Event Abstract Back to Event Evolution of the insulin-like growth factor binding protein (IGFBP) family in vertebrates Dan Larhammar1*, Görel Sundström1, Christina A. Bergqvist1, Cunming Duan2 and Daniel Ocampo Daza1 1 Uppsala University, Department of Neuroscience, Sweden 2 University of Michigan, Department of Molecular, United States The IGFBPs are made from six distinct genes in placental mammals and several more in teleost fishes. Due to uneven rates of evolution in the different parts of the IGFBP proteins, it has been difficult to resolve their evolutionary history. Opposing views have favoured either block (chromosome) or serial duplications. We have combined sequence-based phylogenies with data on chromosomal locations in a large number of species and arrive at the following duplication scenario which is supported by the phylogenies of four adjacent gene families: An ancestral vertebrate IGFBP gene underwent a local gene duplication resulting in a gene pair. Subsequently, the two basal vertebrate tetraploidizations quadrupled this pair, after which one gene was lost from two of the pairs. This resulted in the six genes found in placental mammals. Teleost fishes have undergone a third tetraploidization that doubled the IGFBP repertoire to twelve members whereupon differential losses occurred in different lineages. The five sequenced teleost genomes retain 9-11 of the IGFBP genes. The aminoterminal domain is involved in IGF binding and has 12 perfectly conserved cysteines except in mammalian IGFBP-6, which has ten. Teleost fish IGFBP-6 has lost four additional cysteines, leaving only six, implying important structural differences. Interestingly, IGFBP-4 seems to have been lost independently in opossum and birds. The duplicates of IGFBP-1, 2 and 5 have been retained in all five sequenced teleost genomes suggesting important roles for these duplicates. The great ages for the IGFBP genes strongly suggest that they evolved distinct functions in early vertebrate evolution. Keywords: comparative endocrinology Conference: 25th Conference of the European Comparative Endocrinologists, Pécs, Hungary, 31 Aug - 4 Sep, 2010. Presentation Type: Conference Presentation Topic: Comparative endocrinology Citation: Larhammar D, Sundström G, Bergqvist CA, Duan C and Ocampo Daza D (2010). Evolution of the insulin-like growth factor binding protein (IGFBP) family in vertebrates. Front. Endocrinol. Conference Abstract: 25th Conference of the European Comparative Endocrinologists. doi: 10.3389/conf.fendo.2010.01.00046 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Aug 2010; Published Online: 30 Aug 2010. * Correspondence: Dr. Dan Larhammar, Uppsala University, Department of Neuroscience, Uppsala, Sweden, dan.larhammar@neuro.uu.se Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Dan Larhammar Görel Sundström Christina A Bergqvist Cunming Duan Daniel Ocampo Daza Google Dan Larhammar Görel Sundström Christina A Bergqvist Cunming Duan Daniel Ocampo Daza Google Scholar Dan Larhammar Görel Sundström Christina A Bergqvist Cunming Duan Daniel Ocampo Daza PubMed Dan Larhammar Görel Sundström Christina A Bergqvist Cunming Duan Daniel Ocampo Daza Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.