Dual System Approach Research Articles

Brain Tumor Detection and Classification using YOLOv10 and AI Chatbot Using LLMs

The integration of advanced medical imaging techniques and artificial intelligence (AI) has greatly improved the early detection and diagnosis of brain tumors. This paper introduces a novel system for brain tumor detection and classification using the YOLOv10 (You Only Look Once) model, enhanced by an AI chatbot powered by Large Language Models (LLMs). Leveraging the real-time object detection capabilities of YOLOv10, the system accurately classifies brain tumors from MRI images into four categories: Glioma, Meningioma, Pituitary, and No Tumor. This deep learning-based approach ensures swift and precise analysis of complex medical images. In addition, an AI chatbot is integrated to provide seamless interaction and information retrieval for both patients and healthcare professionals. Utilizing LLMs, the chatbot offers advanced conversational abilities, delivering detailed explanations about tumor types, potential treatments, and further medical advice based on the detected tumor characteristics. This dual-system approach aims to enhance diagnostic accuracy while providing real-time, accessible support, ultimately improving decision-making for medical practitioners and enhancing patient outcomes. The proposed system exemplifies the synergy between cutting-edge AI technologies and medical diagnostics, showcasing the potential to revolutionize patient care.

Habits and the subexploration of better transportation options: A dual-system approach

In psychology, choices are influenced by either goal-directed or habitual systems, which are represented by model-based (MB) and model-free (MF) reinforcement learning algorithms. This paper introduces these concepts into the transportation literature and shows that individuals with habitual tendencies often fail to consider new, potentially superior, alternatives. Across two experiments, participants chose between two bus options, with a third, objectively superior option introduced in a later phase. In both experiments, participants engaging in habitual behavior were less likely to explore the new alternative. Furthermore, we found habitual tendencies were moderated by self-reported stress levels, which is consistent with previous results in the psychological literature. This implies that new transportation modes or routes may remain underused as travelers adhere to habitual patterns, disregarding the introduction of potentially better alternatives, and prompt for public policies that aim to promote goal-directed behavior.

A review of antibody, aptamer, and nanomaterials synergistic systems for an amplified electrochemical signal.

The synergy between biomolecules with inorganic nanomaterials and nanoparticles has been investigated over the past years, primarily to improve biomarker reception, generate signals, and amplify the signals generated. In this paper, several articles on aptamer-based and antibody-based electrochemical biosensors that target antigens were examined. Among the key characteristics identified were the electrochemical platform development, which includes the usage of nanomaterials as electroactive or electrocatalytic labels, crosslinking of the biological agent with inorganic compounds, and electrode coating to provide an electronic source and support efficient electron transfer. A single approach using labeled or unlabeled biological receptors has become advantageous due to its simple architecture and more straightforward application method. However, the dual system approach allows the incorporation of more nanomaterials to boost the signal and add more features to the electrochemical system. The dual system approach uses a capture and reporter probe in a competitive or sandwich detection format. The reporter probe is often labeled by an electroactive or electrocatalytic compound or immobilized in a nanocarrier, resulting in an increase in measured peak current in proportion to the target's concentration. The reported limit of detection and linear range for each platform is presented to assess its efficiency. Generally, the dual system aptasensor showed higher sensitivity, stability, and reproducibility than the immunosensor in comparable settings. The aptasensor showed promising results for the development of point-of-care type applications.

On the finite-time stability and stabilisation of LTI systems via an S-variable approach

This paper deals with the finite-time boundedness (FTB) of linear time-invariant systems that are affected by a disturbance generated by an exosystem. By using a time-invariant quadratic Lyapunov function, Finsler's lemma and a dual system approach, new sufficient linear matrix inequalities (LMIs) conditions are given for analysis and synthesis for FTB. These results are extended: first, to finite-time stability (FTS) of linear time-invariant systems, second, to their input–output FTS associated, or not, to FTB. All the conditions are given in terms of LMIs, which make them easily tractable. Finally, the computational efficiency and the conservatism reduction of our approach are illustrated through an illustrative example.

The dual-system approach is a useful heuristic but does not accurately describe behavior.

We argue that the dual-system approach and, particularly, the default-interventionist framework favored by De Neys unnecessarily constrains process models, limiting their range of application. In turn, the accommodations De Neys makes for these constraints raise questions of parsimony and falsifiability. We conclude that the extent to which processes possess features of system 1 versus system 2 must be tested empirically.

A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity.

Impulsivity generally refers to a deficit in inhibition, with a focus on understanding the neural circuits which constitute the “brake” on actions and gratification. It is likely that increased impulsivity can arise not only from reduced inhibition, but also from a heightened or exaggerated excitatory “drive.” For example, an action which has more vigor, or is fueled by either increased incentive salience or a stronger action-outcome association, may be harder to inhibit. From this perspective, this review focuses on impulse control as a competition over behavioral output between an initially learned response-reward outcome association, and a subsequently acquired opposing inhibitory association. Our goal is to present a synthesis of research from humans and animal models that supports this dual-systems approach to understanding the behavioral and neural substrates that contribute to impulsivity, with a focus on the neuromodulatory role of serotonin. We review evidence for the role of serotonin signaling in mediating the balance of the “drive” and “brake” circuits. Additionally, we consider parallels of these competing instrumental systems in impulsivity within classical conditioning processes (e.g., extinction) in order to point us to potential behavioral and neural mechanisms that may modulate the competing instrumental associations. Finally, we consider how the balance of these competing associations might contribute to, or be extracted from, our experimental assessments of impulsivity. A careful understanding of the underlying behavioral and circuit level contributions to impulsivity is important for understanding the pathogenesis of increased impulsivity present in a number of psychiatric disorders. Pathological levels of impulsivity in such disorders are likely subserved by deficits in the balance of motivational and inhibitory processes.

Fishnition: Developing Models From Cognition Toward Consciousness.

A challenge to developing a model for testing animal consciousness is the pull of opposite intuitions. On one extreme, the anthropocentric view holds that consciousness is a highly sophisticated capacity involving self-reflection and conceptual categorization that is almost certainly exclusive to humans. At the opposite extreme, an anthropomorphic view attributes consciousness broadly to any behavior that involves sensory responsiveness. Yet human experience and observation of diverse species suggest that the most plausible case is that consciousness functions between these poles. In exploring the middle ground, we discuss the pros and cons of “high level” approaches such as the dual systems approach. According to this model, System 1 can be thought of as unconscious; processing is fast, automatic, associative, heuristic, parallel, contextual, and likely to be conserved across species. Consciousness is associated with System 2 processing that is slow, effortful, rule-based, serial, abstract, and exclusively human. An advantage of this model is the clear contrast between heuristic and decision-based responses, but it fails to include contextual decision-making in novel conditions which falls in between these two categories. We also review a “low level” model involving trace conditioning, which is a trained response to the first of two paired stimuli separated by an interval. This model highlights the role of consciousness in maintaining a stimulus representation over a temporal span, though it overlooks the importance of attention in subserving and also disrupting trace conditioning in humans. Through a critical analysis of these two extremes, we will develop the case for flexible behavioral response to the stimulus environment as the best model for demonstrating animal consciousness. We discuss a methodology for gauging flexibility across a wide variety of species and offer a case study in spatial navigation to illustrate our proposal. Flexibility serves the evolutionary function of enabling the complex evaluation of changing conditions, where motivation is the basis for goal valuation, and attention selects task-relevant stimuli to aid decision-making processes. We situate this evolutionary function within the Temporal Representation Theory of consciousness, which proposes that consciousness represents the present moment in order to facilitate flexible action.

Satiety does not alter the ventral striatum's response to immediate reward in bulimia nervosa.

Individuals with bulimia nervosa (BN) cycle between periods of binge-eating and compensatory behavior and periods of dietary restraint, suggesting extremes of under and overcontrol that may be metabolic-state related. This study examined the influence of hunger and satiety on impulsivity and neural responding during decision-making. Twenty-three women remitted from BN (RBN) and 20 healthy comparison women (CW) performed a delay discounting task after a 16-hr fast and following a standardized meal during functional neuroimaging. A dual-systems approach examined reward valuation (decision trials where the early reward option was available immediately) and cognitive control (all decision trials). Interactions of Group × Visit (Hungry, Fed) for immediate reward revealed that CW had greater activation when hungry versus fed in the ventral striatum and dorsal caudate, whereas RBN had greater response when fed versus hungry in the dorsal caudate. Compared to CW, RBN showed decreased response when hungry within the left dorsal caudate and ventral striatum and increased response when fed in bilateral dorsal caudate. No differences were found within cognitive control regions or with choice behavior. Reward sensitivity is normally increased when hungry and decreased when fed; our findings in CW provide further support of hunger-based reward sensitivity within the striatum. However, RBN showed no differences for hunger and satiety in the ventral striatum and greater activation in the dorsal caudate when fed compared to hungry. This suggests RBN may be less sensitive to reward when hungry but do not devalue reward when satiated, indicating altered metabolic modulation of self-regulatory control. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Time Is Money: The Effect of Mode-of-Thought on Financial Decision-Making.

The dual-system approach holds that deliberative decisions and in-depth evaluation processes lead people to better financial decisions. However, research identifies situations where optimal economic decisions may stem from a more intuitive decision process. In the current work, we present three experimental studies that examined how these two modes-of-thought affect financial decisions. In Study 1, deliberative processes were indeed associated with better one-shot descriptive-based financial decisions. However, Study 2 showed that when participants were asked to make repeated decisions and were required to learn from their experience, the advantage of deliberative over intuitive processes was eliminated. In addition, when participants employed intuitive processes, the quality of their financial decisions improved significantly with experience. Finally, Study 3 showed that the deliberative processing style may lose its advantage when information is not fully available. Overall, these findings suggest that deliberation may contribute to financial decision-making in one-shot decisions. However, when information is lacking, and decisions are repetitive, intuitive processes might be just as good.

Physical activity after cardiac rehabilitation: Explicit and implicit attitudinal components and ambivalence.

Physical activity is crucial in the treatment of cardiac disease. In addition to sociocognitive theories of behavior change, attitudinal ambivalence and nonconscious factors have also been demonstrated to predict physical activity. We propose an extension to the theory of planned behavior with a dual-systems approach including explicit and implicit attitudes, and different types of attitudinal ambivalence as moderators to predict the physical activity of patients after discharge from inpatient cardiac rehabilitation.The sample comprised N = 111 cardiac patients who provided daily diary reports of intention, cognitive, affective, and implicit attitudes for 21 days after discharge (86% male, Mage = 62, SDage = 11, n = 2,017 days). Daily moderate-to-vigorous (MVPA) and light (LPA) physical activity were measured using accelerometers. Five types of ambivalence were calculated. Analyses included Bayesian multilevel modeling.Patients with more positive affective attitudes and more positive implicit attitudes had a higher intention. Higher ambivalence weakened the affective attitudes-intention relationship. On days with more positive implicit attitudes than usual, intention was lower, but only when ambivalence was low. Patients with higher ambivalence engaged in less MVPA. On days with extremely low ambivalence, implicit attitudes were negatively associated with tomorrow's MVPA. Patients with more positive affective attitudes engaged in more LPA, but only when their ambivalence was very low. On days with higher ambivalence than usual, the next day's LPA was shorter. However, another type of ambivalence showed the opposite effect.The results emphasize the importance of affective and implicit attitudes and ambivalence for the physical activity of cardiac patients. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Innovative dual system approach for selective eradication of cancer cells using viral-based delivery of natural bacterial toxin\u2013antitoxin system

The inactivation of p53, a tumor suppressor, and the activation of the RAS oncogene are the most frequent genetic alterations in cancer. We have shown that a unique E. coli MazF-MazE toxin–antitoxin (TA) system can be used for selective and effective eradication of RAS-mutated cancer cells. This out of the box strategy holds great promise for effective cancer treatment and management. We provide proof of concept for a novel platform to selectively eradicate cancer cells using an adenoviral delivery system based on the adjusted natural bacterial system. We generated adenoviral vectors carrying the mazF toxin (pAdEasy-Py4-SV40mP-mCherry-MazF) and the antitoxin mazE (pAdEasy-RGC-SV40mP-MazE-IRES-GFP) under the regulation of RAS and p53, resp. The control vector carries the toxin without the RAS-responsive element (pAdEasy-ΔPy4-SV40mP-mCherry-MazF). In vitro, the mazF-mazE TA system (Py4-SV40mP-mCherry-MazF+RGC-SV40mP-MazE-IRES-GFP) induced massive, dose-dependent cell death, at 69% compared to 19% for the control vector, in a co-infected HCT116 cell line. In vivo, the system caused significant tumor growth inhibition of HCT116 (KRASmut/p53mut) tumors at 73 and 65% compared to PBS and ΔPY4 control groups, resp. In addition, we demonstrate 65% tumor growth inhibition in HCT116 (KRASmut/p53wt) cells, compared to the other two control groups, indicating a contribution of the antitoxin in blocking system leakage in WT RAS cells. These data provide evidence of the feasibility of using mutations in the p53 and RAS pathway to efficiently kill cancer cells. The platform, through its combination of the antitoxin (mazE) with the toxin (mazF), provides effective protection of normal cells from basal low activity or leakage of mazF.

Evolutionary mechanisms of choice: Hayekian perspectives on neurophilosophical foundations of neuroeconomics

AbstractHayek’s seminal contribution to theoretical neurosciences,The Sensory Order(1952) remains neglected in current efforts at integrating the neurosciences, psychology and economics. I defend the view that Hayek presents the case for an evolutionary alternative to leading paradigms in the field and look at two in more detail: the good-based model in neuroeconomics and the dual systems approach in behavioural economics. In both cases, essential Hayekian insights remain valid in the context of modern neuroscience, allow for taking account of recent research, and sketch a dynamic and selectionist model of choice.

The Differential Relationship between Self-Control and Peer Influences over Time: Toward an Integrative Model of Offending Using a Dual-Systems Approach

The purpose of this study is to explore an alternative approach to unravel how both self-control and peer influence relate to offending. Deriving from a dual-systems framework, this study hypothesizes that individuals with varying levels of self-control will be differentially susceptible to the effects of both exposure to deviant peers and informal socializing with peers. Analyses are based on a sample of serious youthful offenders from the Pathways to Desistance Study. The results indicate that exposure to deviant peers has a stronger impact on offending for individuals with higher self-control, consistent with the hypothesis. However, individuals with higher self-control are more vulnerable to unstructured and unsupervised socializing with peers than those lower in self-control, which counters the hypothesis.

Gait and Knee Flexion In Vivo Kinematics of Asymmetric Tibial Polyethylene Geometry Cruciate Retaining Total Knee Arthroplasty.

The preservation of the posterior cruciate ligament in cruciate retaining (CR) total knee arthroplasty (TKA) designs has the potential to restore healthy knee biomechanics; however, concerns related to kinematic asymmetries during functional activities still exist in unilateral TKA patients. As there is a limited data available regarding the ability of the contemporary CR TKA design with concave medial and convex lateral tibial polyethylene bearing components to restore healthy knee biomechanics, this study aimed to investigate in vivo three-dimensional knee kinematics in CR TKA patients during strenuous knee flexion activities and gait. Using a combined computer tomography and dual fluoroscopic imaging system approach, in vivo kinematics of 15 unilateral CR TKA patients (comparison of replaced and contralateral nonreplaced knee) were evaluated during sit-to-stand, step-ups, single-leg deep lunge, and level walking. The patient cohort was followed-up at an average of 24.5 months ( ± 12.6, range 13-42) from surgical procedure. Significantly smaller internal knee rotation angles were observed for the contemporary CR TKA design during step-ups (2.6 ± 5.8 vs. 6.3 ± 6.6 degrees, p < 0.05) and gait (0.6 ± 4.6 vs. 6.3 ± 6.8 degrees, p < 0.05). Significantly larger proximal and anterior femoral translations were measured during sit-to-stand (34.7 ± 4.5 vs. 29.9 ± 3.1 mm, p < 0.05; -2.5 ± 2.9 vs. -8.1 ± 4.4 mm, p < 0.05) and step-ups (34.1 ± 4.5 vs. 30.8 ± 2.9 mm, p < 0.05; 2.2 ± 3.2 vs. -3.5 ± 4.5 mm, p < 0.05). Significantly smaller ranges of varus/valgus and internal/external rotation range of motion were observed for CR TKA, when compared with the nonoperated nee, during strenuous activities and gait. The preservation of the posterior cruciate ligament in the contemporary asymmetric bearing geometry CR TKA design with concave medial and convex lateral tibial polyethylene bearing components has the potential to restore healthy knee biomechanics; however, the study findings demonstrate that native knee kinematics were not fully restored in patients with unilateral asymmetric tibial polyethylene bearing geometry CR TKA during functional activities.

Improving robot dual-system motor learning with intrinsically motivated meta-control and latent-space experience imagination

Combining model-based and model-free learning systems has been shown to improve the sample efficiency of learning to perform complex robotic tasks. However, dual-system approaches fail to consider the reliability of the learned model when it is applied to make multiple-step predictions, resulting in a compounding of prediction errors and performance degradation. In this paper, we present a novel dual-system motor learning approach where a meta-controller arbitrates online between model-based and model-free decisions based on an estimate of the local reliability of the learned model. The reliability estimate is used in computing an intrinsic feedback signal, encouraging actions that lead to data that improves the model. Our approach also integrates arbitration with imagination where a learned latent-space model generates imagined experiences, based on its local reliability, to be used as additional training data. We evaluate our approach against baseline and state-of-the-art methods on learning vision-based robotic grasping in simulation and real world. The results show that our approach outperforms the compared methods and learns near-optimal grasping policies in dense- and sparse-reward environments.

Traditional Students as Second Class Citizens through Modern Day Tracking

We used a qualitative case study approach to examine the schooling experiences of 40 current high school seniors and 20 alumni from an urban STEAM career academy comprised of 98% African American students from low-income families. Using tracking as a theoretical lens, we found that students in the high school STEAM career academy were stratified using a more modern, dual system approach - and were labeled as traditional and college preparatory. These schooling practices led to the traditional tracked students being treated as second class citizens as well as being denied access to high-quality curricula to prepare them to be college and career ready. Based on our findings, we recommend that school personnel customize curricula based on the interests of students and enable them all to participate in college preparatory activities as well as work-based learning experiences.

The Role of Plausibility in the Experience of Spatial Presence in Virtual Environments

In the present study, we examine the effect of plausibility violations in a virtual environment (VE) on spatial presence. After reviewing research on the association between plausibility and spatial presence, we present a dual-systems approach to understanding the effect of plausibility (or violations thereof) on spatial presence. We conceptualize the feeling of being present in a VE as a lower-order cognitive process. Perceptions of plausibility violations might represent higher-order cognitive processes that could interfere with spatial presence. We present data from an experimental study in which we manipulated the external consistency (i.e., the plausibility) of the VE, cognitive load (to interfere with higher-order cognitive processes), and immersion to examine its effect on spatial presence. Results show that immersion was the most important factor driving the presence experience. We found no difference between low and high plausibility in spatial presence. Subsequent equivalence tests showed that the group exposed to the implausible VE did not feel less present than the group exposed to the plausible VE. We discuss the findings of our studies in the light of our theoretical considerations and previous research.

Generation of a conditional Flpo/FRT mouse model expressing constitutively active TGF\u03b2 in fibroblasts

Transforming growth factor (TGFβ) is a secreted factor, which accumulates in tissues during many physio- and pathological processes such as embryonic development, wound healing, fibrosis and cancer. In order to analyze the effects of increased microenvironmental TGFβ concentration in vivo, we developed a conditional transgenic mouse model (Flpo/Frt system) expressing bioactive TGFβ in fibroblasts, a cell population present in the microenvironment of almost all tissues. To achieve this, we created the genetically-engineered [Fsp1-Flpo; FSFTGFβCA] mouse model. The Fsp1-Flpo allele consists in the Flpo recombinase under the control of the Fsp1 (fibroblast-specific promoter 1) promoter. The FSFTGFβCA allele consists in a transgene encoding a constitutively active mutant form of TGFβ (TGFβCA) under the control of a Frt-STOP-Frt (FSF) cassette. The FSFTGFβCA allele was created to generate this model, and functionally validated by in vitro, ex vivo and in vivo techniques. [Fsp1-Flpo; FSFTGFβCA] animals do not present any obvious phenotype despite the correct expression of TGFβCA transgene in fibroblasts. This [Fsp1-Flpo; FSFTGFβCA] model is highly pertinent for future studies on the effect of increased microenvironmental bioactive TGFβ concentrations in mice bearing Cre-dependent genetic alterations in other compartments (epithelial or immune compartments for instance). These dual recombinase system (DRS) approaches will enable scientists to study uncoupled spatiotemporal regulation of different genetic alterations within the same mouse, thus better replicating the complexity of human diseases.

Adoption of Multi-screen Multitasking in Young Generation of China

Presently, people are increasingly becoming screen jugglers and frequently involving multitasking through multiple screens. The current study is focused on explaining multi-screen multitasking behavior of the younger generation in China. People like to self-regulate their routine behaviors to be productive and organized. Recent research in social psychology suggests that self-regulation occurs both deliberately and intuitively. This dual system approach of self-regulation promotes the idea that both reflective and impulsive forces are involved in determining human behavior. Owing to this conception, the present research opted for a dual system approach of self-regulation as the theoretical basis. Empirical data has been collected from university students in China and a total of 345 responses have been used for the analysis which has been performed through structural equation modeling in SmartPLS 3.0. The results indicate that the factors of both deliberative and automatic self-regulation are effective in determining multi-screen multitasking behavior.

Prosodically controlled derivations in the mental lexicon

Abstract Swedish morphemes are classified as prosodically specified or prosodically unspecified, depending on lexical or phonological stress, respectively. Here, we investigate the allomorphy of the suffix -( i ) sk , which indicates the distinction between lexical and phonological stress; if attached to a lexically stressed morpheme, it takes a non-syllabic form (- sk ), whereas if attached to a phonologically stressed morpheme, an epenthetic vowel is inserted (- isk ). Using mismatch negativity (MMN), we explored the neural processing of this allomorphy across lexically stressed and phonologically stressed morphemes. In an oddball paradigm, participants were occasionally presented with congruent and incongruent derivations, created by the suffix -( i ) sk , within the repetitive presentation of their monomorphemic stems. The results indicated that the congruent derivation of the lexically stressed stem elicited a larger MMN than the incongruent sequences of the same stem and the derivational suffix, whereas after the phonologically stressed stem a non-significant tendency towards an opposite pattern was observed. We argue that the significant MMN response to the congruent derivation in the lexical stress condition is in line with lexical MMN, indicating a holistic processing of the sequence of lexically stressed stem and derivational suffix. The enhanced MMN response to the incongruent derivation in the phonological stress condition, on the other hand, is suggested to reflect combinatorial processing of the sequence of phonologically stressed stem and derivational suffix. These findings bring a new aspect to the dual-system approach to neural processing of morphologically complex words, namely the specification of word stress.