Summary The main object of this enquiry was to assess the success of 70-mm, film in the detection of tuberculous lesions. Integral to such an object were (i) assessments of the nature and magnitude of discrepancies by the same observer at different times and by different observers in judging such film: (ii) similar assessments in respect of large film: and (iii) the decision as to the presence and “true” nature of any lesion (“truth” session). The plan of the enquiry, moreover, has enabled us to contrast the advantages and disadvantages of different practices of film-reading and different procedures in recall of cases that might be introduced in routine radiographical work. The main results of the investigation were these: 1. Irrespective of size of film, variability ( i.e. , inconsistency in readings, regardless of “truth”) was appreciably lower in successive judgments by the same reader than it was between those of different readers. 2. Within-reader variability was nearly as great with large film as it was with small. Between-reader variability was, if anything, greater on large film than on small. 3. Accuracy ( i.e. , agreement with “truth”) was better in readings of large film than of small, but even on large-film readings loss of genuine cases was considerable. 4. Accuracy decreased when attempts at increased precision of diagnosis were made, and was especially low in attempted diagnosis of “activity” of lesions. 5. Accuracy was worse in the detection of minimal lesions than of “tuberculosis, other stage”; but inaccuracy in judgments of activity was striking, even with lesions more advanced than minimal. 6. Comparison of the relative efficacy in detecting positive cases by single and dual readings of film showed that the optimum results was obtained by independent dual reading together with follow-up of cases called positive on either or both readings; the worst by consideration only of those cases called positive on both readings. Dual small-film reading by two independent observers, with follow-up of disagreement as well as agreement cases, gave as good a result as did single large-film reading (though not as good as independent dual large-film reading). 7. With a combination of preliminary small-film screening and follow-up large-film diagnosis, the optimum procedure elicited less than 82 per cent. of active lesions and less than 86 per cent. of clinically significant lesions. 8. “False positive” readings were produced in as high a proportion of large-film readings as of small, whatever the method of reading. With dual reading, the increased pick-up of true cases was accompanied by an appreciable increase in false positives. In general, the methods prodcuing the more successful pick-up of genuine cases produced also a higher proportion of unnecessary recalls. 9. The frequency of “false positive” readings depends on the real incidence of tuberculosis in the population surveyed and also on the incidence therein of “difficult true negatives.” For this reason the proportions of “false positives” recorded here are not compared with those of previous investigations. 10. As a result of these initial findings, the following recommendations seem worthy of presentation here: No patient attending a chest clinic should be dismissed as normal unless, in addition to negative clinical findings, the chest X-ray has been scrutinised independently by two readers who both report no evidence of respiratory disorder. It is inadvisable to attempt the diagnosis of activity from X-rays, especially in the case of a minimal lesions. There is need for systematic training in the reading of films and for the investigation of the possibility of mechanical and objective aids to consistency in film reading. For mass surveys, small film could be used as efficiently as standard X-ray if “presence” of a lesion is taken as the only criterion and no attempt to assess significance or activity is made. In chest clinic work, the time and work involved in dual readings of small film followed by dual reading of large film for all recalled cases might be less economical than the use of large film from the outset.
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