The present study was conducted to know the effects of combined exercise on inflammatory markers and hormones relevant to obesity. Obese middle aged women(age: 46.4±6, BMI: 33.1±2.9, %Fat: 33.5±3.5) had done yoga for stretching, running for aerobic exercise(55‐65 %VO2max for first 1‐6 weeks and 66‐75 %VO2max for later 7‐12 weeks), and dumbbell exercise for resistant exercise(55‐65 %1RM for first 1‐6 weeks and 66‐75 %1RM for later 7‐12 weeks) for a hour per exercise, differently progressed by the day in every week. Blood plasma was extracted at the beginning of exercise, 6 weeks after beginning exercise, and 12 weeks after beginning exercise to analyse inflammatory markers(CRP, TNF‐α), obesity‐related hormones(leptin, adiponectin). One‐way ANOVA was used for data analysis. CRP, TNF‐α decreased at 12 weeks after beginning exercise, comparing to that at the beginning of exercise, but were not statistically significant. Leptin decreased and Adiponectin increased statistically significantly at 12 weeks after beginning exercise, comparing to those at the beginning of exercise(p<.05). Therefore, the combined exercise may be the preventive action against vascular diseases.