Abstract We study Le Potier’s strange duality conjecture on a rational surface. We focus on the strange duality map $SD_{c_n^r,L}$ that involves the moduli space of rank $r$ sheaves with trivial 1st Chern class and 2nd Chern class $n$, and the moduli space of one-dimensional sheaves with determinant $L$ and Euler characteristic 0. We show there is an exact sequence relating the map $SD_{c_r^r,L}$ to $SD_{c^{r-1}_{r},L}$ and $SD_{c_r^r,L\otimes K_X}$ for all $r\geq 1$ under some conditions on $X$ and $L$ that applies to a large number of cases on $\mathbb{P}^2$ or Hirzebruch surfaces. Also on $\mathbb{P}^2$ we show that for any $r>0$, $SD_{c^r_r,dH}$ is an isomorphism for $d=1,2$, injective for $d=3,$ and moreover $SD_{c_3^3,rH}$ and $SD_{c_3^2,rH}$ are injective. At the end we prove that the map $SD_{c_n^2,L}$ ($n\geq 2$) is an isomorphism for $X=\mathbb{P}^2$ or Fano rational-ruled surfaces and $g_L=3$, and hence so is $SD_{c_3^3,L}$ as a corollary of our main result.