must be reported in newtons, or (b) the amount of work performed, which should be reported in joules. Solutions consistent with the SI and using proper scientific terminology are simple and would improve the advancement and use of knowledge in sports science. During an endurance training program, exercise duration, relative or absolute mean velocity, distance traveled, and power output are manipulated. Within strength and power training programs, variables to be considered are repetitions and sets, rest period durations, and the load lifted. In team sports, performance quantification includes displacement, distance traveled, velocity, and acceleration. These physical quantities should replace the vague and inaccurate term workload. The quantification of physical performance should be accomplished using the SI for clarity of communication and seamless use across all subdisciplines of sports science.

Role of the glycemic level on in the functional state of the myocardium in patients with coronary heart disease and type 2 diabetes mellitus

Abstract Clinical studies show that hyperglycemia is significant factor that worsens the prognosis and course of the cardiovascular diseases. At the same time, there is evidence that an increased level of glycemia in patients with type 2 diabetes mellitus (DM2) is associated with a better outcome of cardiovascular complications compared to the same patients, but with a normal level of glycemia. Aim To investigate the effect of the glycemia level on the functional state of the myocardium in patients with coronary heart disease (CHD) and DM2. Methods The study included patients with a chronic CHD associated with DM2, who were divided into 2 groups. Group 1 included patients with glycated hemoglobin (HbA1c) &amp;lt;8%, and 2 - patients with HbA1c ≥8%. The function of the heart, according to echocardiography (Echo-KG) and the contractile properties of trabeculae isolated from the right atrial auricle obtained during coronary bypass surgery were studied. To assess the contractile function of the trabeculae, exposure to periods of rest was used [4]. Post-rest inotropic reaction was evaluated. The level of expression of Ca2+-ATPase (SERCA2a) and ryanodine receptors (RyR2) of the sarcoplasmic reticulum (SR) was also determined in the patients ' myocardial samples by immunoblotting. Results According to the clinical characteristics, the patients of the groups were comparable, including age and duration of the disease of DM2. According to the Echo-KG data, it was found that in patients of group 1, the values of the end systolic and diastolic volumes, the thickness of the interventricular septum and the mass of the myocardium of the left ventricle (LV) were significantly lower in comparison with the corresponding indicators of patients of group 2. The rate of early LV filling (E) was significantly lower in group 1. At the same time, the rate of rapid LV filling did not have significant differences between groups. The amplitude of post-rest contractions of the trabeculae of patients in both groups was potentiated for short periods of rest, but with an increase in the duration of rest periods, it increased significantly only in group 2. After long periods of rest, the post-rest inotropic response of group 1 patient myocardium was not potentiated. As is known, post-rest potentiation characterizes the function of the SR. So, it is indicates better preservation of SR function in patients with HbA1c ≥8%. This statement is confirmed by the data on the expression of Ca2+ - transporting CP proteins SERCA2a and RyR2. Our studies have shown that the expression level of SERCA2a and RyR2 is significantly higher in the myocardium of patients with HbA1c ≥8% compared to patients with HbA1c &amp;lt;8%. Conclusion In the patients with CHD and DM2, an increased level of HbA1c is associated with better the functional state of the myocardium according to the contractile activity of isolated trabeculae, as well as the whole heart, which associated with higher SERCA2a and RyR2 expression. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Russian Science Foundation

Effect of Rest Period Duration between Sets of Repeated Sprint Skating Ability Test on the Skating Ability of Ice Hockey Players.

The aim of this study was to determine the effects of two different rest periods, 2 min and 3 min, between consecutive sets of a repeated sprint skating ability (RSSA) test, on the skating ability of ice hockey players. Two RSSA tests, RSSA-2 and RSSA-3, were assessed on 24 ice hockey players. In RSSA-2, six sets of 3 × 80 m sprint skating, with 2 min passive recovery between two consecutive sets was allowed. In RSSA-3, the recovery period between the sets was 3 min. Average speed, average heart rate (HRaver), peak heart rate (HRpeak), blood lactate concentration ([BLa]), and rate of perceived exertion (RPE) were measured in both RSSA-2 and RSSA-3 tests. In all the sets, except set 1, the average speed of the subjects was significantly (p < 0.05) higher in RSSA-3 than the respective set in RSSA-2. Average HR and RPE were higher in RSSA-2 than RSSA-3 in most of the sets. For any given set, no difference in HRpeak was noted between RSSA-2 and RSSA-3. Post-sprint (Set 6) [BLa] was significantly (p < 0.05) higher in RSSA-3 than RSSA-2. This study concludes that the 3 min rest period is more beneficial than the 2 min rest period, for (1) increasing skating speed and (2) reducing overall cardiac workload and perceived fatigue.

Effects of Different Rest Period Durations Prior to Blood Pressure Measurement: The Best Rest Trial.

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A Rest Quality Metric Using a Cluster-Based Analysis of Accelerometer Data and Correlation With Digital Medicine Ingestion Data: Algorithm Development.

BackgroundAdherence to medication regimens and patient rest are two important factors in the well-being of patients with serious mental illness. Both of these behaviors are traditionally difficult to record objectively in unsupervised populations.ObjectiveA digital medicine system that provides objective time-stamped medication ingestion records was used by patients with serious mental illness. Accelerometer data from the digital medicine system was used to assess rest quality and thus allow for investigation into correlations between rest and medication ingestion.MethodsLongest daily rest periods were identified and then evaluated using a k-means clustering algorithm and distance metric to quantify the relative quality of patient rest during these periods. This accelerometer-derived quality-of-rest metric, along with other accepted metrics of rest quality, such as duration and start time of the longest rest periods, was compared to the objective medication ingestion records. Overall medication adherence classification based on rest features was not performed due to a lack of patients with poor adherence in the sample population.ResultsExplorations of the relationship between these rest metrics and ingestion did seem to indicate that patients with poor adherence experienced relatively low quality of rest; however, patients with better adherence did not necessarily exhibit consistent rest quality. This sample did not contain sufficient patients with poor adherence to draw more robust correlations between rest quality and ingestion behavior. The correlation of temporal outliers in these rest metrics with daily outliers in ingestion time was also explored.ConclusionsThis result demonstrates the ability of digital medicine systems to quantify patient rest quality, providing a framework for further work to expand the participant population, compare these rest metrics to gold-standard sleep measurements, and correlate these digital medicine biomarkers with objective medication ingestion data.

Roundtable on Preseason Heat Safety in Secondary School Athletics: Environmental Monitoring During Activities in the Heat.

To develop best-practice recommendations using thermal indices to determine work-to-rest ratios and facilitate further implementation of environmental monitoring for heat safety in secondary school athletics in the United States. A narrative review of the current literature on environmental monitoring for heat safety during athletics was conducted by content experts. A list of action-oriented recommendations was established from the narrative review and further refined using the Delphi method. Assessment of wet bulb globe temperature at the site of activity and throughout the duration of the event is recommended to assist clinicians and administrators in making appropriate decisions regarding the duration and frequency of activity and rest periods. Activity-modification guidelines should be predetermined and approved by stakeholders and should outline specific actions to be followed, such as the work-to-rest ratio, frequency and timing of hydration breaks, and adjustment of total exercise duration, equipment, and clothing. Furthermore, integration of exertional heat illness injury data with environmental condition characteristics is critical for the development of evidence-based heat safety guidelines for secondary school athletics. Athletic trainers play an essential role in conducting prospective injury data collection, recording onsite wet bulb globe temperature levels, and implementing recommendations to protect the health and safety of athletes.

Evaluation of the self-healing performance of polyurethane-modified bitumen using bitumen bond strength (BBS) test and CT scan

Upgrading the self-healing property of bituminous mixtures is of great importance to extend the pavement service life and road safety with fewer maintenance treatments. The objective of this paper is to investigate the effect of bitumen modification with different percentages of toluene diisocyanate (TDI-Co) polyurethane polymer on the healing property using bitumen bond strength (BBS) test. Moreover, the effects of factors such as temperature and rest period duration were also investigated at three different temperatures (25, 35, and 45°C) and during 6 or 24 hours rest periods. Besides, to evaluate the accuracy of the measured healing values, samples were CT scanned at 25 °C. It was concluded that the use of polyurethane polymer increased the self-healing performance of the bitumen and increasing the polymer content, has intensified this improvement. It was also found that higher temperatures, as well as healing time extension, increase the healing rate and healing performance of modified bitumen. Following the findings from the BBS test, CT scanned images also showed that the healing rate is negligible at 25°C, and there is no change in large cracks.

The Influence of Movement Tempo on Acute Neuromuscular, Hormonal, and Mechanical Responses to Resistance Exercise-A Mini Review.

Wilk, M, Tufano, JJ, and Zajac, A. The influence of movement tempo on acute neuromuscular, hormonal, and mechanical responses to resistance exercise-a mini review. J Strength Cond Res 34(8): 2369-2383, 2020-Resistance training studies mainly analyze variables such as the type and order of exercise, intensity, number of sets, number of repetitions, and duration and frequency of rest periods. However, one variable that is often overlooked in resistance training research, as well as in practice, is premeditated movement tempo, which can influence a myriad of mechanical and physiological factors associated with training and adaptation. Specifically, this article provides an overview of the available scientific literature and describes how slower tempos negatively affect the 1-repetition maximum, the possible load to be used, and the number of repetitions performed with a given load, while also increasing the total time under tension, which can mediate acute cardiovascular and hormonal responses. As a result, coaches should consider testing maximal strength and the maximal number of repetitions that can be performed with each movement tempo that is to be used during training. Otherwise, programming resistance training using various movement tempos is more of a trial-and-error approach, rather than being evidence or practice based. Furthermore, practical applications are provided to show how movement tempo can be adjusted for a variety of case study-type scenarios.

The Effect of an Oxytocin Rest Period on Cesarean Delivery Blood Loss [35P

INTRODUCTION: Studies have demonstrated that two hours of oxytocin exposure can desensitize uterine oxytocin receptors; which may increase blood loss during delivery. Oxytocin's half-life is 10–15 minutes, previous work suggests that it takes approximately 60 minutes to be eliminated. Our objective was to determine if a greater than 60-minute oxytocin rest period prior to cesarean delivery had an impact on blood loss. METHODS: An IRB-approved retrospective cohort study of 272 women who underwent primary cesarean delivery after oxytocin augmentation between January 2013 and December 2017 at Stony Brook University Hospital was conducted. Women with a prior cesarean delivery, a cesarean hysterectomy, multiple gestation, and a greater than 240 minute oxytocin rest period were excluded. The primary outcome was percentage change between pre- and post-operative hematocrit (Hct) in women with less than 60-minute oxytocin rest period (60 min). RESULTS: There was no difference in demographic or obstetric characteristics between the groups. Women in the &gt;60 min group had a higher cumulative dose (5112+4765 mU vs. 77017325 mU, P=.003), longer duration of oxytocin administration (671±458 min vs. 892±558 min, P=.001), and were more likely to receive uterotonics (6.7% vs. 15.2%, P=.047). No significant difference in percent change in HCT (-17.3±8.6 vs. -17.8±8.7, P=.635) was identified. Linear regression demonstrated a weak relationship between cervical dilation and percent change in Hct. (R2=0.048, P&lt;.001). CONCLUSION: No significant correlation between duration of oxytocin rest period and blood loss was found. Women receiving oxytocin augmentation do not appear to benefit from oxytocin rest periods before proceeding to cesarean delivery.

The association of glycemia level and myocardial functional indices in patients with coronary heart disease and type 2 diabetes mellitus

Introduction. The strict control of glycemia does not always lead to positive effects associated with a decrease in cardiovascular complications. Moreover, the combined development of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) makes it challenging to control glycemic levels adequately. Objective. To study the relationship between glycemia and functional myocardial parameters in patients with coronary artery disease and type 2 diabetes mellitus. Material and Methods . The study included patients with a diagnosis of chronic coronary artery disease associated with type 2 diabetes mellitus. We studied the echocardiography-based structural and functional parameters of the heart and the contractile properties of the myocardium in patients ex vivo depending on the level of glycated hemoglobin (НbА1с). The ex vivo studies were performed on trabeculae isolated from the right atrial appendage obtained during coronary artery bypass surgery. The contractile function of trabeculae was assessed based on an extrasystolic effect and a resting effect (post-rest reaction). Results . Patients were divided into two groups according to the HbA1c level: group 1 included patients with HbA1c less than 8%; group 2 comprised patients with HbA1c more than 8%. The main clinical baseline parameters were similar between the groups. The ejection fraction (EF) was higher, whereas the thickness of the left ventricular posterior wall (LVPW) was lower in patients of group 1 compared to the corresponding parameters of group 2. The ex vivo study of myocardial contractility showed that extrasystolic contractions occurred at earlier extrasystolic intervals in patients of group 2, suggesting higher excitability of the cardiomyocyte membranes. At the same time, post-extrasystolic contractions of trabeculae in patients of group 2 had significant potentiation. The amplitude of post-rest trabeculae contractions was potentiated at short rest periods in patients of both groups. However, post-rest contractions significantly increased with an increase in the duration of rest periods only in group 2. Post-rest inotropic response in patients of group 1 did not have any potentiation after long rest periods. Conclusions . The results of this study based on the contractility of isolated trabeculae showed that the increased HbA1c levels are better indicators of the myocardial functional state.

Exposure to chronic light–dark phase shifts during the prepartum nonlactating period attenuates circadian rhythms, decreases blood glucose, and increases milk yield in the subsequent lactation

Maintaining metabolic balance is a key factor in the health of dairy cattle during the transition from pregnancy to lactation. Little is known regarding the role of the circadian timing system in the regulation of physiological changes during the transition period. We hypothesized that disruption of the cow's circadian timing system by exposure to chronic light-dark phase shifts during the prepartum period would negatively affect the regulation of homeostasis and cause metabolic disturbances, leading to reduced milk production in the subsequent lactation. The objective was to determine the effect of exposure to chronic light-dark phase shift during the last 5 wk prepartum of the nonlactating dry period on core body temperature, melatonin, blood glucose, β-hydroxybutyric acid (BHB) and nonesterified fatty acid (NEFA) concentrations, and milk production. Multiparous cows were moved to tiestalls at 5 wk before expected calving and assigned to control (CTR; n = 16) or phase-shifted (PS; n = 16) treatments. Control cows were exposed to 16 h of light and 8 h of dark. Phase-shifted cows were exposed to the same photoperiod; however, the light-dark cycle was shifted 6 h every 3 d until parturition. Resting behavior and feed intake were recorded daily. Core body temperature was recorded vaginally for 48 h at 23 and 9 d before expected calving using calibrated data loggers. Blood concentrations of melatonin, glucose, BHB, and NEFA were measured during the pre- and postpartum periods. Milk yield and composition were measured through 60 DIM. Treatment did not affect feed intake or body condition. Cosine fit analysis of 24-h core body temperature and circulating melatonin indicated attenuation of circadian rhythms in the PS treatment compared with the CTR treatment. Phase-shifted cows had lower rest consolidation, as indicated by more total resting time, but shorter resting period durations. Phase-shifted cows had lower blood glucose concentration compared with CTR cows (4 mg/mL decrease), but BHB and NEFA concentrations were similar between PS and CTR cows. Milk yield and milk fat yield were greater in PS compared with CTR cows (2.8 kg/d increase). Thus, exposure to chronic light-dark phase shifts during the prepartum period attenuated circadian rhythms of core body temperature, melatonin, and rest-activity behavior and was associated with increased milk fat and milk yield in the postpartum period despite decreased blood glucose pre- and postpartum. Therefore, less variation in central circadian rhythms may create a more constant milieu that supports the onset of lactogenesis.

Оцінка ефективності застосування еластичної підкладки як засобу для скорочення термінів адаптації до знімних пластинчастих протезів в процесі ранньої ортопедичної реабілітації пацієнтів

Objectives. Study of ways to increase the efficiency of immediate prosthetic treatment of patients with asymmetric distally unlimited defects of dental rows by using clinical relining of partial removable dentures with elastic material to reduce the time of adaptation to dentures and normalize the functional activity of the masticatory muscles. Materials and methods. The efficiency of clinical relining of partial removable dentures using an elastic lining with Ufi Gel P from VOCO (Germany) was evaluated by electromyographic examination with BioEMG III electromyograph from BioRESEARCH Associates, Inc. (USA). The bioelectrical activity of the temporal and masseter muscles was evaluated during maximum voluntary clenching and mastication. The quantitative indicators of the amplitude of biopotentials (μV) and the qualitative characteristics of the chewing cycles were evaluated. Results. Our study has revealed that patients with asymmetric distally unlimited defects of dental rows had shown a significant decrease in the amplitude of biopotentials of the masticatory muscles compared to patients in the control group during maximum voluntary clenching and chewing, as well as a significant asymmetry of the bioelectric activity of the masticatory muscles on the right and left. During mastication there were significant differences in the size and duration of chewing cycles, a decrease in the duration of rest periods and the average number of chewing movements increased almost two times compared with intact dentition. A month after prosthetics, the indicators of bioelectrical activity of the masticatory muscles improved in both study groups of patients, but the most significant increase in amplitude was observed in the second group with a soft lining. There was also revealed a significant increase in the symmetry of bioelectric activity of the masticatory muscles, an improvement in the characteristics of the masticatory cycles and normalization of the activity and rest periods duration ratio in patients of the second group, while in patients of the 1st clinical group the indicators of symmetry did not change significantly. The average number of chewing movements required to chew the hazelnut kernel decreased to 38.7±16.2 and 29.3±10.7 respectively, in groups 1 and 2, which indicates an increase of masticatory efficiency. Conclusions. In the framework of this study, the high efficiency of elastic lining for the successful rehabilitation of patients with asymmetric distally unlimited defects in case of early prosthodontic interventions was proved. Our observations have shown that the use of the soft lining significantly increases the functional parameters of the masticatory system, shortens the period of adaptation to removable dentures and supports the formation of the alveolar processes relief without irregularities.

Функциональный анализ результатов использования эластической подкладки «Ufi Gel P» компании «VOCO» (Германия) как средства для сокращения сроков адаптации к съемным пластиночным протезам в процессе ортопедической реабилитации пациентов с асимметричными дистально неограниченными дефектами зубных рядов на ранних этапахФункциональный анализ результатов использования эластической подкладки «Ufi Gel P» компании «VOCO» (Германия) как средства для сокращения сроков адаптации к съемным пластиночным протезам в процессе

Objectives. Study of ways to increase the efficiency of immediate prosthetic treatment of patients with asymmetric distally unlimited defects of dental rows by using clinical relining of partial removable dentures with Ufi Gel P material from VOCO (Germany) to reduce the time of adaptation to dentures and normalize the functional activity of the masticatory muscles. Materials and methods. The efficiency of clinical relining of partial removable dentures using an elastic lining with Ufi Gel P from VOCO (Germany) was evaluated by electromyographic examination with BioEMG III electromyograph from BioRESEARCH Associates, Inc. (USA). The bioelectrical activity of the temporal and masseter muscles was evaluated during maximum voluntary clenching and mastication. The quantitative indicators of the amplitude of biopotentials (μV) and the qualitative characteristics of the chewing cycles were evaluated. Results. Our study has revealed that patients with asymmetric distally unlimited defects of dental rows had shown a significant decrease in the amplitude of biopotentials of the masticatory muscles compared to patients in the control group during maximum voluntary clenching and chewing, as well as a significant asymmetry of the bioelectric activity of the masticatory muscles on the right and left. During mastication there were significant differences in the size and duration of chewing cycles, a decrease in the duration of rest periods and the average number of chewing movements increased almost two times compared with intact dentition. A month after prosthetics, the indicators of bioelectrical activity of the masticatory muscles improved in both study groups of patients, but the most significant increase in amplitude was observed in the second group with a soft lining. There was also revealed a significant increase in the symmetry of bioelectric activity of the masticatory muscles, an improvement in the characteristics of the masticatory cycles and normalization of the activity and rest periods duration ratio in patients of the second group, while in patients of the 1st clinical group the indicators of symmetry did not change significantly. The average number of chewing movements required to chew the hazelnut kernel decreased to 38.7±16.2 and 29.3±10.7 respectively, in groups 1 and 2, which indicates an increase of masticatory efficiency. Conclusions. In the framework of this study, the high efficiency of Ufi Gel P (VOCO) elastic lining for the successful rehabilitation of patients with asymmetric distally unlimited defects in case of early prosthodontic interventions was proved. Our observations have shown that the use of the Ufi Gel P (VOCO) soft lining significantly increases the functional parameters of the masticatory system, shortens the period of adaptation to removable dentures and supports the formation of the alveolar processes relief without irregularities.

1812P - Modalities of biosimilar filgrastim use in clinical practice in > 1000 patients receiving chemotherapy regimens with a rest period of ≤ 14 days: The TOPAZE study

BackgroundInternational guidelines recommend the use of granulocyte colony stimulating factors (G-CSF), such as filgrastim, to prevent chemotherapy-induced febrile neutropenia (FN) and maintain chemotherapy dose to improve clinical outcomes. However, there are no clear recommendations for regimens with a rest period (duration between two cytotoxic administrations, within one cycle or between two different cycles) of≤14 days. This study aimed to describe modalities of daily clinical use of biosimilar filgrastim in patients (pts) receiving chemotherapy regimens with a rest period of≤14 days. MethodsThis multicentre, prospective, non‐interventional study was performed in France in pts receiving biosimilar filgrastim during cytotoxic chemotherapy with rest period of≤14 days. ResultsA total of 1080 pts were enrolled, of which 953 were included in the full analysis set: 144 had lymphoma (DLBCL, N=39; Hodgkin’s lymphoma, N=105), and 809 had solid tumours (breast, N=299; lung, N=144; gastrointestinal [GI], N=366 [colorectal, N=203; pancreatic, N=106; gastric N=39; oesophageal, N=18]). The Table shows modalities of filgrastim treatment for pts receiving chemotherapy for curative intent. Similar results were reported in pts receiving chemotherapy for palliative intent. Pts with solid tumours were planned to receive filgrastim on Day 2 of treatment for ≤5 days duration. Pts with lymphoma were planned to receive filgrastim on Day ≥3 for 4–8 days duration. Of the patients receiving chemotherapy for curative intent, FN was reported in 2 pts with GI cancer, 1pt with lung cancer and 7 pts with lymphoma. ConclusionsBiosimilar filgrastim treatment in pts receiving chemotherapy with a rest period of≤14 days results in a low incidence of FN in real-world clinical practice. Editorial acknowledgementCaroline McGown of Spirit Medical Communications Ltd, supported by Sandoz. Table1812P Modalities of use of biosimilar filgrastim in patients receiving chemotherapy for curative intentTableFull group N (%)Lymphoma 144 (15.1)Solid tumours 809 (85)Subgroup (intent of chemotherapy)DLBCL (i) N=35HL (i) N=100Breast cancer (c) N=139GI cancers (c) N=126Lung cancer (c) N=58Regimen‡biw N=23m N=12biw N=100qw N=91biw N=37m N=11qw N=1biw N=120m N=5qw N=1m N=57Relative dose intensity with planned dose, % Mean (SD)97.7 (4.4)-109.5 (94.9)100.9 (21.8)97.2 (10.4)95.2 (12.6)-99.5 (24.0)96.4 (8.0)-95.1 (28.4)Patients with at least one episode of grade 4 neutropenia†Yes n (%)3 (13.0)1 (8.3)11 (11.0)02 (5.4)001 (0.8)002 (3.5)Number of patients with at least one episode of FN†Yes n (%)1 (4.3)1 (8.3)5 (5.0)00002 (1.7)001 (1.8)DLBCL: R-ACVBP; R-CHOP 14.HL: ABVD; increased-dose BEACOPP.Breast cancer: eribulin; paclitaxel weekly.Digestive cancers: simplified FolFOx4 (colorectal, gastric and oesophageal cancers); FolFlrinOx (pancreatic cancer).Lung cancer: carboplatin + paclitaxel (weekly); vinorelbine + platinum salt (carboplatin or cisplatin) 21-day cycle.biw, twice weekly regimen; c, curative; DLBCL, diffuse large B-cell lymphoma; FN, febrile neutropenia; GI, gastrointestinal; HL, Hodgkin’s lymphoma; i, induction; m, mixed regimen; N, number of patients in group; n, number of patients with event; qw, once weekly regimen; SD, standard deviation.†Note: percentages are calculated compared to completed data (i.e. not including missing data).‡The most frequently used chemotherapies in the overall study population were: Legal entity responsible for the studySandoz. FundingSandoz. DisclosureJ.M. Phelip: Advisory / Consultancy: Roche; Advisory / Consultancy: Merck; Advisory / Consultancy: Amgen; Advisory / Consultancy: Sanofi; Advisory / Consultancy: Bayer; Advisory / Consultancy: Servier; Advisory / Consultancy: Lilly; Advisory / Consultancy: MSD; Advisory / Consultancy: Pierre Favre; Research grant / Funding (institution): Merck Serono. P. Souquet: Honoraria (self), Speaker Bureau / Expert testimony, Non-remunerated activity/ies: Sandoz (a Novartis company). M. Declerck: Full / Part-time employment: Sandoz. E. Nabirotchkina: Full / Part-time employment: Sandoz. O. Tredan: Non-remunerated activity/ies: Sandoz; Honoraria (self): Roche; Honoraria (self): Novartis; Honoraria (self): Pfizer; Honoraria (self): Lilly; Honoraria (self): Astra-Zeneca; Honoraria (self): MSD-Merck; Honoraria (self): BMS. All other authors have declared no conflicts of interest.

Fatigue and self-healing characterization of asphalt composites containing rock asphalts

Fatigue cracking is one of the major distresses that causes early pavement failures. One of the solutions to delay the occurrence of pavement failure by fatigue cracking is to use materials that not only can resist such cracking but also can heal them over time. This is therefore necessary to evaluate the impact of such materials on fatigue cracking resistance and self-healing properties of asphalt mixtures. The increasing use of alternative materials such as rock asphalts has made this need even more pronounced. Fittingly, this paper presents the findings from a study that utilizes a fracture test and a combined fatigue-healing test to evaluate the influence of different sources of rock asphalts-Buton, Qingchuan (QC) and Uintaite Modifier (UM) on the fatigue and self-healing properties of fine aggregate matrix (FAM) mixture. The fracture test results indicate that rock asphalt can effectively improve the cracking resistance of asphalt mortars or FAM. The viscoelastic continuum damage (VECD) analyses of the combined fatigue-healing test results show that rock asphalt can significantly enhance the fatigue cracking resistance of FAM mixture. The results also show that, at same volume concentration of binder, UM rock asphalt and QC rock asphalt enhance fatigue cracking resistance of FAM very similarly but much better than does the Buton rock asphalt. An increase in the concentration of Buton rock asphalt made the FAM mixture even more resistant to fatigue cracking. Similarly, test results show that, at same volume concentration of binder, QC rock asphalt exhibited the best self-healing properties followed by UM and Buton rock asphalt, respectively. This ranking was more pronounced with longer rest period durations. Test results also indicate that, at same rest period, 8% Buton rock asphalt healed better than 20% Buton rock asphalt. In addition, this paper also uses these materials to demonstrate an experimental and analytical approach to quantity both fatigue cracking resistance and self-healing properties using a viscoelastic continuum damage model and a single unified testing protocol with asphalt mortars or FAM. This approach can also be easily applied to evaluate other similar materials such as reclaimed asphalt pavements (RAP).