Objective. To determine the criteria for the application of preventive measures for individual computer program «Medical and psychological prevention of complications, and the normalization of physiological parameters in a hypertensive patient».Design and methods. With the financial support of the Government of the Russian Federation, the State contract № 6464r/9021 of 28.12.2008, we have developed and registered in the Federal Institute of Industrial Property preventive medical computer program «Medical and psychological prevention of complications, and the normalization of physiological parameters in a hypertensive patient» № 2011618469, state registration number 01200951860. We examined 180 patients (120 hypertensives and 60 controls) aged 20–70 years (mean age 35,5 ± 7,2 years), patients of the main group had a primary diagnosis of hypertension (I, II, III degree). We performed clinical neurological, standard laboratory and instrumental diagnostic examinations and psychodiagnostic testing, as well as the pulse measurements by cardiointervalography followed by mathematical analysis of the data by a special program.Results. Analysis of reactions in the interim period of adaptation (14–21 day) has shown its important role to predict the outcome of preventive measures. According to our data 88,2 % patients with hypertension III degree and 94,4 % patients with hypertension II degree demonstrated normalization of the blood pressure and improvement in general state, and the approach was beneficial in 100 % patients with hypertension I degree. Mean recovery time after hypertensive crisis was 15,0 ± 5,0 minutes in patients with hypertension I degree, 30,0 ± 10,0 minutes in patients with hypertension II degree (p < 0,001), and 45,1 ± 27,4 minutes in patients with III degree (p < 0,05). Patients, who used personal computer software, demonstrated the reduction of irritability, fatigue, improved sleep, memory, increased work effiiency, disappearance of sleepiness, and there was an increase in self-confidence.Conclusions. Thus, our results show that the use of individual computer program «B/P rate» leads to the reduction of the frequency and duration of hypertensive crises, as well as to the improvement of cognitive function and psychosocial parameters.