Night Sleep Duration Research Articles

The effect of Ramadan fasting on sebum production: association with nutritional intakes and sleeping pattern

Background: Sebum production is associated with several factors including hormonal, and nutritional factors. Sleeping pattern could also affect changes in androgen levels associated with sebum production and acne. During Ramadan, moslems are obliged to fast from dawn to sunset, causing nutritional intake and sleeping pattern changes.
 Objectives: This study was aimed to find association between nutritional intake and sleeping pattern during Ramadan with sebum production.
 Methods: Ramadan fasting practitioners (40 male, mean age ±SD : 19.19±1.03 years) were evaluted before and 3 weeks into Ramadan fasting. Parameters assessed were nutrient intakes (using 24-hour food recalls), sleep quality and duration (using Pittsburgh Sleep Quality Index) and sleep diary. Sebum productions were measured using SebutapeR technique.
 Results: Significant decreases were found in protein (p=0.014), total fat (p=0.031), milkshake(p=0.001) and cheese intakes (p=0.013). Glycemic load was also decreased significantly (p=0.006). Despite no reduction in total sleep duration, night sleep duration was significantly reduced during Ramadan (p=0.000) associated with more subjects with poor sleep quality (p=0.039). Sebum production was increased significantly during Ramadan (p=0.028)
 Conclusion: Despite lower glycemic load and dairy products intakes, and lower sleep duration, Ramadan fasting was associated with increased sebum production. It was likely a result of circadian rhythm shift in sebaceous glands activities.
 Bangladesh Journal of Medical Science Vol.18(3) 2019 p.546-551

Nightmares Are Associated With Future Suicide Attempt and Non-Suicidal Self-Injury in Adolescents.

To determine which sleep variables, including sleep duration, sleep quality, insomnia symptoms, and nightmares, were significantly and independently associated with subsequent adolescent suicidal behavior and non-suicidal self-injury (NSSI). A prospective longitudinal study was conducted in Shandong, China. Participants were 7,072 adolescents initially assessed in November and December in 2015 and reassessed 1 year later in 2016. Self-administered structured questionnaires were used to assess suicidal behavior, NSSI, night sleep duration, insomnia symptoms, sleep quality, nightmares, impulsivity, depression, and family demographics. Logistic regression analyses were performed to examine the associations between sleep variables and suicidal behavior and NSSI. At 1-year follow-up, 190 participants (2.7%) attempted suicide and 621 (8.8%) engaged in NSSI. Insomnia symptoms and frequent nightmares (several times a month) at baseline were significantly associated with subsequent suicide attempt and NSSI 1 year later. After adjustment for covariates including adolescent and family demographics, depression, impulsiveness, and prior suicide attempt/NSSI, frequent nightmares in the past year remained significant for suicide attempt (OR = 1.96; 95% CI, 1.15-3.33) and NSSI (OR = 1.52; 95% CI, 1.10-2.08). With further adjustment for insomnia symptoms, sleep quality, and sleep duration, the associations between frequent nightmares and subsequent suicide attempt and NSSI had almost no change. Insomnia, short sleep duration, and poor sleep quality were not independently associated with subsequent suicide attempt and NSSI. Frequent nightmares were independently associated with subsequent suicide attempt and NSSI among adolescents. Assessing and intervening for nightmares may have important implications for early identification of adolescents at risk and prevention of adolescent self-harm and suicide.

Association between objective sleep duration and bone mineral density in older postmenopausal women from the Study of Osteoporotic Fractures (SOF).

Both long and short self-reported sleep durations are associated with low bone mineral density (BMD) in men and women. The association between sleep duration measured by actigraphy and BMD in postmenopausal women is unknown. The Study of Osteoporotic Fractures (SOF) ancillary sleep study was used to determine the association between sleep duration and BMD at the total hip and femoral neck in postmenopausal women ≥ 75years old. Sleep duration was assessed by wrist actigraphy (average 4 nights) and questionnaire. BMD was compared between postmenopausal women with short (< 6h/night) vs. NIH-recommended (7-8h/night) sleep durations. Data were analyzed using a 2-sample t test (unadjusted) and multivariate regression model (adjusted). Simple linear regression was used to estimate the difference in BMD per additional hour of sleep when sleep duration was considered as a continuous, rather than dichotomized, variable. Total hip BMD was higher in women with actigraphically assessed shorter sleep duration in unadjusted models only. No clinically or statistically significant differences in total hip or femoral neck BMD were observed according to nocturnal sleep duration after adjusting for body mass index (BMI) in dichotomized (N = 874) or continuous (N = 1624) sleep duration models or when subjective sleep duration was used. When sleep duration included daytime naps, longer sleep duration was associated with lower total hip BMD (β = - 0.005, p = 0.04). Nocturnal sleep duration, whether assessed objectively (actigraphy) or subjectively (questionnaire), was not independently associated with BMD in older postmenopausal women.

Sleep and daytime sleepiness in adolescents with and without ADHD: differences across ratings, daily diary, and actigraphy.

Children with attention-deficit/hyperactivity disorder (ADHD) experience greater sleep problems than their peers. Although adolescence is generally a developmental period characterized by insufficient sleep, few studies have used a multi-informant, multi-method design, to examine whether sleep differs in adolescents with and without ADHD. Targeted recruitment was used to enroll an approximately equal number of eighth-grade adolescents (mean age=13years) with (n=162) and without ADHD (n=140). Adolescents and parents completed global ratings of sleep problems; adolescents, parents, and teachers completed ratings of daytime sleepiness. Adolescents wore actigraphs and completed a daily sleep diary for approximately 2weeks. Adolescents with ADHD were more likely than adolescents without ADHD to obtain insufficient sleep on school days (per diary) and weekends (per diary and actigraphy). Adolescents with ADHD were also more likely to report falling asleep in class and to have stayed up all night at least twice in the previous 2weeks (14% and 5% reported all-nighters for ADHD and comparison, respectively). In regression analyses controlling for a number of variables known to impact sleep (e.g. pubertal development, sex, medication use, having an externalizing, anxiety, or depression diagnosis), ADHD remained associated with shorter diary and actigraphy school night sleep duration, adolescent- and parent-reported daytime sleepiness, and parent-reported difficulties initiating and maintaining sleep and total sleep disturbance. Controlling for other variables, the odds of being classified with clinically elevated parent-reported sleep disturbance were 6.20 times greater for adolescents with ADHD. Findings provide some of the clearest evidence yet that adolescents with ADHD experience more sleep problems and sleepiness than their peers without ADHD. It may be especially important to assess for sleep problems in adolescents with ADHD and to evaluate whether existing sleep interventions are effective, or can be optimized, for use in adolescents with ADHD who also have sleep problems.

0789 Why So Slangry? (Sleepy and Angry) Nightly Sleep Duration and Efficiency Predict Individual Teens’ Next-Day Reports of Mood

0789 Why So Slangry? (Sleepy and Angry) Nightly Sleep Duration and Efficiency Predict Individual Teens’ Next-Day Reports of Mood

0774 Night-sleep Duration Trajectories And Behavior In Preschool-aged Children From The EDEN Cohort

0774 Night-sleep Duration Trajectories And Behavior In Preschool-aged Children From The EDEN Cohort

Delayed Lactogenesis II is Associated With Lower Sleep Efficiency and Greater Variation in Nightly Sleep Duration in the Third Trimester.

Metabolic and hormonal disturbances are associated with sleep disturbances and delayed onset of lactogenesis II. The aim of this study was to measure sleep using wrist actigraphy during gestation weeks 22 and 32 to determine if sleep characteristics were associated with blood glucose, body mass index, gestational related disease, delayed onset of lactogenesis II, or work schedule. Demographic data were collected at study intake from primiparous women who wore a wrist actigraph during gestation weeks 22 (n = 50) and 32 (n = 44). Start and end sleep time, total nighttime sleep, sleep efficiency, wake after sleep onset, and sleep fragmentation were measured. Night to night variability was assessed with the root mean square of successive difference. Blood glucose levels, body mass index, and gestational disease data were abstracted from medical charts. Timing of lactogenesis II was determined by survey. Between gestation week 22 and 32, sleep efficiency decreased and fragmentation increased (p < .05). During gestation week 32, blood glucose was negatively correlated with sleep duration, and positively related to fragmentation (p < .05). Women who experienced delayed lactogenesis II had lower sleep efficiency and greater fragmentation (p < .05), and greater night-to-night variability in sleep start and end time, efficiency, and duration during gestation week 32 (p < .05). Women with better sleep efficiency and more stable nightly sleep time are less likely to experience delayed onset of lactogenesis II. Interventions to improve sleep may improve maternal health and breastfeeding adequacy.

Depression, emotional eating and long-term weight changes: a population-based prospective study

BackgroundEmotional eating (i.e. eating in response to negative emotions) has been suggested to be one mechanism linking depression and subsequent development of obesity. However, studies have rarely examined this mediation effect in a prospective setting and its dependence on other factors linked to stress and its management. We used a population-based prospective cohort of adults and aimed to examine 1) whether emotional eating mediated the associations between depression and 7-year change in body mass index (BMI) and waist circumference (WC), and 2) whether gender, age, night sleep duration or physical activity moderated these associations.MethodsParticipants were Finnish 25- to 74-year-olds who attended the DILGOM study at baseline in 2007 and follow-up in 2014. At baseline (n = 5024), height, weight and WC were measured in a health examination. At follow-up (n = 3735), height, weight and WC were based on measured or self-reported information. Depression (Center for Epidemiological Studies - Depression Scale), emotional eating (Three-Factor Eating Questionnaire-R18), physical activity and night sleep duration were self-reported. Age- and gender-adjusted structural equation models with full information maximum likelihood estimator were used in the analyses.ResultsDepression and emotional eating were positively associated and they both predicted higher 7-year increase in BMI (R2 = 0.048) and WC (R2 = 0.045). The effects of depression on change in BMI and WC were mediated by emotional eating. Night sleep duration moderated the associations of emotional eating, while age moderated the associations of depression. More specifically, emotional eating predicted higher BMI (P = 0.007 for the interaction) and WC (P = 0.026, respectively) gain in shorter sleepers (7 h or less), but not in longer sleepers (9 h or more). Depression predicted higher BMI (P < 0.001 for the interaction) and WC (P = 0.065, respectively) increase in younger participants, but not in older participants.ConclusionsOur findings offer support for the hypothesis that emotional eating is one behavioural mechanism between depression and development of obesity and abdominal obesity. Moreover, adults with a combination of shorter night sleep duration and higher emotional eating may be particularly vulnerable to weight gain. Future research should examine the clinical significance of our observations by tailoring weight management programs according to these characteristics.

Dynamics of quality of dream and cognitive functions for the patients of young age with primary insomnia on background the reception of Sonmelat forte

The aim of the study was to assess the quality of sleep, cognitive functions and the effect of insomnia on work and social adaptation in young patients suffering from primary insomnia (in accordance with the DSM-5 and ICD-10 criteria for insomnia) and their dynamics under the influence of Sonmelate forte.Materials and methods. The study involved 23 patients (mean age – 41,3±2,8 years) with chronic primary insomnia and a duration of insomnia disorders of 7,79±2,4 months. The control group consisted of 20 healthy individuals (mean age 40,6±2,3 years) with no insomnia. In order to treat insomnia, patients took Sonmelate Forte (combination of 5 mg of melatonin immediate and 5 mg of melatonin sustained release) 1 tablet 30 minutes before sleep for 30 days.Results of the study. Chronic primary insomnia in young patients contributes to the development of mild manifestations of cognitive dysfunction in the form of impaired short-term visual and auditory memory, decreased concentration, stability and increased attention depletion, and also contributes to the development of emotional disturbances (anxiety, depression), work and socialmaladjustment. Sonmelat Forte is an effective and safe means of treating chronic primary insomnia in young patients, helping to reduce sleep latency, night and early awakenings, increase night sleep duration and decrease daytime sleepiness, promotes regression of mild cognitive dysfunction in young patients (improvement in short-term visual and auditory memory, attention span), improves the patient’s emotional state and daytime functioning by decreasing daytime oh sleepiness and general fatigue, contributing, thus, to increase the level of social and work adaptation.

A combination of Eschscholtzia californica Cham. and Valeriana officinalis L. extracts for adjustment insomnia: A prospective observational study

Eschscholtzia californica Cham. and Valeriana officinalis L. have long been used for the management of sleep disorders and anxiety. Use of a fixed combination of these two plant extracts (Phytostandard® d’Eschscholtzia et de Valériane, PiLeJe Laboratoire, France) was investigated in an observational study. Adults with adjustment insomnia according to the criteria of the International Classification of Sleep Disorders and with an insomnia severity index (ISI) score >7 enrolled by GPs took a maximum of four tablets of the eschscholtzia and valerian combination every night for four weeks. Within one month, ISI score decreased by approximately 30% (from 16.09 ± 3.67 at inclusion (V1) to 11.32 ± 4.78 at 4 weeks (V2); p < 0.0001). Night sleep duration significantly increased between the first and the fourth week of supplement intake, sleep efficiency increasing from 78.4% ± 12.5 to 84.6% ± 10.2 (p = 0.002). There was no improvement in sleep latency. The number of awakenings decreased by approximately 25% and their total duration by approximately 25 min. Anxiety score significantly decreased by 50% from 13.9 ± 7.3 at V1 to 6.7 ± 6.3 at V2 (p < 0.0001). The supplement was well tolerated. These results suggest that the tested combination of eschscholtzia and valerian extracts could be beneficial for the management of insomnia in adults and deserves further investigation.

Short Sleep in Pupils in Japan: Current Status and Associated Factors

Background: Japan is the most sleepless nation in the world. This study aimed to understand short sleep pupils in Japan. Since academic performance is known to worsen with sleep problems, self-reported academic performance (s-rAP) was also investigated. Methods: A total of 1766 completed questionnaires were obtained from grades 7 to 12 pupils in Japan. Queries included issues on sleeping, eating, defecation, physical activity, screen time, after-school activity (ASA), body mass index (BMI) and s-rAP. Multinomial logistic regression analysis, multiple comparison tests and multiple regression analysis were used adequately. Results: Short sleep pupils were defined as follows in reference to the mean minus 1.5 times the standard deviation of weekend night sleep duration: 7 hours or less for junior high school pupils and 6 hours or less for high school pupils. The rate of short sleep pupils for school nights was 49.9% in junior high school and 48.4% in high school. Multinomial logistic regression analysis revealed that longer weekday screen time and longer ASA were significantly associated with short sleep pupils for school and weekend nights. However, s-rAP was not associated with short sleep pupils. Multiple comparison tests revealed that school night sleep duration, school and weekend night bed time, weekend wake time, sleepiness, eating breakfast, screen time and BMI were significantly different among AP categories. There were no significant differences for s-rAP values between 10-15 and more than 15 hours ASA per week. According to multiple regression analysis, sleep duration was not selected as a significant predictor of s-rAP, while sleepiness, eating breakfast, grade, school day screen time and BMI were selected. Conclusions: The association between s-rAP and sleep duration remains inconclusive. A recommendation about sleep duration might be gauged from when pupils feel less sleepy.

Sex Moderates Relationships Among School Night Sleep Duration, Social Jetlag, and Depressive Symptoms in Adolescents

Social jetlag, a misalignment between sleep timing on the weekend and during the work week, is associated with depressive symptoms among adults across both sexes. A previous study found that later sleep timing was associated with depressive symptoms in women but not men. To date, however, no research has investigated whether the association between social jetlag and depression varies by sex among adolescents. The current study assessed self-reported sleep, depressive symptoms, and demographic information from 3058 adolescents (48% female, mean [SD] age 15.59 [0.77] years) from the age 15 wave of the Fragile Families and Child Wellbeing Study (FFCWS). Social jetlag was calculated as the absolute value of the midpoint of sleep on the weekend minus the midpoint of sleep during the school week. Depressive symptoms were measured through a modified 5-item version of the Center for Epidemiologic Studies Depression Scale (CES-D). We assessed whether the associations among sleep duration on school nights, social jetlag, and depressive symptoms were similar between male and female adolescents using multiple linear regression. In fully adjusted models, sex moderated the association between school night total sleep time and depressive symptoms ( p < 0.001) and between social jetlag and depressive symptoms ( p = 0.037). In females, but not in males, school night total sleep time was negatively associated with depressive symptoms ( p < 0.001), whereas social jetlag ( p < 0.001) was positively and independently associated with depressive symptoms. The results indicate the importance of regular sleep timing across the week and adequate sleep duration for the maintenance of optimal emotional health among female adolescents.

Early polysomnographic characteristics associated with neurocognitive development at 36 months of age

BackgroundFew studies on the relationship between sleep quantity and/or quality and cognition have been conducted among preschoolers from the healthy general population. We aimed to identify, among 3-year-old children, early polysomnography (PSG) sleep factors associated with estimated intelligence quotient (IQ) using the Weschler Preschool and Primary Scale Intelligence-III test (WPPSI-III) and its indicators: full-scale (FISQ), verbal (VIQ), and performance (PIQ) intelligence quotients. MethodsWe included full-term children from the French birth-cohort AuBE with PSG recording at term (M0) and/or six months (M6), and available WPPSI-III scores at three years. Sleep and arousal characteristics of these infants were evaluated during day and night sleep periods. Relationships between IQ scores and sleep parameters were estimated using models with the child as a repeated effect adjusted for time (night/day), maturation (M0/M6), tobacco exposure (yes/no), anxiety-depressive scores during pregnancy, maternal age, duration of breastfeeding and child's gender. ResultsA total of 118 PSG recordings were obtained, representing a total of 78 unique children (38 with one PSG and 40 with two PSG). No correlations were found between night and day sleep durations at M0 or M6. Mean VIQ, PIQ, and FSIQ scores were within normal ranges. In multivariate models, longer sleep duration and higher sleep efficiency during the day were negatively associated with all IQ scores. More frequent arousals during the night were associated with lower VIQ scores. ConclusionEarly sleep characteristics such as night sleep fragmentation or longer naps could be associated with impaired cognitive function at three years of age.

The problem of insomnia in infant/young children: issues of diagnosis and treatment

OBJECTIVE To obtain further evidence of the efficacy of dormikind in infant/young children. MATERIAL AND METHODS The study was performed in the group of 114 patients, aged 6 months to 2.5 years, with sleep and sleep initiation disorders. Sixty-four patients received treatment with dormikind (group 1) and 50 patients received behavioral therapy (group 2) for 28 days. RESULTS AND CONCLUSION In group 1, sleep initiation decreased by 1.7 times and reached 26.2±4.8 minutes, the number of children sleeping on hands dropped by 8.7 times and sleeping in the parent's bed by 2 times. In group 2, the same characteristics changed by 1.1, 1.3 and 1.5 times, respectively, and sleep initiation reached 33.4±2.9 minutes. The number of patients of group 1 falling asleep in their own beds increased by 3.2 times vs 1.2 times in group 2. Duration of night sleep increased and frequency of awakening reduced as well. The significant positive dynamics was noted in the emotional-behavior state of children after therapy: the total score significantly improved by 2.9 times to the end of treatment compared to group 2 (by 1.3 times). IMOS score showed significant difference between the groups on «total recovery» and «significant improvement». Therefore, the high efficacy and safety of dormikind in children have been confirmed.

Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma.

Background Sleep duration and snoring are correlated with tumorigenesis while their associations with esophageal squamous cell carcinoma (ESCC) are unclear. The purpose of this study is to investigate the impacts of night sleep duration and snoring on ESCC risk.Methods This study included a total of 527 esophageal squamous cell carcinoma patients and 505 gender- and age- matched healthy controls from five hospitals in China. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression models.Results Subjects with sleep duration <7 h (adjusted OR 3.18, 95%CI 1.55-6.53) and regular snoring (adjusted OR 2.56, 95%CI 1.82-3.59) were exposed to high esophageal squamous cell carcinoma risk. After the multivariate models adjusted for body mass index (BMI), the results changed slightly. In the stratified analysis regarding gender, the similar trends occurred in both men and women, and BMI ≥25.0 kg/m2 (adjusted OR 0.68, 95%CI 0.48-0.96) was associated with decreased esophageal squamous cell carcinoma risk in men. Additionally, the esophageal squamous cell carcinoma risk attributable to sleep duration <7 h and regular snoring could be completely or partially diminished in subjects with BMI ≥25.0 kg/m2.Conclusion In both genders, short sleep duration (<7h) and regular snoring were significantly related to increased risk of esophageal squamous cell carcinoma independently.

A dose-response association of night sleep duration with hypertension in a Chinese rural population: the Henan Rural Cohort Study

The purpose of the study was to determine if there was a relationship between night sleep duration and hypertension, and to evaluate as to whether blood lipid levels played a role in this relationship. A total of 37,317 participants aged 18–79 years were included in this study. Night sleep duration was classified as <5, 5-, 6-, 7-, 8-, 9-, and ≥10 hours. Logistic regression and restricted cubic spline analysis was carried out to evaluate the association of sleep duration with hypertension. Compared with reference sleep duration (7 hours), in males, the multivariate odds ratios (ORs) (95% confidence interval [95% CI]) of the groups with longest sleep duration (≥10 hours) and shortest sleep duration (<5 hours) for hypertension was 1.52 (1.25–1.84) and 1.07 (0.80–1.44), respectively. Similarly, the longest sleep duration was associated with diagnosed hypertension (1.21, 1.00–1.45) in females. The OR for an indirect effect of sleep duration through low-density lipoprotein cholesterol (LDL-C) on hypertension was 1.085 (95% CI 1.038–1.137). Overall, a 3.5% possibility of hypertension being associated with sleep duration was attributable to LDL-C. In summary, a relationship between sleep duration and hypertension was observed in this rural population. LDL-C appeared to partially mediate the effect of sleep duration on hypertension in males.

Association of night-waking and inattention/hyperactivity symptoms trajectories in preschool-aged children

The objective was to study the longitudinal associations between inattention/hyperactivity symptoms and night-waking in preschool-years, in light of their joint evolution. Within the French birth-cohort study EDEN, repeated measures of 1342 children’s night-waking and inattention/hyperactivity symptoms were collected at age 2, 3 and 5–6 through questionnaires. Trajectories were computed using group-based modeling. Logistic regressions, adjusted for confounding factors, were used to measure the association between trajectories and to determine risk factors for belonging to the identified joint trajectories. Two night-waking trajectories were observed, 20% of the children had a trajectory of “common night-waking”, and 80% a trajectory of “rare night-waking”. The children were distributed in three inattention/hyperactivity trajectories, a low (47%), medium (40%) and high one (13%). Both night-waking and inattention/hyperactivity trajectories showed persistence of difficulties in preschool years. The risk of presenting a high inattention/hyperactivity trajectory compared to a low one was of 4.19[2.68–6.53] for common night-wakers, compared to rare night-wakers. Factors associated with joint trajectories were parent’s education level and history of childhood behavioral problems, and the child’s gender, night-sleep duration and collective care at 2 years of age. Results suggest that children presenting behavioral difficulties would benefit from a systematic investigation of their sleep quality and conversely.

Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort

ObjectiveDeficiency in 25-hydroxyvitamin D (25OHD) has been associated with sleep disorders in adults. Only three cross-sectional studies were performed in children; which showed an association between 25OHD deficiency and both obstructive sleep apnea syndrome and primary snoring. No longitudinal study has been performed in children from the general population. We analyzed the association between cord-blood vitamin D levels at birth and night-sleep duration trajectories for children between 2 and 5–6 years old in a non-clinical cohort. MethodWe included 264 children from the French EDEN mother-child birth-cohort with cord-blood 25OHD level determined by radio-immunoassay at birth, and night-sleep trajectories for children between 2 and 5–6 years old obtained by the group-based trajectory modeling method. Associations between 25OHD and sleep trajectories were assessed by multinomial logistic regression adjusted for maternal and child characteristics. ResultsThe trajectories short sleep (<10h30/night), medium-low sleep (10h30-11h00/night), medium-high sleep (≈11h30/night), long sleep (≥11h30/night) and changing sleep (decreased from ≥11h30 to 10h30-11h00/night) represented 5%, 46%, 37%, 4% and 8% of the children, respectively. The mean 25OHD level was 19 ng/ml (SD = 11, range 3–63). It was 12 (SD = 7), 20 (SD = 11), 19 (SD = 10), 14 (SD = 7) and 16 (SD = 8) ng/ml for children with short, medium-low, medium-high, long and changing sleep trajectories, respectively. On adjusted analysis, for each 1-ng/ml decrease in 25OHD level, the odds of belonging to the short sleep versus medium-high sleep trajectory was increased (odds ratio = 1.12, 95% confidence interval [1.01–1.25]). We found no other significant association between 25OHD level and other trajectories. ConclusionA low 25OHD level at birth may be associated with an increased probability of being a persistent short sleeper in preschool years. These results need confirmation.

Abstract P200: Night Sleep Duration and Hypertension in Chinese Rural Population: The Henan Rural Cohort Study

Aim: The purpose of the study was to evaluate the association between night sleep duration and hypertension, and to examine whether the mediation effect of night sleep duration and hypertension exists in rural population based on the factors of blood lipids. Methods: Night sleep duration was classified into &lt;5h, 5-h, 6-h, 7-h, 8-h, 9-h and ≥10h. Logistic regression and restricted cubic spline were performed to evaluate the association of night sleep duration with hypertension. Mediation analysis was used to explore the mediation effect of night sleep duration and hypertension. Results: Among the 37, 317 participants, a total of 12, 333 suffered from hypertension. Compared with reference, fully-adjusted OR of hypertension, undiagnosed and diagnosed hypertension were 1.52(1.25-1.84), 1.68(1.32-2.14) and 1.32(1.03-1.69) respectively among male sleeping for 10h at night. Additionally, the dose-response relationship of night sleep duration with prevalent hypertension risk was also found in male (Figure 1, P &lt;0.05). Mediation analyses showed that the OR for hypertension among male (total effect, 1.089; 95% CI , 1.040, 1.139). Low density lipoprotein cholesterol (LDL-C) showing the OR , 1.003(95% CI , 1.001, 1.005) for indirect effect and 1.085(1.038, 1.137) for direct effect partly mediated their association. Conclusion: A dose-response association of night sleep duration and hypertension was found in male but not in female. Additionally, LDL-C mediated the association between night sleep duration and hypertension among male. Figure 1. Relation of night sleep duration for hypertension from restricted cubic splines.

Physical Activity and Sleep/Wake Behavior, Anthropometric, and Metabolic Profile in Pediatric Narcolepsy Type 1.

Objectives: Regular physical activity is routinely recommended in children and adolescents suffering from narcolepsy type 1 (NT1), but controlled studies analyzing its influence on sleep/wake behavior, metabolic, and anthropometric profile in pediatric NT1 are lacking.Methods: Fifty consecutive drug-naïve NT1 children and adolescents were assessed through actigraphic, clinical, and metabolic evaluations. Patients were compared with respect to their engagement in leisure-time physical activities (LTPA): patients engaged in LTPA (n = 30) and patients not engaged (No-LTPA, n = 20), respectively.Results: LTPA patients presented lower BMI, with different BMI categories distribution and higher HDL cholesterol, when compared with No-LTPA subjects. Increased night-sleep duration, higher sleep quality, and reduction of nap frequency were documented through actigraphy in LTPA subjects. Subjective sleepiness, as measured by ESS-CHAD, was also lower in LTPA subjects while cataplexy frequency proved similar between the two groups.Discussion: In pediatric NT1 patients, regular engagement in LTPA is associated with significant differences on sleepiness, anthropometric and metabolic profile and objectively assessed sleep/wake behavior. Engagement in LTPA is beneficial and should be strongly encouraged in pediatric NT1 patients.