Dual-network Hydrogel Research Articles

Multiresponsive Microcapsules for Prevention of Intrauterine Adhesion.

Intrauterine adhesion (IUA) has a significant negative impact on women's reproductive health. One of the development trends of biomaterials for prevention of IUA is improving the stability and multifaceted functions. Here, we propose a multiresponsive microcapsule (A/G-Fe3O4-Se) with an alginate (ALG) and gelatin methacryloyl (GelMA) dual-network hydrogel shell loaded with magnetic nanoparticles (Fe3O4-Se) and an ultrasound-responsive decafluoropentane core for the prevention of IUA using a microfluidic technique. The microcapsules inherited the biofriendly advantages of ALG and GelMA. The encapsulated magneto-responsive Fe3O4-Se made the microcapsule flexibly change the distribution to adapt to the irregular shape of the uterus and better exert the therapeutic effect. Besides, the A/G-Fe3O4-Se microcapsules demonstrated antioxidant, antibacterial, and pro-healing properties in vitro. Moreover, in the IUA rat models, we also observed a reduction in oxidative stress, better endometrial regeneration, and improved endometrial receptivity and pregnancy rates after treatment of the microcapsules. Consequently, the A/G-Fe3O4-Se microcapsules can be used as a promising strategy for the treatment of damaged endometrium as well as prevention of IUA.

An Amidoxime-functionalized chitosan dual-network hydrogel: Enhanced uranium-water separation capacity.

The source and after treatment of uranium, a key aspect of its use as a nuclear fuel, had been a topic of intense debate among developers. Therefore, a novel antimicrobial amidoxime-functionalized chitosan/polyacrylamide dual network hydrogel (CP-AO) had been developed utilizing a straightforward methodology. The results demonstrated excellent adsorption capacity and selectivity for uranium extraction under varying conditions, the U(VI) removal was above 94 % when pH was 4. Batch adsorption experiments revealed that CP-AO attained a maximum uranium adsorption capacity of 886.73 mg/g at 298 K, which was higher than most reported adsorbents. The kinetic and thermodynamic studies presented that adsorption process for CP-AO conformed to spontaneous monolayer chem-adsorption, and it can reach equilibrium quickly within 120 min. In addition, the adsorption mechanism revealed that the chemical-interaction between CP-AO hydrogel and U(VI) was attributed to -OH, -NH2 and amidoxime group. Notably, the hydrogel showed optimistic anti-biosludge performance against three common bacteria (E. coli, S. aureus and B. subtilis) owing to effects of chitosan. CP-AO also especially was susceptible to be recycled, its adsorption capacity was 2.8 mg/g and 38.67 mg/g in simulated and actual seawater, respectively. Hence, this work provides a promising material for the extraction of uranium resources and new insights.

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.

Circadian rhythm disruption, commonly caused by factors such as jet lag and shift work, is increasingly recognized as a critical factor impairing wound healing. Although melatonin is known to regulate circadian rhythms and has potential in wound repair, its clinical application is limited by low bioavailability. To address these challenges, we developed an alginate-based dual-network hydrogel as a delivery system for melatonin, ensuring its stable and sustained release at the wound site. This approach enhances the efficacy of melatonin in modulating the wound healing process. We investigated the effects of circadian rhythm disruption on the wound microenvironment under the influence of the melatonin-loaded hydrogel with a focus on its biocompatibility, hemostatic properties, and antioxidant response functions. Additionally, we elucidated the mechanisms by which the melatonin-loaded hydrogel system promotes wound healing. Our findings provide insights into the relationship between circadian rhythm disruption and wound healing, offering a promising strategy for the management of chronic wounds associated with circadian rhythm disorders.

A drug-carrying composite hydrogel with pH sensitivity for bone tissue engineering

Many tissue engineering materials have been developed in response to the need for cartilage repair surgery so far, but the complication regarding implant-induced infections remains one of the most challenging problems. Hydrogel is an excellent candidate for biomedical applications due to its biocompatibility, absorption capacity, and tunable mechanical properties. How to design the hydrogel as tissue engineering materials to achieve the task of repairing cartilage and avoiding the complication arouses wide interest. In this work, a new pH-responsive dual network hydrogel of immobilizing hydroxyapatite (HA) is synthesized to control anti-inflammatory drug release. The hydroxyethyl methacrylate (HEMA) is coupled with HA, and the radical polymerization of HEMA-HA with acrylic acid (AA) is carried out in a polyvinyl alcohol (PVA) solution to form a dual-network composite hydrogel. When the mass ratio of AA to HEMA-HA is 30/1, the hydrogel shows a porous honeycomb structure and resistance to water loss. In particular, the volume of the hydrogel can well respond to the pH change in the solution. The tensile strength and elongation at break reach 333±9.32 KPa and 278±13.89%, respectively, exhibiting resistance to tensile fatigue. The hydrogel possesses good bioactivity. It can serve for drug delivery, and the drug release rate is 51.35±2.39% at 48h. The work opens a window to design specific hydrogel for tissue engineering.

Construction of strontium-loaded injectable lubricating hydrogel and its role in promoting repair of cartilage defects.

Injuries such as articular cartilage defects are prevalent factors in the development and progression of joint diseases. The discontinuity of the articular surface due to cartilage defects significantly accelerates the onset of arthritis. Cartilage tissue-engineered scaffolds are essential for restoring the continuity of the articular surface. This study presents a dual-network hydrogel, GelMA-FT/Sr2+, which demonstrates excellent lubrication properties and accelerates the healing of cartilage defects. The hydrogel is composed of a methacrylated gelatin (GelMA) network, an N-fluorenylmethoxycarbonyl-L-tryptophan (FT) network, and strontium ions (Sr2+). The results indicate that the hydrogel exhibits lubricating properties, and the incorporation of Sr2+ extends the degradation time of the hydrogel. Additionally, the hydrogel shows biocompatibility and enhances chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into cartilage. In vivo studies further confirm the hydrogel's efficacy in promoting the repair of cartilage defects in a rat model of cartilage injury. In conclusion, the GelMA-FT/Sr2+ hydrogel is a promising scaffold for cartilage tissue engineering, notable for its excellent lubrication properties, ability to recruit stem cells, and effectiveness in facilitating cartilage defect repair.

Thermosensitive, injectable, antibacterial glabridin liposome/chitosan dual network hydrogel for diabetic wound healing.

Thermosensitive hydrogels show great potential in healing diabetic wounds, but they are still challenged by the long healing time, risk of infectivity, and accumulation of melanin. Herein, a dual network hydrogel is designed, which consists of chlorogenic acid (CA) modified chitosan (CS) (CA@CS), poly(N-isopropylacrylamide) (PNIPAm), and glabridin liposomes (GL). The gelation transition temperature of the hydrogel is 32-34°C, which thus endows it with superior injectability at ambient temperature. Moreover, GL/PNIPAm/CA@CS also exhibits excellent biocompatibility, and can promote the growth of epidermal cells, and the healing of diabetic wounds. GL/PNIPAm/CA@CS can also control the immune reactions by enhancing the release of CD206, and decreasing the formation of CD86 and ROS, which further promotes the production of CD31 and VEGF, and reduces the expression of pro-inflammatory factors, thus aiding in the healing of diabetic wounds. Furthermore, GL/PNIPAm/CA@CS can also suppress the growth bacterial, which can thus decrease the wound microbiota levels and facilitate the recovery of diabetic wounds. More importantly, it can reduce melanin production by 80% due to the action of glabridin. Consequently, GL/PNIPAm/CA@CS shows significant promise in enhancing the wound healing in future and decreasing the accumulation of melanin.

Silicon-Enhanced PVA Hydrogels in Flexible Sensors: Mechanism, Applications, and Recycling.

Hydrogels, known for their outstanding water absorption, flexibility, and biocompatibility, have been widely utilized in various fields. Nevertheless, their application is still limited by their relatively low mechanical performance. This study has successfully developed a dual-network hydrogel with exceptional mechanical properties by embedding amino-functionalized polysiloxane (APSi) networks into a polyvinyl alcohol (PVA) matrix. This hydrogel effectively dissipates energy through dense sacrificial bonds between the networks, allowing for precise control over its tensile strength (ranging from 0.07 to 1.46 MPa) and toughness (from 0.06 to 2.17 MJ/m3) by adjusting the degree of crosslinking in the polysiloxane network. Additionally, the hydrogel exhibits excellent conductivity (10.97 S/cm) and strain sensitivity (GF = 1.43), indicating its potential for use in wearable strain sensors. Moreover, at the end of its life (EOL), the sensor waste can be repurposed as an adsorbent material for metal ions in water treatment, achieving the recycling of hydrogel materials and maximizing resource utilization.

A slime-inspired phycocyanin/κ-carrageenan-based hydrogel bandage with ultra-stretchability, self-healing, antioxidative, and antibacterial activity for wound healing.

Hydrogels have attracted extensive attention as wound dressing owing to their excellent multifunctionality, flexibility, and biocompatibility. Due to the frequent movement and stretching of skin as well as complex surface of wound, traditional wound dressings have difficulty to adapt to motion and irregular wounds. Furthermore, excessive reactive oxygen species (ROS) and bacterial infection can induce delayed wound healing. To this end, we developed a set of versatile phycocyanin-based dual network hydrogels (PPC hydrogels) with polyvinyl alcohol (PVA) and κ-carrageenan (CRG) as substrate via forming of borate ester bonds, hydrogen bonds, and electrostatic interaction. The PPC hydrogels not only possessed adaptivity, ultra-stretchability (7036.12%), efficient self-healing and injectability, but also possessed antioxidative and antibacterial capacities conferred by C-phycocyanin (PC) and rhein. Moreover, the hydrogels also exhibited excellent hemostatic ability and high biocompatibility. More remarkably, the PPC-I hydrogel could accelerate wound healing by effect of anti-inflammation (downregulating TNF-α and IL-6) and promoting collagen deposition and angiogenesis (upregulating CD31), which may be utilized as hydrogel bandages and applied to motion and irregular wounds, thereby promising the application prospect of the hydrogels as wound dressing.

Modulation of gel characteristics in surimi-curdlan gel system by different valence metal cations: Mechanical properties, ionic distribution and microstructure visualization.

The valence state of metal cations is a potential factor in regulating the structural properties of surimi gels. In this study, Surimi-Curdlan dual network (SCDN) gel was prepared by NaCl, KCl, CaCl2, and MgCl2, combined with the concept of dual network hydrogel. The effects of different valence metal cations on mechanical properties, water state, microstructure, protein structure and composition of SCDN gel were studied. The results showed that the monovalent metal cations conferred higher G' and G" to the SCDN gel and promoted the unfolding of the α-helix structure in the proteins, providing more binding sites for adequate binding of protein and curdlan. It also increased the compatibility of proteins and curdlan, forming a regular and tight three-dimensional network structure. The monovalent metal cations enhanced the gel's mechanical properties such as strength and hardness, and retained more water through the net-trapping effect. However, the divalent metal cation-mediated SCDN gels had low G' and G", inadequate unfolding of the protein secondary structure and the aggregates formed by each of them were dispersed in the gel system, resulting in an inhomogeneous gel structure and texture. This structural feature reduced water retention and gel strength. After comprehensive comparative analysis, K+ has the potential to replace Na+ in preparing SCDN gel. This study provides some insights into the development of sodium alternatives for the surimi gel industry.

Robust and low swelling polyacrylamide/sodium alginate dual-network hydrogels via multiple freezing strategy toward amphibious motion sensors

The swelling and disintegration behavior of conventional hydrogels in liquid environments significantly affects their mechanical and ionic conductive properties, thereby limiting their widespread application in underwater setting. Herein, we propose a multiple freezing (MF) strategy for the construction of polyacrylamide/sodium alginate (PAM/SA) dual-network hydrogels that exhibit excellent anti-swelling properties and high toughness. The MF strategy employs a combination of freeze casting and refreezing to promote a cascading enhancement of polymer network density, resulting in a highly dense polymer network. This dense network structure endows the hydrogel with impressive tensile strength (3.491 MPa), exceptional elongation at break (435.71 %), and high toughness (5.291 MJ m⁻3), along with remarkable ionic conductivity (142.75 mS m⁻1) and sensitivity (GF = 2.278). These properties enable the hydrogel to function as a flexible sensor capable of detecting various human movement patterns. Its excellent resistance to swelling makes it an ideal material for underwater sensors, effectively monitoring different swimming strokes. This strategy provides a straightforward and effective means to enhance the mechanical strength and adaptability of traditional hydrogels in aquatic environments, demonstrating significant potential for applications in underwater sensing.

An antifouling electrochemical biosensor based on chitosan and DNA dual-network hydrogel for ATP quantification in complex biofluids

Adenosine triphosphate (ATP) plays a crucial role in energy conduction, cellular respiration, and signal transduction, and its level is highly related to the human health status. However, the detection of ATP in complex biological fluids such as serum with electrochemical sensors remains a great challenge due to the severe biofouling. Inspiring by the layered micro-nano structures of biological surfaces such as rose petal and water strider, we herein construct a robust electrochemical biosensor for ATP assaying in human serum based on a composite hydrogel with a network microstructure. Chitosan hydrogel and DNA hydrogel were combined to form a dual network structure and modified on the electrode surface, which can effectively enlarge the surface area and hydrophilicity of the modified electrode surface. Meanwhile, abundant aptamers were immobilized on the porous hydrogel surface to specifically recognize ATP molecules. The electrochemical biosensor possessed ATP recognition and antifouling capability, and it exhibited a linear range from 0.1 pM to 1 μM for ATP detection, with a remarkably low limit of detection of 0.033 pM. Moreover, the biosensor was capable of determining ATP levels in human sera and cell lysates with satisfying accuracy comparable to the ELISA kits. This strategy for antifouling biosensor construction holds great potential for biomarker detection in complex biofluids and clinical diagnosis.

Novel high-strength, recyclable, microbial-resistant, and freeze-thaw dual topological network hydrogel cooling media

The demand for multifunctional hydrogels, offering high mechanical strength, efficient cooling, and antimicrobial properties, is growing in food preservation. Here, a dual-network (DN) hydrogel PM@Cur, which includes curcumin, is fabricated through chemical crosslinking and hydrogen bonding interactions. The resulting hydrogels can withstand more than five freeze-thaw cycles at −80 °C, and resist brittleness after liquid nitrogen treatment. PM@Cur also exhibits surface hydrophobicity (contact angle >90°) for both water and organic solvents. These properties meet the mechanical, anti-fouling, and recyclable demands for hydrogel coolants. The antimicrobial assays in vitro confirmed that the inclusion of curcumin provided the PM@Cur with photodynamic antimicrobial capacity. Finally, the prepared PM@Cur hydrogel ice cubes have been confirmed to exhibit better anti-melting properties than traditional ice cubes, thus enabling the preservation of strawberries and shrimp. This study presents an innovative solution for producing advanced functional integrated hydrogels, offering a promising and safer option for food coolants.\\.

Rapid photochromism and water-driven ultra-fast fading of cellulose-based composite hydrogels enabled by sodium tungstate

The potential ability of photochromic hydrogel as smart response material is determined by its coloration and fading speed. However, it is still a huge challenge to improve both the coloration and fading speed simultaneously. This paper presents the successful development of robust hydrogels with fast photoresponse and water-driven ultra-fast fading speed through the implementation of a dual-network preparation strategy. In the dual-network hydrogel, sodium tungstate contributed to its discoloration and crosslink. The obtained hydrogel exhibited fast photochromic response within 20 s under visible light irradiation. In addition, the photochromic response was achieved in 30 s under actual sunlight irradiation. Particularly, rapid fading of photochromic hydrogels was achieved by applying deionized water while leaving it naturally for 90 s. Furthermore, the simulated house experiments showed that the use of this hydrogel as smart glass could decrease the indoor temperature by about 5 °C. The photochromic hydrogel in this paper possesses excellent reversible repeatability, flexibility and foldability, and it exhibits promising potential for use in flexible information storage devices, visual displays and artificial intelligence systems, smart windows and other applications.

Self-Powered Machine-Learning-Assisted Material Identification Enabled by a Thermogalvanic Dual-Network Hydrogel with a High Thermopower.

Wearable devices equipped with high-performance flexible sensors that can identify diverse physical information free from batteries are playing an indispensable role in various fields. However, previous studies on flexible sensors have primarily focused on their elasticity and temperature-sensing capability, with few reports on material identification. In this paper, a thermogalvanic dual-network hydrogel is fabricated with [Fe(CN)6]3-/4- as a redox couple and lithium magnesium silicate, Gdm+ and lithium bromideas key electrolytes to optimize the interconnected porous structure of the gel, which shows excellent mechanical and thermoelectric properties with a thermopower as high as 4.01mV K-1. A self-powered material identification ring is developed based on the temperature-triggered thermoelectric response of the gel in conjunction with machine learning, which can actively infer materials without an external power connection by analyzing the voltage signals correlated with interfacial heat transfer produced upon contact with different materials. The proposed gel ring has important applications for future areas such as human-computer interaction and haptic-associated artificial intelligence.

Carbon nanotube reinforced ionic liquid dual network conductive hydrogels: Leveraging the potential of biomacromolecule sodium alginate for flexible strain sensors

The rapid evolution of multifunctional wearable smart devices has significantly expanded their applications in human-computer interaction and motion health monitoring. Central to these devices are flexible sensors, which require high stretchability, durability, self-adhesion, and sensitivity. Biomacromolecules have attracted attention in sensor design for their biocompatibility, biodegradability, and unique mechanical properties. This study employs a “one-pot” method to integrate ionic liquids and multi-walled carbon nanotubes into a dual-network hydrogel framework, utilizing tannic acid, sodium alginate, acrylamide, and 2-acrylamido-2-methylpropane sulfonic acid. Tannic acid and sodium alginate, natural biomacromolecules, form a robust physical cross-linking network, while P(AM-AMPS) creates a chemical cross-linking network. Ionic liquids enhance carbon nanotube dispersion, resulting in a hybrid hydrogel with remarkable tensile strength (0.12 MPa), adhesive properties (0.039 MPa), and sensing performance (GF 0.12 for 40 %–100 % strain, GF 0.24 for 100 %–250 % strain). This hydrogel effectively monitors large joint movements (fingers, wrists, knees) and subtle biological activities like swallowing and vocalization. Integrating natural biomacromolecules into this composite hydrogel sensor not only enhances the functionality and biocompatibility of flexible wearable devices but also paves the way for innovations in biomedicine and bioelectronics.

Tough, self-healing, and freeze-resistant composite dual-network hydrogels for the decontamination of surface uranium (Ⅵ)

Hydrogels have attracted widespread attention in the field of surface radioactivity decontamination due to their mild and rapid decontamination processes, as well as their tunable properties. However, fabricating decontamination hydrogels with suitable mechanical properties and environmental adaptability remains challenging. In this study, a tough and freeze-resistant hydrogel (PEAG) was prepared based on graphene oxide (GO), polyvinyl alcohol (PVA), agar (AG), and ethylene glycol (EG) for efficient removal of surface radioactive uranium (VI). Due to the dynamic action of borax and the formation of a nanocomposite dual-network structure, PEAG possesses improved modulus and excellent self-healing properties, allowing the hydrogel to be easily applied to surfaces and to perform operations such as stretching and peeling. In addition, it is found that the PEAG achieves excellent decontamination rates for radioactive uranium (VI) on glass (88.53±1.43 %), stainless steel (86.72±3.41 %), rubber (67.0±2.43 %), ceramics (82.39±1.78 %), and cement (64.52±1.72 %) surfaces, respectively. XPS and contact angle experiments demonstrated that the improved decontamination performance of PEAG is mainly due to the abundant hydroxyl and carbonyl functional groups in the graphene oxide adsorbent, which provide a rich source of complexation sites and enhance its hydrophilic properties for PEAG. Additionally, due to the incorporation of EG, the PEAG hydrogel exhibits good environmental adaptability, which can retain internal moisture and maintain softness and decontamination stability at low temperatures of −20°C. Therefore, PEAG hydrogel is a promising and sustainable candidate material for various surface radioactive decontamination scenarios.

Construction and Performance Study of an Injectable Dual-Network Hydrogel Dressing with Inherent Drainage Function.

With the widespread utilization of moist wound dressings, the extended healing time and increased risk of wound infection caused by excessively moist environments have garnered significant attention. The development of hydrogel dressings that can effectively control the wound moisture level and promote healing is very important. Inspired by the pore-opening perspiration effect of the skin, this study constructed an injectable dual-network hydrogel, CMCS-OSA/AG/MXene, by the composition of a dynamic covalent network of carboxymethyl chitosan and oxidized sodium alginate based on the Schiff base and hydrogen bond network of the thermosensitive low-melting-point agar with the advantage of the upper critical solution temperature (UCST) effect. Under near-infrared (NIR) light stimulation, the CMCS-OSA/AG/MXene hydrogel shows characteristics conducive to rapid removal of wound exudate while maintaining an appropriate moist environment for the wound and excellent antibacterial effects with its photothermal responses. The excellent conductivity of the hydrogel can also promote cell proliferation under external electrical stimulation (ES). Further validation through animal experiments on a full-thickness skin defect model demonstrates the excellent capability of CMCS-OSA/AG/MXene in accelerating wound healing. This work provides an innovative approach to the development of injectable hydrogel dressing materials with inherent drainage functionality and shows a new avenue to wound moisture control and wound healing promotion.

Preparation and characterization of functional dual network hydrogel for motion monitoring in smart bra

The smart bra is a kind of sports underwear with providing health monitoring and comfort protection for women breast in sports. Developing smart sensing materials that combine comfort and functionality for sensing breast condition remains a challenge. Here, natural polysaccharide sodium alginate (SA), acrylamide (AM) monomer and chitosan (CS) and polypyrrole (PPy) in-situ polymerized from pyrole (Py) monomer were used as raw materials to successfully synthesize double network conductive hydrogel by two-step method. The results show that in the hydrogels, the entanglement and interpenetration of macromolecules produce toughness (tensile/compressive strength is ∼0.248 MPa/∼2.836 MPa), elasticity (tensile/compression elastic recovery rate is∼94.06 %/∼98.41 %) and durability (after 30 tensile/compression cycles conducting at 25 %, 50 % and 100 % constant strain keep at high recovery rate). The rich moisture content provides its adhesion (adhesion strength ∼4.7557 kPa) and flexibility (bending stiffness 1.0843 cN cm∼), presenting sufficient adhesion reliability and robustness to different substrates. The addition of PPy enables the hydrogel to have conductivity (6.77 × 10−2 S cm−1) and sensing performance (tensile/compression sensitivity is ∼1.94/∼1.43). The conductive hydrogel, as a flexible strain sensor, shows good adhesion, flexibility, elasticity and sensitivity in application of sports smart bra, can detect both the tensile behavior of skin and the compression state of tissue through its mechano-electricity, and accurately sense the changes of physiological parameters during movement. The conductive hydrogel with high elasticity and strength has broad application prospects in smart bra.

In situ photocrosslinkable hydrogel treats radiation-induced skin injury by ROS elimination and inflammation regulation

The clinical management of radiation-induced skin injury (RSI) poses a significant challenge, primarily due to the acute damage caused by an overabundance of reactive oxygen species (ROS) and the ongoing inflammatory microenvironment. Here, we designed a dual-network hydrogel composed of 5 % (w/v) Pluronic F127 diacrylate and 2 % (w/v) hyaluronic acid methacryloyl, termed the FH hydrogel. To confer antioxidant and anti-inflammation properties to the hydrogel, we incorporated PVP-modified Prussian blue nanoparticles (PPBs) and resveratrol (Res) to form PHF@Res hydrogels. PHF@Res hydrogels not only exhibited multiple free radical scavenging activities (DPPH, ABTS), but also displayed multiple enzyme-like activities (POD-, catalase). Meanwhile, PHF@Res-2 hydrogels significantly suppressed intracellular ROS and promoted the migration of fibroblasts in a high-oxidative stress environment. Moreover, in the RSI mouse model, the PHF@Res-2 hydrogel regulated inflammatory factors and collagen deposition, significantly reduced epithelial hyperplasia, promoted limb regeneration and neovascularization, and accelerated wound healing, outperforming the commercial antiradiation formulation, Kangfuxin. The PHF@Res-2 hydrogel dressing shows great potential in accelerating wound healing in RSI, offering tremendous promise for clinical wound management and regeneration.

Preparation of a chitosan/polyvinyl alcohol-based dual-network hydrogel for use as a potential wound-healing material for the sustainable release of drugs

Treating chronic wounds poses significant challenges in clinical medicine due to bacterial infection, reactive oxygen species (ROS) accumulation, and excessive inflammation. This study aimed to address these issues by developing a wound dressing with antibacterial, antioxidant, and anti-inflammatory properties. Chitosan was functionally modified with acrolein to covalently bind to epigallocatechin gallate (EGCG), enabling a high EGCG load. Subsequently, polyvinyl alcohol (PVA) and EGCG-modified chitosan were crosslinked to prepare a new double-network hydrogel with added cysteine (CSAEC/P50). CSAEC/P50 demonstrated optimal mechanical properties (low swelling rate, high water retention, and optimal flexibility), low hemolysis, high coagulation properties, and antibacterial and antioxidant activities. Cell scratch tests indicated that CSAEC/P50 can promote NIH3T3 cell migration. Immunofluorescence results showed that CSAEC/P50 promoted the transformation of proinflammatory M1 macrophages to anti-inflammatory M2 macrophages. These findings suggest that CSAEC/P50 has significant potential for use in wound dressing applications.